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31. 发明申请

US20100286702A1 METHOD KIT FOR TREATING BONY DEFECTS 有权
标题翻译：用于处理宝石缺陷的方法套件
公开(公告)号：US20100286702A1
公开(公告)日：2010-11-11
申请号：US12754388
申请日：2010-04-05
申请人： James W. Ahern , Arthur Gertzman , Karen Roche , Moon Hae Sunwoo , Steven Wolfe , Stephen D. Kuslich , John E. Kuslich
发明人： James W. Ahern , Arthur Gertzman , Karen Roche , Moon Hae Sunwoo , Steven Wolfe , Stephen D. Kuslich , John E. Kuslich
IPC分类号： A61B17/58
CPC分类号： A61B17/7098 , A61B2017/00004 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/30011 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2250/0023 , A61F2310/00293
摘要： The present invention is a kit and a method of using a kit for treating bone including a fill material mixture made of osteoconductive material, osteoinductive material and a lubricating carrier, a porous container to receive the fill material mixture and a tool that flowably introduces the fill material mixture into the porous container.
摘要翻译：本发明是使用用于治疗骨的试剂盒和方法，包括由骨传导材料，骨诱导材料和润滑载体制成的填充材料混合物，用于接收填充材料混合物的多孔容器和可流动地引入填充物的工具材料混合物进入多孔容器。

32. 发明申请

US20100274362A1 Cartilage particle tissue mixtures optionally combined with a cancellous construct 审中-公开
标题翻译：软骨颗粒组织混合物任选地与松质骨构建体组合
公开(公告)号：US20100274362A1
公开(公告)日：2010-10-28
申请号：US12657207
申请日：2010-01-14
申请人： Avner Yayon , Katherine G. Truncale , Hilla Barkay-Olami , Alex B. Callahan , Arthur A. Gertzman , Yen-Chen Huang , Morris L. Jacobs , John C. Munson , Eric J. Semler , Roman Shikhanovich , Baruch Stern , Moon Hae Sunwoo , William W. Tomford , Judith I. Yannariello-Brown
发明人： Avner Yayon , Katherine G. Truncale , Hilla Barkay-Olami , Alex B. Callahan , Arthur A. Gertzman , Yen-Chen Huang , Morris L. Jacobs , John C. Munson , Eric J. Semler , Roman Shikhanovich , Baruch Stern , Moon Hae Sunwoo , William W. Tomford , Judith I. Yannariello-Brown
IPC分类号： A61F2/02 , A61K9/19 , A61K9/00 , A61K38/18 , A61P19/00
CPC分类号： A61K9/19 , A61K35/32 , A61K38/1825 , A61L27/3612 , A61L27/3654 , A61L27/54 , A61L2300/414 , A61L2300/602
摘要： Mixtures, such as gels or pastes, comprising freeze-milled cartilage particles and exogenous growth factors are used for repairing chondral defects. Such mixtures may be applied to constructs comprising cancellous bone for implantation at the defect site. Suitable growth factors include variants of FGF-2, particularly variants that include a sole amino acid substitution for asparagine at amino acid 111 of the β8-β9 loop of the FGF-2 peptide. Such FGF-2 variants are released slowly and continuously at a constant rate from cartilage pastes. In other embodiments, the amino acid substituted for asparigine is glycine. Other variants that may be used include FGF-9 variants having truncated chains and a sole amino acid substitution in the β8-β9 loop of the FGF-9 peptide either for tryptophan at amino acid 144 or for asparagine at amino acid 143.
摘要翻译：使用包含冷冻研磨的软骨颗粒和外源生长因子的混合物，例如凝胶或糊剂来修复软骨缺陷。可以将这样的混合物施用于包含用于在缺损部位植入的松质骨的构建体。合适的生长因子包括FGF-2的变体，特别是包括在FGF-2肽的8-＆amp; B9环的氨基酸111处的天冬酰胺的唯一氨基酸取代的变体。这样的FGF-2变体以软骨糊剂的恒定速率缓慢且连续地释放。在其它实施方案中，取代天冬酰胺的氨基酸是甘氨酸。可以使用的其它变体包括FGF-9变体，其具有截短的链和唯一的氨基酸取代在FGF-9肽的8-＆Bgr9环中，对于在氨基酸144处的色氨酸或在氨基酸143处的天冬酰胺。

33. 发明申请

US20090043389A1 CARTILAGE IMPLANT PLUG WITH FIBRIN GLUE AND METHOD FOR IMPLANTATION 审中-公开
标题翻译：具有纤维玻璃的植入植入物插入物和植入物的方法
公开(公告)号：US20090043389A1
公开(公告)日：2009-02-12
申请号：US12191490
申请日：2008-08-14
申请人： GORDANA VUNJAK-NOVAKOVIC , Arthur A. Gertzman , Moon Hae Sunwoo , William W. Tomford , Katherine G. Truncale
发明人： GORDANA VUNJAK-NOVAKOVIC , Arthur A. Gertzman , Moon Hae Sunwoo , William W. Tomford , Katherine G. Truncale
IPC分类号： A61F2/08
CPC分类号： A61F2/28 , A61B17/00491 , A61F2/30756 , A61F2/3094 , A61F2/3859 , A61F2/4644 , A61F2002/2817 , A61F2002/2839 , A61F2002/2867 , A61F2002/30004 , A61F2002/30062 , A61F2002/30112 , A61F2002/30113 , A61F2002/30121 , A61F2002/30125 , A61F2002/30136 , A61F2002/30153 , A61F2002/30179 , A61F2002/30224 , A61F2002/30225 , A61F2002/30228 , A61F2002/3028 , A61F2002/30759 , A61F2002/30764 , A61F2002/4635 , A61F2210/0004 , A61F2230/0004 , A61F2230/0006 , A61F2230/0008 , A61F2230/0019 , A61F2230/0058 , A61F2230/0063 , A61F2230/0069 , A61F2250/0014 , A61F2310/00365 , A61F2310/00383 , A61L27/3608 , A61L27/3612 , A61L27/3654 , A61L27/3683 , A61L27/48 , A61L27/52 , A61L2430/06
摘要： The invention is directed toward a cartilage repair assembly comprising a shaped structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that said shaped bone and cartilage cap when centered in the bore does not engage the side wall of the bore in an interference fit and is surrounded by milled cartilage and carrier. A method for inserting the assembly into a cartilage defect area is disclosed.
摘要翻译：本发明涉及一种软骨修复组件，其包括具有整体上覆软骨帽的软骨下骨的成形结构，其被处理以除去生物可吸收载体中的细胞碎片和蛋白聚糖和研磨的软骨。成形结构的尺寸适于装配在软骨缺损区域中的钻孔中，使得当在孔中心定位时所述成形的骨和软骨帽不会以过盈配合接合孔的侧壁并被碾磨的软骨和载体包围。公开了一种将组件插入软骨缺损区域的方法。

34. 发明授权

US07488348B2 Cartilage allograft plug 有权
标题翻译：软骨同种异体移植插头
公开(公告)号：US07488348B2
公开(公告)日：2009-02-10
申请号：US11151270
申请日：2005-06-14
申请人： Katherine G. Truncale , Moon Hae Sunwoo , Arthur A. Gertzman , William W. Tomford , Judith I. Yannariello-Brown
发明人： Katherine G. Truncale , Moon Hae Sunwoo , Arthur A. Gertzman , William W. Tomford , Judith I. Yannariello-Brown
IPC分类号： A61F2/28
CPC分类号： A61F2/30756 , A61F2/28 , A61F2/30767 , A61F2/3859 , A61F2002/2817 , A61F2002/2839 , A61F2002/30004 , A61F2002/30062 , A61F2002/3021 , A61F2002/30224 , A61F2002/30233 , A61F2002/3024 , A61F2002/30678 , A61F2002/30764 , A61F2210/0004 , A61F2230/0067 , A61F2230/0069 , A61F2250/0014 , A61F2310/00365 , A61F2310/00383 , A61L27/3608 , A61L27/3612 , A61L27/3654 , A61L27/3683
摘要： The invention is directed toward a cartilage repair assembly comprising a cylindrically shaped allograft structure of subchondral bone with an integral overlying smaller diameter cartilage cap which is treated to remove cellular debris and proteoglycans. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that the subchondral bone of the structure engages the side wall of the bone portion of the drilled bore in an interference fit while the cartilage cap is spaced from cartilage portion of the side wall of the drilled bore forming a gap in which a milled cartilage and biocompatible carrier mixture is placed allowing cell transfer throughout the defect area. A method for inserting the shaped allograft structure into a cartilage defect area is also disclosed.
摘要翻译：本发明涉及一种软骨修复组件，其包括软骨下骨的圆柱形同种异体移植结构，其具有整体上覆的较小直径软骨帽，其被处理以除去细胞碎片和蛋白聚糖。该成形结构的尺寸适于装配在软骨缺损区域中的钻孔中，使得该结构的软骨下骨以过盈配合接合钻孔的骨部分的侧壁，同时软骨帽与软骨部分的软骨部分间隔开钻孔的侧壁形成间隙，其中放置了碾磨的软骨和生物相容的载体混合物，允许细胞转移到整个缺陷区域。还公开了将成形的同种异体移植结构插入软骨缺损区域的方法。

35. 发明申请

US20080188939A1 Allograft tissue purification process for cleaning bone 审中-公开
标题翻译：用于清洁骨的同种异体移植组织净化过程
公开(公告)号：US20080188939A1
公开(公告)日：2008-08-07
申请号：US12072152
申请日：2008-02-25
申请人： Carl Alexander DePaula , Devin Joshua Mahony , Moon Hae Sunwoo , Arthur A. Gertzman
发明人： Carl Alexander DePaula , Devin Joshua Mahony , Moon Hae Sunwoo , Arthur A. Gertzman
IPC分类号： A61F2/28 , A61L2/025
CPC分类号： A61L27/365 , A61F2/4644 , A61F2002/2835 , A61F2002/4646 , A61L2/0011 , A61L2/0088 , A61L27/3608 , A61L27/3683 , A61L2430/02
摘要： A method for producing a cleaned bone graft with osteoinductivity above 2.0 suitable for transplantation into a human. The first step is sonicating a bone graft in a nonionic detergent in an ultrasonic cleaner at a temperature ranging from about 33° C. to about 37° C. and for a time period ranging from 15 minutes to 2 hours effective to produce a cleaned bone graft essentially free from bone marrow. The bone graft is sonicated in purified water in an ultrasonic cleaner at a temperature ranging from about 33° C. to about 37° C. a plurality of times to remove the detergent producing a cleaned bone graft. The bone graft is then sonicated in hydrogen peroxide in an ultrasonic cleaner at a temperature ranging from about 33° C. to about 37° C. for a time period ranging from 10 minutes to about 2 hours effective to retain osteoinductivity of the bone graft and again sonicated in purified water in an ultrasonic cleaner at a temperature ranging from about 33° C. to about 37° C. a plurality of times to produce a cleaned bone graft. The final step is sonicating the bone graft in an alcohol at a temperature ranging from 33° C. to 37° C. for 30 minutes to 2 hours, all of the steps being effective to reduce any initially present viruses at least two logs and bacteria at least ten logs and the bone graft is finally sonicated in purified water to remove the alcohol.
摘要翻译：一种生物活性高于2.0的清洁骨移植物的方法，适用于人类移植。第一步是将超声波清洗机中的非离子洗涤剂中的骨移植物在约33℃至约37℃的温度范围内超声处理15分钟至2小时的时间段，以有效地产生清洁的骨骼移植物基本上不含骨髓。将骨移植物在超声波清洗器中的纯净水中在约33℃至约37℃的温度范围内超声处理多次以除去产生清洁的骨移植物的洗涤剂。然后将骨移植物在超声波清洗器中在约33℃至约37℃的温度范围内在过氧化氢中超声处理10分钟至约2小时的时间段，从而有效地保持骨移植物的骨诱导性，在超声波清洗机中，在约33℃至约37℃的温度范围内，再次在净化水中超声处理多次以产生清洁的骨移植物。最后一步是在33℃至37℃的温度范围内将骨移植物超声处理30分钟至2小时，所有步骤均有效地减少任何最初存在的病毒至少两个原木和细菌将至少十个原木和骨移植物最终在纯化水中超声处理以除去醇。

36. 发明申请

US20060204544A1 Allograft bone composition having a gelatin binder 审中-公开
标题翻译：具有明胶粘合剂的同种异体移植骨组合物
公开(公告)号：US20060204544A1
公开(公告)日：2006-09-14
申请号：US11433362
申请日：2006-05-15
申请人： Moon Hae Sunwoo , Arthur Gertzman , Barbara Merboth
发明人： Moon Hae Sunwoo , Arthur Gertzman , Barbara Merboth
IPC分类号： A61K35/32
CPC分类号： A61K6/08 , A61F2/28 , A61F2002/30059 , A61F2002/30153 , A61F2230/0019 , A61L27/222 , A61L27/3608 , A61L27/365 , A61L27/54 , A61L2300/406 , A61L2300/414 , A61L2430/02
摘要： The invention is directed toward an osteoimplant for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing composition of demineralized allograft bone material mixed with an aqueous phosphate buffered gelatin which when lyophilized to remove water from the composition crosslinks the gelatin to form a solid structure and when rehydrated is flexible
摘要翻译：本发明涉及一种用于骨缺损部位的骨植入物，以在该部位促进新骨生长，其包括与磷酸盐缓冲明胶水混合的脱矿质同种异体移植骨材料的新的骨生长诱导组合物，当将其冻干以从组合物交联明胶以形成固体结构，并且当再水合是柔性时

37. 发明授权

US06548080B1 Method for partially demineralized cortical bone constructs 有权
标题翻译：部分软化皮质骨构建体的方法
公开(公告)号：US06548080B1
公开(公告)日：2003-04-15
申请号：US10124424
申请日：2002-04-18
申请人： Arthur A. Gertzman , Moon Hae Sunwoo
发明人： Arthur A. Gertzman , Moon Hae Sunwoo
IPC分类号： A61F228
CPC分类号： A61L27/3847 , A61B17/86 , A61F2/28 , A61F2/3094 , A61F2/446 , A61F2/447 , A61F2002/2817 , A61F2002/2839 , A61F2002/30059 , A61F2002/302 , A61F2002/3023 , A61F2002/30843 , A61F2002/30892 , A61F2002/30894 , A61F2230/0065 , A61F2230/0069 , A61F2310/00293 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3691 , A61L31/005 , A61L2430/02 , Y10S514/801 , Y10S514/802
摘要： The invention is directed toward a sterile bone structure for application to a bone defect site to promote new bone growth at the site comprising a partially demineralized cortical bone structure, said bone structure comprising a cross sectional surface are ranging from 85% to 95% of the original bone surface area before demineralization with the remaining partially demineralized cortical bone structure having an outer demineralized layer ranging in thickness from about 0.05 mm to about 0.14 mm and a mineralized core.
摘要翻译：本发明涉及一种用于骨缺损部位的无菌骨结构，以促进包括部分软化皮质骨结构的部位的新骨生长，所述骨结构包括截面为85％至95％脱矿质前的原始骨表面积与剩余部分去矿物质的皮质骨结构具有厚度约0.05mm至约0.14mm的外部软化层和矿化核。

38. 发明授权

US08292968B2 Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles 有权
标题翻译：松质骨构建体，软骨颗粒和松质骨构建体和软骨颗粒的组合
公开(公告)号：US08292968B2
公开(公告)日：2012-10-23
申请号：US12931427
申请日：2011-02-01
申请人： Katherine G. Truncale , Eric J. Semler , Arthur A. Gertzman , Moon Hae Sunwoo , William W. Tomford , Roman Shikhanovich
发明人： Katherine G. Truncale , Eric J. Semler , Arthur A. Gertzman , Moon Hae Sunwoo , William W. Tomford , Roman Shikhanovich
IPC分类号： A61F2/28
CPC分类号： A61F2/30756 , A61B17/00491 , A61F2/28 , A61F2/3094 , A61F2/3859 , A61F2/3872 , A61F2002/2817 , A61F2002/2839 , A61F2002/2842 , A61F2002/30057 , A61F2002/30059 , A61F2002/30062 , A61F2002/30224 , A61F2002/30225 , A61F2002/30227 , A61F2002/30233 , A61F2002/30235 , A61F2002/30327 , A61F2002/30331 , A61F2002/30354 , A61F2002/30387 , A61F2002/30448 , A61F2002/30459 , A61F2002/30461 , A61F2002/30492 , A61F2002/30604 , A61F2002/30759 , A61F2002/30762 , A61F2002/30764 , A61F2002/30772 , A61F2002/30785 , A61F2002/30789 , A61F2002/30795 , A61F2002/3085 , A61F2002/30932 , A61F2002/3096 , A61F2002/4635 , A61F2002/4646 , A61F2002/4649 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2220/005 , A61F2220/0066 , A61F2220/0075 , A61F2230/0069 , A61F2250/0039 , A61F2310/00365 , A61L27/3608 , A61L27/3612 , A61L27/3654 , A61L27/48 , A61L27/54 , A61L2300/414 , A61L2300/43 , A61L2430/06 , C08L89/00
摘要： A construct for repairing articular cartilage defects includes a cap member and a base member. The cap member has an upper section and a stem depending from a central region thereof. The upper section includes a peripheral region. The stem includes a cavity. The base member has first and second ends, the first end including an annular recess dimensioned such that the stem is receivable therein. The first end also includes an annular edge positioned laterally outwardly from the annular recess, for abutting and supporting the peripheral region of the upper section when the stem is received in the annular recess. The base member further includes an island which is surrounded by the annular recess and receivable in the cavity of the stem, such that the island is abuttable with and may thereby support the central region of the upper section when the stem is received in the annular recess.
摘要翻译：用于修复关节软骨缺损的构造包括帽构件和基底构件。盖构件具有从其中心区域悬垂的上部部分和茎部。上部包括外围区域。杆包括一个空腔。基部构件具有第一端和第二端，第一端包括尺寸为使得杆可接收在其中的环形凹部。第一端还包括从环形凹部横向向外定位的环形边缘，用于当杆被容纳在环形凹部中时抵靠并支撑上部的周边区域。基部构件还包括岛，该岛由环形凹部包围并且可接收在杆的空腔中，使得当杆被容纳在环形凹部中时，岛可抵靠并且从而支撑上部的中心区域。

39. 发明申请

US20120205274A1 ALLOGRAFT BONE COMPOSITION HAVING A GELATIN BINDER 审中-公开
标题翻译：具有凝胶粘合剂的骨骼组合物（ALLOGRAFT BONE COMPOSITION WITH GELATIN BINDER）
公开(公告)号：US20120205274A1
公开(公告)日：2012-08-16
申请号：US13456461
申请日：2012-04-26
申请人： Moon Hae Sunwoo , Arthur A. Gertzman , Barbara L. Merboth
发明人： Moon Hae Sunwoo , Arthur A. Gertzman , Barbara L. Merboth
IPC分类号： A61K35/32 , A61P19/00 , A61J1/00 , A61K9/00
CPC分类号： A61K6/08 , A61F2002/30059 , A61K35/32 , A61K38/1875 , A61L27/20 , A61L27/222 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3691 , A61L27/3695 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/52 , A61L27/54 , A61L2300/404 , A61L2300/406 , A61L2300/414 , A61L2430/02 , A61K2300/00 , C08L5/08
摘要： The invention is directed toward an osteoimplant for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing composition of demineralized allograft bone material mixed with an aqueous phosphate buffered gelatin which when lyophilized to remove water from the composition crosslinks the gelatin to form a solid structure and when rehydrated is flexible
摘要翻译：本发明涉及一种用于骨缺损部位的骨植入物，以在该部位促进新骨生长，其包括与磷酸盐缓冲明胶水混合的脱矿质同种异体移植骨材料的新的骨生长诱导组合物，当将其冻干以从组合物交联明胶以形成固体结构，并且当再水合是柔性时

40. 发明申请

US20090319045A1 Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles 审中-公开
标题翻译：松质骨构建体，软骨颗粒和松质骨构建体和软骨颗粒的组合
公开(公告)号：US20090319045A1
公开(公告)日：2009-12-24
申请号：US12381072
申请日：2009-03-05
申请人： Katherine G. Truncale , Eric J. Semler , Arthur A. Gertzman , Moon Hae Sunwoo , William W. Tomford , Roman Shikhanovich , Alex B. Callahan , Judith I. Yannariello-Brown , Morris L. Jacobs , John C. Munson , Yen-Chen Huang
发明人： Katherine G. Truncale , Eric J. Semler , Arthur A. Gertzman , Moon Hae Sunwoo , William W. Tomford , Roman Shikhanovich , Alex B. Callahan , Judith I. Yannariello-Brown , Morris L. Jacobs , John C. Munson , Yen-Chen Huang
IPC分类号： A61F2/28 , A61F2/02
CPC分类号： A61F2/30756 , A61B17/00491 , A61F2/28 , A61F2/3094 , A61F2/3859 , A61F2/3872 , A61F2002/2817 , A61F2002/2839 , A61F2002/2842 , A61F2002/30057 , A61F2002/30059 , A61F2002/30062 , A61F2002/30224 , A61F2002/30225 , A61F2002/30227 , A61F2002/30233 , A61F2002/30235 , A61F2002/30327 , A61F2002/30331 , A61F2002/30354 , A61F2002/30387 , A61F2002/30448 , A61F2002/30459 , A61F2002/30461 , A61F2002/30492 , A61F2002/30604 , A61F2002/30759 , A61F2002/30762 , A61F2002/30764 , A61F2002/30772 , A61F2002/30785 , A61F2002/30789 , A61F2002/30795 , A61F2002/3085 , A61F2002/30932 , A61F2002/3096 , A61F2002/4635 , A61F2002/4646 , A61F2002/4649 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2220/005 , A61F2220/0066 , A61F2220/0075 , A61F2230/0069 , A61F2250/0039 , A61F2310/00365 , A61L27/3608 , A61L27/3612 , A61L27/3654 , A61L27/48 , A61L27/54 , A61L2300/414 , A61L2300/43 , A61L2430/06 , C08L89/00
摘要： Constructs that are at least partially constructed of allograft cancellous bone are disclosed, along with cartilage particles that may be used with the constructs for repairing articular cartilage defects. A multi-piece construct includes a base member, a cap member and at least one pin that secures the cap member to the base member. The base member may be constructed of mineralized cancellous bone, and is used to replace the subchondral bone removed when a surgeon cuts a bore in the area of an adjacent cartilage defect. The base member includes a blind bore and first and second through-going transverse bores in opposite sides of a wall of the base member. The cap member includes an upper section that has a thickness that is similar to that of a patient's surrounding articular cartilage layer and a stem depending from the upper section that is dimensioned to be received in and by the blind bore of the base member. The stem includes a transverse through-going bore, which may be aligned with the transverse through-going bores of the base member to receive the pin therein when the construct has been assembled. The cap member is at least partially formed of demineralized allograft cancellous bone, into which a mixture containing lyophilized, freeze-milled allograft cartilage particles may be infused for the repair of articular cartilage defects. The cartilage particles have a size within a range of from about 10 microns to about 210 microns.
摘要翻译：公开了至少部分由同种异体移植松质骨构成的构造物，以及可用于修复关节软骨缺损的构建体的软骨颗粒。多件式构件包括底座构件，帽构件以及将盖构件固定到基座构件的至少一个销。基部构件可以由矿化松质骨构成，并且当外科医生切割相邻软骨缺损区域中的孔时，用于替代被去除的软骨下骨。基部构件包括盲孔以及在基部构件的壁的相对侧中的第一和第二穿过横向孔。盖构件包括具有与患者周围的关节软骨层的厚度相似的厚度的上部部分和从上部部分延伸的杆部，该上部部分的尺寸设计成被接纳在基部构件的盲孔内和通过该盲孔。所述杆包括横向通孔，所述横向通孔可以与所述基部构件的横向贯穿孔对齐，以在所述构造件已经组装时将其插入其中。盖构件至少部分地由软化的同种异体移植松质骨形成，含有冻干的冷冻研磨的同种异体移植软骨颗粒的混合物可以被注入其中，用于修复关节软骨缺损。软骨颗粒的尺寸在约10微米至约210微米的范围内。

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