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31. 发明授权

US09636470B2 Device for dosing and dry nebulization 有权
公开(公告)号：US09636470B2
公开(公告)日：2017-05-02
申请号：US11887392
申请日：2006-04-07
申请人： Gerhard Pohlmann , Horst Windt , Oliver Nolte , Wolfgang Koch
发明人： Gerhard Pohlmann , Horst Windt , Oliver Nolte , Wolfgang Koch
IPC分类号： A61M11/02 , A61M15/00 , A61M16/14 , A61M11/06 , B05B7/14 , A61M16/20 , A61M16/00
CPC分类号： A61M11/06 , A61M11/065 , A61M15/0065 , A61M15/0086 , A61M16/14 , A61M16/202 , A61M2016/0027 , A61M2202/064 , B05B7/1404
摘要： The invention relates to a device (1) for dosing and dry nebulization of nebulizable material, comprising a nebulization channel (3), which has a first attachment piece and a second attachment piece, and a source of compressed carrier gas connected to the first attachment piece via a valve for the purpose of sending a carrier gas pressure pulse into the nebulization channel. The device is characterized in that between the first attachment piece and second attachment piece, and above the nebulization channel, a reservoir open only towards the nebulization channel, and used for receiving the nebulizable material, is connected to the nebulization channel such that it is gas-tight with respect to the environment, and that, when the valve is closed, a pressure compensation takes place in the nebulization channel and in the reservoir. The invention also relates to the use of this device for inhaled administration of a powdered pharmaceutical preparation, and to a method for dosing and dry nebulization of nebulizable material by means of such a device.

32. 发明授权

US09020881B2 Public solution model in an enterprise service architecture 有权
标题翻译：企业服务架构中的公共解决方案模型
公开(公告)号：US09020881B2
公开(公告)日：2015-04-28
申请号：US12339304
申请日：2008-12-19
申请人： Gerd Martin Ritter , Stefan A. Baeuerle , Frank Brunswig , Thomas Fiedler , Jens Freund , Reiner Hammerich , Baré Said , Guenter Pecht-Seibert , Wolfgang Koch
发明人： Gerd Martin Ritter , Stefan A. Baeuerle , Frank Brunswig , Thomas Fiedler , Jens Freund , Reiner Hammerich , Baré Said , Guenter Pecht-Seibert , Wolfgang Koch
IPC分类号： G06F17/30 , G06Q10/10
CPC分类号： G06Q10/10 , G06F17/30294
摘要： A computer-implemented system may include an application platform comprising a platform model of a plurality of business objects, each of the business objects comprising a model of data and associated logic, and a public solution model comprising a subset of the platform model. The system may also include a business application, wherein a data model and access logic of the business application are defined based on the public solution model, and wherein the application platform is to provide services to the business application based on the data model, the access logic and the platform model.
摘要翻译：计算机实现的系统可以包括包括多个业务对象的平台模型的应用平台，每个业务对象包括数据模型和相关联的逻辑，以及包括平台模型的子集的公共解决方案模型。该系统还可以包括商业应用，其中基于公共解决方案模型来定义业务应用的数据模型和访问逻辑，并且其中所述应用平台将基于所述数据模型向所述业务应用提供服务，所述访问逻辑和平台模型。

33. 发明授权

US08910627B2 Apparatus for the aerosolization of large volumes of dry powder 有权
标题翻译：用于雾化大量干粉的装置
公开(公告)号：US08910627B2
公开(公告)日：2014-12-16
申请号：US13264422
申请日：2010-04-22
申请人： Peter Iwatschenko , Gerhard Pohlmann , Horst Windt , Wolfgang Koch , Michel Kist
发明人： Peter Iwatschenko , Gerhard Pohlmann , Horst Windt , Wolfgang Koch , Michel Kist
IPC分类号： A61M16/10 , A61M11/02 , A61M11/06 , A61M15/00 , A61M11/00 , A61M16/20 , B05B7/14 , A61M16/08
CPC分类号： A61M16/0069 , A61M11/001 , A61M11/02 , A61M11/06 , A61M15/0005 , A61M15/0006 , A61M15/0021 , A61M15/0065 , A61M15/0085 , A61M15/0086 , A61M16/0003 , A61M16/0666 , A61M16/0808 , A61M16/0833 , A61M16/085 , A61M16/1005 , A61M16/1065 , A61M16/107 , A61M16/202 , A61M16/208 , A61M2016/003 , A61M2016/1025 , A61M2202/064 , A61M2205/07 , A61M2205/3334 , A61M2205/42 , A61M2240/00 , B05B7/1413 , B05B7/1422
摘要： The claimed subject matter relates to a device for dosing and aerosolization of aerosolizable material. The device comprises: a body with an aerosolization channel with a distal attachment portion connectable to a source of carrier gas which provides pressure pulses to the aerosolization channel; a proximal attachment portion for outputting aerosolized material and a reservoir for receiving aerosolizable material. The reservoir comprises walls and is connected in a gas-tight manner to the body and in fluid connection with the aerosolization channel. At least part of the walls of the device are self-exciting membranes that can be put into oscillation by the pressure pulses.
摘要翻译：所要求保护的主题涉及可雾化材料的计量和雾化装置。该装置包括：具有雾化通道的主体，其具有可连接到载气源的远端连接部分，其向气雾化通道提供压力脉冲; 用于输出气雾化材料的近端附接部分和用于接收可雾化材料的储存器。储存器包括壁并且以气密的方式连接到主体并与雾化通道流体连接。装置的壁的至少一部分是自激振膜，可通过压力脉冲进入振荡。

34. 发明申请

US20130142782A1 HUMIDIFIED PARTICLES COMPRISING A THERAPEUTICALLY ACTIVE SUBSTANCE 有权
标题翻译：包含治疗活性物质的湿润颗粒物
公开(公告)号：US20130142782A1
公开(公告)日：2013-06-06
申请号：US13817173
申请日：2011-08-22
申请人： Daniela Rahmel , Friedemann Taut , Christian De Muynck , Markus Rast , Peter Iwatschenko , Gerhard Pohlmann , Wolfgang Koch , Horst Windt
发明人： Daniela Rahmel , Friedemann Taut , Christian De Muynck , Markus Rast , Peter Iwatschenko , Gerhard Pohlmann , Wolfgang Koch , Horst Windt
IPC分类号： A61K9/12 , A61M15/00
CPC分类号： A61K9/122 , A61K9/0073 , A61K9/0075 , A61K9/0082 , A61M11/002 , A61M11/003 , A61M15/00 , A61M15/009 , A61M16/0666 , A61M16/1065 , A61M16/142 , A61M16/16 , A61M2205/505 , A61M2205/7518 , Y10T137/0318
摘要： The invention relates to aerosolized and humidified particles comprising a therapeutically active substance which can be obtained by suspending dry inhalable particles in a carrier gas, adding water vapor and causing condensation of water on the particles. The invention further relates to methods to generate these particles, and apparatus useful to carry out such methods.
摘要翻译：本发明涉及雾化和加湿的颗粒，其包含治疗活性物质，其可以通过将干燥的可吸入颗粒悬浮在载体气体中，加入水蒸气并使水在颗粒上冷凝而获得。本发明还涉及产生这些颗粒的方法以及用于实施这些方法的装置。

35. 发明申请

US20110066660A1 SYSTEMS AND METHODS FOR PROVIDING MOCKUP BUSINESS OBJECTS 有权
标题翻译：用于提供MOCKUP业务对象的系统和方法
公开(公告)号：US20110066660A1
公开(公告)日：2011-03-17
申请号：US12950740
申请日：2010-11-19
申请人： Michael Aakolk , Frank Brunswig , Wolfgang Koch , Abhay A. Tiple
发明人： Michael Aakolk , Frank Brunswig , Wolfgang Koch , Abhay A. Tiple
IPC分类号： G06F17/30
CPC分类号： G06F8/20
摘要： Methods and apparatus, including computer program products, are provided for a mockup business object. The mockup business object implemented within a computer framework including other business objects. In one exemplary embodiment, the method may include generating, within the computer framework, the mockup business object based on a metadata stored within the computer framework, when the mockup business object does not exist within the computer framework. The method may also include determining whether a structure of the mockup business object has changed based on the metadata, when the mockup business object does exist within the computer framework. Moreover, the method may include modifying the mockup business object based on the result of the determining step.
摘要翻译：为模拟业务对象提供了包括计算机程序产品在内的方法和设备。在包括其他业务对象的计算机框架内实现的模拟业务对象。在一个示例性实施例中，当计算机框架内不存在模型业务对象时，该方法可以包括在计算机框架内基于存储在计算机框架内的元数据来生成模型业务对象。该方法还可以包括当模拟商业对象确实存在于计算机框架内时，基于元数据来确定模型业务对象的结构是否已经改变。此外，该方法可以包括基于确定步骤的结果修改模型业务对象。

36. 发明申请

US20100315904A1 DIRECTION-FINDING METHOD AND INSTALLATION FOR DETECTION AND TRACKING OF SUCCESSIVE BEARING ANGLES 审中-公开
标题翻译：用于检测和跟踪连续轴承角的方向寻找方法和安装
公开(公告)号：US20100315904A1
公开(公告)日：2010-12-16
申请号：US12793227
申请日：2010-06-03
申请人： Kevin BRINKMANN , Jörg Hurka , Martina Daun , Wolfgang Koch , Eicke Ruthotto
发明人： Kevin BRINKMANN , Jörg Hurka , Martina Daun , Wolfgang Koch , Eicke Ruthotto
IPC分类号： G01S15/00
CPC分类号： G01S3/8083 , G01S3/8006
摘要： A direction-finding method and apparatus for detection and tracking of successive bearing angles of sound-emitting targets, wherein intensity plots of successive clock cycles in a waterfall plot show bearing traces of successive bearing angles, and preferred bearing traces are marked by a tracker. In order to automate the setting and deletion of trackers, starting from trace state vectors, which are determined at the time t=k−1, are each associated with one bearing trace and each have a bearing angle as well as its time derivative, which is referred to as the bearing rate, and possibly an intensity and its time derivative, which is referred to as the intensity rate, and trace errors associated with the trace state vectors for the time t=k, predicted state vectors are predicted together with predicted estimation errors. Bearing traces are displayed as a function of a trace quality
摘要翻译：一种用于检测和跟踪声发射目标的连续支承角度的测向方法和装置，其中瀑布图中连续时钟周期的强度图示出了连续承受角度的轨迹，并且优选的支承轨迹由跟踪器标记。为了自动化跟踪器的设置和删除，从在时间t = k-1确定的跟踪状态矢量开始，每个都与一个轴承轨迹相关联，并且每个具有一个方位角以及其时间导数，被称为轴承速率，并且可能的强度及其时间导数（被称为强度率）以及与时间t = k的跟踪状态向量相关联的跟踪误差，预测状态向量与预测的估计误差。轴承轨迹显示为跟踪质量的函数

37. 发明申请

US20090000615A1 Device for Dosing and Dry Nebulization 有权
标题翻译：剂量和干雾化装置
公开(公告)号：US20090000615A1
公开(公告)日：2009-01-01
申请号：US11887392
申请日：2006-04-07
申请人： Gerhard Pohlmann , Horst Windt , Oliver Nolte , Wolfgang Koch
发明人： Gerhard Pohlmann , Horst Windt , Oliver Nolte , Wolfgang Koch
IPC分类号： A61M11/00 , A61M16/10
CPC分类号： A61M11/06 , A61M11/065 , A61M15/0065 , A61M15/0086 , A61M16/14 , A61M16/202 , A61M2016/0027 , A61M2202/064 , B05B7/1404
摘要： The invention relates to a device (1) for dosing and dry nebulization of nebulizable material, comprising a nebulization channel (3), which has a first attachment piece and a second attachment piece, and a source of compressed carrier gas connected to the first attachment piece via a valve for the purpose of sending a carrier gas pressure pulse into the nebulization channel. The device is characterized in that between the first attachment piece and second attachment piece, and above the nebulization channel, a reservoir open only towards the nebulization channel, and used for receiving the nebulizable material, is connected to the nebulizaton channel such that it is gas-tight with respect to the environment, and that, when the valve is closed, a pressure compensation takes place in the nebulization channel and in the reservoir. The invention also relates to the use of this device for inhaled administration of a powdered pharmaceutical preparation, and to a method for dosing and dry nebulization of nebulizable material by means of such a device.
摘要翻译：本发明涉及一种用于对可雾化材料进行计量和干燥雾化的装置（1），其包括具有第一附接件和第二附接件的雾化通道（3）和连接到第一附件的压缩载气源以通过阀门将载气压力脉冲发送到雾化通道中。该装置的特征在于，在第一附接件和第二附接件之间并且在雾化通道上方，仅朝向雾化通道打开并用于接收可雾化材料的储存器连接到喷雾通道，使得其为气体相对于环境，并且当阀关闭时，在雾化通道和储存器中进行压力补偿。本发明还涉及该装置用于粉末状药物制剂的吸入施用，以及通过这种装置对可雾化材料进行给药和干燥雾化的方法。

38. 发明授权

US06852852B2 Method of producing regioselectively substituted esters of oligo- and polysaccharides 失效
标题翻译：制备低聚和多糖区域选择性酯的方法
公开(公告)号：US06852852B2
公开(公告)日：2005-02-08
申请号：US10272898
申请日：2002-10-17
申请人： Erik-Andreas Klohr , Wolfgang Koch , Dieter Klemm , René Dicke
发明人： Erik-Andreas Klohr , Wolfgang Koch , Dieter Klemm , René Dicke
IPC分类号： C12P19/00 , C08B3/06 , C08B31/04 , C08B33/02 , C08B37/00 , C08B37/16 , C08L101/16 , C07H1/00 , C08B3/00 , C08B31/02
CPC分类号： C08B33/02 , C08B3/06 , C08B31/04 , C08B37/0012
摘要： A method of producing a cellueose ether that is predominantly substituted in the C2 position of the anhydroglucose unit of the cellulose is described. The regioselectively substituted saccharide ester produced according to the method of the present invention is selected from the group consisting of oligo-saccharide ester and polysaccharide ester, having a partial average degree of substitution (AS) at the C2 position of its anhydroglucose unit of at least 90% relative to the total AS. Also described is a blood plasma expander comprising the regioselectively substituted ester.
摘要翻译：描述了在纤维素的脱水葡萄糖单元的C2位置主要代替的纤维素醚的生产方法。根据本发明方法制备的区域选择性糖酯酯选自低聚糖酯和多糖酯，其至少在其脱水葡萄糖单元的C2位置具有部分平均取代度（AS） 90％相对于总AS。还描述了包含区域选择性取代的酯的血浆扩张器。

39. 发明授权

US06413021B1 Rotating cutting tool 有权
标题翻译：旋转刀具
公开(公告)号：US06413021B1
公开(公告)日：2002-07-02
申请号：US09655383
申请日：2000-09-05
申请人： Wolfgang Koch , Christian Ertl
发明人： Wolfgang Koch , Christian Ertl
IPC分类号： B26D112
CPC分类号： B23D77/025 , Y10T407/1926 , Y10T407/1934 , Y10T407/1942 , Y10T407/1952
摘要： A cutting tool for high-speed machining has at least one cutting insert that is interchangeably mounted to a main body of the tool. At least parts of the supporting surface of the cutting insert and of the receiving surface of the main body of the tool, when viewed in cross section perpendicular to the axis of rotation, are of an approximately V-shaped configuration and are engaged with each other. The crown region and also at least one of the end regions of the V-shaped supporting surface and receiving surface are mutually relieved. A bearing surface on the main body of the tool, in order to radially support the cutting insert, is arranged in such a way that a mounted cutting insert is tilted such that the supporting surface of the main body and the receiving surface come into mutual contact at only two points.
摘要翻译：用于高速加工的切割工具具有至少一个可互换地安装到工具的主体上的切削刀片。当从垂直于旋转轴线的横截面观察时，切削刀片的支撑表面和工具主体的接收表面的至少部分具有大致V形构造并且彼此接合。冠状区域以及V形支撑表面和接收表面的端部区域中的至少一个相互减轻。为了径向地支撑切削刀片，工具主体上的支承面被布置成使得安装的切削刀片倾斜，使得主体的支撑表面和接收表面相互接触只有两点。

40. 发明授权

US5717087A Thermoplastic and biodegradable polysaccharide esters/polysaccharide ether esters containing maleic acid addition product groups 失效
标题翻译：含有马来酸加成产物的热塑性和可生物降解的多糖酯/多糖醚酯
公开(公告)号：US5717087A
公开(公告)日：1998-02-10
申请号：US692028
申请日：1996-08-02
申请人： Jochen Kalbe , Reinhard Koch , Hanns Peter Muller , Jurgen Engelhardt , Wolfgang Koch , Volkhard Muller
发明人： Jochen Kalbe , Reinhard Koch , Hanns Peter Muller , Jurgen Engelhardt , Wolfgang Koch , Volkhard Muller
IPC分类号： A61K47/36 , A61K9/20 , A61K47/38 , C08B13/00 , C08B31/04 , C08B37/00 , C08J5/00 , C08L5/00 , C08L101/16 , C09D105/00 , D01F2/24 , D21H19/44 , D21H19/52
CPC分类号： C08B13/00 , A61K9/2054 , A61K9/2059 , C08B31/04 , Y02W30/43
摘要： The present invention relates to thermoplastic and biodegradable polysaccharide esters/polysaccharide ether esters, which are characterised in that they can be represented by the general structure ##STR1## wherein Polysaccharide-O represents the substituted OH groups of a polymeric saccharide unit and wherein A is a linear polyether chain of the following structure A=(E--O)n wherein E signifies a linear aliphatic or aromatic branched or unbranched chain having 2 to 11 C atoms, n is an integer equal to or greater than 0 and both B and D are a maleic acid addition product of the following structure ##STR2## wherein F is an aliphatic, saturated, monounsaturated or polyunsaturated carbon skeleton, which may optionally be provided with further substituents and wherein C can be a hydrogen atom, one or more substituents from the group dihydroxyethyl, hydroxypropyl, hydroxybutyl, methyl, ethyl, benzyl, dihydroxypropyl, carboxyalkyl, sulphoalkyl or cyanoethyl.
摘要翻译：本发明涉及热塑性和可生物降解的多糖酯/多糖醚酯，其特征在于它们可以由通式结构表示，其中多糖-O代表聚合糖单元的取代的OH基团，其中A是具有以下结构的线性聚醚链A =（EO）n，其中E表示具有2至11个C原子的直链脂族或芳族支链或非支链，n为等于或大于0的整数，B和D均为马来酸加成具有以下结构的产物其中F是脂族饱和的单不饱和或多不饱和碳骨架，其可以任选地被提供另外的取代基，并且其中C可以是氢原子，一个或多个二羟基乙基，羟丙基，羟基丁基，甲基，乙基，苄基，二羟基丙基，羧基烷基，磺基烷基或氰基乙基。

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