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1. 发明授权

US5779694A Magnetic stereotactic system for treatment delivery 失效
公开(公告)号：US5779694A
公开(公告)日：1998-07-14
申请号：US96214
申请日：1993-07-19
申请人： Matthew A. Howard , Marc Mayberg , M. Sean Grady , Rogers C. Ritter , George T. Gillies
发明人： Matthew A. Howard , Marc Mayberg , M. Sean Grady , Rogers C. Ritter , George T. Gillies
IPC分类号： A61B19/00 , A61M25/01 , A61N2/04 , A61N2/10 , A61M37/00 , A61K9/22 , A61M1/00
CPC分类号： A61M25/0105 , A61B34/73 , A61M25/0127 , A61B2034/733 , A61B2090/363 , A61B34/10 , A61B34/70 , A61B90/10 , A61M2025/1052 , A61M25/0158
摘要： A treatment delivery apparatus comprises a metallic object and a treatment carrier device which is connected by a heat-sensitive biodegradable connector link to the magnetic object. This carrier device contains the treatment, i.e. the drug, to be transported. An electromagnet is positioned outside of the body part for producing a magnetic field which captures the magnetic object. This electromagnet may be either a simple coil system attached to a robotic arm which moves the electromagnet adjacent the body part, or a multicoil electromagnet system surrounding the body part. In either case, the robotically moved electromagnet or multicoil electromagnet system moves the magnetic object within the body part to a desired location. A computer controls either the robotic arm or multicoil current magnitudes and directions. This computer also provides visualization for observing the location and movement of the magnetic object and carrier device. Upon reaching the desired location, the magnetic object is heated, which causes the heat-sensitive biodegradable connector link to melt, which separates the drug-containing carrier device from the magnetic object. The electromagnet means then moves the magnetic object back out of the body part. The treatment-containing carrier device remains in the desired location and the drug is delivered to the specific location.

2. 发明授权

US5707335A Magnetic stereotactic system and treatment delivery 失效
公开(公告)号：US5707335A
公开(公告)日：1998-01-13
申请号：US464279
申请日：1995-06-05
申请人： Matthew A. Howard , Marc Mayberg , M. Sean Grady , Rogers C. Ritter , George T. Gillies
发明人： Matthew A. Howard , Marc Mayberg , M. Sean Grady , Rogers C. Ritter , George T. Gillies
IPC分类号： A61B19/00 , A61M25/01 , A61N2/04 , A61N2/10 , A61N2/00
CPC分类号： A61M25/0105 , A61B34/73 , A61M25/0127 , A61B2034/733 , A61B2090/363 , A61B34/10 , A61B34/70 , A61B90/10 , A61M2025/1052 , A61M25/0158
摘要： A treatment delivery apparatus comprises a metallic object and a treatment carrier device which is connected by a heat-sensitive biodegradable connector link to the magnetic object. This carrier device contains the treatment, i.e. the drug, to be transported. An electromagnet is positioned outside of the body part for producing a magnetic field which captures the magnetic object. This electromagnet may be either a simple coil system attached to a robotic arm which moves the electromagnet adjacent the body part, or a multicoil electromagnet system surrounding the body part. In either case, the robotically moved electromagnet or multicoil electromagnet system moves the magnetic object within the body part to a desired location. A computer controls either the robotic arm or multicoil current magnitudes and directions. This computer also provides visualization for observing the location and movement of the magnetic object and carrier device. Upon reaching the desired location, the magnetic object is heated, which causes the heat-sensitive biodegradable connector link to melt, which separates the drug-containing carrier device from the magnetic object. The electromagnet means then moves the magnetic object back out of the body part. The treatment-containing carrier device remains in the desired location and the drug is delivered to the specific location.

3. 发明授权

US5125888A Magnetic stereotactic system for treatment delivery 失效
标题翻译：用于治疗传递的磁立体定向系统
公开(公告)号：US5125888A
公开(公告)日：1992-06-30
申请号：US463340
申请日：1990-01-10
申请人： Matthew A. Howard , Marc Mayberg , M. Sean Grady , Rogers C. Ritter , George T. Gillies
发明人： Matthew A. Howard , Marc Mayberg , M. Sean Grady , Rogers C. Ritter , George T. Gillies
IPC分类号： A61B19/00 , A61M25/01 , A61N2/04 , A61N2/10
CPC分类号： A61M25/0105 , A61B34/73 , A61M25/0127 , A61B2034/733 , A61B2090/363 , A61B34/10 , A61B34/70 , A61B90/10 , A61M2025/1052 , A61M25/0158
摘要： A treatment delivery apparatus comprises a metallic object and a treatment carrier device which is connected by a heat-sensitive biodegradable connector link to the magnetic object. This carrier device contains the treatment, i.e. the drug, to be transported. An electromagnet is positioned outside of the body part for producing a magnetic field which captures the magnetic object. This electromagnet may be either a simple coil system attached to a robotic arm which moves the electromagnet adjacent the body part, or a multicoil electromagnet system surrounding the body part. In either case, the robotically moved electromagnet or multicoil electromagnet system moves the magnetic object within the body part to a desired location. A computer controls either the robotic arm or multicoil current magnitudes and directions. This computer also provides visualization for observing the location and movement of the magnetic object and carrier device. Upon reaching the desired location, the magnetic object is heated, which causes the heat-sensitive biodegradable connector link to melt, which separates the drug-containing carrier device from the magnetic object. The electromagnet means then moves the magnetic object back out of the body part. The treatment-containing carrier device remains in the desired location and the drug is delivered to the specific location.
摘要翻译：处理递送装置包括通过热敏生物降解连接器连接到磁性物体的金属物体和处理载体装置。该载体装置包含待运输的药物，即药物。电磁体位于身体部分的外部，用于产生捕获磁性物体的磁场。该电磁铁可以是附接到机身臂的简单线圈系统，该机器人手臂围绕身体部分移动电磁体，或围绕身体部分的多电磁体系统。在任一情况下，机器人移动的电磁体或多电磁体系统将身体部分内的磁性物体移动到期望的位置。计算机控制机器臂或多电流电流幅度和方向。该计算机还提供用于观察磁性物体和载体装置的位置和移动的可视化。在到达所需位置时，磁性物体被加热，这导致热敏生物降解连接器连接件熔化，从而将含药物载体装置与磁性物体分开。然后，电磁体装置将磁性物体移出身体部分。含处理剂的载体装置保持在期望的位置，药物被输送到特定位置。

4. 发明授权

US06884591B2 Peripheral marker of blood brain barrier permeability 有权
标题翻译：血脑屏障渗透性的外周标志物
公开(公告)号：US06884591B2
公开(公告)日：2005-04-26
申请号：US09891023
申请日：2001-06-25
申请人： Damir Janigro , Marc Mayberg , Gene Barnett
发明人： Damir Janigro , Marc Mayberg , Gene Barnett
IPC分类号： G01N33/574 , G01N33/53 , G01N33/567
CPC分类号： G01N33/574
摘要： The present invention relates generally to a peripheral marker or marker of blood brain barrier integrity and methods of using them in the diagnosis, prognosis, and treatment of a variety of diseases. The preferred embodiments of the present invention relate to methods, compositions, kits, and assays useful in determining the integrity or permeability of a blood brain barrier. The various embodiments of the present invention can be used to identify subjects at risk for developing a disease associated with increased permeability of the blood brain barrier, as well as to provide insight on the ability of an agent or agents to pass the blood brain barrier. Preferably, increased levels of S100β protein are used alone or in combination with other markers of diseased state in order to diagnose and prognosticate permeability of the BBB.
摘要翻译：本发明一般涉及血脑屏障完整性的外周标志物或标志物，以及在各种疾病的诊断，预后和治疗中使用它们的方法。本发明的优选实施方案涉及可用于确定血脑屏障的完整性或渗透性的方法，组合物，试剂盒和测定法。本发明的各种实施方案可以用于鉴定风险发生与血脑屏障通透性增加相关的疾病风险的受试者，以及提供对药物或药剂通过血脑屏障的能力的洞察。优选地，增加水平的S100beta蛋白质单独使用或与其他患病状态标记物组合使用以诊断和预测BBB的通透性。

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