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31. 发明授权

US09295391B1 Spectrally encoded miniature endoscopic imaging probe 有权
标题翻译：光谱编码微型内窥镜成像探头
公开(公告)号：US09295391B1
公开(公告)日：2016-03-29
申请号：US09709162
申请日：2000-11-10
申请人： Guillermo J. Tearney , Brett Eugene Bouma , Milen Stefanov Shishkov , Jonathan Jay Rosen
发明人： Guillermo J. Tearney , Brett Eugene Bouma , Milen Stefanov Shishkov , Jonathan Jay Rosen
IPC分类号： A61B6/00 , A61B5/00
CPC分类号： A61B5/0059 , A61B1/00096 , A61B1/0017 , A61B1/043 , A61B1/07 , A61B5/0062 , A61B5/0071 , A61B5/0084 , G02B21/0036 , G02B21/0048 , G02B21/0064
摘要： A spectrally encoded endoscopic probe having high resolution and small diameter comprising at least one flexible optical fiber; an energy source; a grating through which said energy is transmitted such that the energy spectrum is dispersed; a lens for focusing the dispersed energy spectrum onto a sample such that the impingement spot for each wavelength is a separate position on the sample, the wavelength spectrum defining a wavelength encoded axis; means for mechanically scanning the sample with focused energy in a direction perpendicular to the wavelength encoded axis; a means for receiving energy reflected from the sample; and, a means for detecting the received reflected energy. The probe grating and lens delivers a beam of multi-spectral light having spectral components extending in one dimension across a target region and which is moved to scan in another direction. The reflected spectrum is measured to provide two dimensional imaging of the region.
摘要翻译：一种具有高分辨率和小直径的光谱编码内窥镜探针，包括至少一个柔性光纤; 能源; 所述能量通过所述光栅传播，使得能谱被分散; 用于将分散的能谱聚焦到样品上的透镜，使得每个波长的冲击点是样品上的分离位置，所述波长谱定义波长编码轴; 用于在垂直于波长编码轴的方向上以聚焦能量机械扫描样品的装置; 用于接收样品反射的能量的方法; 以及用于检测所接收的反射能量的装置。探测光栅和透镜提供具有在一个维度上延伸穿过目标区域并且被移动以沿另一个方向扫描的光谱分量的多光谱光束。测量反射光谱以提供该区域的二维成像。

32. 发明授权

US09060689B2 Apparatus, method and system for performing phase-resolved optical frequency domain imaging 有权
标题翻译：用于执行相位分辨光学频域成像的装置，方法和系统
公开(公告)号：US09060689B2
公开(公告)日：2015-06-23
申请号：US11445990
申请日：2006-06-01
申请人： Guillermo J. Tearney , Brett Eugene Bouma , Johannes F. De Boer , Benjamin J. Vakoc , Seok-Hyun Yun
发明人： Guillermo J. Tearney , Brett Eugene Bouma , Johannes F. De Boer , Benjamin J. Vakoc , Seok-Hyun Yun
IPC分类号： G01N21/55 , A61B5/00 , G01N21/45 , G01N21/47 , G01N21/49 , G01B9/02
CPC分类号： A61B5/0073 , A61B5/0066 , A61B2560/0223 , G01B9/02091 , G01N21/45 , G01N21/4795 , G01N21/49
摘要： Apparatus, system and method are provided which utilize signals received from a reference and a sample. In particular, a radiation is provided which includes at least one first electro-magnetic radiation directed to the sample and at least one second electro-magnetic radiation directed to the reference. A frequency of the radiation varies over time. An interference can be detected between at least one third radiation associated with the first radiation and at least one fourth radiation associated with the second radiation. It is possible to obtain a particular signal associated with at least one phase of at least one frequency component of the interference, and compare the particular signal to at least one particular information. Further, it is possible to receive at least one portion of the radiation and provide a further radiation, such that the particular signal can be calibrated based on the further signal.
摘要翻译：提供了使用从参考和样本接收的信号的装置，系统和方法。特别地，提供了一种辐射，其包括指向样品的至少一个第一电磁辐射和指向该参考的至少一个第二电磁辐射。辐射的频率随时间而变化。可以在与第一辐射相关联的至少一个第三辐射与与第二辐射相关联的至少一个第四辐射之间检测干扰。可以获得与干扰的至少一个频率分量的至少一个相位相关联的特定信号，并将特定信号与至少一个特定信息进行比较。此外，可以接收辐射的至少一部分并提供另外的辐射，使得可以基于另外的信号来校准特定信号。

33. 发明申请

US20150029513A1 SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIUM WHICH PROVIDE MICROSCOPIC IMAGES OF AT LEAST ONE ANATOMICAL STRUCTURE AT A PARTICULAR RESOLUTION 有权
标题翻译：系统，方法和计算机可访问介质，提供特定解决方案中至少一个解剖结构的微观图像
公开(公告)号：US20150029513A1
公开(公告)日：2015-01-29
申请号：US14455355
申请日：2014-08-08
申请人： Guillermo J. Tearney , BRETT EUGENE BOUMA , JOSEPH A. GARDECKI , LlNBO LlU
发明人： Guillermo J. Tearney , BRETT EUGENE BOUMA , JOSEPH A. GARDECKI , LlNBO LlU
IPC分类号： G01B9/02
CPC分类号： A61B5/0066 , A61B5/0044 , A61B5/0075 , A61B5/0084 , G01B9/02091 , G02B6/32
摘要： Exemplary embodiments of systems and methods can be provided which can generate data associated with at least one portion of a sample. For example, at least one first radiation can be forwarded to the portion through at least one optical arrangement. At least one second radiation can be received from the portion which is based on the first radiation. Based on an interaction between the optical arrangement and the first radiation and/or the second radiation, the optical arrangement can have a first transfer function. Further, it is possible to forward at least one third radiation to the portion through such optical arrangement (or through another optical arrangement), and receive at least one fourth radiation from the portion which is based on the third radiation. Based on an interaction between the optical arrangement (or the other optical arrangement) and the third radiation and/or the fourth radiation, the optical arrangement (or the other optical arrangement) can have a second transfer function. The first transfer function can be at least partially different from the second transfer function. The data can be generated based on the second and fourth radiations.
摘要翻译：可以提供可以生成与样品的至少一部分相关联的数据的系统和方法的示例性实施例。例如，可以通过至少一个光学布置将至少一个第一辐射转发到该部分。可以从基于第一辐射的部分接收至少一个第二辐射。基于光学布置和第一辐射和/或第二辐射之间的相互作用，光学装置可以具有第一传递函数。此外，可以通过这种光学装置（或通过另一种光学装置）将至少一个第三辐射转发到该部分，并且从基于第三辐射的部分接收至少一个第四辐射。基于光学布置（或另一个光学布置）和第三辐射和/或第四辐射之间的相互作用，光学布置（或另一个光学布置）可以具有第二传递函数。第一传递函数可以至少部分地不同于第二传递函数。可以基于第二和第四辐射来生成数据。

34. 发明授权

US08416818B2 Process and apparatus for a wavelength tuning source 有权
公开(公告)号：US08416818B2
公开(公告)日：2013-04-09
申请号：US13160335
申请日：2011-06-14
申请人： Brett Eugene Bouma , Seok-Hyun (Andy) Yun , Wang-Yuhl (William) Oh , Johannes F. De Boer , Guillermo J. Tearney
发明人： Brett Eugene Bouma , Seok-Hyun (Andy) Yun , Wang-Yuhl (William) Oh , Johannes F. De Boer , Guillermo J. Tearney
IPC分类号： H01S3/10
CPC分类号： G01J3/10 , A61B5/0059 , A61B5/0066 , G01B9/02004 , G01B9/02091 , G01J3/12 , G01J9/0215 , G01N21/4795 , G02B27/48 , H01S3/08009 , H01S3/08063 , H01S3/105 , H01S5/141 , H01S5/146 , H01S5/4087
摘要： An apparatus and source arrangement for filtering an electromagnetic radiation can be provided which may include at least one spectral separating arrangement configured to physically separate one or more components of the electromagnetic radiation based on a frequency of the electromagnetic radiation. The apparatus and source arrangement may also have at least one continuously rotating optical arrangement which is configured to receive at least one signal that is associated with the one or more components. Further, the apparatus and source arrangement can include at least one beam selecting arrangement configured to receive the signal.

35. 发明申请

US20120281237A1 SPECKLE REDUCTION IN OPTICAL COHERENCE TOMOGRAPHY BY PATH LENGTH ENCODED ANGULAR COMPOUNDING 有权
标题翻译：通过路径长度编码角度化合物进行光学相干光谱中的光谱减少
公开(公告)号：US20120281237A1
公开(公告)日：2012-11-08
申请号：US13465517
申请日：2012-05-07
申请人： Guillermo J. Tearney , Nicusor Iftimia , Brett Eugene Bouma
发明人： Guillermo J. Tearney , Nicusor Iftimia , Brett Eugene Bouma
IPC分类号： G01B9/02 , G02B27/12
CPC分类号： A61B5/0066 , A61B5/0059 , A61B5/6852 , G01B9/02028 , G01B9/02082 , G01B9/02087 , G01B9/02091 , G01J9/0215 , G01N21/4795 , G02B26/105 , G02B27/48
摘要： Accordingly, exemplary embodiments of an apparatus probe catheter and method can be provided for irradiating a structure. In particular, an interferometer may forward forwarding an electromagnetic radiation. In addition, a sample arm may receive the electromagnetic radiation, and can include an arrangement which facilitates a production of at least two radiations from the electromagnetic radiation so as to irradiate the structure. Such exemplary arrangement can be configured to delay a first radiation of the at least two radiations with respect to a second radiation of the at least two radiations.
摘要翻译：因此，可以提供用于照射结构的装置探针导管和方法的示例性实施例。具体地，干涉仪可以转发电磁辐射。此外，样品臂可以接收电磁辐射，并且可以包括便于从电磁辐射产生至少两个辐射以便照射结构的装置。这种示例性布置可以被配置为相对于至少两个辐射的第二辐射来延迟所述至少两个辐射的第一辐射。

36. 发明申请

US20110275899A1 SPECTRALLY ENCODED MINIATURE ENDOSCOPIC IMAGING PROBE 审中-公开
标题翻译：光谱编码微型内窥镜成像探头
公开(公告)号：US20110275899A1
公开(公告)日：2011-11-10
申请号：US13187106
申请日：2011-07-20
申请人： Guillermo J. Tearney , Brett Eugene Bouma , Milen Stefanov Shishkov , Jonathan Jay Rosen
发明人： Guillermo J. Tearney , Brett Eugene Bouma , Milen Stefanov Shishkov , Jonathan Jay Rosen
IPC分类号： A61B1/06
CPC分类号： A61B5/0059 , A61B1/00096 , A61B1/0017 , A61B1/043 , A61B1/07 , A61B5/0062 , A61B5/0071 , A61B5/0084 , G02B21/0036 , G02B21/0048 , G02B21/0064
摘要： A spectrally encoded endoscopic probe having high resolution and small diameter comprising at least one flexible optical fiber; an energy source; a grating through which said energy is transmitted such that the energy spectrum is dispersed; a lens for focusing the dispersed energy spectrum onto a sample such that the impingement spot for each wavelength is a separate position on the sample, the wavelength spectrum defining a wavelength encoded axis; means for mechanically scanning the sample with focused energy in a direction perpendicular to the wavelength encoded axis; a means for receiving energy reflected from the sample; and, a means for detecting the received reflected energy. The probe grating and lens delivers a beam of multi-spectral light having spectral components extending in one dimension across a target region and which is moved to scan in another direction. The reflected spectrum is measured to provide two dimensional imaging of the region.
摘要翻译：一种具有高分辨率和小直径的光谱编码内窥镜探针，包括至少一个柔性光纤; 能源; 所述能量通过所述光栅传播，使得能谱被分散; 用于将分散的能谱聚焦到样品上的透镜，使得每个波长的冲击点是样品上的分离位置，所述波长谱定义波长编码轴; 用于在垂直于波长编码轴的方向上以聚焦能量机械扫描样品的装置; 用于接收样品反射的能量的方法; 以及用于检测所接收的反射能量的装置。探测光栅和透镜提供具有在一个维度上延伸穿过目标区域并且被移动以沿另一个方向扫描的光谱分量的多光谱光束。测量反射光谱以提供该区域的二维成像。

37. 发明授权

US07995210B2 Devices and arrangements for performing coherence range imaging using a common path interferometer 有权
标题翻译：使用公共路径干涉仪进行相干距离成像的装置和装置
公开(公告)号：US07995210B2
公开(公告)日：2011-08-09
申请号：US11285301
申请日：2005-11-21
申请人： Guillermo J. Tearney , Brett Eugene Bouma
发明人： Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： G01B9/02 , G01B11/02
CPC分类号： A61B5/6852 , A61B5/0066 , G01B9/02004 , G01B9/02044 , G01B9/0205 , G01B9/02057 , G01B9/02091 , G01B2290/70 , G01D5/35303 , G01N21/4795
摘要： Devices, arrangements and apparatus adapted to propagate at least one electro-magnetic radiation are provided. In particular, a probe housing, a sample arm section and a reference arm section can be included. For example, the sample arm section can be at least partially situated within the probe housing, and configured to propagate a first portion of the electro-magnetic radiation that is intended to be forwarded to a sample. The reference arm section can be at least partially situated within the probe housing, and configured to propagate a second portion of the electro-magnetic radiation that is intended to be forwarded to a reference. In addition or as an alternative, an interferometer may be situated within the probe housing. The first and second portions may travel along substantially the same paths, and the electro-magnetic radiation can be generated by a narrowband light source that has a tunable center wavelength. Further, the first and second portions may be at least partially transmitted via at least one optical fiber. A splitting arrangement may be provided which splits the electro-magnetic radiation into the first and second portions, and positioned closer to the sample than to the source of the electro-magnetic radiation, and the first and second portions may be adapted to propagate in different directions. An apparatus may be provided that is configured to control an optical path length of the second portion.
摘要翻译：提供适于传播至少一个电磁辐射的装置，装置和装置。特别地，可以包括探针壳体，样品臂部分和参考臂部分。例如，样品臂部分可以至少部分地位于探针壳体内，并且被配置为传播旨在被转发到样品的电磁辐射的第一部分。参考臂部分可以至少部分地位于探针壳体内，并且被配置为传播旨在被转发到参考的电磁辐射的第二部分。另外或作为替代，干涉仪可以位于探针外壳内。第一和第二部分可以沿着基本上相同的路径行进，并且电磁辐射可以由具有可调谐中心波长的窄带光源产生。此外，第一和第二部分可以经由至少一根光纤至少部分地传输。可以提供分裂装置，其将电磁辐射分裂成第一和第二部分，并且比电磁辐射源更靠近样品定位，并且第一和第二部分可适于以不同的方式传播方向。可以提供被配置为控制第二部分的光路长度的装置。

38. 发明授权

US07859679B2 System, method and arrangement which can use spectral encoding heterodyne interferometry techniques for imaging 有权
标题翻译：可以使用频谱编码外差干涉测量技术进行成像的系统，方法和布置
公开(公告)号：US07859679B2
公开(公告)日：2010-12-28
申请号：US11445131
申请日：2006-05-31
申请人： Brett Eugene Bouma , Guillermo J. Tearney , Dvir Yelin , Seok-Hyun Yun
发明人： Brett Eugene Bouma , Guillermo J. Tearney , Dvir Yelin , Seok-Hyun Yun
IPC分类号： G01B9/02 , G01B11/02
CPC分类号： G01N21/4795 , A61B5/0066 , A61B5/0084 , A61B5/7257
摘要： Systems, arrangements and methods for obtaining three-dimensional imaging data are provided. For example, a broadband light source can provide a particular radiation. A first electro-magnetic radiation can be focused and diffracted, and then provided to at least one sample to generate a spectrally-encoded line. A second electro-magnetic radiation may be provided to a reference, which may include a double-pass rapidly-scanning optical delay, where the first and second electro-magnetic radiations can be based on the particular radiation. An interference between a third electro-magnetic radiation (associated with the first electro-magnetic radiation) and a fourth electro-magnetic radiation (associated with the second electro-magnetic radiation) can be detected. The spectrally-encoded line may be scanned over the sample in a direction approximately perpendicular to the line. Image data containing three-dimensional information can then be obtained based on the interference. The exemplary imaging methods and systems can be used in a small fiber optic or endoscopic probe.
摘要翻译：提供了用于获得三维成像数据的系统，布置和方法。例如，宽带光源可以提供特定的辐射。可以将第一电磁辐射聚焦和衍射，然后提供给至少一个样品以产生光谱编码的线。可以将第二电磁辐射提供给参考，其可以包括双遍快速扫描光学延迟，其中第一和第二电磁辐射可以基于特定辐射。可以检测第三电磁辐射（与第一电磁辐射相关联）和第四电磁辐射（与第二电磁辐射相关联）之间的干扰。光谱编码的线可以在大致垂直于线的方向上扫描样品。然后可以基于干扰获得包含三维信息的图像数据。示例性的成像方法和系统可以用于小型光纤或内窥镜探针。

39. 发明授权

US07742173B2 Methods, arrangements and systems for polarization-sensitive optical frequency domain imaging of a sample 有权
标题翻译：样品的偏振敏感光学频域成像的方法，布置和系统
公开(公告)号：US07742173B2
公开(公告)日：2010-06-22
申请号：US11697012
申请日：2007-04-05
申请人： Seok-Hyun Yun , Johannes F. De Boer , Guillermo J. Tearney , Brett Eugene Bouma
发明人： Seok-Hyun Yun , Johannes F. De Boer , Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： G01B9/02
CPC分类号： G01N21/4795 , G01B9/02002 , G01B9/02004 , G01B9/02011 , G01B9/02091 , G01B2290/70
摘要： Arrangements and methods are provided for obtaining data associated with a sample. For example, at least one first electro-magnetic radiation can be provided to a sample and at least one second electro-magnetic radiation can be provided to a reference (e.g., a non-reflective reference). A frequency of such radiation(s) can repetitively vary over time with a first characteristic period. In addition, a polarization state of the first electro-magnetic radiation, the second electro-magnetic radiation, a third electro-magnetic radiation (associated with the first radiation) or a fourth electro-magnetic radiation (associated with the second radiation) can repetitively vary over time with a second characteristic period which is shorter than the first period. The data for imaging at least one portion of the sample can be provided as a function of the polarization state. In addition or alternatively, the third and fourth electro-magnetic radiations can be combined so as to determine an axial reflectance profile of at least one portion of the sample.
摘要翻译：提供了用于获取与样本相关的数据的安排和方法。例如，可以向样品提供至少一个第一电磁辐射，并且可以向参考（例如，非反射参考）提供至少一个第二电磁辐射。这种辐射的频率可以在第一特征周期内随时间重复地变化。此外，第一电磁辐射，第二电磁辐射，第三电磁辐射（与第一辐射相关联）或第四电磁辐射（与第二辐射相关联）的极化状态可以重复地随着时间而变化，其具有比第一周期短的第二特征周期。用于成像至少一部分样品的数据可以作为偏振态的函数提供。另外或替代地，可以组合第三和第四电磁辐射，以便确定样品的至少一部分的轴向反射率分布。

40. 发明申请

US20100094576A1 APPARATUS AND METHOD FOR RANGING AND NOISE REDUCTION OF LOW COHERENCE INTERFEROMETRY LCI AND OPTICAL COHERENCE TOMOGRAPHY OCT SIGNALS BY PARALLEL DETECTION OF SPECTRAL BANDS 有权
标题翻译：通过平行检测光谱仪的低相干干涉LCI和光学相干TOMOGRAPHY OCT信号的范围和噪声降低的装置和方法
公开(公告)号：US20100094576A1
公开(公告)日：2010-04-15
申请号：US12570443
申请日：2009-09-30
申请人： Johannes F. de Boer , Guillermo J. Tearney , Brett Eugene Bouma
发明人： Johannes F. de Boer , Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： G01B9/02 , G06F19/00
CPC分类号： G01B9/02007 , A61B5/0059 , A61B5/0066 , A61B5/7257 , G01B9/02008 , G01B9/0201 , G01B9/02032 , G01B9/02044 , G01B9/02045 , G01B9/02079 , G01B9/0209 , G01B9/02091 , G01B2290/45 , G01N21/4795
摘要： Apparatus and method for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source is split into N spectral bands. The N spectral bands are individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band is detected by a separate photo detector and amplified. For each spectral band the signal is band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is reduced by a factor equal to the number of spectral bands. The signal remains the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.
摘要翻译：通过检测并行的一组光谱带来增加光学相干断层扫描和低相干干涉测量（“LCI”）信号的灵敏度的装置和方法，每个频带是光频率的唯一组合。 LCI宽带宽源分为N个频谱带。 N个光谱带被单独检测和处理，以使信噪比增加N倍。每个光谱带由单独的光检测器检测并被放大。对于每个光谱带，信号通过模拟电子装置在信号带周围进行带通滤波，并且被数字化，或者，信号可以被数字化并且在软件中进行带通滤波。结果，对信号的散粒噪声贡献减小了等于光谱带数的因子。信号保持不变。喷射噪声的降低增加了系统的动态范围和灵敏度。

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