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31. 发明授权

US08591033B2 Tear film measurement 有权
标题翻译：撕裂膜测量
公开(公告)号：US08591033B2
公开(公告)日：2013-11-26
申请号：US13195353
申请日：2011-08-01
申请人： Donald R. Korb , Benjamin T. Gravely
发明人： Donald R. Korb , Benjamin T. Gravely
IPC分类号： A61B3/10
CPC分类号： G01B11/0675 , A61B3/101
摘要： The invention comprises an apparatus for measuring the relative thickness of the lipid layer component of the precorneal tear film on the surface of an eye after distribution of the lipid layer subsequent to blinking is disclosed. An illuminator directs light to the lipid layer of a patient's eye. The illuminator is a broad spectrum light source covering the visible region and is a lambertion light emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer. A collector collects and focuses the specularly reflected light such that the interference patterns on the tear film lipid layer are observable. The collector also produces an output signal representative of the specularly reflected light which is suitable for further analysis, such as projection on to a high resolution video monitor or analysis by or storage in a computer. In order to facilitate ease of measurement, the patient's head may be positioned on an observation platform when the illuminator directs light to the lipid layer of the patient's eye.
摘要翻译：本发明包括一种用于测量在眨眼之后脂质层分布之后眼前表面上的预角膜撕裂膜的脂质层组分的相对厚度的装置。照明器将光引导到患者眼睛的脂质层。照明器是覆盖可见光区域的广谱光源，是一个薄片光发射器，使得光源从脂质层镜面反射并在脂质层中发生建设性和相消干涉。收集器收集并聚焦镜面反射光，使得可以观察到泪膜脂质层上的干涉图案。收集器还产生表示镜面反射光的输出信号，其适用于进一步分析，例如投影到高分辨率视频监视器上，或由计算机分析或存储在计算机中。为了便于测量，当照明器将光引导到患者眼睛的脂质层时，患者的头部可以位于观察平台上。

32. 发明申请

US20120236260A1 TEAR FILM MEASUREMENT 有权
标题翻译：眼膜测量
公开(公告)号：US20120236260A1
公开(公告)日：2012-09-20
申请号：US13455628
申请日：2012-04-25
申请人： Donald R. Korb , Benjamin T. Gravely
发明人： Donald R. Korb , Benjamin T. Gravely
IPC分类号： A61B3/14
CPC分类号： A61B3/101
摘要： A method for measuring the relative thickness of the lipid layer component of the precorneal tear film on the surface of an eye. Light is directed to the lipid layer of a patient's eye with an illuminator that is a broad spectrum light source covering the visible region and is a lambertion light emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer. The specularly reflected light is collected and focused using a collector such that the interference patterns on the tear film lipid layer are observable. The collector also produces an output signal representative of the specularly reflected light which is suitable for further analysis.
摘要翻译：用于测量眼表面上的角膜前泪膜的脂质层成分的相对厚度的方法。光被引导到患者眼睛的脂质层，其中照射器是覆盖可见区域的宽光谱光源，并且是透明光发射器，使得光源被镜面反射从脂质层并经历建构性和相消干涉脂质层。使用收集器收集和聚焦镜面反射光，使得可以观察到泪膜脂质层上的干涉图案。集电极还产生代表镜面反射光的输出信号，适用于进一步的分析。

33. 发明授权

US08215774B2 Ocular surface interferometry (OSI) devices and systems for imaging and measuring ocular tear film layer thickness(es) 有权
标题翻译：用于成像和测量眼泪膜层厚度的眼表干涉测量（OSI）装置和系统
公开(公告)号：US08215774B2
公开(公告)日：2012-07-10
申请号：US12798324
申请日：2010-04-01
申请人： Donald R. Korb , William L. Weber , Randal B. Chinnock , Benjamin T. Gravely , Stephen M. Grenon , Michael Zelina
发明人： Donald R. Korb , William L. Weber , Randal B. Chinnock , Benjamin T. Gravely , Stephen M. Grenon , Michael Zelina
IPC分类号： A61B3/14 , A61B3/10
CPC分类号： A61B3/101 , A61B3/0025 , A61B3/0041 , A61B3/1005 , A61B3/14 , G06T7/0012 , G06T2207/30041
摘要： Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). The measured TFLT can be used to diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device can also be focused on the lipid layer of the tear film to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image. The resulting image can be processed and analyzed to measure a tear film layer thickness (TFLT), including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT).
摘要翻译：公开了用于测量眼泪膜的泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）的眼表干涉测量（OSI）装置，系统和方法。测量的TFLT可用于诊断干眼综合征（DES）。在某些公开的实施例中，可以控制多波长光源以照射眼泪膜。从多波长光源发射的光在泪膜中经历光波干涉相互作用。成像装置可以集中在泪膜的脂质层上，以捕获与第一图像中的背景信号结合的来自泪膜的镜面反射光的光波干涉相互作用。成像装置还可以聚焦在泪膜的脂质层上，以捕获包含存在于第一图像中的背景信号的第二图像。可以从第一图像中减去第二图像以减少和/或消除第一图像中的背景信号以产生所得图像。可以对所得图像进行处理和分析，以测量泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）。

34. 发明授权

US08192026B2 Tear film measurement 有权
标题翻译：撕裂膜测量
公开(公告)号：US08192026B2
公开(公告)日：2012-06-05
申请号：US11900314
申请日：2007-09-11
申请人： Benjamin T. Gravely , Donald R. Korb
发明人： Benjamin T. Gravely , Donald R. Korb
IPC分类号： A61B3/00 , A61B3/10
CPC分类号： A61B3/101
摘要： The disclosure comprises a method for measuring the relative thickness of the lipid layer component of the precorneal tear film on the surface of an eye after distribution of the lipid layer subsequent to blinking. Light is directed to the lipid layer of a patient's eye with an illuminator. The illuminator is a broad spectrum light source covering the visible region and is a lambertion light emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer. The specularly reflected light is collected and focused using a collector such that the interference patterns on the tear film lipid layer are observable. The collector also produces an output signal representative of the specularly reflected light suitable for further analysis, such as projection on to a high resolution video monitor or analysis by or storage in a computer.
摘要翻译：本公开内容包括一种用于在眨眼之后脂质层分布之后测量眼表面上的眼前表面泪液的脂质层组分的相对厚度的方法。光照射器被引导到患者眼睛的脂质层。照明器是覆盖可见光区域的广谱光源，是一个薄片光发射器，使得光源从脂质层镜面反射并在脂质层中发生建设性和相消干涉。使用收集器收集和聚焦镜面反射光，使得可以观察到泪膜脂质层上的干涉图案。收集器还产生表示适于进一步分析的镜面反射光的输出信号，例如投影到高分辨率视频监视器或由计算机分析或存储在计算机中。

35. 发明授权

US07988294B2 Tear film measurement 有权
标题翻译：撕裂膜测量
公开(公告)号：US07988294B2
公开(公告)日：2011-08-02
申请号：US12633057
申请日：2009-12-08
申请人： Donald R. Korb , Benjamin T. Gravely
发明人： Donald R. Korb , Benjamin T. Gravely
IPC分类号： A61B3/10
CPC分类号： G01B11/0675 , A61B3/101
摘要： The invention comprises an apparatus for measuring the relative thickness of the lipid layer component of the precorneal tear film on the surface of an eye after distribution of the lipid layer subsequent to blinking is disclosed. An illuminator directs light to the lipid layer of a patient's eye. The illuminator is a broad spectrum light source covering the visible region and is a lambertion light emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer. A collector collects and focuses the specularly reflected light such that the interference patterns on the tear film lipid layer are observable. The collector also produces an output signal representative of the specularly reflected light which is suitable for further analysis, such as projection on to a high resolution video monitor or analysis by or storage in a computer. In order to facilitate ease of measurement, the patient's head may be positioned on an observation platform when the illuminator directs light to the lipid layer of the patient's eye.
摘要翻译：本发明包括一种用于测量在眨眼之后脂质层分布之后眼前表面上的预角膜撕裂膜的脂质层组分的相对厚度的装置。照明器将光引导到患者眼睛的脂质层。照明器是覆盖可见光区域的广谱光源，是一个薄片光发射器，使得光源从脂质层镜面反射并在脂质层中发生建设性和破坏性干扰。收集器收集并聚焦镜面反射光，使得可以观察到泪膜脂质层上的干涉图案。收集器还产生表示镜面反射光的输出信号，其适用于进一步分析，例如投影到高分辨率视频监视器上，或由计算机分析或存储在计算机中。为了便于测量，当照明器将光引导到患者眼睛的脂质层时，患者的头部可以位于观察平台上。

36. 发明申请

US20100085540A1 TEAR FILM MEASUREMENT 有权
标题翻译：眼膜测量
公开(公告)号：US20100085540A1
公开(公告)日：2010-04-08
申请号：US12633057
申请日：2009-12-08
申请人： Donald R. Korb , Benjamin T. Gravely
发明人： Donald R. Korb , Benjamin T. Gravely
IPC分类号： A61B3/10
CPC分类号： G01B11/0675 , A61B3/101
摘要： The invention comprises an apparatus for measuring the relative thickness of the lipid layer component of the precorneal tear film on the surface of an eye after distribution of the lipid layer subsequent to blinking is disclosed. An illuminator directs light to the lipid layer of a patient's eye. The illuminator is a broad spectrum light source covering the visible region and is a lambertion light emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer. A collector collects and focuses the specularly reflected light such that the interference patterns on the tear film lipid layer are observable. The collector also produces an output signal representative of the specularly reflected light which is suitable for further analysis, such as projection on to a high resolution video monitor or analysis by or storage in a computer. In order to facilitate ease of measurement, the patient's head may be positioned on an observation platform when the illuminator directs light to the lipid layer of the patient's eye.
摘要翻译：本发明包括一种用于测量在眨眼之后脂质层分布之后眼前表面上的预角膜撕裂膜的脂质层组分的相对厚度的装置。照明器将光引导到患者眼睛的脂质层。照明器是覆盖可见光区域的广谱光源，是一个薄片光发射器，使得光源从脂质层镜面反射并在脂质层中发生建设性和相消干涉。收集器收集并聚焦镜面反射光，使得可以观察到泪膜脂质层上的干涉图案。收集器还产生代表镜面反射光的输出信号，其适用于进一步分析，例如投影到高分辨率视频监视器上，或由计算机分析或存储在计算机中。为了便于测量，当照明器将光引导到患者眼睛的脂质层时，患者的头部可以位于观察平台上。

37. 发明申请

US20080319323A1 Tear film measurement 有权
标题翻译：撕裂膜测量
公开(公告)号：US20080319323A1
公开(公告)日：2008-12-25
申请号：US11900314
申请日：2007-09-11
申请人： Benjamin T. Gravely , Donald R. Korb
发明人： Benjamin T. Gravely , Donald R. Korb
IPC分类号： A61B6/00
CPC分类号： A61B3/101
摘要： The invention comprises a method for measuring the relative thickness of the lipid layer component of the precorneal tear film on the surface of an eye after distribution of the lipid layer subsequent to blinking. Light is directed to the lipid layer of a patient's eye with an illuminator. The illuminator is a broad spectrum light source covering the visible region and is a lambertion light emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer. The specularly reflected light is collected and focused using a collector such that the interference patterns on the tear film lipid layer are observable. The collector also produces an output signal representative of the specularly reflected light which is suitable for further analysis, such as projection on to a high resolution video monitor or analysis by or storage in a computer. In order to facilitate ease of measurement, the patient's head may be positioned on an observation platform when the illuminator directs light to the lipid layer of the patient's eye.
摘要翻译：本发明包括一种用于在眨眼之后脂质层分布后测量眼表面上的眼前膜泪膜的脂质层组分的相对厚度的方法。光照射器被引导到患者眼睛的脂质层。照明器是覆盖可见光区域的广谱光源，是一个薄片光发射器，使得光源从脂质层镜面反射并在脂质层中发生建设性和破坏性干扰。使用收集器收集和聚焦镜面反射光，使得可以观察到泪膜脂质层上的干涉图案。收集器还产生表示镜面反射光的输出信号，其适用于进一步分析，例如投影到高分辨率视频监视器上，或由计算机分析或存储在计算机中。为了便于测量，当照明器将光引导到患者眼睛的脂质层时，患者的头部可以位于观察平台上。

38. 发明申请

US20130053733A1 METHODS AND SYSTEMS FOR TREATING MEIBOMIAN GLAND DYSFUNCTION USING RADIO-FREQUENCY ENERGY 有权
标题翻译：使用无线电频率处理MEIBOMIAN GLAND DYSFUNCTION的方法和系统
公开(公告)号：US20130053733A1
公开(公告)日：2013-02-28
申请号：US13590828
申请日：2012-08-21
申请人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely , Steven Bacich
发明人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely , Steven Bacich
IPC分类号： A61N5/00 , A61N7/00 , A61M37/00
CPC分类号： G01N33/227 , A61B5/4836 , A61B18/12 , A61B2018/046 , A61B2018/048 , A61B2562/0247 , A61B2562/0271 , A61F9/007 , A61F9/00718 , A61F2007/0004 , A61F2007/0059 , A61H7/003 , A61H7/005 , A61H9/0057 , A61H9/0071 , A61H9/0078 , A61H23/0236 , A61H23/0245 , A61H23/0263 , A61H39/086 , A61H2015/0014 , A61H2201/0176 , A61H2201/0207 , A61H2201/0214 , A61H2201/5038 , A61H2201/5043 , A61H2205/024 , A61N1/403 , A61N7/00 , Y10T436/170769 , Y10T436/173076 , Y10T436/173845 , Y10T436/178459 , Y10T436/19 , Y10T436/206664
摘要： A method of treating meibomian gland dysfunction is disclosed. The method includes directing RF energy to an internal portion of a meibomian gland, selectively targeting an obstruction within a duct of the meibomian gland with the applied RF energy to melt, loosen, or soften the obstruction, and expressing the obstruction from the duct of the meibomian gland. An apparatus for treating meibomian gland dysfunction is also disclosed. The apparatus comprises at least one RF electrode configured to direct RF energy to an internal portion of a meibomian gland located in an eyelid of an eye, the at least one RF electrode further configured to selectively target an obstruction within a duct of the meibomian gland with the applied RF energy to melt, loosen, or soften the obstruction. The apparatus also comprises at least one expressor configured to express the obstruction from the duct of the meibomian gland.
摘要翻译：公开了治疗睑板腺功能障碍的方法。该方法包括将RF能量引导到睑板腺的内部部分，以施加的RF能量选择性地靶向睑板腺管道内的阻塞物，以熔化，松动或软化阻塞物，并且将来自管道的阻塞物睑板腺还公开了一种治疗睑板腺功能障碍的装置。该装置包括至少一个RF电极，其被配置为将RF能量引导到位于眼睛的眼睑中的睑板腺的内部部分，所述至少一个RF电极还被配置为选择性地将睑板腺的管道内的阻塞物对准，应用的射频能量来融化，松动或软化障碍物。该装置还包括至少一个构造成从睑板腺的管道表达梗阻的表达器。

39. 发明申请

US20120136285A1 SYSTEM FOR OUTER EYELID HEAT AND PRESSURE TREATMENT FOR TREATING MEIBOMIAN GLAND DYSFUNCTION 有权
标题翻译：用于治疗脑血管性功能障碍的外眼热疗和压力治疗系统
公开(公告)号：US20120136285A1
公开(公告)日：2012-05-31
申请号：US13367908
申请日：2012-02-07
申请人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely
发明人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely
IPC分类号： A61F9/00
CPC分类号： A61F7/12 , A61B18/12 , A61B2017/00084 , A61B2018/046 , A61B2018/048 , A61F7/007 , A61F9/00772 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61N7/00
摘要： A system for treating meibomian gland dysfunction. A controller controls heat applied to the outside of the eyelid to provide conductive heat transfer to the meibomian glands. The application of heat assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. A force is also applied to the outside of the patient's eyelid during the application of heat to improve conductive heat transfer and reduce blood flow in the eyelid that causes convective heat loss. Thus, the application of force can further increase the temperature level and/or reduce the time to reach desired temperature levels for removing obstructions or occlusions. Reaching increased temperature levels may improve the melting, loosening, or softening of obstructions or occlusions in the meibomian glands while reducing the amount of time to reach desired temperature levels and/or aid in reducing discomfort to the patient during treatment.
摘要翻译：治疗睑板腺功能障碍的系统。控制器控制施加到眼睑外部的热量，以向睑板腺提供传导热传递。热的应用有助于睑板腺中阻塞或闭塞的表达，以恢复足够的脂质流向脂质层以治疗干眼症。在施加热量的同时也将力施加到患者眼皮的外侧，以改善导电传热并减少引起对流热损失的眼睑中的血流。因此，施加力可以进一步增加温度水平和/或减少达到期望温度水平以消除障碍物或闭塞的时间。达到增加的温度水平可以改善睑板腺中的阻塞物或闭塞的熔化，松动或软化，同时减少达到期望温度水平的时间量和/或有助于减轻治疗期间对患者的不适。

40. 发明授权

US08128674B2 System for outer eyelid heat and pressure treatment for treating meibomian gland dysfunction 有权
标题翻译：用于治疗睑板腺功能障碍的外眼睑热压治疗系统
公开(公告)号：US08128674B2
公开(公告)日：2012-03-06
申请号：US12015683
申请日：2008-01-17
申请人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely
发明人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely
IPC分类号： A61F7/00
CPC分类号： A61F7/12 , A61B18/12 , A61B2017/00084 , A61B2018/046 , A61B2018/048 , A61F7/007 , A61F9/00772 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61N7/00
摘要： A system for treating meibomian gland dysfunction. A controller controls heat applied to the outside of the eyelid to provide conductive heat transfer to the meibomian glands. The application of heat assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. A force is also applied to the outside of the patient's eyelid during the application of heat to improve conductive heat transfer and reduce blood flow in the eyelid that causes convective heat loss. Thus, the application of force can further increase the temperature level and/or reduce the time to reach desired temperature levels for removing obstructions or occlusions. Reaching increased temperature levels may improve the melting, loosening, or softening of obstructions or occlusions in the meibomian glands while reducing the amount of time to reach desired temperature levels and/or aid in reducing discomfort to the patient during treatment.
摘要翻译：治疗睑板腺功能障碍的系统。控制器控制施加到眼睑外部的热量，以向睑板腺提供传导热传递。热的应用有助于睑板腺中阻塞或闭塞的表达，以恢复足够的脂质流向脂质层以治疗干眼症。在施加热量的同时也将力施加到患者眼皮的外侧，以改善导电传热并减少引起对流热损失的眼睑中的血流。因此，施加力可以进一步增加温度水平和/或减少达到期望温度水平以消除障碍物或闭塞的时间。达到增加的温度水平可以改善睑板腺中的阻塞物或闭塞的熔化，松动或软化，同时减少达到期望温度水平的时间量和/或有助于减轻治疗期间对患者的不适。

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