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31. 发明授权

US08114028B2 Analysis system for determining an analyte in a body fluid and disposable integrated sample acquisition and analysis element 有权
标题翻译：用于确定体液中的分析物和一次性综合样品采集和分析元件的分析系统
公开(公告)号：US08114028B2
公开(公告)日：2012-02-14
申请号：US12548479
申请日：2009-08-27
申请人： Hans List , Volker Zimmer , Michael Keil
发明人： Hans List , Volker Zimmer , Michael Keil
IPC分类号： A61B5/00
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/150175 , A61B5/150358 , A61B5/150435 , A61B5/150511 , A61B5/150572 , A61B5/15186 , A61B2562/0295
摘要： An analyte determination analysis system with a disposable integrated sample acquisition and analysis element is disclosed. A piercing element has a tip for generating a bodily puncture wound and a test strip having a body fluid sample receiving zone to perform an analysis on a body fluid sample. A reusable analysis instrument comprises a coupling unit that couples the integrated sample acquisition and analysis element to a drive that drives a piercing element in a piercing movement comprising two phases: a propulsion phase wherein the piercing element moves on a puncture path in a puncture direction and a retraction phase wherein the piercing element moves opposite to the puncture direction after reaching a reversal point. A measuring and analysis unit measures a variable characteristic for the determination of the analyte and determines a desired analysis result on the basis of the measurement. The sample receiving zone of the test strip forms a sample contact. The piercing element, located parallel to the test strip, moves on a movement path relative to the test strip a puncture path. The piercing element, located adjacent to the sample contact, has a capillary channel with a sample inlet for body fluid entry after the piercing and a sample outlet for body fluid exit. The piercing element movement has a sample transfer position wherein the sample outlet is adjacent to the sample receiving zone such that the body fluid may be transferred from the capillary channel through the sample outlet to the sample receiving zone.
摘要翻译：公开了一种具有一次性集成样品采集和分析元件的分析物测定分析系统。穿刺元件具有用于产生身体穿刺伤口的尖端和具有体液样品接收区以对体液样品进行分析的测试条。一种可重复使用的分析仪器包括耦合单元，该耦合单元将集成采样和分析元件耦合到驱动器，该驱动器以穿刺运动的方式驱动穿刺元件，所述穿孔运动包括两相：推进阶段，其中穿刺元件在穿刺方向上在穿刺路径上移动，其中穿刺元件在达到反转点之后与穿刺方向相反移动。测量和分析单元测量用于测定分析物的可变特性，并且基于测量确定期望的分析结果。测试条的样品接收区形成样品接触。刺穿元件平行于测试条移动，相对于测试条在穿刺路径上移动。位于邻近样品接触处的刺穿元件具有毛细通道，其具有用于在穿刺之后进入体液的样品入口和用于体液排出的样品出口。穿刺元件移动具有样品转移位置，其中样品出口与样品接收区相邻，使得体液可以从毛细通道通过样品出口转移到样品接收区。

32. 发明申请

US20120035639A1 REUSE PROTECTION FOR LANCET SYSTEM 有权
标题翻译：重新保护LANCET系统
公开(公告)号：US20120035639A1
公开(公告)日：2012-02-09
申请号：US13210795
申请日：2011-08-16
申请人： Richard Forster , Susanne Gentsch , Andreas Gorshoefer , Michael Keil , Thomas Weiss
发明人： Richard Forster , Susanne Gentsch , Andreas Gorshoefer , Michael Keil , Thomas Weiss
IPC分类号： A61B5/151
CPC分类号： A61B5/15153 , A61B5/1411 , A61B5/150022 , A61B5/150412 , A61B5/150519 , A61B5/150572 , A61B5/150824 , A61B5/15115 , A61B5/15163 , A61B5/15176 , A61B5/1518
摘要： A lancet magazine for use in a lancing aid is described comprising a plurality of lancets each having a lancet body at the proximal end of the lancet and a lancet tip at the distal end of the lancet, where the proximal end of the lancet points in the direction of the proximal end of the housing of the lancet magazine and the distal end of the lancet is aligned in the direction of the distal end of the housing and the lancets in the unused state are completely surrounded by the housing. Furthermore, an extension unit is movably connected to the housing in such a manner that the housing can be extended by movement of the extension unit in the direction of the distal end of the housing such that the lancet is prevented from emerging from the lancet magazine.
摘要翻译：一种用于穿刺辅助装置的柳叶刀盒，其特征在于，包括多个在柳叶刀的近端具有刺血针主体的柳叶刀和位于柳叶刀前端的刺血针头，其中，柳叶刀盒的壳体的近端的方向和柳叶刀的前端在壳体的远端的方向上对准，未使用状态的刺血针被壳体完全包围。此外，延伸单元以这样的方式可移动地连接到壳体，使得可以通过延伸单元在壳体的远端的方向上的移动来延伸壳体，使得防止柳叶刀从刺血针盒中出来。

33. 发明申请

US20110004002A1 Process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates 有权
标题翻译：制备2-烷氧基亚甲基-4,4-二氟-3-氧代丁酸烷基酯的方法
公开(公告)号：US20110004002A1
公开(公告)日：2011-01-06
申请号：US12919842
申请日：2009-02-27
申请人： Volker Maywald , Sebastian Peer Smidt , Bernd Wolf , Christopher Koradin , Thomas Zierke , Michael Rack , Michael Keil
发明人： Volker Maywald , Sebastian Peer Smidt , Bernd Wolf , Christopher Koradin , Thomas Zierke , Michael Rack , Michael Keil
IPC分类号： C07D231/14 , C07C69/66
CPC分类号： C07D231/14 , C07C67/343 , C07C69/72
摘要： A process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates (VI) where R is methyl or ethyl, from crude reaction mixtures of alkyl 4,4-difluoroacetoacetates (I) by a) reacting where M is a sodium or potassium ion, and without additional solvent to form an enolate (V) b) releasing the corresponding alkyl 4,4-difluoroacetoacetate (I) from the enolate (V) by means of acid, c) removing the salt formed from cation M and acid anion as a solid and d) converting (I), without isolation from the crude reaction mixture, to the alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrate (VI), and the use of (VI) for preparing 1-methyl-3-difluoromethyl-pyrazol-3-ylcarboxyates VII
摘要翻译：由烷基4,4-二氟乙酰乙酸酯（I）的粗反应混合物制备R为甲基或乙基的2-烷氧基亚甲基-4,4-二氟-3-氧代丁酸烷基酯（VI）的方法，通过a）使M 钠离子或钾离子，无另外的溶剂以形成烯醇化物（Ⅴ）b）通过酸从烯醇化物（Ⅴ）中释出相应的4,4-二氟乙酰乙酸烷基酯（Ⅰ），c）除去由阳离子M形成的盐和酸阴离子作为固体，以及d）将（I）从粗反应混合物中分离出来，转化为2-烷氧基亚甲基-4,4-二氟-3-氧代丁酸烷基酯（VI），以及（VI）用于制备1-甲基-3-二氟甲基 - 吡唑-3-基羧酸酯VII

34. 发明授权

US07820846B2 Bifunctional phenyliso(thio)cyanates, processes and intermediates products for their preparation 有权
标题翻译：双官能苯基（硫代）氰酸酯，其制备方法和中间体产品
公开(公告)号：US07820846B2
公开(公告)日：2010-10-26
申请号：US10532931
申请日：2003-10-29
申请人： Gerhard Hamprecht , Michael Puhl , Bernd Wolf , Norbert Götz , Michael Keil , Robert Reinhard , Ingo Sagasser , Werner Seitz
发明人： Gerhard Hamprecht , Michael Puhl , Bernd Wolf , Norbert Götz , Michael Keil , Robert Reinhard , Ingo Sagasser , Werner Seitz
IPC分类号： C07C255/50
CPC分类号： C07D213/76 , C07C303/34 , C07C307/06 , C07C331/28 , C07C2601/14 , C07D207/20 , C07D211/18 , C07D211/70 , C07D295/26 , C07D307/52 , C07D319/06 , C07D333/20
摘要： A process for preparing phenyl iso(thio)cyanates of the formula I in which a compound of the formula II or its HCl adduct is reacted with a phosgenating agent where W is oxygen or sulfur and Ar and A are as defined in claim 1 is described. Moreover, the invention relates to the use of the phenyl iso(thio)cyanates for preparing crop protection agents.
摘要翻译：描述式I的苯基异（硫代）氰酸酯的方法，其中将式II化合物或其HCl加合物与W是氧或硫的光气反应剂和Ar和A如权利要求1中所定义的相同。此外，本发明涉及苯基异（硫代）氰酸酯用于制备作物保护剂的用途。

35. 发明申请

US20100087640A1 Method for production of aryl-substituted annelated pyrimidines 审中-公开
标题翻译：芳基取代的环状嘧啶的制备方法
公开(公告)号：US20100087640A1
公开(公告)日：2010-04-08
申请号：US12521877
申请日：2008-01-10
申请人： Bernd Wolf , Volker Maywald , Michael Keil , Manuel Budich , Michael Rack , Manfred Ehresmann
发明人： Bernd Wolf , Volker Maywald , Michael Keil , Manuel Budich , Michael Rack , Manfred Ehresmann
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to a process for preparing aryl-substituted fused pyrimidines of the general formula (I) in which L1 to L5 are H, halogen, CN, NO2, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy etc.; Y1 to Y3 are C—RY or N; RY is H or optionally substituted C1-C4-alkyl or two adjacent RY together form a ring; X is OH, Cl or Br; which comprises (i) the reaction of a 2-phenylmalonate with a compound (III) or a tautomer thereof, in the presence of a suitable base, where the alcohol, released during the reaction, of the formula R—OH is continuously removed from the reaction mixture under reduced pressure; giving a compound of the formula (I) or a salt thereof in which X is OH, and, if X in the compounds of the general formula (I) is chlorine or bromine, (ii) the reaction of the compounds of the formula (I) obtained in step (i) or the salts with a halogenating agent.
摘要翻译：本发明涉及制备通式（I）的芳基取代的稠合嘧啶的方法，其中L 1至L 5为H，卤素，CN，NO 2，C 1 -C 4烷基，C 1 -C 4卤代烷基，C 1 -C 4 - 烷氧基，C1-C4-卤代烷氧基等; Y1至Y3为C-RY或N; RY为H或任选取代的C 1 -C 4烷基或两个相邻的RY一起形成环; X是OH，Cl或Br; 其包括（i）2-苯基丙二酸酯与化合物（III）或其互变异构体在合适的碱的存在下反应，其中反应期间释放的醇与式R-OH的连续从减压下的反应混合物; 得到其中X是OH的式（I）化合物或其盐，并且如果通式（I）的化合物中的X是氯或溴，则（ii）式（I）化合物 I）或与卤化剂的盐。

36. 发明申请

US20080293941A1 Method For Production Of 1-Alkyl-3-Phenyluracils 有权
标题翻译： 1-烷基-3-苯基尿嘧啶的制备方法
公开(公告)号：US20080293941A1
公开(公告)日：2008-11-27
申请号：US11913208
申请日：2006-05-18
申请人： Joachim Gebhardt , Sandra Lohr , Michael Keil , Thomas Schmidt , Jan Hendrik Wevers , Helmut Zech , Rudolf Haberler
发明人： Joachim Gebhardt , Sandra Lohr , Michael Keil , Thomas Schmidt , Jan Hendrik Wevers , Helmut Zech , Rudolf Haberler
IPC分类号： C07D239/54
CPC分类号： C07D239/54
摘要： The present invention relates to a process for preparing 1-alkyl-3-phenyluracils of the formula I where the variables R1 to R7 are as defined in the description by reacting 3-phenyluracils of the formula II and alkylating agents of the formula III R1-L1 III, with one another, wherein during the entire reaction the pH is kept in a range from 1 to 6 by adding base a little at a time.
摘要翻译：本发明涉及一种制备式I的1-烷基-3-苯基尿嘧啶的方法，其中变量R1至R7如说明书中所定义，通过使式II的3-苯基尿嘧啶与式III的烷基化剂反应， in-line-formula description =“In-line Formulas”end =“lead”？> R1-L1 III，<？in-line-formula description =“In-line Formulas”end =“tail”？> ，其中在整个反应期间，通过一次添加碱几乎将pH保持在1至6的范围内。

37. 发明授权

US07314948B2 Method for producing alkyl nitrites and alkyl dinitrites 有权
标题翻译：亚硝酸烷基酯和二硝基烷基酯的制备方法
公开(公告)号：US07314948B2
公开(公告)日：2008-01-01
申请号：US10485209
申请日：2002-08-02
申请人： Steffen Kudis , Rene Lochtman , Manfred Ehresmann , Michael Keil , Joachim Gebhardt , Michael Rack , Ralf Schimetzek
发明人： Steffen Kudis , Rene Lochtman , Manfred Ehresmann , Michael Keil , Joachim Gebhardt , Michael Rack , Ralf Schimetzek
IPC分类号： C07C23/02
CPC分类号： C07C201/04 , C07C203/00
摘要： In a continuous process for the preparation of alkyl nitrites and dinitrites, an alkanol or dialkanol is first mixed with an aqueous mineral acid, the reaction mixture obtained is then reacted with an inorganic nitrite and the product obtained can then be isolated immediately.
摘要翻译：在制备亚硝酸烷基酯和二硝酸烷基酯的连续方法中，首先将烷醇或二烷醇与无机酸水溶液混合，然后将得到的反应混合物与无机亚硝酸盐反应，然后立即分离得到的产物。

38. 发明申请

US20060009659A1 Method for the production of benzophenonen 有权
标题翻译：二苯甲酮生产方法
公开(公告)号：US20060009659A1
公开(公告)日：2006-01-12
申请号：US10535710
申请日：2003-12-01
申请人： Volker Maywald , Nico Hoffmann , Michael Keil , Uwe Vogelbacher , Jan Wevers
发明人： Volker Maywald , Nico Hoffmann , Michael Keil , Uwe Vogelbacher , Jan Wevers
IPC分类号： C07C45/46
CPC分类号： C07C51/363 , C07C45/46 , C07C45/81 , C07C51/60 , C07C49/84 , C07C65/21
摘要： A process for preparing benzophenones of the formula I, where X may be chlorine, hydroxyl, methoxy or C1-C6-alkylcarbonyloxy, and Y may be chlorine or bromine, by reacting an acid chloride of the formula II where X and Y are as defined above with 3,4,5-trimethoxytoluene, which comprises carrying out the reaction in the presence of a) an aromatic hydrocarbon as a diluent and b) from 0.01 to 0.2 mol % of an iron catalyst, based on the acid chloride, c) at a temperature between 60° C. and the boiling point of the particular diluent.
摘要翻译：制备式I的二苯甲酮的方法，其中X可以是氯，羟基，甲氧基或C 1 -C 6 - 烷基羰氧基，Y可以是氯或溴，通过使式II的酰氯与其中X和Y如上所定义的酰氯与3,4,5-三甲氧基甲苯反应，其包括在a）芳族烃作为稀释剂存在下进行反应，和b）从0.01至 0.2mol％的铁催化剂，基于酰氯，c）在60℃和特定稀释剂的沸点之间的温度下。

39. 发明授权

US06670482B2 Process and novel intermediates for preparing isoxazolin-3-ylacyl benzenes 有权
标题翻译：制备异恶唑啉-3-基酰基苯的方法和新型中间体
公开(公告)号：US06670482B2
公开(公告)日：2003-12-30
申请号：US10223019
申请日：2002-08-19
申请人： Wolfgang von Deyn , Joachim Gebhardt , Michael Rack , Rene Lochtman , Norbert Götz , Michael Keil , Matthias Witschel , Helmut Hagen , Ulf Misslitz , Ernst Baumann
发明人： Wolfgang von Deyn , Joachim Gebhardt , Michael Rack , Rene Lochtman , Norbert Götz , Michael Keil , Matthias Witschel , Helmut Hagen , Ulf Misslitz , Ernst Baumann
IPC分类号： C07D26104
CPC分类号： C07D413/10 , C07C251/48 , C07C319/14 , C07D261/04 , C07D261/08 , C07C323/09
摘要： The present invention describes a process for preparing isoxazoles of the formula I where: R1 is hydrogen, C1-C6-alkyl, R2 is hydrogen, C1-C6-alkyl, R3, R4, R5 are each hydrogen, C1-C6-alkyl or R4 and R5 together form a bond, R6 is a heterocyclic ring, n is 0, 1 or 2; which comprises preparing an intermediate of the formula VI where R1, R3, R4 and R5 are each as defined above, followed by halogenation, thiomethylation, oxidation and acylation to give compounds of the formula I. Furthermore, the invention describes novel intermediates for preparing the compounds of the formula I and novel processes for preparing the intermediates.
摘要翻译：本发明描述了制备式I的异恶唑的方法，其中R 1是氢，C 1 -C 6烷基，R 2是氢，C 1 -C 6烷基，R 3，R 4， R 5各自为氢，C 1 -C 6 - 烷基或R 4和R 5一起形成键，R 6为杂环，n为0,1或2;其包括制备中间体其中R 1，R 3，R 4和R 5各自如上所定义，然后进行卤化，硫甲基化，氧化和酰化，得到式I化合物。此外，本发明描述了制备式I化合物的新型中间体和制备中间体的新方法。

40. 发明授权

US5585520A Process for the preparation of O-substituted hydroxylammonium salts 失效
标题翻译：制备O-取代羟基铵盐的方法
公开(公告)号：US5585520A
公开(公告)日：1996-12-17
申请号：US592351
申请日：1996-01-11
申请人： Ulrich Klein , Ernst Buschmann , Michael Keil , Norbert G otz , Albrecht Harreus
发明人： Ulrich Klein , Ernst Buschmann , Michael Keil , Norbert G otz , Albrecht Harreus
IPC分类号： C07C239/20 , C07C213/00
CPC分类号： C07C239/20
摘要： Preparation of O-substituted hydroxylammonium salts IR.sup.1 --CHX--O--NH.sub.2.HL (I)(L=halogen, hydrogensulfate; X=H, alkyl; R.sup.1 =unsubst. or subst. phenyl, thienyl, furanyl, pyrrolyl or --CR.sup.2 .dbd.CR.sup.3 R.sup.4 ; R.sup.2, R.sup.3, R.sup.4 =H, halogen or alkyl) by reaction of an acetone oxime O-allyl or --O--benzyl ether II ##STR1## with water and a mineral acid H--L with continuous removal of the acetone formed in this process, by carrying out the hydrolysis batchwise at 0.degree.-50.degree. C. and under a pressure of 10-500 mbar is described.The O-substituted hydroxylammonium salts I are intermediates for plant protection agents and pharmaceuticals.
摘要翻译： PCT No.PCT / EP94 / 02239 Sec。 371日期1996年1月11日 102（e）日期1996年1月11日PCT提交1994年7月8日PCT公布。第WO95 / 04032号公报。日期：1995年2月9日O-取代羟基铵盐IR1-CHX-O-NH2HL（I）（L =卤素，硫酸氢盐; X = H，烷基; R1 =未取代的苯基，噻吩基，呋喃基，吡咯基或-CR2 = CR3R4; R2，R3，R4 = H，卤素或烷基），通过丙酮肟O-烯丙基或-O-苄基醚II（II）与水和无机酸HL与连续描述了在该方法中形成的丙酮的去除方法，在0-50℃和10-500mbar的压力下间歇地进行水解。 O-取代的羟基铵盐I是植物保护剂和药物的中间体。

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