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31. 发明授权

US3973019A Pharmaceutical compositions containing 1,4-bis-(5'-nitroimidazolyl-2'-methylene-imino) piperazine compounds for treating protozoal diseases and methods for treating such diseases 失效
标题翻译：含有用于治疗原生动物疾病的1,4-双 - （5（4-硝基咪唑基-2（40-亚甲基 - 亚氨基）哌嗪）化合物的药物组合物及其治疗方法
公开(公告)号：US3973019A
公开(公告)日：1976-08-03
申请号：US535096
申请日：1974-12-20
申请人： Erhardt Winkelmann , Wolfgang Raether
发明人： Erhardt Winkelmann , Wolfgang Raether
IPC分类号： A61K31/495
CPC分类号： A61K31/495
摘要： 1,4-BIS-5'-NITROIMIDAZOLYL-2'-METHYLENE-IMINO) PIPERAZINES OF THE FORMULA ##SPC1##In which R.sub.1 is hydrogen, methyl, ethyl or 2-hydroxyethyl and R.sub.2 is hydrogen or methyl, are prepared by reaction of 5-nitro-imidazolyl-2-aldehydes or the functional derivatives thereof with 1,4-diamino-piperazines. Pharmaceutical compositions containing these compounds for treating protozoal diseases and methods of treating protozoal diseases with these compounds are disclosed.
摘要翻译： 1,4-BIS-5'-NITROIMIDAZOLYL-2'-METHYLENE-IMINO）式中R1是氢，甲基，乙基或2-羟乙基，R2是氢或甲基的哌嗪是通过5-硝基 - 咪唑基-2-醛或其功能衍生物与1,4-二氨基 - 哌嗪。公开了含有这些用于治疗原生动物疾病的化合物的药物组合物和用这些化合物治疗原生动物疾病的方法。

32. 发明授权

US3951963A 0-(Substituted-aminoalkyl)-5-nitroimidazole-(2)-aldoximes 失效
标题翻译： O-（取代的 - 氨基烷基）-5-硝基咪唑 - （2） - 肟
公开(公告)号：US3951963A
公开(公告)日：1976-04-20
申请号：US448376
申请日：1974-03-05
申请人： Erhardt Winkelmann , Ulrich Gebert , Wolfgang Raether
发明人： Erhardt Winkelmann , Ulrich Gebert , Wolfgang Raether
IPC分类号： C07D233/95 , C07D401/12 , C07D233/32 , C07D403/12 , C07D413/12
CPC分类号： C07D233/95
摘要： Novel 0-(dialkylaminoalkyl)-1-alkyl-5-nitroimidazole-(2)-aldoximes are described as well as their manufacture and use for treating protozoal diseases. The novel compounds correspond to the general formula ##SPC1##In which R.sup.1 stand for a hydrogen atom, a methyl, ethyl or hydroxyethyl group, Z stands for a linear or branched alkylene chain of 2 to 3 carbon atoms, and R.sup.2 and R.sup.3 each stands for an identical or different lower alkyl radical having from 1 to 4 carbon atoms or the group --NR.sup.2 R.sup.3 can be part of a saturated heterocyclic ring which may contain further substituents preferably a methyl group or/and hetero atoms, such as, especially the pyrrolidine, piperidine, morpholine, thiamorpholine, tetrahydro-1,4-thiazine-1,1-dioxide and piperazine ring, and HX can be a non-toxic, physiologically acceptable acid.
摘要翻译：描述了新的O-（二烷基氨基烷基）-1-烷基-5-硝基咪唑 - （2） - 肟类及其制备和用于治疗原生动物疾病的用途。所述新化合物对应于通式为：其中R 1代表氢原子，甲基，乙基或羟基乙基，Z表示2至3个碳原子的直链或支链亚烷基链，R2和R3各代表相同或具有1至4个碳原子的不同的低级烷基或基团-NR2R3可以是饱和杂环的一部分，其可以含有其它取代基，优选甲基或/和杂原子，例如特别是吡咯烷，哌啶，吗啉，四氢-1,4-噻嗪-1,1-二氧化物和哌嗪环，HX可以是无毒的生理上可接受的酸。

33. 发明授权

US3950539A Substituted diaminoguanidines 失效
标题翻译：取代的二氨基鸟嘌呤
公开(公告)号：US3950539A
公开(公告)日：1976-04-13
申请号：US550917
申请日：1975-02-19
申请人： Hans Militzer , Erhardt Winkelmann , Wolfgang Raether
发明人： Hans Militzer , Erhardt Winkelmann , Wolfgang Raether
IPC分类号： C07C281/16 , C07C67/00 , C07C239/00 , C07C281/18 , A61K31/165 , C07C103/22
CPC分类号： C07C281/18
摘要： Substituted diamino-guanidines are described as well as their manufacture and their use as medicaments against protozoa, especially against coccidiosis.
摘要翻译：描述了取代的二氨基胍，以及它们的制备及其作为抗原虫，特别是抗球虫病的药物的用途。

34. 发明授权

US5188832A Agents directed against parasites of fishes and insects 失效
标题翻译：代理针对渔业和渔业部门的代理人
公开(公告)号：US5188832A
公开(公告)日：1993-02-23
申请号：US480158
申请日：1990-02-14
申请人： Heinz Mehlhorn , Horst Taraschewski , Gunter Schmahl , Wolfgang Raether , Manfred Rosner
发明人： Heinz Mehlhorn , Horst Taraschewski , Gunter Schmahl , Wolfgang Raether , Manfred Rosner
IPC分类号： A01N43/707 , A61K31/53 , A61K31/535 , A61K31/54
CPC分类号： A61K31/54 , A61K31/53 , A61K31/535
摘要： A method of using certain triazine-dione compounds for the control of endo- and ectoparasites of fish and/or insects. The compounds may be combined with aids to form an agent for controlling the endo- or ectoparasites.
摘要翻译：使用某些三嗪二酮化合物控制鱼和/或昆虫的内寄生虫和外寄生虫的方法。化合物可与助剂组合以形成用于控制内寄生虫或外寄生虫的药剂。

35. 发明授权

US4855299A Coccidiocidal compositions 失效
标题翻译：杀微生物剂组合物
公开(公告)号：US4855299A
公开(公告)日：1989-08-08
申请号：US118322
申请日：1987-11-09
申请人： Wolfgang Raether
发明人： Wolfgang Raether
IPC分类号： A61K31/35 , A61K31/44 , A61K31/47 , A61K31/50 , A61K31/505
CPC分类号： A61K31/70
摘要： Coccidiocidal agents which contain the polyether antibiotic monensin or its salt in combination with one or more active substances from the group comprising methyl benzoquate, nicarbazin, amprolium, beclotiamine or halofuginone or its salts show synergistic effects.
摘要翻译：含有聚醚抗生素莫能菌素或其盐与一种或多种活性物质组合的杀微生物剂包括苯甲酸甲酯，尼卡巴嗪，安普罗铵，比洛溴胺或卤夫酮或其盐显示出协同效应。

36. 发明授权

US4824847A Coccidiocidal compositions 失效
标题翻译：杀微生物剂组合物
公开(公告)号：US4824847A
公开(公告)日：1989-04-25
申请号：US117960
申请日：1987-11-09
申请人： Wolfgang Raether
发明人： Wolfgang Raether
IPC分类号： A23K20/195 , A61K31/35 , A61K31/44 , A61K31/47 , A61K31/505 , A61K31/51 , A61P33/02
CPC分类号： A61K31/47 , A23K20/195 , A61K31/35 , A61K31/44 , A61K31/505 , A61K31/51
摘要： Coccidiocidal compositions which contain the polyether antibiotic lasalocid A or its salt or ester in combination with one or more active substances from the group comprising meticlorpindol, methyl benzoquate, nicarbazin, amprolium, beclotiamine or halofuginone or its salts show synergistic effects.
摘要翻译：含有聚醚抗生素拉沙里菌素A或其盐或酯与一种或多种活性物质组合的杀微生物剂组合物，所述活性物质包括甲基吲哚酚，苯甲酸甲酯，尼卡巴嗪，安普罗铵，比洛溴胺或卤夫酮或其盐显示出协同效应。

37. 发明授权

US4260615A Antimalarial compositions 失效
公开(公告)号：US4260615A
公开(公告)日：1981-04-07
申请号：US954900
申请日：1978-10-26
申请人： Wolfgang Raether , Walter Durckheimer , Hans Seidenath
发明人： Wolfgang Raether , Walter Durckheimer , Hans Seidenath
IPC分类号： C07D219/06 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/49 , A61K31/505 , A61K31/53 , A61K31/635 , A61P33/02 , A61K31/435
CPC分类号： A61K31/635 , A61K31/44 , A61K31/47 , A61K31/49 , A61K31/505 , A61K31/53 , Y10S514/895
摘要： Antimalarial compositions are disclosed containing as the active ingredient a mixture of a tetrahydroacridone of the general formula I ##STR1## in which R.sup.1 represents methyl, phenyl, p-chlorophenyl, m-chlorophenyl, p-fluorophenyl, p-trifluoromethylphenyl, o-trifluoromethylphenyl or o-chloro-p-trifluoromethylphenyl,R.sup.2 represents hydrogen or methyl, andR.sup.3 represents fluorine or chlorine,or a salt of such a compound with a physiologically compatible acid or base, with(a) 6-methoxy-.alpha.-(5-vinyl-2-quinuclidinyl)-4-quinoline-methanol (Quinine),(b) 7-chloro-4-(diethylamino-1-methyl-butylamino)-quinoline (Chloroquine),(c) .alpha.-(2-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol (Mefloquine),(d) 8-(4-amino-1-methylbutylamino)-6-methoxy-quinoline (Primaquine),(e) 2,4-diamino-5-p-chlorophenyl-6-ethylpyrimidine (Pyrimethamine),(f) 4,6-diamino-1-(p-chlorophenyl)-1,2-dihydro-2,2-dimethyl-s-triazine (Cycloguanil),(g) 2,4-diamino-5-(3,4,5-trimethoxybenzyl)-pyrimidine (Trimethoprim),(h) N'-(5,6-dimethoxy-4-pyrimidyl)-sulfanilamide (Sulfadoxine), or(i) 4,4'-diaminodiphenylsulfone (Dapsone),or with a salt of a compound sub (a) to (i), with a physiologically compatible acid or base, the mixtures being in a proportion by weight of between 25:1 and 1:300 (tetrahydroacridone to compound sub (a) to (i)) in admixture with a pharmaceutically acceptable carrier and/or adjuvant.

38. 发明授权

US4198407A Substituted 2-phenyl-1,2,4-triazine-3,5(2H,4H)-diones, and coccidiostatic agents containing same 失效
标题翻译：取代的2-苯基-1,2,4-三嗪-3,5（2H，4H） - 二酮和含有它们的抗球虫药
公开(公告)号：US4198407A
公开(公告)日：1980-04-15
申请号：US906638
申请日：1978-05-16
申请人： Manfred Rosner , Wolfgang Raether
发明人： Manfred Rosner , Wolfgang Raether
IPC分类号： C07D253/06 , A23K1/16 , A61K31/53 , A61P33/02 , C07D253/075
CPC分类号： C07D253/075 , C07C323/00
摘要： Novel substituted 2-phenyl-1,2,4-triazine-3,5-(2H,4H)-diones are described as well as a process for their manufacture. The novel compounds may be used as chemotherapeutics, especially as coccidiostatic agents.
摘要翻译：描述了新的取代的2-苯基-1,2,4-三嗪-3,5-（2H，4H） - 二酮及其制备方法。新化合物可用作化学治疗剂，特别是作为抗球虫药。

39. 发明授权

US4156778A Substituted bis-benzimidazolyl compounds; preparation and use thereof 失效
标题翻译：取代的双苯并咪唑基化合物; 制备和使用
公开(公告)号：US4156778A
公开(公告)日：1979-05-29
申请号：US886517
申请日：1978-03-14
申请人： Manfred Rosner , Heinz Loewe , Wolfgang Raether
发明人： Manfred Rosner , Heinz Loewe , Wolfgang Raether
IPC分类号： C07D409/14 , A61K31/425 , A61K31/505 , A61K31/55 , A61P31/12 , A61P33/02 , C07D233/24 , C07D235/18 , C07D239/06 , C07D239/70 , C07D307/68 , C07D333/38 , C07D403/14 , C07D405/14 , C07D235/20
CPC分类号： C07D239/06 , C07D233/24 , C07D235/18 , C07D239/70 , C07D307/68 , C07D333/38
摘要： Substituted bis-benzimidazolyl compounds of the formula ##STR1## are disclosed, wherein A is thiophenediyl, furanediyl, phenylene, or phenoxyphenylene, and R.sup.1 is ##STR2## where R.sup.2 -R.sup.10 are independently hydrogen, alkyl, aminoalkyl, N-alkylaminoalkyl, N,N-dialkylaminoalkyl, or phenyl, or any two of R.sup.2 -R.sup.10 taken together are C.sub.2 -C.sub.4 alkylene, as are methods of making the compounds, which are useful as chemotherapeutic agents in the treatment of protozoal and viral diseases.
摘要翻译：公开了取代的式“IMAGE”的双苯并咪唑基化合物，其中A是噻吩二基，呋喃二基，亚苯基或苯氧基亚苯基，并且R 1是其中R 2 -R 10独立地是氢，烷基，氨基烷基，N-烷基氨基烷基，N，N-二烷基氨基烷基或苯基，或者R 2 -R 10中的任何两个一起是C 2 -C 4亚烷基，以及制备化合物的方法，其可用作化学治疗剂用于治疗原生动物和病毒性疾病。

40. 发明授权

US4046896A 1-Methyl-2-(pyridyl-oxymethyl)-5-nitro-imidazoles 失效
标题翻译： 1-甲基-2-（吡啶基 - 氧甲基）-5-硝基 - 咪唑
公开(公告)号：US4046896A
公开(公告)日：1977-09-06
申请号：US686540
申请日：1976-05-14
申请人： Erhardt Winkelmann , Wolfgang Raether
发明人： Erhardt Winkelmann , Wolfgang Raether
IPC分类号： C07D401/12 , A61K31/44 , C07D233/22
CPC分类号： C07D401/12
摘要： The invention provides 1-methyl-2-(pyridyl-oxymethyl)-5-nitro-imidazoles and processes for preparing them. The compounds are useful in the therapy of diseases provoked by protozoa.
摘要翻译：本发明提供1-甲基-2-（吡啶基 - 氧甲基）-5-硝基 - 咪唑及其制备方法。该化合物可用于治疗由原生动物引起的疾病。

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