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31. 发明授权

US06186972B1 Methods and apparatus for treating ischemic heart disease by providing transvenous myocardial perfusion 有权
标题翻译：通过提供经静脉心肌灌注治疗缺血性心脏病的方法和装置
公开(公告)号：US06186972B1
公开(公告)日：2001-02-13
申请号：US09208807
申请日：1998-12-09
申请人： James A. Nelson , Ascher Shmulewitz , John Burton
发明人： James A. Nelson , Ascher Shmulewitz , John Burton
IPC分类号： A61B1900
CPC分类号： A61B17/3478 , A61B17/320758 , A61B18/1492 , A61B2017/00252 , A61B2017/22077
摘要： Methods and apparatus for supplying retrograde perfusion of chronically ischemic myocardium by forming one or more transmural passageways between a cardiac chamber and the coronary venous vasculature. The placement, size and number of the passageways are selected, and portions of the venous vasculature or coronary ostium optionally partially or completely occluded, to maintain a parameter related to the pressure attained in the venous vasculature to a value less than a predetermined value.
摘要翻译：通过在心室和冠状静脉血管之间形成一个或多个透壁通道来供应慢性缺血心肌逆行灌注的方法和装置。选择通道的位置，大小和数量，并且静脉血管或冠状口的部分可选地部分或完全闭塞，以将与静脉脉管系统中获得的压力相关的参数保持在小于预定值的值。

32. 发明授权

US5655548A Method for treatment of ischemic heart disease by providing transvenous myocardial perfusion 失效
标题翻译：通过提供经静脉心肌灌注治疗缺血性心脏病的方法
公开(公告)号：US5655548A
公开(公告)日：1997-08-12
申请号：US714466
申请日：1996-09-16
申请人： James A. Nelson , Ascher Shmulewitz
发明人： James A. Nelson , Ascher Shmulewitz
IPC分类号： A61B17/00 , A61B17/32 , A61F2/02 , A61F2/06 , A61F2/94 , A61M25/00 , A61B19/00 , A61M1/10
CPC分类号： A61F2/94 , A61B17/320016 , A61F2/064 , A61F2/2493 , A61B2017/00247 , A61B2017/00252 , A61B2018/00392 , A61F2220/0016 , A61M25/0021 , A61M25/0075
摘要： Methods are provided for use in open surgical and transluminal methods for supplying long-term retrograde perfusion of the myocardium via a conduit disposed between the left ventricle and the coronary sinus. In a first method, an opening is formed between the left ventricle and the coronary sinus, and the coronary ostium is partially occluded using a stent that prevents the pressure in the coronary sinus from exceeding a predetermined value. In an alternative method, a first end of a conduit is inserted transeptally through the right atrium and obliquely into the posterior septal endocardium of the left ventricle via the posterior pyramidal space, while a second end of the conduit is inserted into the coronary sinus via the coronary ostium. A pressure-limiting valve is included in the conduit. In either method, the outlet from the left ventricle to the coronary sinus may include a one-way valve to prevent backflow from the coronary sinus into the left ventricle during cardiac diastole.
摘要翻译：提供了用于开放式外科和腔内方法的方法，用于通过设置在左心室和冠状窦之间的导管供应心肌的长期逆行灌注。在第一种方法中，在左心室和冠状窦之间形成开口，并且使用防止冠状窦压力超过预定值的支架部分闭塞冠状口。在替代方法中，导管的第一端通过右心房横切插入，并经由后金字塔形空间倾斜地插入左心室的后隔膜心内膜，而导管的第二端经由第二端插入冠状窦冠状口。管道中包括一个限压阀。在任一方法中，从左心室到冠状窦的出口可以包括单向阀，以防止心脏舒张期期间从冠状窦逆流到左心室。

33. 发明授权

US5610164A (Thiophen-2-yl)-piperidin or tetrahydropyridin azabicyclocarboxamides 失效
标题翻译：（噻吩-2-基） - 哌啶或四氢吡啶氮杂双环羧酰胺
公开(公告)号：US5610164A
公开(公告)日：1997-03-11
申请号：US685132
申请日：1996-07-24
申请人： Reinhardt B. Baudy , James A. Nelson , Mira A. Kanzelberger
发明人： Reinhardt B. Baudy , James A. Nelson , Mira A. Kanzelberger
IPC分类号： C07D451/02 , A61K31/435
CPC分类号： C07D451/02
摘要： This invention provides compounds having the structure ##STR1## wherein R is hydrogen, alkyl, alkenyl, alkynyl, --COR.sup.2, phenyl, or phenylalkyl; the dotted line represents an optional double bond;R.sup.1 is hydrogen, --OH, OR.sup.3, or is absent if the optional double bond is present;R.sup.2 and R.sup.3 are each, independently, alkyl, alkenyl, alkynyl, phenyl, or phenylalkyl;R.sup.4 is hydrogen, --OR.sup.5, alkyl, alkenyl, alkynyl, --COR.sup.5, --CO.sub.2 R.sup.5, --CONR.sup.5 R.sup.6, perhaloalkyl, halogen, phenyl, or phenylalkyl;R.sup.5 and R.sup.6 are each, independently, hydrogen, alkyl, alkenyl, alkynyl, phenyl, or phenylalkyl; andn=0-2or a pharmaceutically acceptable salt thereof that are useful as antipsychotic, antidepressant and anxiolytic agents useful in the treatment and relief of the symptoms of these disease states.
摘要翻译：本发明提供了具有结构“IMAGE”的化合物，其中R是氢，烷基，烯基，炔基，-COR 2，苯基或苯基烷基; 虚线表示可选的双键; R1是氢，-OH，OR3，如果存在任选的双键，则不存在; R2和R3各自独立地为烷基，烯基，炔基，苯基或苯基烷基; R 4是氢，-OR 5，烷基，烯基，炔基，-COR 5，-CO 2 R 5，-CONR 5 R 6，全卤代烷基，卤素，苯基或苯基烷基; R 5和R 6各自独立地为氢，烷基，烯基，炔基，苯基或苯基烷基; 和n = 0-2或其药学上可接受的盐，其可用作抗精神病药，抗抑郁药和抗焦虑剂，其用于治疗和缓解这些疾病状态。

34. 发明授权

US5459154A N-hydroxyureas as 5-lipoxygenase inhibitors and inhibitors of oxidative modification of low density lipoprotein 失效
标题翻译： N-羟基脲作为5-脂氧合酶抑制剂和低密度脂蛋白的氧化修饰抑制剂
公开(公告)号：US5459154A
公开(公告)日：1995-10-17
申请号：US148603
申请日：1993-11-08
申请人： Michael S. Malamas , James A. Nelson
发明人： Michael S. Malamas , James A. Nelson
IPC分类号： C07D263/32 , C07D277/24 , C07D277/30 , A61K31/42 , A61K31/425
CPC分类号： C07D263/32 , C07D277/24
摘要： This invention relates to compounds having 5-lipoxygenase inhibiting properties and inhibition of oxidative modification of low density lipoprotein which have the formula: ##STR1## wherein: R.sup.1 and R.sup.3 are independently hydrogen, halogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, trifluoromethyl, or C.sub.1 -C.sub.6 trifluoroalkoxy;R.sub.2 is hydrogen or methyl;R.sup.4 is hydrogen, methyl or hydroxy;R.sup.5 is hydrogen, --NH.sub.2, C.sub.1 -C.sub.6 alkyl, aryl, aralkyl, or --N.dbd.C(CH.sub.3).sub.2 ;X and Y are independently O or S;and n is 0 or 1; or a pharmaceutically acceptable salt thereof.Compounds which inhibit 5-lipoxygenase are useful in the treatment of diseases mediated by leukotrienes such as inflammation or bronchoconstriction. Compounds which inhibit oxidative metabolism of low density lipoprotein are useful in the inhibition of atherosclerotic plaque formation.
摘要翻译：本发明涉及具有5-脂氧合酶抑制性质和抑制低密度脂蛋白氧化修饰的化合物，其具有下式：其中：R1和R3独立地是氢，卤素，C1-C6烷基，C1-C6烷氧基，三氟甲基，或C 1 -C 6三氟烷氧基; R2是氢或甲基; R4是氢，甲基或羟基; R5是氢，-NH2，C1-C6烷基，芳基，芳烷基或-N = C（CH3）2; X和Y独立地为O或S; 并且n为0或1; 或其药学上可接受的盐。抑制5-脂氧合酶的化合物可用于治疗由白细胞三烯介导的疾病，例如炎症或支气管收缩。抑制低密度脂蛋白氧化代谢的化合物可用于抑制动脉粥样硬化斑块形成。

35. 发明授权

US5169944A Methods and compositions for the enteral administration of hepatobiliary MRI contrast agents 失效
标题翻译：肝胆MRI造影剂肠内给药的方法和组成
公开(公告)号：US5169944A
公开(公告)日：1992-12-08
申请号：US685083
申请日：1991-04-12
申请人： James A. Nelson , Udo P. Schmiedl , Linnar L. Teng , Jerry C. Bommer
发明人： James A. Nelson , Udo P. Schmiedl , Linnar L. Teng , Jerry C. Bommer
IPC分类号： A61K49/06 , A61K49/18 , G01R33/28
CPC分类号： G01R33/5601 , A61K49/06 , A61K49/1812 , Y10T436/24
摘要： Hepatobiliary magnetic resonance imaging of a human or animal subject is enhanced by enterally administering to the subject an effective amount of a lipophilic contrast enhancing agent. Representative contrast enhancing agents include manganese mesoporphyrin, manganese deuteroporphyrin, manganese pheophorbide and manganese pyrophenophoribide, and, when administered orally, an enteric delivery agent.
摘要翻译：通过向受试者进行有效量的亲脂性对比增强剂的肠道施用来增强人或动物受试者的肝胆管磁共振成像。代表性的对比增强剂包括锰中卟啉，锰氘卟啉，锰偏硼酸锰和焦苯丙酮酸锰，口服给药时，是肠道输送剂。

36. 发明授权

US4577222A Apparatus and method for cross sectional imaging of a body 失效
标题翻译：用于身体横截面成像的装置和方法
公开(公告)号：US4577222A
公开(公告)日：1986-03-18
申请号：US444613
申请日：1982-11-26
申请人： Robert A. Kruger , James A. Nelson
发明人： Robert A. Kruger , James A. Nelson
IPC分类号： A61B6/00 , A61B6/02 , G06T11/00 , H04N5/32
CPC分类号： A61B6/481 , A61B6/02 , A61B6/504 , G06T11/005
摘要： The disclosure is directed to a method and apparatus for generating a processed image of a cross-section through a body. Fluoroscopic tomography is achieved wherein a series of video frames of a cross-section of a body can be viewed in real time. In this manner, for example, one can monitor the progress of a bolus of contrast material moving through a blood vessel in the cross-section being viewed. In a form of the disclosure, a recorded series of frames of a principal plane of a body being imaged can be processed to obtain a corresponding series of frames that represent a plane of interest that is spaced from the principal plane, thereby avoiding the necessity of re-exposure for each new plane to be viewed. In accordance with the disclosed method, a body is disposed between a combination of a source of radiation and an associated detector, such that a beam of radiation from the source impinges angularly on the body and passes through to the detector. Relative rotational motion is effected between the beam and the body, such that a principal plane of interest in the body remains substantially in focus during the relative rotational motion. A series of frames of electronic video signals are derived from the detector, at different rotational positions, the frames representing images of the radiation transmission characteristics of the body at a series of successive times. The series of frames are temporally filtered and then displayed. In a preferred embodiment, the temporal filtering step comprises filtering the series of frames of video signals with a filter function having a temporal frequency response that corresponds substantially the temporal frequency of the movement of a bolus of contrast material through the region being imaged.
摘要翻译：本公开涉及一种用于通过身体产生横截面的经处理图像的方法和装置。实现了透视断层摄影，其中可以实时观看身体横截面的一系列视频帧。以这种方式，例如，可以监视在所观察的横截面中移动通过血管的大量造影剂的进展。以本公开的形式，可以处理正在成像的身体的主平面的记录的一系列帧，以获得表示与主平面间隔开的感兴趣平面的相应系列的帧，从而避免必要每次新飞机重新曝光要被观看。根据所公开的方法，身体设置在辐射源和相关联的检测器的组合之间，使得来自源的辐射束成角度地撞击在身体上并且通过到检测器。在梁和本体之间进行相对旋转运动，使得在相对旋转运动期间，主体中的感兴趣的主平面保持基本上聚焦。电子视频信号的一系列帧在不同的旋转位置处从检测器导出，这些帧代表身体在一系列连续时间的辐射传播特性的图像。一系列帧被时间过滤，然后显示。在优选实施例中，时间滤波步骤包括用具有时间频率响应的滤波器函数对视频信号的一系列帧进行滤波，该时间频率响应基本上对应于通过所成像的区域的大量对比材料的运动的时间频率。

37. 发明授权

US4351333A Peritoneal fluid treatment apparatus, package and method 失效
公开(公告)号：US4351333A
公开(公告)日：1982-09-28
申请号：US181219
申请日：1980-08-22
申请人： Harrison Lazarus , James A. Nelson
发明人： Harrison Lazarus , James A. Nelson
IPC分类号： A61B17/34 , A61B19/02 , A61M25/00 , A61M25/01 , A61M5/00
CPC分类号： A61M25/0111 , A61B17/3415 , A61B50/33 , A61M25/002
摘要： The cannula of a conventional intravascular catheter is placed into the peritoneal cavity through a small shallow incision in antiseptically prepared skin. The stylet or trocar of the conventional catheter is removed; and a stainless steel elongated flexible guide is inserted through the catheter's cannula into the peritoneal cavity. The catheter's cannula is removed and a flexible elongated cannula inserted into the cavity over the guide and secured in place with a suture. Fluid operation means is connected to the elongated cannula by connector means to permit fluid treatment after removal of the guide. Apparatus to effect peritoneal fluid treatment are placed in sterile openable sealed packages for storage and transport.

38. 发明申请

US20100106236A1 Self Cleaning Catheter and Methods of Use Thereof 有权
标题翻译：自清洁导管及其使用方法
公开(公告)号：US20100106236A1
公开(公告)日：2010-04-29
申请号：US12373854
申请日：2007-07-13
申请人： James A. Nelson
发明人： James A. Nelson
IPC分类号： A61M25/00 , A61M16/04 , A61F2/84
CPC分类号： A61M25/00
摘要： An improved catheter is provided for insertion into a trachea, blood vessel, bladder or urinary tract of a patient. The self cleaning catheter can be easily inserted and removed from the patient without retained, solid components falling into a patient's trachea, blood vessels, bladder, or urinary tract when the catheter is removed from the patient. The self cleaning catheter has a flexible cylindrical sleeve on the exterior of a cylindrical member that can be withdrawn to the interior of the catheter prior to removal from the patient's body. Alternatively, the catheter has a design allowing an end of the catheter to fold inward on itself prior to removal from the patient's body.
摘要翻译：提供改进的导管用于插入患者的气管，血管，膀胱或泌尿道。当导管从患者身上取出时，自清洁导管可以容易地从患者插入和取出，而没有保留的固体组分落入病人的气管，血管，膀胱或尿道。自清洁导管在圆柱形构件的外部具有柔性圆柱形套筒，其可以在从患者身体移除之前被抽出到导管内部。或者，导管具有允许导管的端部在从患者身体移除之前向内折叠的设计。

39. 发明授权

US07271163B2 Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives 失效
标题翻译：环戊基[b] [1,4]二氮杂[6,7,1-hi]吲哚及其衍生物
公开(公告)号：US07271163B2
公开(公告)日：2007-09-18
申请号：US10898029
申请日：2004-07-23
申请人： Annmarie L. Sabb , Robert L. Vogel , James A. Nelson , Sharon J. Rosenzweig-Lipson , Gregory S. Welmaker , Joan E. Sabalski
发明人： Annmarie L. Sabb , Robert L. Vogel , James A. Nelson , Sharon J. Rosenzweig-Lipson , Gregory S. Welmaker , Joan E. Sabalski
IPC分类号： A61K31/55 , A61P25/00 , A61P25/24 , C07D243/00
CPC分类号： C07D209/94 , A61K31/55 , C07D487/06
摘要： This invention provides compounds of the formulae: wherein: R1 is hydrogen, —C(O)CH3 or alkyl of 1-6 carbon atoms; R2 and R3 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, cycloalkyl, alkoxy of 1-6 carbon atoms, —CH2OH, fluoroalkyl, alkyl sulfonamide of 1-6 carbon atoms, alkyl amide of 1-6 carbon atoms, amino, alkylamino of 1-6 carbon atoms, dialkylamino of 1-6 carbon atoms per alkyl moiety, fluoroalkoxy of 1-6 carbon atoms, acyl of 2-7 carbon atoms, aryl, or aroyl; R4 and R5 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, halogen, fluoroalkyl, —CN, alkyl sulfonamide of 1-6 carbon atoms, alkyl amide of 1-6 carbon atoms, amino, alkylamino of 1-6 carbon atoms, dialkylamino of 1-6 carbon atoms per alkyl moiety, fluoroalkoxy of 1-6 carbon atoms, acyl of 2-7 carbon atoms, or aroyl; R6 and R7 are each independently hydrogen, C1-C6 alkyl or cycloalkyl; or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions containing these compounds and methods for their use, including treatment of obsessive-compulsive disorder, panic disorder, depression, anxiety, generalized anxiety disorder, schizophrenia, migraine, sleep disorders, eating disorders, obesity, epilepsy, and spinal cord injury.
摘要翻译：本发明提供下式的化合物：其中：R 1是氢，-C（O）CH 3或1-6个碳原子的烷基; R 2和R 3各自独立地为氢，1-6个碳原子的烷基，环烷基，1-6个碳原子的烷氧基，-CH 2 1-6个碳原子的烷基磺酰胺，1-6个碳原子的烷基酰胺，1-6个碳原子的烷基氨基，1-6个碳原子的烷基氨基，每个烷基部分1-6个碳原子的二烷基氨基，1个碳原子的氟代烷氧基 -6个碳原子，2-7个碳原子的酰基，芳基或芳酰基; R 4和R 5各自独立地为氢，1-6个碳原子的烷基，1-6个碳原子的烷氧基，卤素，氟烷基，-CN，烷基 1-6个碳原子的磺酰胺，1-6个碳原子的烷基酰胺，1-6个碳原子的烷基氨基，每个烷基部分1-6个碳原子的二烷基氨基，1-6个碳原子的氟烷氧基，2- 7个碳原子或芳酰基; R 6和R 7各自独立地为氢，C 1 -C 6烷基或环烷基; 或其药学上可接受的盐，以及含有这些化合物的药物组合物及其使用方法，包括治疗强迫症，恐慌症，抑郁症，焦虑症，广泛性焦虑症，精神分裂症，偏头痛，睡眠障碍，进食障碍，肥胖，癫痫和脊髓损伤。

40. 发明授权

US5806129A Paint roller assembly with lock equipped end member 失效
标题翻译：油漆滚筒组件带锁定端部构件
公开(公告)号：US5806129A
公开(公告)日：1998-09-15
申请号：US714015
申请日：1996-09-11
申请人： James A. Nelson
发明人： James A. Nelson
IPC分类号： B05C17/02
CPC分类号： B05C17/02
摘要： A paint roller assembly includes a wire frame having a spindle on which a wire cage is rotatably mounted with end mounting bearing members. An outermost bearing member includes an annular wall provided with a flexible arm having a stop at its distal end. The stop normally abuts an end of a tubular paint roller to lock same against lengthwise movement. A paint barrier on the bearing member defines an area for momentary reception of the arm and stop during roller removal and installation procedures.
摘要翻译：漆辊组件包括具有主轴的线框架，线架可旋转地安装有端部安装轴承部件。最外面的轴承构件包括设置有在其远端具有止动件的柔性臂的环形壁。止动件通常邻接管状油漆辊的端部以将其相对于纵向运动锁定。轴承构件上的油漆屏障限定了在滚筒拆卸和安装过程中暂时接收臂的位置并停止。

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