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1. 发明授权

US3951963A 0-(Substituted-aminoalkyl)-5-nitroimidazole-(2)-aldoximes 失效
标题翻译： O-（取代的 - 氨基烷基）-5-硝基咪唑 - （2） - 肟
公开(公告)号：US3951963A
公开(公告)日：1976-04-20
申请号：US448376
申请日：1974-03-05
申请人： Erhardt Winkelmann , Ulrich Gebert , Wolfgang Raether
发明人： Erhardt Winkelmann , Ulrich Gebert , Wolfgang Raether
IPC分类号： C07D233/95 , C07D401/12 , C07D233/32 , C07D403/12 , C07D413/12
CPC分类号： C07D233/95
摘要： Novel 0-(dialkylaminoalkyl)-1-alkyl-5-nitroimidazole-(2)-aldoximes are described as well as their manufacture and use for treating protozoal diseases. The novel compounds correspond to the general formula ##SPC1##In which R.sup.1 stand for a hydrogen atom, a methyl, ethyl or hydroxyethyl group, Z stands for a linear or branched alkylene chain of 2 to 3 carbon atoms, and R.sup.2 and R.sup.3 each stands for an identical or different lower alkyl radical having from 1 to 4 carbon atoms or the group --NR.sup.2 R.sup.3 can be part of a saturated heterocyclic ring which may contain further substituents preferably a methyl group or/and hetero atoms, such as, especially the pyrrolidine, piperidine, morpholine, thiamorpholine, tetrahydro-1,4-thiazine-1,1-dioxide and piperazine ring, and HX can be a non-toxic, physiologically acceptable acid.
摘要翻译：描述了新的O-（二烷基氨基烷基）-1-烷基-5-硝基咪唑 - （2） - 肟类及其制备和用于治疗原生动物疾病的用途。所述新化合物对应于通式为：其中R 1代表氢原子，甲基，乙基或羟基乙基，Z表示2至3个碳原子的直链或支链亚烷基链，R2和R3各代表相同或具有1至4个碳原子的不同的低级烷基或基团-NR2R3可以是饱和杂环的一部分，其可以含有其它取代基，优选甲基或/和杂原子，例如特别是吡咯烷，哌啶，吗啉，四氢-1,4-噻嗪-1,1-二氧化物和哌嗪环，HX可以是无毒的生理上可接受的酸。

2. 发明授权

US4105763A 1-Methyl-2-(phenyl-oxymethyl)-5-nitro-imidazoles 失效
标题翻译： 1-甲基-2-（苯基 - 氧甲基）-5-硝基 - 咪唑
公开(公告)号：US4105763A
公开(公告)日：1978-08-08
申请号：US734765
申请日：1976-10-22
申请人： Erhardt Winkelmann , Wolfgang Raether
发明人： Erhardt Winkelmann , Wolfgang Raether
IPC分类号： C07D233/94 , A61K31/415 , A61K31/535 , C07D233/95 , C07D413/12
CPC分类号： C07D233/94
摘要： New 1-methyl-2-(phenyl-oxymethyl)-5-nitro-imidazoles are disclosed as well as a process for their manufacture. The new compounds are suitable for the treatment of protozoal diseases and show a marked activity against helminths, ectoparasites and ticks.
摘要翻译：公开了新的1-甲基-2-（苯基 - 氧甲基）-5-硝基 - 咪唑及其制备方法。新化合物适用于治疗原生动物疾病，并显示针对蠕虫，外寄生虫和蜱的明显活性。

3. 发明授权

US4053482A 1-Methyl-2-(substituted thiomethyl)-5-nitro-imidazoles 失效
标题翻译： 1-甲基-2-（取代的甲硫基）-5-硝基咪唑
公开(公告)号：US4053482A
公开(公告)日：1977-10-11
申请号：US674429
申请日：1976-04-07
申请人： Erhardt Winkelmann , Wolfgang Raether
发明人： Erhardt Winkelmann , Wolfgang Raether
IPC分类号： C07D233/94 , C07D405/12 , C07D409/12 , A61K31/415
CPC分类号： C07D233/94
摘要： Certain 1-methyl-2-(substituted thiomethyl)-5-nitro-imidazoles are described as well as a process for their manufacture. The compounds are suitable for the treatment of protozoal diseases, especially of trichomoniasis and of fungus diseases, especially dermatomycoses.

4. 发明授权

US4046896A 1-Methyl-2-(pyridyl-oxymethyl)-5-nitro-imidazoles 失效
标题翻译： 1-甲基-2-（吡啶基 - 氧甲基）-5-硝基 - 咪唑
公开(公告)号：US4046896A
公开(公告)日：1977-09-06
申请号：US686540
申请日：1976-05-14
申请人： Erhardt Winkelmann , Wolfgang Raether
发明人： Erhardt Winkelmann , Wolfgang Raether
IPC分类号： C07D401/12 , A61K31/44 , C07D233/22
CPC分类号： C07D401/12
摘要： The invention provides 1-methyl-2-(pyridyl-oxymethyl)-5-nitro-imidazoles and processes for preparing them. The compounds are useful in the therapy of diseases provoked by protozoa.
摘要翻译：本发明提供1-甲基-2-（吡啶基 - 氧甲基）-5-硝基 - 咪唑及其制备方法。该化合物可用于治疗由原生动物引起的疾病。

5. 发明授权

US4057634A Antiprotozoal(1-alkyl-5-nitro-imidazolyl-2-alkyl)-pyridazines 失效
标题翻译：抗原雄虫（1-烷基-5-硝基 - 咪唑-2-基） - 哒嗪
公开(公告)号：US4057634A
公开(公告)日：1977-11-08
申请号：US698850
申请日：1976-06-23
申请人： Erhardt Winkelmann , Akhileswer Sinharay , Wolfgang Raether
发明人： Erhardt Winkelmann , Akhileswer Sinharay , Wolfgang Raether
IPC分类号： A01N43/48 , A01N9/22 , A61K31/495 , C07D237/06
CPC分类号： A01N43/48
摘要： New (1-alkyl-5-nitro-imidazolyl-2-alkyl)-heteroaryl compounds are disclosed as well as a process for their manufacture.The new compounds are effective against pathogens, such as bacteria and protozoa, as well as against fungi.
摘要翻译：公开了新的（1-烷基-5-硝基 - 咪唑-2-基） - 杂芳基化合物及其制备方法。

6. 发明授权

US4031232A 1-Alkyl-2-(phenoxymethyl)-5-nitro-imidazoles and process for their manufacture 失效
标题翻译： 1-烷基-2-（苯氧基甲基）-5-硝基 - 咪唑及其制备方法
公开(公告)号：US4031232A
公开(公告)日：1977-06-21
申请号：US641091
申请日：1975-12-15
申请人： Erhardt Winkelmann , Wolfgang Raether
发明人： Erhardt Winkelmann , Wolfgang Raether
IPC分类号： C07D233/54 , C07D233/94 , A61K31/415 , C07D233/95
CPC分类号： C07D233/64 , C07C323/00 , C07D233/94
摘要： 1-Alkyl-2-(phenoxymethyl)-5-nitro-imidazoles are described as well as a process for their manufacture. The compounds are active against trichomonads and amoebae and are especially suitable for the treatment of Fluor genitalis.
摘要翻译：描述1-烷基-2-（苯氧基甲基）-5-硝基 - 咪唑及其制备方法。该化合物对毛滴虫和变形虫有活性，特别适用于治疗生殖器外阴。

7. 发明授权

US4001415A Composition for and method of treating diseases caused by protozoa 失效
标题翻译：用于治疗由PROTOZOA引起的疾病的组合物和方法
公开(公告)号：US4001415A
公开(公告)日：1977-01-04
申请号：US610459
申请日：1975-09-04
申请人： Erhardt Winkelmann , Wolfgang Raether
发明人： Erhardt Winkelmann , Wolfgang Raether
IPC分类号： A61K31/44
CPC分类号： A61K31/44
摘要： New 1-alky-2-(pyridyl-sulfinylmethyl)-5-nitro-imidazoles and 1-alkyl-2-(pyridyl-sulfonylmethyl)-5-nitro-imidazoles are described according to the formula I ##STR1## in which R stands for a methyl, ethyl or hydroxyethyl group and Z stands for a --SO-- or --SO.sub.2 -- group and the pyridine ring is linked to the sulfinyl or the sulfonyl group in 2, 3 or 4 position as well as a process for their manufacture.The novel compounds have a pronounced activity against protozoae, especially trichomonads and amebae.

8. 发明授权

US3992397A (1-Alkyl-5-nitro-imidazolyl-2-alkyl)-heteroaryl compounds and process for their manufacture 失效
标题翻译：（1-烷基-5-硝基 - 咪唑-2-基） - 杂芳基化合物及其制备方法
公开(公告)号：US3992397A
公开(公告)日：1976-11-16
申请号：US532005
申请日：1974-12-12
申请人： Erhardt Winkelmann , Wolfgang Raether
发明人： Erhardt Winkelmann , Wolfgang Raether
IPC分类号： C07D233/91 , C07D233/92 , C07D233/94 , C07D403/12 , C07D257/04
CPC分类号： C07D233/94
摘要： New (1-alkyl-5-nitro-imidazolyl-2-alkyl)-heteroaryl compounds and process for their manufacture are described. The new compounds are well compatible and are effective against bacteria and protozoa as well as against fungi. They are especially active against trichomonads and amebae.
摘要翻译：描述了新的（1-烷基-5-硝基 - 咪唑-2-基） - 杂芳基化合物及其制备方法。新化合物很好地相容，对细菌和原生动物以及对真菌有效。他们对毛滴虫和阿米巴特别活跃。

9. 发明授权

US4078086A Anthraquinone-bis-amidines and process for preparing them 失效
标题翻译：蒽醌 - 双脒及其制备方法
公开(公告)号：US4078086A
公开(公告)日：1978-03-07
申请号：US685792
申请日：1976-05-12
申请人： Erhardt Winkelmann , Wolfgang Raether
发明人： Erhardt Winkelmann , Wolfgang Raether
IPC分类号： A61K31/155 , C07C67/00 , C07C239/00 , C07C257/10 , C07D207/22 , C07D211/72 , C07D223/06 , C07D295/195 , C07C123/00
CPC分类号： C07D295/195 , C07D207/22 , C07D211/72 , C07D223/06
摘要： Novel compounds of anthraquinone-bis-amidines are prepared which are suitable for combating diseases caused by trichomonads.
摘要翻译：制备新颖的蒽醌 - 双脒化合物，适用于对抗由滴虫引起的疾病。

10. 发明授权

US3973019A Pharmaceutical compositions containing 1,4-bis-(5'-nitroimidazolyl-2'-methylene-imino) piperazine compounds for treating protozoal diseases and methods for treating such diseases 失效
标题翻译：含有用于治疗原生动物疾病的1,4-双 - （5（4-硝基咪唑基-2（40-亚甲基 - 亚氨基）哌嗪）化合物的药物组合物及其治疗方法
公开(公告)号：US3973019A
公开(公告)日：1976-08-03
申请号：US535096
申请日：1974-12-20
申请人： Erhardt Winkelmann , Wolfgang Raether
发明人： Erhardt Winkelmann , Wolfgang Raether
IPC分类号： A61K31/495
CPC分类号： A61K31/495
摘要： 1,4-BIS-5'-NITROIMIDAZOLYL-2'-METHYLENE-IMINO) PIPERAZINES OF THE FORMULA ##SPC1##In which R.sub.1 is hydrogen, methyl, ethyl or 2-hydroxyethyl and R.sub.2 is hydrogen or methyl, are prepared by reaction of 5-nitro-imidazolyl-2-aldehydes or the functional derivatives thereof with 1,4-diamino-piperazines. Pharmaceutical compositions containing these compounds for treating protozoal diseases and methods of treating protozoal diseases with these compounds are disclosed.
摘要翻译： 1,4-BIS-5'-NITROIMIDAZOLYL-2'-METHYLENE-IMINO）式中R1是氢，甲基，乙基或2-羟乙基，R2是氢或甲基的哌嗪是通过5-硝基 - 咪唑基-2-醛或其功能衍生物与1,4-二氨基 - 哌嗪。公开了含有这些用于治疗原生动物疾病的化合物的药物组合物和用这些化合物治疗原生动物疾病的方法。

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