专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明授权

US07078404B2 Acyl-3-carboxyphenylurea derivatives, processes for preparing them and their use 有权
公开(公告)号：US07078404B2
公开(公告)日：2006-07-18
申请号：US10410892
申请日：2003-04-10
申请人： Elisabeth Defossa , Dieter Kadereit , Karl Schoenafinger , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Alfons Enhsen
发明人： Elisabeth Defossa , Dieter Kadereit , Karl Schoenafinger , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Alfons Enhsen
IPC分类号： A61K31/50 , C07D241/04 , C07D263/32 , C07D307/06 , C07C243/09
CPC分类号： C07C275/54
摘要： The invention relates to acyl-3-carboxyphenylurea derivatives and to their physiologically tolerated salts and physiologically functional derivatives.The invention relates to compounds of formula I, in which the radicals have the given meanings, and to their physiologically tolerated salts and processes for preparing them. The compounds are, for example, suitable for use as antidiabetics.

32. 发明申请

US20050143456A1 Carboxamide-substituted phenylurea derivatives, process for their preparation and their use as medicaments 审中-公开
标题翻译：羧酰胺取代的苯基脲衍生物，其制备方法及其作为药物的用途
公开(公告)号：US20050143456A1
公开(公告)日：2005-06-30
申请号：US10978674
申请日：2004-11-01
申请人： Elisabeth Defossa , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Erich Roedern , Stefan Peukert , Alfons Enhsen , Armin Bauer , Bernd Neises , Karl Wendt
发明人： Elisabeth Defossa , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Erich Roedern , Stefan Peukert , Alfons Enhsen , Armin Bauer , Bernd Neises , Karl Wendt
IPC分类号： C07D295/12 , A61K31/17 , A61K31/197 , A61K31/198 , A61K31/221 , A61K31/223 , A61K31/245 , A61K31/27 , A61K31/277 , A61K31/357 , A61K31/36 , A61K31/40 , A61K31/404 , A61K31/4045 , A61K31/433 , A61K31/4406 , A61K31/4409 , A61K31/445 , A61K31/4545 , A61K31/5375 , A61P3/04 , A61P3/10 , A61P7/02 , A61P9/10 , A61P11/06 , A61P13/12 , A61P17/06 , A61P19/10 , A61P25/00 , A61P25/18 , A61P25/28 , A61P27/00 , A61P29/00 , A61P31/00 , A61P31/18 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C275/54 , C07C313/28 , C07C323/42 , C07D209/08 , C07D209/14 , C07D211/58 , C07D213/40 , C07D285/14 , C07D295/13 , C07D295/205 , C07D317/58 , C07D319/18 , C07D401/04 , A61K31/195
CPC分类号： C07D213/40 , C07C275/54 , C07C323/42 , C07C2601/16 , C07C2602/10 , C07D209/08 , C07D211/58 , C07D285/14 , C07D295/13 , C07D295/205 , C07D317/58 , C07D319/18 , C07D401/04
摘要： The invention relates to carboxamide-substituted phenylurea derivatives and their physiologically tolerated salts and physiologically functional derivatives. Compounds of the formula I in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and process for their preparation are described. The compounds are suitable, for example, for treating type II diabetes.
摘要翻译：本发明涉及羧酰胺取代的苯基脲衍生物及其生理上耐受的盐和生理功能衍生物。描述了其中基团具有所述含义的式I化合物及其生理上可耐受的盐及其制备方法。该化合物适用于例如用于治疗II型糖尿病。

33. 发明申请

US20050065142A1 Substituted benzoylureido-o-benzoylamides, process for their preparation and their use 有权
标题翻译：取代的苯甲酰脲基 - 邻苯甲酰胺，其制备方法及其用途
公开(公告)号：US20050065142A1
公开(公告)日：2005-03-24
申请号：US10899868
申请日：2004-07-27
申请人： Dieter Kadereit , Elisabeth Defossa , Karl Schoenafinger , Thomas Klabunde , Andreas Herling
发明人： Dieter Kadereit , Elisabeth Defossa , Karl Schoenafinger , Thomas Klabunde , Andreas Herling
IPC分类号： A61K31/397 , A61K31/401 , A61K31/404 , A61K31/445 , A61P3/06 , A61P3/08 , A61P3/10 , C07D205/04 , C07D207/10 , C07D207/16 , C07D209/42 , C07D211/60
CPC分类号： C07D207/16 , C07D205/04 , C07D209/42 , C07D211/60
摘要： The invention relates to substituted benzoylureido-o-benzoylamides and to their physiologically tolerated salts and physiologically functional derivatives. The invention relates to compounds of the formula I in which the radicals have the stated meanings, and to the physiologically tolerated salts thereof. The compounds are suitable for example as medicaments for the prevention and treatment of type 2 diabetes.
摘要翻译：本发明涉及取代的苯甲酰脲基 - 邻苯甲酰胺及其生理上耐受的盐和生理功能衍生物。本发明涉及其中基团具有所述含义的式I化合物及其生理上耐受的盐。该化合物适用于例如用于预防和治疗2型糖尿病的药物。

34. 发明授权

US5550232A Diastereomers of 1-(isopropoxycarbonyloxy) ethyl 3-cephem 4-carboxylate 失效
标题翻译： 1-（异丙氧基羰基氧基）乙基3-头孢烯-4-羧酸酯的非对映异构体
公开(公告)号：US5550232A
公开(公告)日：1996-08-27
申请号：US447229
申请日：1995-05-22
申请人： Gerd Fischer , Elisabeth Defossa , Uwe Gerlach , Rolf H orlein , Norbert Krass , Rudolf Lattrell , Ulrich Stache , Theodor Wollmann , Dieter Isert
发明人： Gerd Fischer , Elisabeth Defossa , Uwe Gerlach , Rolf H orlein , Norbert Krass , Rudolf Lattrell , Ulrich Stache , Theodor Wollmann , Dieter Isert
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D501/00 , C07D501/06 , C07D501/34 , C07D501/56 , C07D501/14
CPC分类号： C07D501/00
摘要： Enterally absorbable diastereomers of 1-(isopropoxycarbonyloxy)ethyl (6R,7R)-7-[2-(2-aminothiazol-4-yl)-2-(Z)-(methoxyimino)acetamido]-3-(methoxymethyl)-3-cephem-4-carboxylate of the formula I ##STR1## and their physiologically acceptable salts and also diastereomerically pure salts of the compounds of the formula II ##STR2## where HX is a mono- or polybasic acid and where X is an inorganic or organic physiologically acceptable anion, and a process for the preparation of these compounds of the formula I or II, which comprises first precipitating the more sparingly soluble diastereomer of the formula IV in the mixing together of 1 equivalent of a solution of the diastereomer mixture of the formula III with 0.2-2 equivalents of a solution of the acid component HY and separating it off by filtration, then precipitating the more readily soluble diastereomer of the formula IV from the filtration solution, it being possible for the acid component HY to be identical or different in the consecutive partial steps and any desired sequence of addition of different acid components HY being possible, and optionally further purifying the obtained salts by crystallization, are described.
摘要翻译： 1-（异丙氧羰基氧基）乙基（6R，7R）-7- [2-（2-氨基噻唑-4-基）-2-（Z） - （甲氧基亚氨基）乙酰氨基] -3-（甲氧基甲基）-3 式I的化合物 - 头孢烯-4-羧酸酯及其生理学上可接受的盐以及式II化合物的非对映体纯盐，其中HX是单或多元酸，其中X是无机或有机的生理学上可接受的阴离子，以及制备这些式I或II化合物的方法，其包括首先将式IV的较微溶的非对映体沉淀在1当量的式（I）的非对映体混合物的溶液中， III与0.2-2当量的酸组分HY的溶液并通过过滤分离，然后从过滤溶液中沉淀出更容易溶解的式IV的非对映异构体，酸组分HY可能相同或不同在一起描述了部分步骤和任何期望的不同酸组分HY的加入顺序是可能的，并且任选地通过结晶进一步纯化得到的盐。

35. 发明授权

US07569700B2 Substituted, bicyclic 8-pyrrolidinobenzimidazoles, methods for their production and their use as medicaments 有权
标题翻译：取代的双环8-吡咯烷基苯并咪唑，其制备方法及其用作药物
公开(公告)号：US07569700B2
公开(公告)日：2009-08-04
申请号：US11855224
申请日：2007-09-14
申请人： Elisabeth Defossa , Karl Schoenafinger , Gerhard Jaehne , Christian Buning , Georg Tschank , Ulrich Werner
发明人： Elisabeth Defossa , Karl Schoenafinger , Gerhard Jaehne , Christian Buning , Georg Tschank , Ulrich Werner
IPC分类号： A61K31/4184 , C07D403/04
CPC分类号： C07D487/04
摘要： The present invention relates to carboxamide derivative compounds of formula I in which R1-R6 and R12 are hereinafter defined and together comprise carboximide derivatives for the therapeutic treatment of diabetes, hyperglycemia, lipid and carbohydrate metabolism disorders, arteriosclerotic manifestations and disorders and other blood sugar related disorders through a metabolic blood sugar-lowering action.
摘要翻译：本发明涉及式I的甲酰胺衍生物化合物，其中R1-R6和R12在下文中定义，并且一起包含用于治疗糖尿病，高血糖症，脂质和碳水化合物代谢紊乱，动脉硬化表现和障碍以及其它血糖相关的二羧酰亚胺衍生物疾病通过代谢降血糖作用。

36. 发明申请

US20090149519A1 PHENYLAMINO-BENZOXAZOLE SUBSTITUTED CARBOXYLIC ACIDS, METHOD FOR THEIR PRODUCTION AND USE THEREOF AS MEDICAMENTS 审中-公开
标题翻译：苯甲酰基苯并噻唑取代的羧酸，其生产方法及其作为药物的用途
公开(公告)号：US20090149519A1
公开(公告)日：2009-06-11
申请号：US12267896
申请日：2008-11-10
申请人： Elisabeth Defossa , Markus Follmann , Thomas Klabunde , Viktoria Dietrich , Gerhard Hessler , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
发明人： Elisabeth Defossa , Markus Follmann , Thomas Klabunde , Viktoria Dietrich , Gerhard Hessler , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
IPC分类号： A61K31/423 , C07D263/48 , A61P3/10
CPC分类号： A61K31/423 , A61K45/06 , C07D263/58 , C07D413/12
摘要： This invention relates to a compound of formula I, wherein R1, R2, R6, R7, R8, R9, R10, m and X are as defined herein, or a physiologically tolerated salt thereof, its pharmaceutical composition and use for lowering blood glucose, treating diabetes, or increasing insulin release.
摘要翻译：本发明涉及式I化合物，其中R 1，R 2，R 6，R 7，R 8，R 9，R 10，m和X如本文所定义，或其生理上耐受的盐，其药物组合物和用于降低血糖，治疗糖尿病或增加胰岛素释放。

37. 发明申请

US20080033042A1 UREA-AND URETHANE-SUBSTITUTED ACYLUREAS, PROCESS FOR THEIR PREPARATION AND THEIR USE 有权
标题翻译：尿素和尿素取代的精油，其制备方法及其使用
公开(公告)号：US20080033042A1
公开(公告)日：2008-02-07
申请号：US11845242
申请日：2007-08-27
申请人： Elisabeth Defossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger
发明人： Elisabeth Defossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger
IPC分类号： A61K31/16 , A61K31/24 , A61P3/00 , A61P5/00 , C07C229/38 , C07C233/37
CPC分类号： C07C275/54 , C07D213/75 , C07D239/96 , C07D295/135
摘要： The invention relates to urea- and urethane-substituted acylureas and to their physiologically tolerated salts and physiologically functional derivatives. In particular, the invention relates to the compounds of the formula I wherein the radicals have meanings described herein, and to their physiologically tolerated salts and to processes for their preparation. The compounds are suitable for example as antidiabetics.
摘要翻译：本发明涉及脲和氨基甲酸酯取代的酰基脲及其生理上耐受的盐和生理功能衍生物。特别地，本发明涉及式I化合物，其中基团具有本文所述的含义及其生理学耐受的盐及其制备方法。该化合物适合于例如抗糖尿病药。

38. 发明授权

US07262220B2 Urea- and urethane-substituted acylureas, process for their preparation and their use 有权
标题翻译：尿素和氨基甲酸酯取代的酰基脲，其制备方法及其用途
公开(公告)号：US07262220B2
公开(公告)日：2007-08-28
申请号：US10616959
申请日：2003-07-11
申请人： Elisabeth Defossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger
发明人： Elisabeth Defossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger
IPC分类号： C07C275/24 , A61K31/277
CPC分类号： C07C275/54 , C07D213/75 , C07D239/96 , C07D295/135
摘要： The invention relates to urea- and urethane-substituted acylureas and to their physiologically tolerated salts and physiologically functional derivatives. In particular, the invention relates to the compounds of the formula I wherein the radicals have meanings described herein, and to their physiologically tolerated salts and to processes for their preparation. The compounds are suitable for example as antidiabetics.
摘要翻译：本发明涉及脲和氨基甲酸酯取代的酰基脲及其生理上耐受的盐和生理功能衍生物。特别地，本发明涉及式I化合物，其中基团具有本文所述的含义及其生理学耐受的盐及其制备方法。该化合物适合于例如抗糖尿病药。

39. 发明授权

US07196114B2 Substituted 3-(benzoylureido) thiophene derivatives, processes for preparing them and their use 有权
标题翻译：取代的3-（苯甲酰基脲基）噻吩衍生物，其制备方法及其应用
公开(公告)号：US07196114B2
公开(公告)日：2007-03-27
申请号：US10780344
申请日：2004-02-17
申请人： Karl Schoenafinger , Elisabeth Defossa , Erich Von Roedern , Dieter Kadereit , Andreas Herling , Hans-Joerg Burger , Thomas Klabunde , Karl-Ulrich Wendt
发明人： Karl Schoenafinger , Elisabeth Defossa , Erich Von Roedern , Dieter Kadereit , Andreas Herling , Hans-Joerg Burger , Thomas Klabunde , Karl-Ulrich Wendt
IPC分类号： A61K31/38 , C07D333/36
CPC分类号： C07D409/04 , C07D333/36 , C07D333/38 , C07D333/44 , C07D413/04
摘要： Substituted 3-(benzoylureido)thiophene derivatives, processes for preparing them and their useThe invention relates to compounds of the formula I where the radicals are as defined, and their physiologically tolerated salts. The compounds are suitable, for example, as medicaments for preventing and treating type 2 diabetes.
摘要翻译：取代的3-（苯甲酰基脲基）噻吩衍生物，其制备方法及其应用

40. 发明申请

US20050182087A1 Cycloalkyl-substituted 7-amino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments 有权
标题翻译：环烷基取代的7-氨基-4-喹诺酮-3-羧酸衍生物，其制备方法及其作为药物的用途
公开(公告)号：US20050182087A1
公开(公告)日：2005-08-18
申请号：US11042770
申请日：2005-01-25
申请人： Elisabeth Defossa , Dieter Kadereit , Thomas Klabunde , Dieter Schmoll , Andreas Herling , Karl-Ulrich Wendt , Sven Ruf
发明人： Elisabeth Defossa , Dieter Kadereit , Thomas Klabunde , Dieter Schmoll , Andreas Herling , Karl-Ulrich Wendt , Sven Ruf
IPC分类号： A61K31/47 , A61K31/4745 , C07D215/36 , C07D471/02
CPC分类号： C07D471/04 , C07D215/36
摘要： Cycloalkyl-substituted 7-amino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments The invention relates to cycloalkyl-substituted 7-amino-4-quinolone-3-carboxylic acid derivatives and to the physiologically tolerated salts and physiologically functional derivatives thereof. The invention relates to compounds of the formula I in which the radicals have the stated meanings, and to the physiologically tolerated salts thereof. The compounds are suitable for example as medicaments for the prevention and treatment of type 2 diabetes.
摘要翻译：环烷基取代的7-氨基-4-喹诺酮-3-羧酸衍生物，其制备方法及其作为药物的用途本发明涉及环烷基取代的7-氨基-4-喹诺酮-3-羧酸衍生物和生理学上耐受的盐及其生理功能衍生物。本发明涉及其中基团具有所述含义的式I化合物及其生理上耐受的盐。该化合物适用于例如用于预防和治疗2型糖尿病的药物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式