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31. 发明授权

US08255193B2 Blood flow bypass catheters and methods for the delivery of medium to the vasculature and body ducts 有权
标题翻译：血流旁路导管和用于将培养基递送到脉管系统和体管的方法
公开(公告)号：US08255193B2
公开(公告)日：2012-08-28
申请号：US12625153
申请日：2009-11-24
申请人： Joseph A. C. Humphrey , George T. Gillies
发明人： Joseph A. C. Humphrey , George T. Gillies
IPC分类号： G06G7/50
CPC分类号： A61M25/0026 , A61M5/007 , A61M25/10 , A61M25/1011 , A61M2025/105
摘要： A catheterization device that may be designed by use of an adaptive genetic algorithm computational fluid dynamics approach, as well as other Global Optimization methods that may include simulated annealing, multistart and interval methods, continuous branch and bound methods, evolutionary algorithms, and tabu search and scatter search methods, as well as other available Global Optimization methods that is able to maximize/optimize the dwell time of an infused agent in the vicinity of a vascular lesion. The device may have an internal by-pass channel that allows the blood upstream of the lesion to continue its pulsatile flow through the vessel in the part of it occluded by the lesion, while simultaneously allowing the disbursement and maximal dwell time of an antithrombolytic or other diagnostic or therapeutic agent needed to treat the lesion. Different embodiments of the catheterization device are disclosed and indications for the use of these devices in the treatment of vascular diseases are discussed.
摘要翻译：可以使用自适应遗传算法计算流体动力学方法设计的导管装置，以及可能包括模拟退火，多部分和间隔方法，连续分支和约束方法，进化算法和禁忌搜索的其他全局优化方法，分散搜索方法，以及其他可用的全局优化方法，其能够最大化/优化输注药剂在血管病变附近的停留时间。该装置可以具有内部旁通通道，其允许病变上游的血液在其被病变部分阻塞的部分中继续通过血管的脉动流动，同时允许抗血栓溶解剂或其它物质的支付和最大停留时间诊断或治疗剂需要治疗病变。公开了导管装置的不同实施例，并且讨论了这些装置在治疗血管疾病中的使用的适应症。

32. 发明授权

US08211083B2 Coaxial catheter systems for transference of medium 有权
标题翻译：用于介质转移的同轴导管系统
公开(公告)号：US08211083B2
公开(公告)日：2012-07-03
申请号：US12760837
申请日：2010-04-15
申请人： William C. Broaddus , Zhi-Jian Chen , George T. Gillies
发明人： William C. Broaddus , Zhi-Jian Chen , George T. Gillies
IPC分类号： A61M31/00
CPC分类号： A61M25/0026 , A61M5/007 , A61M25/00 , A61M25/0045 , A61M25/007 , A61M27/006 , A61M2025/1013
摘要： A method, technique and system is disclosed for the delivery of therapeutic agents and/or into the bulk brain tissues and other parts, tissues and organs of the body, including vasculature. A novel form of coaxial catheter provides a means for implanting an outer tube into the brain, then inserting an inner tube into the outer tube and aligning them such that port holes on both of the tubes will overlap and permit a flux of the therapeutic agent to flow into the brain in such a way as to minimize the effects of trapped air, virtually eliminate backflow of the agent, and avoid the potential for additional damage to the brain since only one surgical placement of the outer tube is needed. Similarly, the method, technique system may be utilized to remove fluids or other medium from the brain, tissues, and organs to minimize the effects of escaped air or negative pressure.
摘要翻译：公开了用于递送治疗剂和/或进入体内的大脑组织和身体其他部位，组织和器官的方法，技术和系统，包括脉管系统。同轴导管的新颖形式提供了一种用于将外管植入大脑中的装置，然后将内管插入外管并对准它们，使得两个管上的孔口将重叠并允许治疗剂的通量流入大脑，以尽可能减少被捕获的空气的影响，实际上消除了药剂的回流，并避免了额外的损害大脑的潜力，因为只需要一个手术放置外管。类似地，该方法技术系统可用于从脑，组织和器官中除去流体或其它介质，以最小化逃逸空气或负压的影响。

33. 发明授权

US08096984B2 Cell delivery catheter and method 有权
标题翻译：细胞输送导管及方法
公开(公告)号：US08096984B2
公开(公告)日：2012-01-17
申请号：US10444884
申请日：2003-05-23
申请人： John Kucharczyk , George T. Gillies , William C. Broaddus , Helen L. Fillmore
发明人： John Kucharczyk , George T. Gillies , William C. Broaddus , Helen L. Fillmore
IPC分类号： A61M31/00
CPC分类号： A61M25/10 , A61M2025/1052
摘要： A cell delivery catheter having one of more apearutres is used to positon and deliver cells to an implant site in a patient.
摘要翻译：使用具有更多对应物之一的细胞递送导管将细胞定位并递送至患者的植入部位。

34. 发明申请

US20100210927A1 MEANS AND METHODS FOR CYTOMETRIC THERAPIES 有权
标题翻译：细胞治疗方法和方法
公开(公告)号：US20100210927A1
公开(公告)日：2010-08-19
申请号：US12513258
申请日：2007-11-01
申请人： George T. Gillies , Helen Fillmore , William C. Broaddus , Boyd M. Evans , Stephen W. Allison
发明人： George T. Gillies , Helen Fillmore , William C. Broaddus , Boyd M. Evans , Stephen W. Allison
IPC分类号： A61B6/12 , A61B6/00 , A61B5/055
CPC分类号： A61B5/0084 , A61B5/0071 , A61B5/0075
摘要： A functionalized tip is incorporated into catheters for the cytometric delivery of cells into the brain and other body parts. For use in the brain, the tip forms part of a neurosurgical probe having a proximal end and a distal end. In addition to the functionalized tip, the probe has at least one cell slurry delivery lumen and a plurality of optical fibers configured along the probe, terminating in the tip to provide the photo-optical capability needed to monitor the viability and physiological behavior of the grafted cells as well as certain characteristics of the cellular environment. Details are also presented of the use of a neurocatheter having a cytometric tip of the type disclosed in the invention, as employed within the context of a feedback and control system for regulating the number of cells delivered to the brain of a patient.
摘要翻译：一个功能化的尖端被并入到导管中，用于将细胞细胞传递到脑和其他身体部位。为了在脑中使用，尖端形成具有近端和远端的神经外科探针的一部分。除了功能化的尖端之外，探针具有至少一个细胞浆液递送腔和沿着探针配置的多个光纤，终止于尖端，以提供监测嫁接的生存力和生理行为所需的光学光学能力细胞以及细胞环境的某些特征。还提供了在用于调节递送到患者脑部的细胞数量的反馈和控制系统的上下文中使用的具有本发明公开的类型的细胞计数尖端的神经导管的用途的细节。

35. 发明申请

US20100160896A1 Blood Flow Bypass Catheters and Methods for the Delivery of Medium to the Vasculature and Body Ducts 有权
标题翻译：血流旁路导管和向脉管系统和体管输送介质的方法
公开(公告)号：US20100160896A1
公开(公告)日：2010-06-24
申请号：US12625153
申请日：2009-11-24
申请人： Joseph A. C. Humphrey , George T. Gillies
发明人： Joseph A. C. Humphrey , George T. Gillies
IPC分类号： A61M25/00 , G06F17/10 , G06N3/12 , G06G7/57
CPC分类号： A61M25/0026 , A61M5/007 , A61M25/10 , A61M25/1011 , A61M2025/105
摘要： A catheterization device that may be designed by use of an adaptive genetic algorithm computational fluid dynamics approach, as well as other Global Optimization methods that may include simulated annealing, multistart and interval methods, continuous branch and bound methods, evolutionary algorithms, and tabu search and scatter search methods, as well as other available Global Optimization methods that is able to maximize/optimize the dwell time of an infused agent in the vicinity of a vascular lesion. The device may have an internal by-pass channel that allows the blood upstream of the lesion to continue its pulsatile flow through the vessel in the part of it occluded by the lesion, while simultaneously allowing the disbursement and maximal dwell time of an antithrombolytic or other diagnostic or therapeutic agent needed to treat the lesion. Different embodiments of the catheterization device are disclosed and indications for the use of these devices in the treatment of vascular diseases are discussed.
摘要翻译：可以使用自适应遗传算法计算流体动力学方法设计的导管装置，以及可能包括模拟退火，多部分和间隔方法，连续分支和约束方法，进化算法和禁忌搜索的其他全局优化方法，分散搜索方法，以及其他可用的全局优化方法，其能够最大化/优化输注药剂在血管病变附近的停留时间。该装置可以具有内部旁通通道，其允许病变上游的血液在其被病变部分阻塞的部分中继续通过血管的脉动流动，同时允许抗血栓溶解剂或其它物质的支付和最大停留时间诊断或治疗剂需要治疗病变。公开了导管装置的不同实施例，并且讨论了这些装置在治疗血管疾病中的使用的适应症。

36. 发明申请

US20090192487A1 System and Method for Intracranial Implantation of Therapeutic or Diagnostic Agents 有权
标题翻译：用于治疗或诊断剂的颅内植入的系统和方法
公开(公告)号：US20090192487A1
公开(公告)日：2009-07-30
申请号：US12375139
申请日：2007-07-18
申请人： William C. Broaddus , Rahul Mahajan , George T. Gillies
发明人： William C. Broaddus , Rahul Mahajan , George T. Gillies
IPC分类号： A61B6/12 , A61M5/00
CPC分类号： A61M31/007 , A61B6/508 , A61B90/11
摘要： A system and related method for delivering the anti-tumoral agent carmustine or other types of diagnostic or therapeutic agents into the brain of a patient with a brain tumor includes an insertion device, a skull mount, and a reformulated geometry of the carmustine compound (or other material) optimized for use in the insertion device and for maximized biodegradation time. The insertion device may be front loaded with the carmustine material (or other material) and inserted through the mount on a skull, to the location of the brain tumor, where the carmustine (or other material) is then released. It should be appreciated that the diagnostic and/or therapeutic system and related method thereof are not necessarily limited to the brain of a subject. It may also be used in the organ structures or tubular structures, as well as portions and locations thereof.
摘要翻译：用于将抗肿瘤剂卡莫司汀或其他类型的诊断或治疗剂递送到患有脑肿瘤的患者的脑中的系统和相关方法包括卡莫司汀化合物的插入装置，颅骨支架和重新配置的几何形状（或其他材料）优化用于插入装置和最大化的生物降解时间。插入装置可以是正面装载有卡莫司汀材料（或其他材料）并通过头骨上的安装件插入脑肿瘤的位置，然后卡莫司汀（或其他材料）然后被释放。应当理解，诊断和/或治疗系统及其相关方法不一定限于受试者的脑部。它还可以用于器官结构或管状结构，以及其部分和位置。

37. 发明授权

US06599274B1 Cell delivery catheter and method 失效
标题翻译：细胞输送导管及方法
公开(公告)号：US06599274B1
公开(公告)日：2003-07-29
申请号：US09574857
申请日：2000-05-19
申请人： John Kucharczyk , George T. Gillies , William C. Broaddus , Helen L. Fillmore
发明人： John Kucharczyk , George T. Gillies , William C. Broaddus , Helen L. Fillmore
IPC分类号： A61M2500
CPC分类号： A61M25/10 , A61M2025/1052
摘要： A cell delivery catheter having one of more apearutres is used to positon and deliver cells to an implant site in a patient.
摘要翻译：使用具有更多对应物之一的细胞递送导管将细胞定位并递送至患者的植入部位。

38. 发明授权

US5779694A Magnetic stereotactic system for treatment delivery 失效
公开(公告)号：US5779694A
公开(公告)日：1998-07-14
申请号：US96214
申请日：1993-07-19
申请人： Matthew A. Howard , Marc Mayberg , M. Sean Grady , Rogers C. Ritter , George T. Gillies
发明人： Matthew A. Howard , Marc Mayberg , M. Sean Grady , Rogers C. Ritter , George T. Gillies
IPC分类号： A61B19/00 , A61M25/01 , A61N2/04 , A61N2/10 , A61M37/00 , A61K9/22 , A61M1/00
CPC分类号： A61M25/0105 , A61B34/73 , A61M25/0127 , A61B2034/733 , A61B2090/363 , A61B34/10 , A61B34/70 , A61B90/10 , A61M2025/1052 , A61M25/0158
摘要： A treatment delivery apparatus comprises a metallic object and a treatment carrier device which is connected by a heat-sensitive biodegradable connector link to the magnetic object. This carrier device contains the treatment, i.e. the drug, to be transported. An electromagnet is positioned outside of the body part for producing a magnetic field which captures the magnetic object. This electromagnet may be either a simple coil system attached to a robotic arm which moves the electromagnet adjacent the body part, or a multicoil electromagnet system surrounding the body part. In either case, the robotically moved electromagnet or multicoil electromagnet system moves the magnetic object within the body part to a desired location. A computer controls either the robotic arm or multicoil current magnitudes and directions. This computer also provides visualization for observing the location and movement of the magnetic object and carrier device. Upon reaching the desired location, the magnetic object is heated, which causes the heat-sensitive biodegradable connector link to melt, which separates the drug-containing carrier device from the magnetic object. The electromagnet means then moves the magnetic object back out of the body part. The treatment-containing carrier device remains in the desired location and the drug is delivered to the specific location.

39. 发明授权

US5707335A Magnetic stereotactic system and treatment delivery 失效
公开(公告)号：US5707335A
公开(公告)日：1998-01-13
申请号：US464279
申请日：1995-06-05
申请人： Matthew A. Howard , Marc Mayberg , M. Sean Grady , Rogers C. Ritter , George T. Gillies
发明人： Matthew A. Howard , Marc Mayberg , M. Sean Grady , Rogers C. Ritter , George T. Gillies
IPC分类号： A61B19/00 , A61M25/01 , A61N2/04 , A61N2/10 , A61N2/00
CPC分类号： A61M25/0105 , A61B34/73 , A61M25/0127 , A61B2034/733 , A61B2090/363 , A61B34/10 , A61B34/70 , A61B90/10 , A61M2025/1052 , A61M25/0158
摘要： A treatment delivery apparatus comprises a metallic object and a treatment carrier device which is connected by a heat-sensitive biodegradable connector link to the magnetic object. This carrier device contains the treatment, i.e. the drug, to be transported. An electromagnet is positioned outside of the body part for producing a magnetic field which captures the magnetic object. This electromagnet may be either a simple coil system attached to a robotic arm which moves the electromagnet adjacent the body part, or a multicoil electromagnet system surrounding the body part. In either case, the robotically moved electromagnet or multicoil electromagnet system moves the magnetic object within the body part to a desired location. A computer controls either the robotic arm or multicoil current magnitudes and directions. This computer also provides visualization for observing the location and movement of the magnetic object and carrier device. Upon reaching the desired location, the magnetic object is heated, which causes the heat-sensitive biodegradable connector link to melt, which separates the drug-containing carrier device from the magnetic object. The electromagnet means then moves the magnetic object back out of the body part. The treatment-containing carrier device remains in the desired location and the drug is delivered to the specific location.

40. 发明授权

US5125888A Magnetic stereotactic system for treatment delivery 失效
标题翻译：用于治疗传递的磁立体定向系统
公开(公告)号：US5125888A
公开(公告)日：1992-06-30
申请号：US463340
申请日：1990-01-10
申请人： Matthew A. Howard , Marc Mayberg , M. Sean Grady , Rogers C. Ritter , George T. Gillies
发明人： Matthew A. Howard , Marc Mayberg , M. Sean Grady , Rogers C. Ritter , George T. Gillies
IPC分类号： A61B19/00 , A61M25/01 , A61N2/04 , A61N2/10
CPC分类号： A61M25/0105 , A61B34/73 , A61M25/0127 , A61B2034/733 , A61B2090/363 , A61B34/10 , A61B34/70 , A61B90/10 , A61M2025/1052 , A61M25/0158
摘要： A treatment delivery apparatus comprises a metallic object and a treatment carrier device which is connected by a heat-sensitive biodegradable connector link to the magnetic object. This carrier device contains the treatment, i.e. the drug, to be transported. An electromagnet is positioned outside of the body part for producing a magnetic field which captures the magnetic object. This electromagnet may be either a simple coil system attached to a robotic arm which moves the electromagnet adjacent the body part, or a multicoil electromagnet system surrounding the body part. In either case, the robotically moved electromagnet or multicoil electromagnet system moves the magnetic object within the body part to a desired location. A computer controls either the robotic arm or multicoil current magnitudes and directions. This computer also provides visualization for observing the location and movement of the magnetic object and carrier device. Upon reaching the desired location, the magnetic object is heated, which causes the heat-sensitive biodegradable connector link to melt, which separates the drug-containing carrier device from the magnetic object. The electromagnet means then moves the magnetic object back out of the body part. The treatment-containing carrier device remains in the desired location and the drug is delivered to the specific location.
摘要翻译：处理递送装置包括通过热敏生物降解连接器连接到磁性物体的金属物体和处理载体装置。该载体装置包含待运输的药物，即药物。电磁体位于身体部分的外部，用于产生捕获磁性物体的磁场。该电磁铁可以是附接到机身臂的简单线圈系统，该机器人手臂围绕身体部分移动电磁体，或围绕身体部分的多电磁体系统。在任一情况下，机器人移动的电磁体或多电磁体系统将身体部分内的磁性物体移动到期望的位置。计算机控制机器臂或多电流电流幅度和方向。该计算机还提供用于观察磁性物体和载体装置的位置和移动的可视化。在到达所需位置时，磁性物体被加热，这导致热敏生物降解连接器连接件熔化，从而将含药物载体装置与磁性物体分开。然后，电磁体装置将磁性物体移出身体部分。含处理剂的载体装置保持在期望的位置，药物被输送到特定位置。

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