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31. 发明授权

US5858457A Process to form mesostructured films 失效
标题翻译：形成介孔结构膜的方法
公开(公告)号：US5858457A
公开(公告)日：1999-01-12
申请号：US937407
申请日：1997-09-25
申请人： C. Jeffrey Brinker , Mark T. Anderson , Rahul Ganguli , Yunfeng Lu
发明人： C. Jeffrey Brinker , Mark T. Anderson , Rahul Ganguli , Yunfeng Lu
IPC分类号： B01J29/04 , B01D71/02 , B01J29/03 , C01B37/00 , C01B37/02 , C01B39/02 , C04B38/00 , C04B41/45 , C09C1/30 , C23C18/12 , B05D5/06
CPC分类号： C09C1/3063 , B01D67/0048 , B01D67/0083 , B01D71/024 , B01D71/025 , B01J29/0308 , C01B37/00 , C01B37/02 , C04B38/0054 , C04B41/009 , C04B41/4582 , C09C1/3045 , C23C18/1216 , C23C18/1254 , B01D2323/08 , B01D2323/14 , B01D2323/50 , B01D2325/023 , B01D2325/26 , C01P2002/72 , C04B2111/00801 , C04B2111/0081
摘要： This invention comprises a method to form a family of supported films film with pore size in the approximate range 0.8-20 nm exhibiting highly ordered microstructures and porosity derived from an ordered micellar or liquid-crystalline organic-inorganic precursor structure that forms during film deposition. Optically transparent, 100-500-nm thick films exhibiting a unique range of microstructures and uni-modal pore sizes are formed in seconds in a continuous coating operation. Applications of these films include sensors, membranes, low dielectric constant interlayers, anti-reflective coatings, and optical hosts.
摘要翻译：本发明包括一种形成孔径在大约0.8-20nm范围内的负载膜薄膜族的方法，其表现出高度有序的微结构和孔隙率，其衍生自在膜沉积期间形成的有序胶束或液晶有机 - 无机前体结构。在连续涂布操作中，在几秒钟内形成光学透明的100-500nm厚的薄膜，其具有独特的微结构范围和单一孔径。这些膜的应用包括传感器，膜，低介电常数中间层，抗反射涂层和光学主机。

32. 发明授权

US5122305A Solid-state radiation-emitting compositions and devices 失效
标题翻译：固态辐射发射组合物和装置
公开(公告)号：US5122305A
公开(公告)日：1992-06-16
申请号：US495580
申请日：1990-03-20
申请人： Carol S. Ashley , C. Jeffrey Brinker , Scott Reed , Timothy J. Shepodd , Leroy E. Leonard , Robert E. Ellefson , John T. Gill , Robert J. Walko , Clifford L. Renschler
发明人： Carol S. Ashley , C. Jeffrey Brinker , Scott Reed , Timothy J. Shepodd , Leroy E. Leonard , Robert E. Ellefson , John T. Gill , Robert J. Walko , Clifford L. Renschler
IPC分类号： C09K11/04 , G21H3/02
CPC分类号： C09K11/04 , G21H3/02
摘要： The invention relates to a composition for the volumetric generation of radiation, wherein a first substance functions as a source of exciting radiation, and a second substance interacts with the exciting radiation to provide a second radiation. The compositions comprise a porous substrate which is loaded with: a source of exciting radiation, a component capable of emitting radiation upon interaction with the exciting radiation, or both. In the composition, a composite is formed from a carrier material and at least one of the source of the exciting radiation or the component which is capable of interacting with the exciting radiation. The composite is then employed for loading a porous substrate, preferably an aerogel substrate.
摘要翻译：本发明涉及一种用于辐射体积产生的组合物，其中第一物质用作激发辐射源，第二物质与激发辐射相互作用以提供第二辐射。组合物包括多孔基底，其加载有：激发辐射源，能够与激发辐射相互作用时发射辐射的成分，或两者。在组合物中，由载体材料和能够与激发辐射相互作用的激发辐射源或组分中的至少一个形成复合材料。然后将复合材料用于装载多孔基材，优选气凝胶基质。

33. 发明申请

US20180169009A1 NANOBIOCOMPOSITE COMPOSITIONS AND METHODS 审中-公开
公开(公告)号：US20180169009A1
公开(公告)日：2018-06-21
申请号：US15577572
申请日：2016-06-01
申请人： Patrick JOHNSON , C. Jeffrey BRINKER , Eric CARNES , Graham TIMMINS , Pavan MUTTIL , STC.UNM
发明人： Patrick Johnson , C. Jeffrey Brinker , Eric Carnes , Graham Timmins , Pavan Muttil
IPC分类号： A61K9/00 , A61K9/16 , A61K47/54 , C08L23/22 , A61K9/12 , A61K9/127
CPC分类号： A61K9/0073 , A61K9/12 , A61K9/1271 , A61K9/1617 , A61K47/543 , C08L23/22
摘要： This disclosure describes compositions, vaccine, and methods that involve a biocomposite material Generally, the biocomposite material includes a cell and a lipid-silica matrix at least partially encapsulating the cell. In some cases, the cell can be viable but not culturable (VBNC). In some cases, the lipid-silica matrix includes a dried sol and/or possesses ordered nanostructure.

34. 发明授权

US09579283B2 Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same 有权
标题翻译：用于靶向递送的多孔纳米颗粒支持的脂质双层（原细胞）及其使用方法
公开(公告)号：US09579283B2
公开(公告)日：2017-02-28
申请号：US14113371
申请日：2012-04-27
申请人： C. Jeffrey Brinker , Eric C. Carnes , Carlee Erin Ashley , Cheryl L. Willman
发明人： C. Jeffrey Brinker , Eric C. Carnes , Carlee Erin Ashley , Cheryl L. Willman
IPC分类号： A61K9/127 , A61K31/704 , A61K31/711 , A61K45/06 , A61K47/48 , C07K14/47 , C12N15/88 , A61K33/24 , A61K39/05 , C12N15/113 , A61K38/00 , A61K48/00
CPC分类号： A61K9/1271 , A61K31/704 , A61K31/711 , A61K33/24 , A61K38/00 , A61K39/05 , A61K45/06 , A61K47/62 , A61K47/6901 , A61K48/0016 , C07K14/47 , C12N15/1135 , C12N15/88 , C12N2310/14 , C12N2320/32 , C12N2810/40
摘要： The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g. siRNA or a protein toxin such as ricin toxin A-chain or diphtheria toxin A-chain) and/or a histone-packaged plasmid DNA disposed within the nanoporous silica core (preferably supercoiled in order to more efficiently package the DNA into protocells) which is optionally modified with a nuclear localization sequence to assist in localizing protocells within the nucleus of the cancer cell and the ability to express peptides involved in therapy (apoptosis/cell death) of the cancer cell or as a reporter, a targeting peptide which targets cancer cells in tissue to be treated such that binding of the protocell to the targeted cells is specific and enhanced and a fusogenic peptide that promotes endosomal escape of protocells and encapsulated DNA. Protocells according to the present invention may be used to treat cancer, especially including hepatocellular (liver) cancer using novel binding peptides (c-MET peptides) which selectively bind to hepatocellular tissue or to function in diagnosis of cancer, including cancer treatment and drug discovery.
摘要翻译：本发明涉及用于特异性靶向肝细胞和其它癌细胞的原细胞，其包含具有支持的脂质双层的纳米多孔二氧化硅核心; 至少一种促进癌细胞死亡的药物（例如传统的小分子，大分子货物（例如siRNA或蛋白质毒素如蓖麻毒素A链或白喉毒素A链）和/或组蛋白包装的质粒DNA 设置在纳米多孔硅芯内（优选超螺旋以更有效地将DNA包装到原细胞中），其任选地用核定位序列修饰以帮助定位癌细胞核内的原细胞，以及表达参与治疗的肽的能力（凋亡/细胞死亡）或作为报告物，靶向肽靶向待治疗的组织中的癌细胞，使得原细胞与靶细胞的结合是特异性和增强的，并且促进内体逃逸的融合肽原细胞和包封的DNA。根据本发明的原细胞可用于治疗癌症，特别是包括肝细胞（肝）癌症选择性结合肝细胞组织或在癌症诊断中起作用的新型结合肽（c-MET肽），包括癌症治疗和药物发现。

35. 发明授权

US08992984B1 Protocells and their use for targeted delivery of multicomponent cargos to cancer cells 有权
标题翻译：原核细胞及其用于将多组分货物靶向递送至癌细胞的用途
公开(公告)号：US08992984B1
公开(公告)日：2015-03-31
申请号：US12909572
申请日：2010-10-21
申请人： C. Jeffrey Brinker , Carlee Erin Ashley , Xingmao Jiang , Juewen Liu , David S. Peabody , Walker Richard Wharton , Eric Carnes , Bryce Chackerian , Cheryl L. Willman
发明人： C. Jeffrey Brinker , Carlee Erin Ashley , Xingmao Jiang , Juewen Liu , David S. Peabody , Walker Richard Wharton , Eric Carnes , Bryce Chackerian , Cheryl L. Willman
IPC分类号： A61K9/14 , A61K9/51
CPC分类号： A61K9/127 , A61K9/1277 , A61K9/5115 , A61K9/5123 , A61K31/513 , A61K31/575 , A61K31/704 , A61K33/24 , A61K49/005
摘要： Various embodiments provide materials and methods for synthesizing protocells for use in targeted delivery of cargo components to cancer cells. In one embodiment, the lipid bilayer can be fused to the porous particle core to form a protocell. The lipid bilayer can be modified with targeting ligands or other ligands to achieve targeted delivery of cargo components that are loaded within the protocell to a target cell, e.g., a type of cancer. Shielding materials can be conjugated to the surface of the lipid bilayer to reduce undesired non-specific binding.
摘要翻译：各种实施方案提供用于合成原细胞以用于向癌细胞靶向递送货物组分的材料和方法。在一个实施方案中，脂质双层可以与多孔颗粒核心融合以形成原细胞。脂质双层可以用靶向配体或其他配体进行修饰，以实现载体在原细胞内的货物组分的靶向递送到靶细胞，例如一种类型的癌症。屏蔽材料可以结合到脂质双层的表面以减少不期望的非特异性结合。

36. 发明授权

US08501057B1 Freezing assisted fabrication of nano and micro hollow cubic metal oxides 有权
标题翻译：冷冻辅助制造纳米和微型中空立方体氧化物
公开(公告)号：US08501057B1
公开(公告)日：2013-08-06
申请号：US13010121
申请日：2011-01-20
申请人： Xingmao Jiang , C. Jeffrey Brinker
发明人： Xingmao Jiang , C. Jeffrey Brinker
IPC分类号： B29C35/02
CPC分类号： C01B33/163 , B82Y30/00 , C01B13/328 , C01P2004/38 , C01P2004/62 , C01P2004/64
摘要： Various embodiments provide materials and methods of forming hollow cubes. The hollow cubes can be formed to include a metal oxide shell layer encasing a cubic hollow space. In one embodiment, the hollow cubes can be formed from an emulsion having aqueous droplets with an interfacial layer encasing an aqueous core. By an exemplary freezing treatment, the aqueous droplets having a spherical shape can be transformed into ice components having a cubic shape. Metal oxide precursors can then be added to react with the encased cube-shaped ice core at the interface with the interfacial layer to form a sol-gel metal oxide shell layer. Hollow cubes can be formed by removing the cube-shaped ice core from the sol-gel metal oxide shell layer.
摘要翻译：各种实施例提供了形成中空立方体的材料和方法。中空立方体可以形成为包括包围立方中空空间的金属氧化物壳层。在一个实施例中，中空立方体可以由具有包含水性芯的界面层的水性液滴的乳液形成。通过示例性的冷冻处理，具有球形形状的水滴可以转变成具有立方体形状的冰组分。然后可以加入金属氧化物前体以与包封的立方体冰芯在与界面层的界面处反应以形成溶胶 - 凝胶金属氧化物壳层。可以通过从溶胶 - 凝胶金属氧化物壳层去除立方体状的冰芯来形成空心立方体。

37. 发明授权

US08187678B2 Ultra-thin microporous/hybrid materials 有权
标题翻译：超细微孔/混合材料
公开(公告)号：US08187678B2
公开(公告)日：2012-05-29
申请号：US12271719
申请日：2008-11-14
申请人： Ying-Bing Jiang , Joseph L. Cecchi , C. Jeffrey Brinker
发明人： Ying-Bing Jiang , Joseph L. Cecchi , C. Jeffrey Brinker
IPC分类号： H05H1/00 , H05H1/24 , C04B41/00 , C23C16/00
CPC分类号： B01D69/122 , B01D67/0002 , B01D67/0079 , B01D67/0083 , B01D67/009 , B01D69/148 , C23C16/401 , C23C16/45536 , C23C16/45555 , Y10T428/24521 , Y10T428/24545 , Y10T428/249953
摘要： Ultra-thin hybrid and/or microporous materials and methods for their fabrication are provided. In one embodiment, the exemplary hybrid membranes can be formed including successive surface activation and reaction steps on a porous support that is patterned or non-patterned. The surface activation can be performed using remote plasma exposure to locally activate the exterior surfaces of porous support. Organic/inorganic hybrid precursors such as organometallic silane precursors can be condensed on the locally activated exterior surfaces, whereby ALD reactions can then take place between the condensed hybrid precursors and a reactant. Various embodiments can also include an intermittent replacement of ALD precursors during the membrane formation so as to enhance the hybrid molecular network of the membranes.
摘要翻译：提供了超薄混合和/或微孔材料及其制造方法。在一个实施方案中，可以形成示例性混合膜，包括在图案化或非图案化的多孔载体上的连续表面活化和反应步骤。表面活化可以使用远程等离子体暴露来局部激活多孔载体的外表面。有机/无机混合前体例如有机金属硅烷前体可以在局部活化的外表面上缩合，由此ALD反应可以在冷凝的杂化前体和反应物之间进行。各种实施方案还可以包括在膜形成期间ALD前体的间歇替代，以增强膜的杂合分子网络。

38. 发明授权

US08092595B1 Self-assembly of water-soluble nanocrystals 有权
标题翻译：水溶性纳米晶体的自组装
公开(公告)号：US08092595B1
公开(公告)日：2012-01-10
申请号：US12038037
申请日：2008-02-27
申请人： Hongyou Fan , C. Jeffrey Brinker , Gabriel P. Lopez
发明人： Hongyou Fan , C. Jeffrey Brinker , Gabriel P. Lopez
IPC分类号： C30B7/04
CPC分类号： C30B7/14 , C30B29/68
摘要： A method for forming an ordered array of nanocrystals where a hydrophobic precursor solution with a hydrophobic core material in an organic solvent is added to a solution of a surfactant in water, followed by removal of a least a portion of the organic solvent to form a micellar solution of nanocrystals. A precursor co-assembling material, generally water-soluble, that can co-assemble with individual micelles formed in the micellar solution of nanocrystals can be added to this micellar solution under specified reaction conditions (for example, pH conditions) to form an ordered-array mesophase material. For example, basic conditions are used to precipitate an ordered nanocrystal/silica array material in bulk form and acidic conditions are used to form an ordered nanocrystal/silica array material as a thin film.
摘要翻译：一种用于形成纳米晶体的有序阵列的方法，其中在有机溶剂中具有疏水性核心材料的疏水性前体溶液加入到表面活性剂在水中的溶液中，然后除去至少一部分有机溶剂以形成胶束纳米晶体的溶液。可以在规定的反应条件（例如，pH条件）下，将能够与形成在纳米晶体的胶束溶液中的单个胶束共同组装的通常为水溶性的前体共组装材料加入到该胶束溶液中，阵列中间相材料。例如，使用基本条件来沉淀有序的纳米晶体/二氧化硅阵列材料的体积形式，并且酸性条件用于形成有序的纳米晶体/二氧化硅阵列材料作为薄膜。

39. 发明授权

US06536604B1 Inorganic dual-layer microporous supported membranes 有权
公开(公告)号：US06536604B1
公开(公告)日：2003-03-25
申请号：US09602579
申请日：2000-06-22
申请人： C. Jeffrey Brinker , Chung-Yi Tsai , Yungfeng Lu
发明人： C. Jeffrey Brinker , Chung-Yi Tsai , Yungfeng Lu
IPC分类号： B01J2900
CPC分类号： B01D69/12 , B01D53/22 , B01D63/06 , B01D67/0048 , B01D67/0083 , B01D71/02 , B01D71/024 , B01D71/027 , B01D2313/42 , B01D2323/08 , B01D2323/24 , B32B2315/02 , C04B35/14 , C04B35/624 , C04B38/0045 , C04B41/009 , C04B41/526 , C04B41/85 , C04B2111/00801 , C04B2111/00862 , C04B2235/3418 , C04B2235/441 , C04B2235/94 , C04B2237/341 , C04B2237/343 , Y10T428/249953 , Y10T428/265 , C04B41/4537 , C04B41/4582 , C04B41/5035 , C04B35/10 , C04B38/00
摘要： The present invention provides for a dual-layer inorganic microporous membrane capable of molecular sieving, and methods for production of the membranes. The inorganic microporous supported membrane includes a porous substrate which supports a first inorganic porous membrane having an average pore size of less than about 25 Å and a second inorganic porous membrane coating the first inorganic membrane having an average pore size of less than about 6 Å. The dual-layered membrane is produced by contacting the porous substrate with a surfactant-template polymeric sol, resulting in a surfactant sol coated membrane support. The surfactant sol coated membrane support is dried, producing a surfactant-templated polymer-coated substrate which is calcined to produce an intermediate layer surfactant-templated membrane. The intermediate layer surfactant-templated membrane is then contacted with a second polymeric sol producing a polymeric sol coated substrate which is dried producing an inorganic polymeric coated substrate. The inorganic polymeric coated substrate is then calcined producing an inorganic dual-layered microporous supported membrane in accordance with the present invention.

40. 发明授权

US06264741B1 Self-assembly of nanocomposite materials 有权
标题翻译：纳米复合材料的自组装
公开(公告)号：US06264741B1
公开(公告)日：2001-07-24
申请号：US09449036
申请日：1999-11-24
申请人： C. Jeffrey Brinker , Alan Sellinger , Yunfeng Lu
发明人： C. Jeffrey Brinker , Alan Sellinger , Yunfeng Lu
IPC分类号： C30B1110
CPC分类号： B82Y30/00 , C09K19/00
摘要： A method of making a nanocomposite self-assembly is provided where at least one hydrophilic compound, at least one hydrophobic compound, and at least one amphiphilic surfactant are mixed in an aqueous solvent with the solvent subsequently evaporated to form a self-assembled liquid crystalline mesophase material. Upon polymerization of the hydrophilic and hydrophobic compounds, a robust nanocomposite self-assembled material is formed. Importantly, in the reaction mixture, the amphiphilic surfactant has an initial concentration below the critical micelle concentration to allow formation of the liquid-phase micellar mesophase material. A variety of nanocomposite structures can be formed, depending upon the solvent evaporazation process, including layered mesophases, tubular mesophases, and a hierarchical composite coating composed of an isotropic worm-like micellar overlayer bonded to an oriented, nanolaminated underlayer.
摘要翻译：提供制备纳米复合自组装的方法，其中至少一种亲水性化合物，至少一种疏水性化合物和至少一种两亲表面活性剂在水性溶剂中与溶剂混合，随后蒸发形成自组装液晶中间相材料。在聚合亲水和疏水化合物时，形成了坚固的纳米复合材料自组装材料。重要的是，在反应混合物中，两亲表面活性剂的初始浓度低于临界胶束浓度以允许形成液相胶束中间相材料。可以形成各种纳米复合结构，这取决于溶剂蒸发过程，包括层状中间相，管状中间相，和由定向的纳米层压底层粘合的各向同性的蠕虫状胶束覆盖层组成的分级复合涂层。

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