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31. 发明申请

US20050214206A1 Antibodies that immunospecifically bind to TRAIL receptors 审中-公开
公开(公告)号：US20050214206A1
公开(公告)日：2005-09-29
申请号：US10981621
申请日：2004-11-05
申请人： Theodora Salcedo , Craig Rosen , Vivian Albert , Robin Humphreys , Tristan Vaughan
发明人： Theodora Salcedo , Craig Rosen , Vivian Albert , Robin Humphreys , Tristan Vaughan
IPC分类号： A61K39/395 , A61K51/00 , C07K16/28 , C07K16/30 , C07K16/46
CPC分类号： C07K16/2878 , A61K45/06 , A61K2039/505 , C07K16/30 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/30
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR7. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR7 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR7.

32. 发明申请

US20050197285A1 Human secreted proteins 审中-公开
标题翻译：人体分泌的蛋白质
公开(公告)号：US20050197285A1
公开(公告)日：2005-09-08
申请号：US10472533
申请日：2002-03-19
申请人： Craig Rosen , Steven Ruben
发明人： Craig Rosen , Steven Ruben
IPC分类号： A61K35/76 , A61K38/00 , C07K14/47 , G01N33/68 , A61K38/17
CPC分类号： G01N33/5005 , A61K38/00 , C07K14/47 , G01N33/5091 , G01N33/68 , A61K35/76 , A61K2300/00
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating gastrointestinal diseases, disorders, and/or conditions related thereto. Antibodies that bind these polypeptides and also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antogonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及人分泌多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗与其有关的胃肠道疾病，病症和/或病症。结合这些多肽并且也包括在本发明中的抗体。本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。本发明进一步包括用于鉴定本发明的多核苷酸和多肽的激动剂和亲和体的筛选方法。本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

33. 发明申请

US20050176103A1 Vascular endothelial growth factor 2 失效
标题翻译：血管内皮生长因子2
公开(公告)号：US20050176103A1
公开(公告)日：2005-08-11
申请号：US11067015
申请日：2005-02-28
申请人： Jing-Shan Hu , Craig Rosen , Liang Cao
发明人： Jing-Shan Hu , Craig Rosen , Liang Cao
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , C07K14/52 , C12N1/21 , C12N15/18 , C07K14/515 , C07H21/04
CPC分类号： C07K14/52 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2799/026
摘要： Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA (RNA) encoding such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.
摘要翻译：公开了人VEGF2多肽，生物活性，诊断学或治疗上有用的片段，类似物或衍生物，以及编码这种VEGF2多肽的DNA（RNA）。还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。这样的多肽可以治疗性地用于刺激伤口愈合和维持血管组织修复。还提供了使用抗体和拮抗剂抑制肿瘤血管发生，从而抑制肿瘤生长，炎症，糖尿病性视网膜病，类风湿性关节炎和牛皮癣的方法。

34. 发明申请

US20050158313A1 Antibodies that specifically bind to Reg IV 审中-公开
标题翻译：特异性结合Reg IV的抗体
公开(公告)号：US20050158313A1
公开(公告)日：2005-07-21
申请号：US11017030
申请日：2004-12-21
申请人： Craig Rosen
发明人： Craig Rosen
IPC分类号： A61K39/395 , C07K16/18 , C07K16/28
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/622
摘要： The present invention relates to antibodies and related molecules that specifically bind to Reg IV. Such antibodies have uses, for example, in the prevention and treatment of gastrointestinal tract cancers, inflammatory bowel disorders, and diabetes. The invention also relates to nucleic acid molecules encoding anti-Reg IV antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially gastrointestinal tract cancers, inflammatory bowel disorders, and diabetes, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to Reg IV.
摘要翻译：本发明涉及特异性结合Reg IV的抗体和相关分子。这样的抗体具有例如用于预防和治疗胃肠道癌症，炎症性肠病和糖尿病的用途。本发明还涉及编码抗Reg IV抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是胃肠道癌症，炎症性肠病和糖尿病的方法和组合物，包括向动物，优选人类施用有效量的一种或更多的与Reg IV特异性结合的抗体或其片段或变体，或相关分子。

35. 发明申请

US20050129614A1 Antibodies that specifically bind to TL5 失效
标题翻译：特异性结合TL5的抗体
公开(公告)号：US20050129614A1
公开(公告)日：2005-06-16
申请号：US10943197
申请日：2004-09-17
申请人： Craig Rosen , Steven Ruben
发明人： Craig Rosen , Steven Ruben
IPC分类号： C07K16/28 , C12N5/24 , A61K51/00 , A61K39/395 , C07K16/30 , C07K16/46
CPC分类号： C07K16/2875 , A61K2039/505 , C07K2317/21 , C07K2317/622 , C07K2317/76
摘要： The present invention relates to antibodies and related molecules that specifically bind to TL5. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including autoimmune disease, rheumatoid arthritis, graft rejection, graft vs. host disease, and lymphadenopathy. The invention also relates to nucleic acid molecules encoding anti-TL5 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer as well as immune system diseases and disorders including autoimmune disease, rheumatoid arthritis, graft rejection, graft vs. host disease, and lymphadenopathy, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to TL5.
摘要翻译：本发明涉及特异性结合TL5的抗体和相关分子。这样的抗体具有例如用于预防和治疗癌症以及包括自身免疫疾病，类风湿性关节炎，移植物排斥，移植物抗宿主病和淋巴结病的免疫系统疾病和病症。本发明还涉及编码抗TL5抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症以及包括自身免疫性疾病，类风湿性关节炎，移植排斥反应，移植物抗宿主病和免疫系统疾病和病症的方法和组合物。淋巴腺病，包括向动物，优选人类施用有效量的特异性结合TL5的一种或多种抗体或其片段或变体或相关分子。

36. 发明申请

US20050069981A1 Human vascular IBP-like growth factor 审中-公开
标题翻译：人血管IBP样生长因子
公开(公告)号：US20050069981A1
公开(公告)日：2005-03-31
申请号：US10951866
申请日：2004-09-29
申请人： Gregg Hastings , Craig Rosen
发明人： Gregg Hastings , Craig Rosen
IPC分类号： A61K38/00 , A61K48/00 , C07K14/475 , C12N15/12 , C07H21/04
CPC分类号： C07K14/65 , A61K38/00 , A61K48/00 , C07K14/475 , C12N2799/026 , G01N33/6893 , G01N33/74 , G01N2333/475 , G01N2500/00
摘要： A human Vascular IBP-Like Growth Factor polypeptide (VIGF) and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for wound healing or tissue regeneration, stimulating implant fixation and angiogenesis. Antagonist against such polypeptides and their use as a therapeutic to treat atherosclerosis, tumors and scarring are also disclosed. Diagnostic assays for identifying mutations in VIGF nucleic acid sequences and altered levels of the VIGF polypeptide are also disclosed.
摘要翻译：公开了一种编码这种多肽的人血管IBP样生长因子多肽（VIGF）和DNA（RNA），以及通过重组技术产生此类多肽的方法。还公开了利用这种多肽用于伤口愈合或组织再生，刺激植入物固定和血管发生的方法。还公开了抗这种多肽的拮抗剂及其作为治疗动脉粥样硬化，肿瘤和瘢痕形成的治疗剂的用途。还公开了用于鉴定VIGF核酸序列中的突变和VIGF多肽的改变水平的诊断测定。

37. 发明申请

US20050009107A1 G-protein parathyroid hormone receptor HLTDG74 失效
标题翻译： G蛋白甲状旁腺激素受体HLTDG74
公开(公告)号：US20050009107A1
公开(公告)日：2005-01-13
申请号：US10921218
申请日：2004-08-19
申请人： Daniel Soppet , Yi Li , Craig Rosen , Steven Ruben
发明人： Daniel Soppet , Yi Li , Craig Rosen , Steven Ruben
IPC分类号： A61K48/00 , C07K14/72 , C12N15/12 , G01N33/53 , C12N5/06 , C12P21/04
CPC分类号： C07K14/723 , A61K48/00 , C12N2799/026
摘要： Human G-protein parathyroid hormone (PTH) receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the PTH receptor receptor polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the PTH receptor receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host. Disclosed embodiments of the invention also include antibodies that bind Human G-Protein parathyroid hormone (PTH) receptor polypeptides and methods for making and using such antibodies.
摘要翻译：公开了人类G蛋白甲状旁腺激素（PTH）受体多肽和编码此类多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及在治疗上使用激动剂和拮抗剂治疗与PTH受体受体多肽的低表达和过表达相关的病症的方法。还公开了用于检测PTH受体受体核酸序列中的突变并检测衍生自宿主的样品中受体的可溶形式水平的诊断方法。本发明的公开的实施方案还包括结合人类G蛋白甲状旁腺激素（PTH）受体多肽的抗体以及制备和使用这些抗体的方法。

38. 发明授权

US08263743B2 Humanized antibodies against TL1A 有权
标题翻译：针对TL1A的人源化抗体
公开(公告)号：US08263743B2
公开(公告)日：2012-09-11
申请号：US12270673
申请日：2008-11-13
申请人： Rodger Smith , Palanisamy Kanakaraj , Viktor Roschke , Craig Rosen , Bridget A. Cooksey
发明人： Rodger Smith , Palanisamy Kanakaraj , Viktor Roschke , Craig Rosen , Bridget A. Cooksey
IPC分类号： C07K16/00
CPC分类号： C07K16/2875 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Disclosed are humanized antibodies that bind specifically to the receptor TNF superfamily member 15 (TNFSF15), also known as TL1A. Methods of making and using the anti-TL1A antibodies are also described. The humanized antibodies may be antagonists and may used to treat or diagnose conditions associated with TL1A function.
摘要翻译：公开了特异性结合受体TNF超家族成员15（TNFSF15）（也称为TL1A）的人源化抗体。还描述了制备和使用抗TL1A抗体的方法。人源化抗体可以是拮抗剂，可用于治疗或诊断与TL1A功能相关的病症。

39. 发明申请

US20080015149A1 Galectin 11 审中-公开
标题翻译：半乳凝素11
公开(公告)号：US20080015149A1
公开(公告)日：2008-01-17
申请号：US11773491
申请日：2007-07-05
申请人： Jian Ni , Reiner Gentz , Craig Rosen , Fu-Tong Lui
发明人： Jian Ni , Reiner Gentz , Craig Rosen , Fu-Tong Lui
IPC分类号： A61K38/17 , A61P11/06 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/08 , C07H21/04 , C07K14/435 , C07K16/18 , C12N15/63 , C12N5/10 , C12P21/00 , G01N33/53
CPC分类号： C12N9/6475 , A61K38/00 , A61K2039/505 , C07K14/47 , C07K14/4726 , C07K14/705 , C07K14/70535 , C07K16/18 , C07K16/2851 , C12N9/6489 , C12N9/6491 , C12N2799/026
摘要： The present invention relates to novel galectin 11 proteins which are members of the galectin superfamily. In particular, isolated nucleic acid molecules are provided encoding the human galectin 11 proteins. Galectin 11 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of galectin 11 activity. Also provided are diagnostic and therapeutic methods.
摘要翻译：本发明涉及作为半乳凝素超家族成员的新型半乳凝素11蛋白。特别地，提供了分离的核酸分子，其编码人galectin11蛋白。还提供了Galectin11多肽，载体，宿主细胞和用于制备它们的重组方法。本发明进一步涉及用于鉴定galectin11活性的激动剂和拮抗剂的筛选方法。还提供诊断和治疗方法。

40. 发明申请

US20070292411A1 Antibodies That Immunospecifically Bind to TRAIL Receptors 审中-公开
标题翻译：免疫特异性结合TRAIL受体的抗体
公开(公告)号：US20070292411A1
公开(公告)日：2007-12-20
申请号：US11745734
申请日：2007-05-08
申请人： Theodora Salcedo , Viktor Roschke , Steven Ruben , Craig Rosen
发明人： Theodora Salcedo , Viktor Roschke , Steven Ruben , Craig Rosen
IPC分类号： A61K39/395 , A61P43/00 , C07K16/28 , C12N5/06 , C12N5/12 , C12P21/08 , G01N33/53
CPC分类号： G01N33/57411 , A61K2039/505 , C07K16/2878 , C07K2317/73 , G01N33/57419
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptors. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TRAIL receptor antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor.
摘要翻译：本发明涉及免疫特异性结合TRAIL受体的抗体和相关分子。这样的抗体具有例如用于预防和治疗癌症和其它增殖性疾病的用途。本发明还涉及编码抗TRAIL受体抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症和其它过度增殖性疾病的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段或其变体，或免疫特异性结合TRAIL受体的相关分子。

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