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31. 发明申请

US20080296157A1 Method and Device for Handling Sedimenting Particles 审中-公开
标题翻译：处理沉淀颗粒的方法和装置
公开(公告)号：US20080296157A1
公开(公告)日：2008-12-04
申请号：US12088009
申请日：2006-09-27
申请人： Gunter Bauer , Torsten Muller , Thomas Schnelle
发明人： Gunter Bauer , Torsten Muller , Thomas Schnelle
IPC分类号： B01D35/06 , B03C5/02 , B03C1/30 , B03C1/02
CPC分类号： B03C1/288 , B01L3/021 , B01L3/0275 , B01L2200/0631 , B01L2200/0668 , B01L2300/0645 , B01L2400/0415 , B01L2400/043 , B03C5/026 , B03C2201/26 , G01N35/0098
摘要： The invention relates to a method for handling particles (1, 2) that are suspended in a carrier liquid (3). The method includes the following steps: the carrier liquid (3) is received with the particles (1, 2) in a liquid siphoning device (10) including at least one siphoning opening (11), electrical and/or magnetic separating fields are generated in the liquid siphoning device (10), a sedimentation movement of the particles (1, 2) is created in the liquid, each particle having a sedimentation speed that depends on the action of the separating fields on the particle (1, 2) and the particles (1, 2) forming a plurality of particle fractions (5, 6) according to the sedimentation speeds thereof, and the particle fractions (5, 6) are separately extracted from the liquid siphoning device (10). The invention also relates to a handling device (100) for handling suspended particles (1, 2).
摘要翻译：本发明涉及一种处理悬浮在载体液体（3）中的颗粒（1,2）的方法。该方法包括以下步骤：载体液体（3）在包括至少一个虹吸孔（11）的液体虹吸装置（10）中与颗粒（1,2）一起接收，产生电和/或磁分离场在液体虹吸装置（10）中，在液体中产生颗粒（1,2）的沉降运动，每个颗粒的沉降速度取决于颗粒（1,2）上的分离场的作用和从液体虹吸装置（10）分别提取根据其沉降速度形成多个颗粒部分（5,6）和颗粒部分（5,6）的颗粒（1,2）。本发明还涉及一种用于处理悬浮颗粒（1,2）的处理装置（100）。

32. 发明申请

US20070151855A1 Microfluidic system and associated operational method 审中-公开
标题翻译：微流控系统及相关操作方法
公开(公告)号：US20070151855A1
公开(公告)日：2007-07-05
申请号：US10597696
申请日：2005-02-03
申请人： Thomas Schnelle , Torsten Muller
发明人： Thomas Schnelle , Torsten Muller
IPC分类号： B03C5/02
CPC分类号： B03C5/005 , B01L3/502761 , B01L3/502776 , B01L2200/0652 , B01L2200/0668 , B01L2300/0864 , B01L2400/0424 , B03C5/026 , G01N15/1056 , G01N15/12 , G01N15/1404 , G01N15/1459 , G01N15/1484 , G01N2015/1006 , G01N2015/1037 , G01N2015/1081 , G01N2015/1477 , G01N2015/149 , G01N2015/1497 , G01N2035/00158
摘要： The invention relates to a microfluidic system, in particular in a cell sorter, including a first carrier power supply (1) which is used to supply a first carrier flow having particles (4) suspended therein, a first carrier power output line (15) which is used to withdraw at least one part of the carrier flow having particles (4) suspended therein, a process chamber (3) which is used to examine, observe, manipulate and/or select the particle (4). The first carrier power supply (1) flows into the process chamber (3) when the first carrier power output line (15) is discharged from the process chamber (3). According to the invention, at least one second carrier power supply (2) flows into the process chamber (3) in order to supply a second carrier flow having particles (5) suspended therein. The invention also relates to a corresponding operational method.
摘要翻译：本发明涉及微流体系统，特别是在细胞分选机中，包括用于提供悬浮在其中的颗粒（4）的第一载体流的第一载体电源（1），第一载体功率输出线（15）其用于抽出具有悬浮在其中的颗粒（4）的载体流的至少一部分，用于检查，观察，操纵和/或选择颗粒（4）的处理室（3）。当第一载体动力输出管线（15）从处理室（3）排出时，第一载体电源（1）流入处理室（3）。根据本发明，至少一个第二载体电源（2）流入处理室（3），以便提供具有悬浮在其中的颗粒（5）的第二载体流。本发明还涉及相应的操作方法。

33. 发明申请

US20080246489A1 Measuring Device For Impedance Spectroscopy and Associated Measuring Method 审中-公开
标题翻译：用于阻抗谱和相关测量方法的测量装置
公开(公告)号：US20080246489A1
公开(公告)日：2008-10-09
申请号：US10599649
申请日：2005-04-07
申请人： Hans Gerard Leonard Coster , Terry Calvin Chilcott , Stefan Lupke , Torsten Muller , Thomas Schnelle
发明人： Hans Gerard Leonard Coster , Terry Calvin Chilcott , Stefan Lupke , Torsten Muller , Thomas Schnelle
IPC分类号： G01N27/02
CPC分类号： B03C5/026 , B01L3/502761 , B01L2200/0668 , B01L2300/0645 , B01L2400/0415 , B01L2400/0454 , B03C2201/24 , G01N15/1031
摘要： The invention relates to a measuring device and a measuring method for investigating particles which are suspended in a carrier liquid, including several measuring electrodes for carrying out electrical measuring of the particles. It is proposed that during electrical measuring, the particles be fixed in a field cage (4).
摘要翻译：本发明涉及一种用于研究悬浮在载液中的颗粒的测量装置和测量方法，包括用于进行颗粒电测量的多个测量电极。提出在电测量期间，将颗粒固定在场笼（4）中。

34. 发明申请

US20070125650A1 Treatment of Biological Samples Using Dielectrophoresis 有权
标题翻译：使用电泳法处理生物样品
公开(公告)号：US20070125650A1
公开(公告)日：2007-06-07
申请号：US11531679
申请日：2006-09-13
申请人： Mario Scurati , Torsten Mueller , Thomas Schnelle
发明人： Mario Scurati , Torsten Mueller , Thomas Schnelle
IPC分类号： B03C5/02
CPC分类号： B03C5/026
摘要： A plurality of planar electrodes (5) in a microchannel (4) is used for separation, lysis and PCR in a chip (10). Cells from a sample are brought to the electrodes (5). Depending on sample properties, phase pattern, frequency and voltage of the electrodes and flow velocity are chosen to trap target cells (16) using DEP, whereas the majority of unwanted cells (17) flushes through. After separation the target cell (16) are lysed while still trapped. Lysis is carried out by applying RF pulses and/or thermally so as to change the dielectric properties of the trapped cells. After lysis, the target cells (16) are amplified within the microchannel (4), so as to obtain separation, lysis and PCR on same chip (1).
摘要翻译：微通道（4）中的多个平面电极（5）用于芯片（10）中的分离，裂解和PCR。来自样品的细胞被带到电极（5）。根据样品性质，选择电极的相图，频率和电压以及流速，以使用DEP捕获靶细胞（16），而大多数不需要的细胞（17）冲洗通过。分离后，靶细胞（16）裂解，同时仍被捕获。通过施加RF脉冲和/或热来进行裂解以改变被捕获的细胞的介电性质。裂解后，在微通道（4）内扩增靶细胞（16），以在同一芯片（1）上获得分离，裂解和PCR。

35. 发明授权

US07879214B2 Method and device for collecting suspended particles 失效
标题翻译：用于收集悬浮颗粒的方法和装置
公开(公告)号：US07879214B2
公开(公告)日：2011-02-01
申请号：US11568895
申请日：2005-05-06
申请人： Thomas Schnelle , Torsten Muller , Jorg Kentsch , Frank Grom , Martin Stelzle
发明人： Thomas Schnelle , Torsten Muller , Jorg Kentsch , Frank Grom , Martin Stelzle
IPC分类号： B03C5/02
CPC分类号： B03C5/026
摘要： A description is given of methods for collecting particles (1, 2) which are suspended in a liquid, including the following steps: providing the liquid containing the suspended particles (1, 2) in a compartment (10) having lateral surfaces (11), wherein at least one electrode (21) is arranged on at least one of the lateral surfaces (11), and generating high-frequency electric fields by means of the at least one electrode (21) so as to form at least one circulating flow (30), by means of which the particles (1, 2) are guided to at least one predetermined collecting area (40) in the compartment (10), wherein the flow (30) is formed in such a way that at least one branch of the flow runs along a longitudinal extent of the at least one electrode (21), and the flow (30) circulates about an axis (31) which is oriented perpendicular to the respectively adjacent lateral surface (11) with the electrode (21). Corresponding devices for collecting particles are also described.
摘要翻译：给出了用于收集悬浮在液体中的颗粒（1,2）的方法的描述，包括以下步骤：将含有悬浮颗粒（1,2）的液体提供在具有侧表面（11）的隔室（10）中，，其中至少一个电极（21）布置在所述侧表面（11）中的至少一个上，并且通过所述至少一个电极（21）产生高频电场，以便形成至少一个循环流（30），所述颗粒（1,2）通过所述颗粒（1,2）被引导到所述隔室（10）中的至少一个预定收集区域（40），其中所述流动（30）形成为使得至少一个流动的分支沿着至少一个电极（21）的纵向延伸，并且流动（30）围绕垂直于相邻的侧表面（11）的电极（21）的轴线（31）循环）。还描述了用于收集颗粒的相应装置。

36. 发明授权

US07276207B2 Microsystem for the dielectric and optical manipulation of particles 失效
标题翻译：微系统用于电介质和光学操纵的粒子
公开(公告)号：US07276207B2
公开(公告)日：2007-10-02
申请号：US10432793
申请日：2001-11-28
申请人： Torsten Muller , Thomas Schnelle , Gunter Fuhr
发明人： Torsten Muller , Thomas Schnelle , Gunter Fuhr
IPC分类号： B01L3/00 , G01N27/447 , G01N27/453
CPC分类号： G01N15/1056 , B03C5/026 , B03C5/028 , H05H3/04
摘要： Described is a fluidic microsystem with at least one compartment for the receiving and/or the through-flow of a liquid and having an electrode arrangement with a multiplicity of electrodes, between which a coaction zone is established, whereby the compartment possesses at least one wall, through which electromagnetic radiation can be linked into the said coaction zone in accord with a predetermined incident direction, and on at least one electrode a cooling apparatus is provided, and on which at least one respective electrode at least one reflector layer is provided, and wherein the respective electrode is at least partially shielded in reference to the incident beam direction, and having at least one heat conducting layer by means of which the respective electrode stands in thermal communication with a wall of the compartment, and/or includes an active cooling element, which is placed in thermal contact with the respective electrode.
摘要翻译：描述了一种流体微系统，其具有至少一个用于液体的接收和/或通过流动的隔室，并且具有多个电极的电极装置，在其间建立了一个共同作用区域，从而隔室具有至少一个壁，电磁辐射可以根据预定的入射方向连接到所述配位区中，并且在至少一个电极上设置有冷却装置，并且在其上设置至少一个相应的电极至少一个反射器层，以及其中相应的电极相对于入射光束方向被至少部分地屏蔽，并且具有至少一个导热层，通过该导热层，相应的电极与隔室的壁热连通，和/或包括主动冷却元件，其被放置成与相应的电极热接触。

37. 发明申请

US20070163883A1 Microfluidic system comprising an electrode arrangement and associated control method 审中-公开
标题翻译：微流体系统包括电极装置和相关联的控制方法
公开(公告)号：US20070163883A1
公开(公告)日：2007-07-19
申请号：US10597674
申请日：2005-02-03
申请人： Thomas Schnelle , Annette Pfennig , Torsten Muller
发明人： Thomas Schnelle , Annette Pfennig , Torsten Muller
IPC分类号： B03C5/02
CPC分类号： B03C5/005 , B03C5/026 , G01N15/1056 , G01N2015/105 , G01N2015/1495
摘要： The invention relates to a microfluidic system, in particular in a cell sorter, including a first carrier power supply (1) which is used to supply a first carrier flow having particles (4) suspended therein, a first carrier power output line (15) which is used to withdraw at least one part of the carrier flow having particles (4) suspended therein, a process chamber (3) which is used to examine, observe, manipulate and/or select the particle (4). The first carrier power supply (1) flows into the process chamber (3) when the first carrier power output line (15) is discharged from the process chamber (3). According to the invention, at least one second carrier power supply (2) flows into the process chamber (3) in order to supply a second carrier flow having particles (5) suspended therein. The invention also relates to a corresponding operational method.
摘要翻译：本发明涉及微流体系统，特别是在细胞分选机中，包括用于提供悬浮在其中的颗粒（4）的第一载体流的第一载体电源（1），第一载体功率输出线（15）其用于抽出具有悬浮在其中的颗粒（4）的载体流的至少一部分，用于检查，观察，操纵和/或选择颗粒（4）的处理室（3）。当第一载体动力输出管线（15）从处理室（3）排出时，第一载体电源（1）流入处理室（3）。根据本发明，至少一个第二载体电源（2）流入处理室（3），以便提供具有悬浮在其中的颗粒（5）的第二载体流。本发明还涉及相应的操作方法。

38. 发明申请

US20070020767A1 Processes and devices for the liquid treatment of suspended particles 审中-公开
标题翻译：用于液体处理悬浮颗粒的方法和装置
公开(公告)号：US20070020767A1
公开(公告)日：2007-01-25
申请号：US10556239
申请日：2004-05-10
申请人： Thomas Schnelle
发明人： Thomas Schnelle
IPC分类号： G01N1/10
CPC分类号： B01L3/502784 , B01J19/0093 , B01J2219/00788 , B01J2219/00853 , B01J2219/00858 , B01J2219/0086 , B01J2219/0097 , B01L3/502761 , B01L2200/0668 , B01L2200/0673 , B01L2400/0415 , B01L2400/0436 , B01L2400/0454 , B03C5/026 , G01N2015/1081 , G01N2015/149 , Y10T436/2575
摘要： Processes are described for the treatment of at least one particle (10-13) with at least one reaction liquid (20) in a main channel (30) of a fluidic microsystem (100) with the following steps: movement of the at least one particle (10-13) with a carrier liquid (40) flowing in a longitudinal direction of the main channel (30) up to a holding device (50), at least a temporary holding of the at least one particle (13) under the action of a holding force exerted by the holding device (50), and supplying of the reaction liquid (20) from at least one lateral channel (31) into the main channel (30) so that the at least one held particle (13) is rinsed by the reaction liquid (20), the holding device (50) being arranged downstream after a mouth (32) of the lateral channel (31) in the main channel (30) and the reaction liquid (20) flowing through the holding device (50) with a direction of flow running in the longitudinal direction of the main channel (30). Fluidic microsystems and electrode arrangements for realizing the processes are also described.
摘要翻译：描述了用于在流体微系统（100）的主通道（30）中用至少一个反应液体（20）处理至少一个颗粒（10-13）的方法，其具有以下步骤：至少一个颗粒（10-13）与载液（40）沿着主通道（30）的纵向方向流动到保持装置（50），至少暂时保持至少一个颗粒（13）由保持装置（50）施加的保持力的作用，以及将反应液体（20）从至少一个横向通道（31）供应到主通道（30）中，使得至少一个保持的颗粒（13）由反应液（20）冲洗，保持装置（50）在主通道（30）中的侧通道（31）的口（32）之后并且反应液（20）流过保持件装置（50），其沿着主通道的纵向方向流动 el（30）。还描述了用于实现该过程的流体微系统和电极装置。

39. 发明授权

US6056861A Process and device for generating resonance phenomena in particle suspensions 失效
标题翻译：用于在颗粒悬浮液中产生共振现象的方法和装置
公开(公告)号：US6056861A
公开(公告)日：2000-05-02
申请号：US77334
申请日：1998-07-27
申请人： Gunter Fuhr , Jan Gimsa , Torsten Muller , Thomas Schnelle
发明人： Gunter Fuhr , Jan Gimsa , Torsten Muller , Thomas Schnelle
IPC分类号： G01N33/483 , B03C5/00 , B03C5/02 , C12M1/00 , C12M1/42 , C12N13/00 , G01N15/00 , H02N13/00 , G01N27/26
CPC分类号： C12N13/00 , B03C5/028 , C12M33/00 , H02N13/00
摘要： A method and a device for position and/or type-selective control of the position and/or change of position of suspended particles in a multielectrode system by the effect of polarization forces that are induced in the particles by alternating electric fields in the multielectrode system, which particles comprise biological or synthetic objects with dimensions essentially corresponding to those of biological cells or cell organelles, viruses or macromolecules, base on the fact that the multielectrode system forms with the particle suspension an electrical network, in which means of resonance are provided for creating a resonant increase or damping of the field strength of the alternating electric fields at certain frequencies in at least one locally demarcated region of the multielectrode system.
摘要翻译： PCT No.PCT / EP96 / 05244 Sec。 371日期：1998年7月27日 102（e）1998年7月27日PCT PCT 1996年11月27日PCT公布。出版物WO97 / 20210 日期：1997年6月5日在多电极系统中通过交替电致使粒子诱导的极化力的作用，位置和/或型式选择性地控制悬浮颗粒的位置和/或位置变化的方法和装置所述多电极系统中的所述颗粒包含基本上对应于生物细胞或细胞器，病毒或大分子的尺寸的生物或合成物体，其基于所述多电极系统与所述粒子悬浮液形成电网，提供谐振以在多电极系统的至少一个局部分界区域中产生在某些频率处的交变电场的场强的共振增加或阻尼。

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