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31. 发明授权

US06630443B2 Human amine transporter antibodies 失效
标题翻译：人类胺转运蛋白抗体
公开(公告)号：US06630443B2
公开(公告)日：2003-10-07
申请号：US09502018
申请日：2000-02-11
申请人： Yi Li , Liang Cao , Craig A. Rosen
发明人： Yi Li , Liang Cao , Craig A. Rosen
IPC分类号： C07K1618
CPC分类号： C07K14/47 , A61K38/00
摘要： A Human amine transporter polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also provided are methods for detecting agonists and antagonists to such polypeptide and the use of agonists and antagonists for treating diseases related to the underexpression and over-expression of the Human amine transporter of the present invention. Also disclosed are methods for detecting mutations in the nucleic acid sequence encoding the polypeptide and for detecting altered levels of the soluble form of the polypeptide.
摘要翻译：公开了人类胺转运蛋白多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法。还提供了用于检测这种多肽的激动剂和拮抗剂的方法，以及使用激动剂和拮抗剂治疗与本发明的人胺转运蛋白的低表达和过表达相关的疾病。还公开了用于检测编码多肽的核酸序列中的突变并检测多肽可溶形式的改变水平的方法。

32. 发明授权

US6156540A Thrombin inhibitor 失效
公开(公告)号：US6156540A
公开(公告)日：2000-12-05
申请号：US171817
申请日：1993-12-22
申请人： Craig A. Rosen , Liang Cao , Mark D. Adams , Rebecca A. Fuldner
发明人： Craig A. Rosen , Liang Cao , Mark D. Adams , Rebecca A. Fuldner
IPC分类号： C07K14/81 , C12N15/12 , C07K14/47 , C12N15/63
CPC分类号： C07K14/8121
摘要： There is provided a thrombin inhibitor polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. The anti-thrombin polypeptide is used to treat various diseases where prevention of blood clotting is necessary and is of therapeutic value. The present invention also discloses a method of producing the anti-thrombin polypeptide and methods for its use as a pharmaceutical composition.

33. 发明授权

US6133422A Thrombin inhibitor 失效
标题翻译：凝血酶抑制剂
公开(公告)号：US6133422A
公开(公告)日：2000-10-17
申请号：US200965
申请日：1998-11-30
申请人： Craig A. Rosen , Liang Cao , Mark D. Adams , Rebecca A. Fuldner
发明人： Craig A. Rosen , Liang Cao , Mark D. Adams , Rebecca A. Fuldner
IPC分类号： C07K14/81 , C12N15/12 , C07K1/00
CPC分类号： C07K14/8121
摘要： There is provided a thrombin inhibitor polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. The anti-thrombin polypeptide is used to treat various diseases where prevention of blood clotting is necessary and is of therapeutic value. The present invention also discloses a method of producing the anti-thrombin polypeptide and methods for its use as a pharmaceutical composition.
摘要翻译：提供了一种凝血酶抑制剂多肽和编码这种多肽的DNA（RNA）。还提供了通过重组技术产生这种多肽的方法。抗凝血酶多肽用于治疗需要预防血液凝固并具有治疗价值的各种疾病。本发明还公开了一种生产抗凝血酶多肽的方法及其用作药物组合物的方法。

34. 发明授权

US5798223A Polynucleotides encoding human amine transporter and methods of using the same 失效
标题翻译：编码人胺转运蛋白的多核苷酸及其使用方法
公开(公告)号：US5798223A
公开(公告)日：1998-08-25
申请号：US471496
申请日：1995-06-06
申请人： Yi Li , Liang Cao , Craig A. Rosen
发明人： Yi Li , Liang Cao , Craig A. Rosen
IPC分类号： A61K38/00 , A61K39/395 , C07H21/04 , C07K14/47 , C07K14/705 , C07K16/18 , C12N15/12 , C12P21/00 , C12N1/15 , C12N5/10
CPC分类号： C07K14/47 , A61K38/00
摘要： A Human amine transporter polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also provided are methods for detecting agonists and antagonists to such polypeptide and the use of agonists and antagonists for treating diseases related to the underexpression and over-expression of the Human amine transporter of the present invention. Also disclosed are methods for detecting mutations in the nucleic acid sequence encoding the polypeptide and for detecting altered levels of the soluble form of the polypeptide.
摘要翻译：公开了人类胺转运蛋白多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法。还提供了用于检测这种多肽的激动剂和拮抗剂的方法，以及使用激动剂和拮抗剂治疗与本发明的人胺转运蛋白的低表达和过表达相关的疾病。还公开了用于检测编码多肽的核酸序列中的突变并检测多肽可溶形式的改变水平的方法。

35. 发明授权

US6090575A Polynucleotides encoding human G-protein coupled receptor GPR1 失效
标题翻译：编码人G蛋白偶联受体GPR1的多核苷酸
公开(公告)号：US6090575A
公开(公告)日：2000-07-18
申请号：US467947
申请日：1995-06-06
申请人： Yi Li , Liang Cao , Jian Ni , Reiner Gentz , Carol J. Bult , Granger G. Sutton, III , Craig A. Rosen
发明人： Yi Li , Liang Cao , Jian Ni , Reiner Gentz , Carol J. Bult , Granger G. Sutton, III , Craig A. Rosen
IPC分类号： A61K48/00 , C07K14/705 , C12N15/12 , C12N5/10 , C12N15/62
CPC分类号： C07K14/705 , A61K48/00
摘要： Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.
摘要翻译：公开了人G-蛋白偶联受体多肽和编码此类多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及分别在治疗上使用激动剂和拮抗剂治疗与G蛋白偶联受体多肽的低表达和过表达相关的病症的方法。还公开了用于检测G蛋白偶联受体核酸序列中的突变和受体的可溶形式的改变水平的诊断方法。

36. 发明授权

US5998164A Polynucleotides encoding human G-protein coupled receptor GPRZ 失效
标题翻译：编码人G蛋白偶联受体GPR2的多核苷酸
公开(公告)号：US5998164A
公开(公告)日：1999-12-07
申请号：US467948
申请日：1995-06-06
申请人： Yi Li , Liang Cao , Jian Ni , Reiner Gentz , Carol J. Bult , Granger G. Sutton, III , Craig A. Rosen
发明人： Yi Li , Liang Cao , Jian Ni , Reiner Gentz , Carol J. Bult , Granger G. Sutton, III , Craig A. Rosen
IPC分类号： A61K38/00 , A61K48/00 , C07K14/705 , C07K14/715 , C12N15/12 , C12N15/62
CPC分类号： C07K14/7158 , C07K14/705 , A61K38/00 , A61K48/00
摘要： Human G-protein coupled receptor or polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.
摘要翻译：公开了人G-蛋白偶联受体或多肽和编码此类多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及分别在治疗上使用激动剂和拮抗剂治疗与G蛋白偶联受体多肽的低表达和过表达相关的病症的方法。还公开了用于检测G蛋白偶联受体核酸序列中的突变和受体的可溶形式的改变水平的诊断方法。

37. 发明授权

US08216569B2 Vascular endothelial growth factor 2 有权
公开(公告)号：US08216569B2
公开(公告)日：2012-07-10
申请号：US11980495
申请日：2007-10-31
申请人： Craig A. Rosen , Vivian R. Albert , Steven M. Ruben , Ruth E. Wager
发明人： Craig A. Rosen , Vivian R. Albert , Steven M. Ruben , Ruth E. Wager
IPC分类号： A61K39/395 , A61K39/00 , C07K16/00 , C07K16/18 , C07K16/22
CPC分类号： C07K16/22 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/52 , C07K16/24 , C07K2317/21 , C07K2317/622 , C12N2799/026 , G01N33/574 , G01N33/74 , Y02A50/41 , Y02A50/422 , Y10S435/81
摘要： Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an animal, preferably a human, an effective amount of one or more VEGF-2 antibodies or fragments or variants thereof.

38. 发明授权

US08168205B2 Streptococcus pneumoniae polypeptides 失效
标题翻译：肺炎链球菌多肽
公开(公告)号：US08168205B2
公开(公告)日：2012-05-01
申请号：US12635794
申请日：2009-12-11
申请人： Charles A. Kunsch , Gil H. Choi , Patrick J. Dillon , Craig A. Rosen , Steven C. Barash , Michael R. Fannon , Brian A. Dougherty
发明人： Charles A. Kunsch , Gil H. Choi , Patrick J. Dillon , Craig A. Rosen , Steven C. Barash , Michael R. Fannon , Brian A. Dougherty
IPC分类号： C07K1/00 , C07K14/00 , C07K17/00 , A61K39/00 , A61K39/02 , A61K39/09 , A61K39/38
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C07K14/315
摘要： The present invention provides polynucleotide sequences of the genome of Streptococcus pneumoniae, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.
摘要翻译：本发明提供了肺炎链球菌基因组的多核苷酸序列，由多核苷酸序列编码的多肽序列，相应的多核苷酸和多肽，载体和包含多核苷酸的宿主，以及其测定和其它用途。本发明还提供了存储在计算机可读介质上的多核苷酸和多肽序列信息，以及便于其使用的基于计算机的系统和方法。

39. 发明授权

US08143026B2 Albumin fusion proteins 有权
标题翻译：白蛋白融合蛋白
公开(公告)号：US08143026B2
公开(公告)日：2012-03-27
申请号：US12534585
申请日：2009-08-03
申请人： Craig A. Rosen , William A. Haseltine , Steven M. Ruben , Paul A. Moore , Jason B. Bock , David LaFleur
发明人： Craig A. Rosen , William A. Haseltine , Steven M. Ruben , Paul A. Moore , Jason B. Bock , David LaFleur
IPC分类号： C12N15/62 , C12N15/81 , C12N15/85 , C12N15/14 , C12N15/16
CPC分类号： C07K14/765 , A61K38/00 , C07K2319/31 , C07K2319/35 , C12N15/62
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
摘要翻译：本发明包括白蛋白融合蛋白。编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法酸，载体和/或宿主细胞。另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗，预防或改善疾病，病症或病症的方法。

40. 发明申请

US20110112177A1 Human G-Protein Coupled Receptor (HETGQ23) 审中-公开
标题翻译：人类G蛋白偶联受体（HETGQ23）
公开(公告)号：US20110112177A1
公开(公告)日：2011-05-12
申请号：US12943202
申请日：2010-11-10
申请人： Daniel R. Soppet , Yi Li , Craig A. Rosen , Steven M. Ruben
发明人： Daniel R. Soppet , Yi Li , Craig A. Rosen , Steven M. Ruben
IPC分类号： A61K31/7052 , C07H21/00 , C12N15/63 , C12N1/00 , C12N5/00 , C12P21/00 , C12N15/74 , C07K14/435 , C07K16/18 , G01N33/53 , C12Q1/68 , A61P9/12 , A61P9/10 , A61P25/00
CPC分类号： C07K14/705
摘要： Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.
摘要翻译：公开了人G-蛋白偶联受体多肽和编码此类多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及分别在治疗上使用激动剂和拮抗剂治疗与G蛋白偶联受体多肽的低表达和过表达相关的病症的方法。还公开了用于检测G蛋白偶联受体核酸序列中的突变和受体的可溶形式的改变水平的诊断方法。

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