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31. 发明授权

US6082016A Cutting edge measuring device for machine tool 失效
标题翻译：机床切削刃测量装置
公开(公告)号：US6082016A
公开(公告)日：2000-07-04
申请号：US81830
申请日：1998-05-20
申请人： Atsushi Otani , Akira Kosho
发明人： Atsushi Otani , Akira Kosho
IPC分类号： B23Q17/22 , B23B25/06 , B23Q17/09 , G01B21/22
CPC分类号： B23Q17/0957 , B23Q17/0928
摘要： A cutting edge measuring device is disclosed, which is simple and small-sized in its construction. The cutting edge measuring device comprises: an arm 13 provided on a headstock 7 and movable between the retracting position A at which the arm does not interrupt a workpiece chucked in a main spindle and the working tool T and the measuring position at which measurement of the cutting edge is carried out; sensors 14a provided on the arm 13 and detecting the cutting edge position at an offset position from the axis of the main spindle with contacting or non-contacting fashion so as to transmit detecting signals; and positioning means 15, 27b, 28b for positioning and retaining the arm 13 at the measuring position B. By this arrangement, the cutting edge measuring device ensures measurement of the cutting edge while a workpiece is chucked in the main spindle.
摘要翻译：公开了一种在其结构中简单且小型化的切削刃测量装置。切削刃测量装置包括：臂13，其设置在主轴箱7上，并且能够在牵引位置A之间移动，在该缩回位置A，臂不中断夹在主轴中的工件和加工工具T以及测量位置切削刃进行; 传感器14a，其设置在臂13上，并且以接触或非接触方式从主轴的轴线偏移位置检测切削刃位置，以便传送检测信号; 以及用于将臂13定位并保持在测量位置B的定位装置15,27b，28b。通过这种布置，切削刃测量装置确保在工件被夹在主轴中时切削刃的测量。

32. 发明授权

US4949443A Numerically controlled lathe 失效
标题翻译：数控车床
公开(公告)号：US4949443A
公开(公告)日：1990-08-21
申请号：US371900
申请日：1989-06-26
申请人： Tatsuhiko Saruwatari , Atsushi Otani , Akira Kosho , Satoru Togawa
发明人： Tatsuhiko Saruwatari , Atsushi Otani , Akira Kosho , Satoru Togawa
IPC分类号： B23B3/16 , B23Q39/02
CPC分类号： B23Q39/027 , B23B3/168 , B23Q2039/008 , B23Q2220/002 , Y10T29/5114 , Y10T29/5124 , Y10T29/5155 , Y10T82/2506 , Y10T82/2543
摘要： A numerically controlled lathe which is capable of effecting combined machining comprises a frame constituting the main body, a main spindle driven to rotate, a main spindle chuck provided on the main spindle to hold a workpiece, a multiple-tool head having a plurality of tools, a turret head and a rear machining head. The multiple-tool head has three servomotors to move it along three axes which are perpendicular to each other. The body of the multiple-tool head has an annular frame structure. At least two rows of rotary and non-rotary tools for machining the workpiece are disposed on the multiple-tool head body in a direction parallel with one of the directions of movement. A tool driving motor is provided on the multiple-tool head body to drive the rotary tools. The rotary tools include a polygon machining tool for machining a polygonal workpiece. The multiple-tool head, the turret head and the rear machining head effect machining simultaneously or successively.
摘要翻译：能够进行组合加工的数控车床包括构成主体的框架，被驱动旋转的主轴，设置在主轴上以保持工件的主轴卡盘，具有多个工具的多工具头，转塔头和后加工头。多刀头具有三个伺服电机，以沿着彼此垂直的三个轴移动它。多刀头的主体具有环形框架结构。用于加工工件的至少两排用于加工工件的旋转和非旋转工具沿与运动方向之一平行的方向设置在多工具头本体上。工具驱动电机设置在多工具头体上以驱动旋转工具。旋转工具包括用于加工多边形工件的多边形加工工具。多刀头，转塔头和后加工头效应同时或相继加工。

33. 发明申请

US20070116685A1 Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith 审中-公开
标题翻译：造血干细胞及其治疗新生血管性眼病的方法
公开(公告)号：US20070116685A1
公开(公告)日：2007-05-24
申请号：US11643571
申请日：2006-12-20
申请人： Martin Friedlander , Atsushi Otani , Karen Silva
发明人： Martin Friedlander , Atsushi Otani , Karen Silva
IPC分类号： A61K35/14 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0692 , A61K48/00 , A61K2035/124 , C12N5/0647
摘要： Isolated, mammalian, bone marrow-derived, hematopoietic stem cell populations contain endothelial progenitor cells (EPC) capable of forming retinal blood vessels. At least about 50% of the cells in the isolated cell population express CD31 and c-kit. Up to about 8% of the cells can express Sca-1, and up to about 4% of the cells can express Flk-1/KDR. The cells can incorporate into the vasculature of the retina when intravitreally injected into the eye, and can thereby stabilize or rebuilt diseased or abnormal retinal blood vessels.
摘要翻译：分离的，哺乳动物，骨髓来源的造血干细胞群含有能够形成视网膜血管的内皮祖细胞（EPC）。分离的细胞群中至少约50％的细胞表达CD31和c-kit。高达约8％的细胞可以表达Sca-1，最多约4％的细胞可以表达Flk-1 / KDR。当玻璃体内注射到眼睛中时，细胞可以并入视网膜的脉管系统中，从而可以稳定或重建患病或异常的视网膜血管。

34. 发明申请

US20060104963A1 Treatment of cone cell degeneration with transfected lineage negative hematopoietic stem cells 审中-公开
标题翻译：用转染谱系阴性造血干细胞治疗锥细胞变性
公开(公告)号：US20060104963A1
公开(公告)日：2006-05-18
申请号：US11168130
申请日：2005-06-28
申请人： Martin Friedlander , Atsushi Otani , Karen Silva , Stacey Moreno
发明人： Martin Friedlander , Atsushi Otani , Karen Silva , Stacey Moreno
IPC分类号： A61K48/00 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0647 , A61K38/00 , A61K48/00 , A61K2035/124 , C12N5/0692
摘要： Transfected, mammalian, adult bone marrow-derived, lineage negative hematopoietic stem cell populations (Lin− HSCs) contain endothelial progenitor cells (EPCs) capable of rescuing retinal blood vessels and neuronal networks in the eye. Preferably at least about 20% of the cells express the cell surface antigen CD31. The transfected stem cells express an antiangiogenic fragment of tryptophanyl tRNA synthetase (TrpRS). The transfected Lin− HSC populations are useful for treatment of ocular vascular diseases and to ameliorate cone cell degeneration in the retina. In a preferred embodiment, the Lin− HSCs are isolated by extracting bone marrow from an adult mammal; separating a plurality of monocytes from the bone marrow; labeling the monocytes with biotin-conjugated lineage panel antibodies to one or more lineage surface antigens; removing of monocytes that are positive for the lineage surface antigens from the plurality of monocytes, and recovering a Lin− HSC population containing EPCs. The treatment may be enhanced by stimulating proliferation of activated astrocytes in the retina using a laser.
摘要翻译：转染的哺乳动物，成年骨髓来源的血清造血干细胞群体（含有HSCs）含有能够拯救眼睛中视网膜血管和神经元网络的内皮祖细胞（EPCs）。优选地，至少约20％的细胞表达细胞表面抗原CD31。转染的干细胞表达色氨酸tRNA合成酶（TrpRS）的抗血管生成片段。转染的HSH-HSC群体可用于治疗眼血管疾病并改善视网膜中的锥细胞变性。在一个优选实施方案中，通过从成年哺乳动物中提取骨髓来分离骨髓间充质干细胞; 从骨髓中分离多个单核细胞; 用与生物素缀合的谱系抗体对一种或多种谱系表面抗原标记单核细胞; 从多个单核细胞中除去对于谱系表面抗原呈阳性的单核细胞，以及回收含有EPCs的LINC-HSC群体。可以通过使用激光刺激视网膜中活化的星形胶质细胞的增殖来增强治疗。

35. 发明授权

US08712244B2 Communication system and time synchronization method 有权
标题翻译：通信系统和时间同步方法
公开(公告)号：US08712244B2
公开(公告)日：2014-04-29
申请号：US13210165
申请日：2011-08-15
申请人： Makoto Hasegawa , Kazuyori Umematsu , Tohru Kazawa , Atsushi Otani
发明人： Makoto Hasegawa , Kazuyori Umematsu , Tohru Kazawa , Atsushi Otani
IPC分类号： H04J14/08 , H04B10/00
CPC分类号： H04J3/0655 , H04J3/0644 , H04J3/0673 , H04J3/0682
摘要： In a communication system using a PON, time synchronization of a slave device such as a base station is realized with respect to a master device such as an L2SW or the base station. Time information acquired by a GPS satellite is corrected by ranging information of a discovery function of an OLT so as to be reflected on time information of each ONU. A propagation delay from the L2SW to the OLT is obtained with the use of a delay estimation mechanism, a propagation delay from the OLT to the ONU which is obtained by ranging is added to obtain a propagation delay from the L2SW to the ONU. The obtained propagation delay from the L2SW to the ONU is added to the transmitted time stamp value whereby a time stamp value received at a base station or femtocell side becomes a time into which the propagation delay to the ONU is incorporated, and absolute values of clock timers can be synchronized with each other. The addition process can be realized by rewriting the time stamp value of the packet within the OLT or the ONU.
摘要翻译：在使用PON的通信系统中，相对于诸如L2SW或基站的主设备实现诸如基站的从设备的时间同步。由GPS卫星获取的时间信息由OLT的发现功能的测距信息进行校正，以反映在每个ONU的时间信息上。通过使用延迟估计机制获得从L2SW到OLT的传播延迟，通过添加通过测距获得的从OLT到ONU的传播延迟，以获得从L2SW到ONU的传播延迟。所获得的从L2SW到ONU的传播延迟被添加到发送的时间标记值，由此在基站或毫微微小区侧接收的时间标记值变为并入到ONU的传播延迟的时间，并且时钟的绝对值定时器可以彼此同步。可以通过重写OLT或ONU内的分组的时间戳值来实现相加处理。

36. 发明授权

US08253968B2 Image forming apparatus, control method, and program for preventing image omission cause by registration error correction 有权
标题翻译：图像形成装置，控制方法和用于防止图像遗漏的程序由于配准误差校正而引起
公开(公告)号：US08253968B2
公开(公告)日：2012-08-28
申请号：US11554655
申请日：2006-10-31
申请人： Atsushi Otani
发明人： Atsushi Otani
IPC分类号： G06K15/00 , H04N1/46
CPC分类号： G03G15/04018 , G03G2215/0158 , G03G2215/0468 , H04N1/3878 , H04N1/506 , H04N2201/0082 , H04N2201/0315 , H04N2201/04713 , H04N2201/04722 , H04N2201/04729 , H04N2201/04731 , H04N2201/04732 , H04N2201/04758 , H04N2201/04789 , H04N2201/04791 , H04N2201/04793
摘要： This invention provides an image forming apparatus capable of preventing image omission caused by registration error correction, a control method therefor, and a program. Error amount information is acquired which is stored in a storage medium and represents the error amount of the scanning line of exposure light in the exposure scanning direction on an image carrier. The image data is modified on the basis of the acquired error amount information. A masked area for restricting the output position of an image visualized on the printing medium is modified on the basis of the modification amount of the modified image data.
摘要翻译：本发明提供了能够防止由注册纠错引起的图像遗漏，其控制方法和程序的图像形成装置。获取存储在存储介质中并且表示在图像载体上的曝光扫描方向上的曝光光的扫描线的误差量的误差量信息。基于获取的误差量信息来修改图像数据。基于修改图像数据的修改量来修改用于限制在打印介质上可视化的图像的输出位置的掩蔽区域。

37. 发明申请

US20060104962A1 Transfected hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith 审中-公开
标题翻译：转染的造血干细胞及其治疗新生血管性眼病的方法
公开(公告)号：US20060104962A1
公开(公告)日：2006-05-18
申请号：US11168010
申请日：2005-06-28
申请人： Martin Friedlander , Atsushi Otani , Karen Silva , Stacey Moreno
发明人： Martin Friedlander , Atsushi Otani , Karen Silva , Stacey Moreno
IPC分类号： A61K48/00 , C12N5/08
CPC分类号： C12N5/0647 , A61K38/00 , A61K48/00 , A61K2035/124 , C12N5/0692
摘要： Transfected, mammalian, adult bone marrow-derived, lineage negative hematopoietic stem cell populations (Lin−HSCs) contain endothelial progenitor cells (EPCs) capable of rescuing retinal blood vessels and neuronal networks in the eye and a gene operably encoding an antiangiogenic fragment of tryptophanyl tRNA synthetase (TrpRS). Preferably at least about 20% of the cells in the transfected Lin−HSC population express the cell surface antigen CD31. The transfected Lin−HSC populations are useful for treatment of ocular vascular diseases. In a preferred embodiment, the Lin−HSCs are isolated by extracting bone marrow from an adult mammal; separating a plurality of monocytes from the bone marrow; labeling the monocytes with biotin-conjugated lineage panel antibodies to one or more lineage surface antigens; removing of monocytes that are positive for the lineage surface antigens from the plurality of monocytes, recovering a Lin−HSC population containing EPCs, and transfecting the recovered cells with DNA operably encoding an antiangiogenic fragment of TrpRS. Methods of preparing transfected stem cell populations of the invention, and methods of treating ocular diseases and injury are also described.
摘要翻译：转染的哺乳动物，成年骨髓来源的谱系负造血干细胞群体（含有HSCs）含有能够拯救眼睛中的视网膜血管和神经元网络的内皮祖细胞（EPCs）和基因可操作地编码色氨酸tRNA合成酶（TrpRS）的抗血管生成片段。优选地，转染的LINH-HSC群体中至少约20％的细胞表达细胞表面抗原CD31。转染的HSP-HSC群体可用于治疗眼血管疾病。在一个优选实施方案中，通过从成年哺乳动物中提取骨髓来分离骨髓间充质干细胞; 从骨髓中分离多个单核细胞; 用与生物素缀合的谱系抗体对一种或多种谱系表面抗原标记单核细胞; 从多个单核细胞中除去对于谱系表面抗原呈阳性的单核细胞，回收含有EPCs的LinC-HSC群体，并用可操作地编码TrpRS抗血管生成片段的DNA转染回收的细胞。还描述了制备本发明的转染干细胞群体的方法，以及治疗眼部疾病和损伤的方法。

38. 发明申请

US20060047985A1 Data storage apparatus and control method thereof 有权
标题翻译：数据存储装置及其控制方法
公开(公告)号：US20060047985A1
公开(公告)日：2006-03-02
申请号：US11208675
申请日：2005-08-22
申请人： Atsushi Otani
发明人： Atsushi Otani
IPC分类号： G06F1/26
CPC分类号： G06F1/3253 , G06F1/3203 , Y02D10/151
摘要： The present invention provides a data storage apparatus capable of reducing an amount of electric current flowing in a bus. The data storage apparatus includes a data storage unit adapted to store data, a plurality of buffer units adapted to output data to the data storage unit through a bus, wherein the bus includes a plurality of signal lines, and wherein the plurality of buffer units are provided on the plurality of signal lines, a determination unit adapted to determine whether the bus is in an operating state in which transmission and reception of data to and from the data storage unit are performed, a reference voltage supply unit adapted to supply a predetermined reference voltage to the plurality of signal lines, a control unit adapted to control, in a case where the determination unit determines that a state of the bus is changed from an operating state to a nonoperating state, the plurality of buffer units to switch output states to predetermined output states to reduce an amount of electric current flowing in the bus through the reference voltage supply unit.
摘要翻译：本发明提供一种能够减少在总线中流动的电流量的数据存储装置。数据存储装置包括适于存储数据的数据存储单元，适于通过总线将数据输出到数据存储单元的多个缓冲单元，其中总线包括多条信号线，并且其中多个缓冲单元是设置在所述多条信号线上的确定单元，用于确定所述总线是否处于进行来自所述数据存储单元的数据的发送和接收的操作状态的判定单元，适于提供预定基准的参考电压供应单元电压到多个信号线，控制单元，其适于在所述确定单元确定所述总线的状态从操作状态改变为非操作状态的情况下控制所述多个缓冲单元将输出状态切换到预定的输出状态以减少通过参考电压供应单元在总线中流动的电流量。

39. 发明申请

US20050129665A1 Isolated lineage negative hematopoietic stem cells and methods of treatment therewith 审中-公开
标题翻译：分离的谱系负造血干细胞及其处理方法
公开(公告)号：US20050129665A1
公开(公告)日：2005-06-16
申请号：US10933634
申请日：2004-09-03
申请人： Martin Friedlander , Atsushi Otani , Karen Da Silva , Stacey Moreno
发明人： Martin Friedlander , Atsushi Otani , Karen Da Silva , Stacey Moreno
IPC分类号： C12N15/09 , A01N63/00 , A61K35/12 , A61K35/28 , A61K48/00 , A61P9/10 , A61P27/02 , C12N5/00 , C12N5/02 , C12N5/078 , C12N5/0789 , C12N5/10 , A61K45/00 , C12N5/08 , C12N5/06
CPC分类号： C12N5/0647 , A61K48/00 , A61K2035/124 , C12N5/0692
摘要： Isolated, mammalian, adult bone marrow-derived, lineage negative hematopoietic stem cell populations (Lin− HSCs) contain endothelial progenitor cells (EPCs) capable of rescuing retinal blood vessels and neuronal networks in the eye. Preferably at least about 20% of the cells in the isolated Lini HSCs express the cell surface antigen CD31. The isolated Lin− HSC populations are useful for treatment of ocular vascular diseases and to ameliorate cone cell degeneration in the retina. In a preferred embodiment, the Lin− HSCs are isolated by extracting bone marrow from an adult mammal; separating a plurality of monocytes from the bone marrow; labeling the monocytes with biotin-conjugated lineage panel antibodies to one or more lineage surface antigens; removing of monocytes that are positive for the lineage surface antigens from the plurality of monocytes, and recovering a Lin− HSC population containing EPCs. The isolated Lin− HSCs also can be transfected with therapeutically useful genes. The treatment may be enhanced by stimulating proliferation of activated astrocytes in the retina using a laser.
摘要翻译：分离的，哺乳动物，成年骨髓来源的谱系负造血干细胞群体（含有HSCs）含有能够拯救眼睛中视网膜血管和神经元网络的内皮祖细胞（EPCs）。优选地，分离的Lini HSC中至少约20％的细胞表达细胞表面抗原CD31。孤立的HSC群体可用于治疗眼血管疾病和改善视网膜中的锥细胞变性。在一个优选实施方案中，通过从成年哺乳动物中提取骨髓来分离骨髓间充质干细胞; 从骨髓中分离多个单核细胞; 用与生物素缀合的谱系抗体对一种或多种谱系表面抗原标记单核细胞; 从多个单核细胞中除去对于谱系表面抗原呈阳性的单核细胞，以及回收含有EPCs的LINC-HSC群体。分离的蛋白质HSCs也可以用治疗有用的基因转染。可以通过使用激光刺激视网膜中活化的星形胶质细胞的增殖来增强治疗。

40. 发明申请

US20050063961A1 Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith 有权
标题翻译：造血干细胞及其治疗新生血管性眼病的方法
公开(公告)号：US20050063961A1
公开(公告)日：2005-03-24
申请号：US10833743
申请日：2004-04-28
申请人： Martin Friedlander , Atsushi Otani , Karen Da Silva , Stacey (Hanekamp) Moreno
发明人： Martin Friedlander , Atsushi Otani , Karen Da Silva , Stacey (Hanekamp) Moreno
IPC分类号： C12N15/09 , A01N63/00 , A61K35/12 , A61K35/28 , A61K48/00 , A61P9/10 , A61P27/02 , C12N5/00 , C12N5/02 , C12N5/078 , C12N5/0789 , C12N5/10 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0647 , A61K48/00 , A61K2035/124 , C12N5/0692
摘要： Isolated, mammalian, adult bone marrow-derived, lineage negative hematopoietic stem cell populations (Lin− HSCs) contain endothelial progenitor cells (EPCs) capable of rescuing retinal blood vessels and neuronal networks in the eye. Preferably at least about 20% of the cells in the isolated Lin− HSCs express the cell surface antigen CD31. The isolated Lin− HSC populations are useful for treatment of ocular vascular diseases. In a preferred embodiment, the Lin− HSCs are isolated by extracting bone marrow from an adult mammal; separating a plurality of monocytes from the bone marrow; labeling the monocytes with biotin-conjugated lineage panel antibodies to one or more lineage surface antigens; removing of monocytes that are positive for the lineage surface antigens from the plurality of monocytes, and recovering a Lin− HSC population containing EPCs. Isolated Lin− HSCs that have been transfected with therapeutically useful genes are also provided, and are useful for delivering genes to the eye for cell-based gene therapy. Methods of preparing isolated stem cell populations of the invention, and methods of treating ocular diseases and injury are also described.
摘要翻译：分离的，哺乳动物，成年骨髓来源的谱系负造血干细胞群（Lin < - > HSCs）含有能够拯救眼睛中视网膜血管和神经元网络的内皮祖细胞（EPCs）。优选地，分离的Lin HSC中至少约20％的细胞表达细胞表面抗原CD31。孤立的Lin < - > HSC群体可用于治疗眼血管疾病。在优选的实施方案中，通过从成年哺乳动物提取骨髓来分离Lin？从骨髓中分离多个单核细胞; 用与生物素缀合的谱系抗体对一种或多种谱系表面抗原标记单核细胞; 从多个单核细胞中除去对于谱系表面抗原呈阳性的单核细胞，以及回收含有EPC的Lin HSC群体。还提供已经用治疗有用的基因转染的分离的Lin < - > HSC，并且可用于将基因递送至眼睛用于基于细胞的基因治疗。还描述了制备本发明的分离的干细胞群体的方法，以及治疗眼部疾病和损伤的方法。

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