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31. 发明申请

US20100316624A1 TREATMENT OF FIBROSES AND LIVER DISORDERS 审中-公开
标题翻译：治疗肝硬化和肝脏疾病
公开(公告)号：US20100316624A1
公开(公告)日：2010-12-16
申请号：US12808859
申请日：2008-12-22
申请人： Hans Loibner , Manfred Schuster
发明人： Hans Loibner , Manfred Schuster
IPC分类号： A61K38/48 , A61K31/7088 , C12N9/48 , C07H21/00 , A61P1/16 , A61P11/00 , A61P21/00 , A61P19/04 , A61P17/00 , A61P13/12
CPC分类号： A61K38/4813 , A01K67/0276 , A01K2207/30 , A01K2217/075 , A01K2227/105 , A01K2227/108 , A01K2267/03 , A01K2267/0368 , A61K48/00 , C12N9/48
摘要： The present invention relates to ACE2 for the therapeutic treatment or prevention of a fibrosis or liver disorder.
摘要翻译：本发明涉及用于治疗或预防纤维化或肝脏疾病的ACE2。

32. 发明申请

US20100310546A1 ACE2 Polypeptide 有权
标题翻译： ACE2多肽
公开(公告)号：US20100310546A1
公开(公告)日：2010-12-09
申请号：US12664641
申请日：2008-06-12
申请人： Manfred Schuster , Hans Loibner , Evelyne Janzek-Hawlat , Bernhard Peball , Stefan Stranner , Bettina Wagner , Robert Weik
发明人： Manfred Schuster , Hans Loibner , Evelyne Janzek-Hawlat , Bernhard Peball , Stefan Stranner , Bettina Wagner , Robert Weik
IPC分类号： A61K38/48 , C12N5/10 , C12N9/48
CPC分类号： A61K38/4813 , A61K38/00 , C07K14/70596 , C12N9/48 , C12N9/64
摘要： The present invention relates to recombinant ACE2 polypeptide, where the ACE2 polypeptide is present as a dimer. The dimer is formed specifically from glycosylated monomers and is used for producing pharmaceutical products with an extended half-life.
摘要翻译：本发明涉及重组ACE2多肽，其中ACE2多肽作为二聚体存在。二聚体特异性地由糖基化单体形成，并用于生产延长半衰期的药物产品。

33. 发明申请

US20060018901A1 Use of antibodies in a very low dose for the vaccination against cancer 审中-公开
标题翻译：以非常低的剂量使用抗体来预防癌症
公开(公告)号：US20060018901A1
公开(公告)日：2006-01-26
申请号：US11185299
申请日：2005-07-20
申请人： Hans Loibner , Gottfried Himmler , Manfred Schuster
发明人： Hans Loibner , Gottfried Himmler , Manfred Schuster
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , A61K2039/505 , A61K2039/545 , A61K2039/55505
摘要： The use of an antibody directed against the cellular membrane antigen EpCAM for the production of a pharmaceutical preparation for the prophyactic and/or therapeutic active immunization against cancer is provided whereby the antibody is in an amount of 1 ng to 9 μg.
摘要翻译：提供了针对细胞膜抗原EpCAM的抗体用于制备用于针对癌症的前列腺和/或治疗性主动免疫的药物制剂，其中所述抗体的量为1ng至9ug。

34. 发明申请

US20050181475A1 Immunogenic monoclonal antibody 审中-公开
标题翻译：免疫原性单克隆抗体
公开(公告)号：US20050181475A1
公开(公告)日：2005-08-18
申请号：US10514529
申请日：2003-05-15
申请人： Hans Loibner , Gunter Waxenecker , Gottfried Himmler , Helmut Eckert , Manfred Schuster , Ralf Kircheis
发明人： Hans Loibner , Gunter Waxenecker , Gottfried Himmler , Helmut Eckert , Manfred Schuster , Ralf Kircheis
IPC分类号： A61K39/00 , A61K47/48 , C07K16/30 , C07K16/42 , C12P21/06 , A61K39/395 , C07H21/04 , C12N5/06
CPC分类号： A61K39/0011 , A61K47/68 , A61K2039/6056 , C07K16/30 , C07K16/4266
摘要： The invention relates to an immunogenic antibody which comprises at least two different epitopes of a tumor-associated antigen.
摘要翻译：本发明涉及包含肿瘤相关抗原的至少两个不同表位的免疫原性抗体。

35. 发明授权

US06351505B1 Method for determining the frequency of a signal 有权
标题翻译：用于确定信号频率的方法
公开(公告)号：US06351505B1
公开(公告)日：2002-02-26
申请号：US09170200
申请日：1998-10-13
申请人： Franz Herrmann , Manfred Schuster
发明人： Franz Herrmann , Manfred Schuster
IPC分类号： H04B110
CPC分类号： G01R23/02 , G01R23/167
摘要： A method for determining a frequency of a signal includes transforming the analog signal to the complex frequency range through a digital filtering, preferably a FFT, so that result vectors with amplitude and phase components are generated in the frequency range. As a result, a continuous sequence of transformation intervals (FFT intervals) develops within a measuring interval that can be predetermined. Subsequently, pairs of result vectors, which belong to the same predetermined frequency, are selected from predetermined transformation intervals (FFT intervals). Associated phase differences are then formed from which a weighted phase difference is determined. The weighted phase difference is used to correct the signal frequency determined from the amplitude spectrum. This method permits very accurate frequency measuring, especially for pulsed HF signals.
摘要翻译：用于确定信号频率的方法包括通过数字滤波（优选FFT）将模拟信号变换到复频率范围，使得在频率范围内产生具有幅度和相位分量的结果矢量。结果，在可以预定的测量间隔内产生连续的变换间隔序列（FFT间隔）。随后，从预定的变换间隔（FFT间隔）中选择属于相同预定频率的结果向量对。然后形成相关的相位差，由此确定加权相位差。加权相位差用于校正从振幅谱确定的信号频率。该方法允许非常精确的频率测量，特别是脉冲HF信号。

36. 发明授权

US5052034A X-ray generator 失效
标题翻译： X光发生器
公开(公告)号：US5052034A
公开(公告)日：1991-09-24
申请号：US604951
申请日：1990-10-29
申请人： Manfred Schuster
发明人： Manfred Schuster
IPC分类号： H01J35/08 , H01J35/10 , H01J35/12
CPC分类号： H01J35/08 , H01J35/10 , H01J35/12 , H01J2235/082
摘要： An X-ray generator has an anode formed by an electrically conductive fluid having a flat surface on which focused electrons are incident, so that X-rays are generated at a solid angle with respect to the surface, with .alpha..sub.2C being the critical angle of total reflection. For enhancing the spectral brilliance of the X-rays, a method and apparatus are disclosed wherein X-rays at a specific angle .alpha..sub.2 are tapped (the "tap angle"), with .alpha..sub.2 satisfying the condition .alpha..sub.2C
摘要翻译： X射线发生器具有由导电流体形成的阳极，该导电流体具有聚焦电子入射的平坦表面，使得相对于表面以立体角产生X射线，其中α2C为临界角全反射为了提高X射线的光谱亮度，公开了一种方法和装置，其中以特定角度α2的X射线被敲击（“抽头角”），其中α2满足条件α2C <α2<3 α2C。

37. 发明授权

US4973964A Method for orienting a radar installation against a target 失效
标题翻译：将雷达装置对准目标的方法
公开(公告)号：US4973964A
公开(公告)日：1990-11-27
申请号：US469289
申请日：1990-01-24
申请人： Manfred Schuster
发明人： Manfred Schuster
IPC分类号： G01S7/40 , G01S13/68
CPC分类号： G01S13/68 , G01S2007/4086 , G01S7/4026
摘要： A method for orienting a radar installation which possesses an at least approximatingly axial-symmetrical antenna radiation or beam characteristic towards a target. The radar beam which is emitted by the radar installation is reflected or scattered back at the target and the backscattered radar beam is evaluated or plotted in a measurement evaluating device of the radar installation for purposes of determining or identifying the target. Employed is a target with three target elements which are arranged in the corners of an at least approximately equilateral triangle, the centerpoint of which corresponds to the desired target point, in which there is effected a separating of the three radar signals which are reflected or scattered back by the three target elements, and that from the values of the amplitudes of the three backscattered radar signals, through the utilization of the measurement evaluating circuit, there is determined the position of the target point which is located between the target elements.
摘要翻译：一种用于定向雷达装置的方法，其具有至少近似于轴对称的天线辐射或射束特性朝向目标。由雷达装置发射的雷达波束被反射或散射回目标，并且背光散射的雷达波束被评估或绘制在雷达装置的测量评估装置中以便确定或识别目标。使用的是具有三个目标元素的目标，其被布置在至少近似等边三角形的角落中，其中心点对应于期望的目标点，其中实现了被反射或分散的三个雷达信号的分离通过三个目标元件返回，并且从三个背向散射雷达信号的振幅的值通过使用测量评估电路，确定位于目标元件之间的目标点的位置。

38. 发明授权

US09051577B2 Glyco-engineered antibodies 有权
标题翻译：糖精工程抗体
公开(公告)号：US09051577B2
公开(公告)日：2015-06-09
申请号：US12373268
申请日：2007-07-11
申请人： Manfred Schuster , Ralf Kircheis , Andreas Nechansky , Wolfgang Jost , Gilbert Gorr
发明人： Manfred Schuster , Ralf Kircheis , Andreas Nechansky , Wolfgang Jost , Gilbert Gorr
IPC分类号： C12N15/82 , C07K16/00 , C07K16/28
CPC分类号： C07K16/283 , C07K16/00 , C07K2317/14 , C07K2317/41 , C07K2317/52 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C12N15/8258
摘要： The present invention relates to an antibody preparation comprising modified antibodies of an animal or derivatives or fragments thereof, specific for an antigen, characterized in that • the antibodies or derivatives or fragments thereof comprise an N-glycan structure free of fucose and xylose, and • at least 90%, preferably at least 95%, more preferred at least 99%, most preferred at least 100% of the modified antibodies, derivatives or fragments thereof lack a C-terminal lysine residue.
摘要翻译：本发明涉及包含对抗原特异性的动物或其衍生物或其片段的修饰抗体的抗体制剂，其特征在于：抗体或其衍生物或片段包含不含岩藻糖和木糖的N-聚糖结构，和至少90％，优选至少95％，更优选至少99％，最优选至少100％的修饰抗体，其衍生物或片段缺少C-末端赖氨酸残基。

39. 发明申请

US20150139942A1 Method for Tretaing a GD2 Positive Cancer 有权
标题翻译： GD2阳性癌症的治疗方法
公开(公告)号：US20150139942A1
公开(公告)日：2015-05-21
申请号：US14409161
申请日：2012-07-31
申请人： Hans Loibner , Manfred Schuster , Evelyne Janzek-Hawlat , Susanne Wiederkum , Bernhard Peball , Stefan Stranner , Oliver Mutschlechner , Franz Groiss , Ruth Ladenstein , Holger Lode
发明人： Hans Loibner , Manfred Schuster , Evelyne Janzek-Hawlat , Susanne Wiederkum , Bernhard Peball , Stefan Stranner , Oliver Mutschlechner , Franz Groiss , Ruth Ladenstein , Holger Lode
IPC分类号： C07K16/30 , A61K31/485 , A61K39/395 , A61K45/06
CPC分类号： C07K16/3084 , A61K31/485 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/24 , C07K2317/734 , C07K2317/76 , A61K2300/00
摘要： The present invention relates to a method for treating a GD2 positive cancer by administering a preparation comprising an anti-GD2 antibody to a patient as a continuous intravenous infusion over 24 hours per day.
摘要翻译：本发明涉及一种治疗GD2阳性癌症的方法，其通过以每天24小时连续静脉内输注给患者施用包含抗GD2抗体的制剂。

40. 发明授权

US08034338B2 Immunogenic recombinant antibody 有权
标题翻译：免疫原性重组抗体
公开(公告)号：US08034338B2
公开(公告)日：2011-10-11
申请号：US10552324
申请日：2004-04-16
申请人： Hans Loibner , Gottfried Himmler , Günter Waxenecker , Manfred Schuster , Thomas Putz
发明人： Hans Loibner , Gottfried Himmler , Günter Waxenecker , Manfred Schuster , Thomas Putz
IPC分类号： A61P39/00 , C07K16/42 , C12N15/63 , C12P21/08 , A61K39/395 , C12N1/00
CPC分类号： C07K16/42 , A61K2039/505 , C07K2317/52 , C07K2319/00
摘要： The invention refers to an immunogenic recombinant antibody designed for immunization of primates comprising at least a part of a murine IgG2a subtype amino acid sequence and a mammalian glycosylation.
摘要翻译：本发明涉及设计用于免疫含有至少一部分鼠IgG2a亚型氨基酸序列和哺乳动物糖基化的灵长类动物的免疫原性重组抗体。

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