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31. 发明申请

US20050130926A1 Gene products differentially expressed in cancerous cells and their methods of use V 有权
标题翻译：在癌细胞中差异表达的基因产物及其使用方法V
公开(公告)号：US20050130926A1
公开(公告)日：2005-06-16
申请号：US10977087
申请日：2004-10-28
申请人： Christoph Reinhard , Anne Jefferson , Vivien Chan , Joerg Kaufmann , Hong Xin , Giulia Kennedy , Greg Harrowe , Hamiduddin Khoja , Venkatakrishna Shyamala
发明人： Christoph Reinhard , Anne Jefferson , Vivien Chan , Joerg Kaufmann , Hong Xin , Giulia Kennedy , Greg Harrowe , Hamiduddin Khoja , Venkatakrishna Shyamala
IPC分类号： A61K38/00 , C07K14/47 , C07K14/72 , C12N9/12 , C12Q1/68 , G01N33/574 , G01N33/68 , A61K39/395 , A61K48/00 , C07H21/04 , C12N9/64
CPC分类号： G01N33/5005 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K2039/505 , C07K14/47 , C07K14/723 , C12N9/1205 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Y207/01037 , G01N33/5008 , G01N33/5011 , G01N33/57415 , G01N33/57419 , G01N33/57496 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要： The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
摘要翻译：本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。这些多核苷酸可用于各种诊断和治疗方法。本发明还提供减少癌细胞生长的方法。这些方法可用于治疗癌症。

32. 发明授权

US06492112B1 Mitogen-activated protein kinase kinase 7 (MKK7) 失效
标题翻译：丝裂原活化蛋白激酶激酶7（MKK7）
公开(公告)号：US06492112B1
公开(公告)日：2002-12-10
申请号：US09206166
申请日：1998-12-07
申请人： Christoph Reinhard , Altaf Kassam , David Pot
发明人： Christoph Reinhard , Altaf Kassam , David Pot
IPC分类号： C12Q148
CPC分类号： C12N9/1205 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： A human gene encoding a novel mitogen-activated (MAP) kinase kinase, MKK7, provides methods and reagents for treating a variety of MKK7-mediated disorders, such as ischemic heart disease, kidney failure, oxidative liver damage, respiratory distress syndrome, heat and radiation burns, septic shock, autoimmune disorders, and inflammatory diseases. MKK7 reagents can also be used to induce or prevent apoptosis.
摘要翻译：编码新的丝裂原活化（MAP）激酶激酶MKK7的人基因提供了用于治疗各种MKK7介导的疾病如心肌缺血，肾衰竭，氧化性肝损伤，呼吸窘迫综合征，热和放射性灼伤，败血性休克，自身免疫性疾病和炎性疾病。 MKK7试剂也可用于诱导或预防凋亡。

33. 发明授权

US08772255B2 Cell transfecting formulations of small interfering RNA related compositions and methods of making and use 有权
标题翻译：小干扰RNA相关组合物的细胞转染制剂及制备和使用方法
公开(公告)号：US08772255B2
公开(公告)日：2014-07-08
申请号：US12053486
申请日：2008-03-21
申请人： Timothy S. Burkoth , Anne B. Jefferson , Christoph Reinhard , Ronald N. Zuckermann
发明人： Timothy S. Burkoth , Anne B. Jefferson , Christoph Reinhard , Ronald N. Zuckermann
IPC分类号： C12N15/113 , A61K47/48
CPC分类号： A61K47/44 , A61K31/7088 , A61K47/6909 , A61K48/00 , C07H21/04 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N15/87 , C12N15/88 , C12N2310/14 , C12N2310/321 , C12N2320/32 , C12Y207/01037 , C12N2310/3521
摘要： Compositions incorporating small interfering ribonucleic acid (siRNA) and certain lipid-conjugated polyamide compound-based delivery vehicles that are particularly useful in the delivery siRNA and other polynucleotides to cells. Also, methods of making and using the compositions.
摘要翻译：包含小干扰核糖核酸（siRNA）和某些基于脂质偶联的聚酰胺化合物的递送载体的组合物，其特别可用于递送siRNA和其它多核苷酸至细胞。而且，制备和使用组合物的方法。

34. 发明授权

US08472025B2 Device and method for detecting reflected and/or emitted light of an object 有权
标题翻译：用于检测物体的反射和/或发射光的装置和方法
公开(公告)号：US08472025B2
公开(公告)日：2013-06-25
申请号：US13144072
申请日：2009-12-04
申请人： Christoph Reinhard , Reto Schletti
发明人： Christoph Reinhard , Reto Schletti
IPC分类号： G01N21/55
CPC分类号： G07D7/121
摘要： A device and a method for detecting reflected and/or emitted light of an object (1) are proposed having at least one illumination device (2) illuminating the object (1) with pulsed light, and having at least one sensor (4, 6) capturing the light reflected and/or emitted by the object (1), and having a transport device transporting the object relative to the illumination device (2) and past the sensor 4, 6) in the direction of transport, and having a power supply (16, 17, 18, 19, 20, 21, 22) for the illumination device (2) providing the illumination device (2) with a current that is a periodic function over time, wherein a period comprises at least two current pulses (23, 24) of different magnitudes.
摘要翻译：提出了一种用于检测物体（1）的反射和/或发射光的装置和方法，其具有至少一个用脉冲光照射物体（1）的照明装置（2），并且具有至少一个传感器（4,6））捕获由物体（1）反射和/或发射的光，并且具有相对于照明装置（2）传送物体并经过传感器4,6的传送装置沿传送方向传送，并具有电力为照明装置（2）提供具有随时间变化的周期性功能的电流（16,17,18,19,20,21,22），其中周期包括至少两个电流脉冲（23,24）不同程度。

35. 发明授权

US07855058B2 Human cyclin-dependent kinase (hPNQALRE) 失效
标题翻译：人细胞周期蛋白依赖性激酶（hPNQALRE）
公开(公告)号：US07855058B2
公开(公告)日：2010-12-21
申请号：US11759726
申请日：2007-06-07
申请人： Christoph Reinhard
发明人： Christoph Reinhard
IPC分类号： C12P21/06 , C12P13/10 , C12N9/12 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12N9/1205 , C07K2319/00
摘要： A human gene encoding a novel cyclin-dependent kinase termed hPNQALRE and its expression products can be used to provide reagents and methods for detecting neoplasia. Compositions and methods for treating proliferative disorders and neoplasia are also provided.
摘要翻译：编码称为hPNQALRE的新型细胞周期蛋白依赖性激酶及其表达产物的人基因可用于提供检测肿瘤的试剂和方法。还提供了治疗增殖性疾病和瘤形成的组合物和方法。

36. 发明授权

US07700359B2 Gene products differentially expressed in cancerous cells 失效
标题翻译：在癌细胞中差异表达的基因产物
公开(公告)号：US07700359B2
公开(公告)日：2010-04-20
申请号：US10948737
申请日：2004-09-22
申请人： Vivien W. Chan , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
发明人： Vivien W. Chan , Jaime Escobedo , Pablo Dominguez Garcia , Rhonda Hansen , Joerg Kaufmann , Giulia C. Kennedy , George Lamson , Edward J. Moler , Filippo Randazzo , Christoph Reinhard , Julie Sudduth-Klinger
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6886 , A61K48/00 , C12Q2600/112 , C12Q2600/136
摘要： The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
摘要翻译：本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。这些多核苷酸可用于各种诊断和治疗方法。本发明还提供减少癌细胞生长的方法。这些方法可用于治疗癌症。

37. 发明授权

US07605246B2 Genes differentially expressed in breast cancer 失效
公开(公告)号：US07605246B2
公开(公告)日：2009-10-20
申请号：US09758575
申请日：2001-01-09
申请人： Joerg Kaufmann , Greg Harrowe , Christoph Reinhard , Sanmao Kang
发明人： Joerg Kaufmann , Greg Harrowe , Christoph Reinhard , Sanmao Kang
IPC分类号： C07H5/00 , C08B37/00 , C07H19/00 , C07H21/00 , C07H21/02 , C12P21/06
CPC分类号： C07K14/47 , C07K16/18 , C07K2319/00
摘要： A polynucleotide sequence as shown in SEQ ID NO:1 is associated with metastatic potential of cancer cells, especially breast cancer cells. Methods are provided for determining the risk of metastasis of a tumor, by determining whether a tissue sample from a tumor expresses a polypeptide or mRNA encoded by a polynucleotide as shown in SEQ ID NO:1. Also provided are therapeutic methods and compositions.

38. 发明申请

US20090143322A1 CELL TRANSFECTING FORMULATIONS OF SMALL INTERFERING RNA RELATED COMPOSITIONS AND METHODS OF MAKING AND USE 有权
标题翻译：小干扰RNA相关组合物的细胞转染制剂及其制备和使用方法
公开(公告)号：US20090143322A1
公开(公告)日：2009-06-04
申请号：US12053486
申请日：2008-03-21
申请人： Timothy S. Burkoth , Anne B. Jefferson , Christoph Reinhard , Ronald N. Zuckermann
发明人： Timothy S. Burkoth , Anne B. Jefferson , Christoph Reinhard , Ronald N. Zuckermann
IPC分类号： A61K48/00 , A61K47/42 , A61P43/00
CPC分类号： A61K47/44 , A61K31/7088 , A61K47/6909 , A61K48/00 , C07H21/04 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N15/87 , C12N15/88 , C12N2310/14 , C12N2310/321 , C12N2320/32 , C12Y207/01037 , C12N2310/3521
摘要： Compositions incorporating small interfering ribonucleic acid (siRNA) and certain lipid-conjugated polyamide compound-based delivery vehicles that are particularly useful in the delivery siRNA and other polynucleotides to cells. Also, methods of making and using the compositions.
摘要翻译：包含小干扰核糖核酸（siRNA）和某些基于脂质偶联的聚酰胺化合物的递送载体的组合物，其特别可用于递送siRNA和其它多核苷酸至细胞。而且，制备和使用组合物的方法。

39. 发明授权

US07501244B2 Determining prognosis of colon or breast cancer by measuring TTK expression 失效
标题翻译：通过测量TTK表达来确定结肠癌或乳腺癌的预后
公开(公告)号：US07501244B2
公开(公告)日：2009-03-10
申请号：US10951477
申请日：2004-09-27
申请人： Christoph Reinhard , Anne B. Jefferson , Vivien W. Chan
发明人： Christoph Reinhard , Anne B. Jefferson , Vivien W. Chan
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： G01N33/6842 , A61K38/00 , A61K2039/505 , C12N9/1205 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , C12Y207/01037 , G01N33/57415 , G01N33/57419 , G01N33/57496 , G01N33/68 , G01N2500/00
摘要： The present invention provides methods for identification of cancerous cells by detection of expression levels of TTK, as well as diagnostic, prognostic and therapeutic methods that take advantage of the differential expression of these genes in mammalian cancer. Such methods can be useful in determining the ability of a subject to respond to a particular therapy, e.g., as the basis of rational therapy. In addition, the invention provides assays for identifying pharmaceuticals that modulate activity of these genes in cancers in which these genes are involved, as well as methods of inhibiting tumor growth by inhibiting activity of TTK.
摘要翻译：本发明提供通过检测TTK的表达水平来鉴定癌细胞的方法，以及利用哺乳动物癌症中这些基因的差异表达的诊断，预后和治疗方法。这样的方法可用于确定受试者对特定疗法的反应能力，例如作为理性治疗的基础。此外，本发明提供了用于鉴定调节这些基因在其中涉及这些基因的癌症中这些基因的活性的药物的测定法，以及通过抑制TTK活性来抑制肿瘤生长的方法。

40. 发明申请

US20070243176A1 Human genes and gene expression products 审中-公开
标题翻译：人类基因和基因表达产物
公开(公告)号：US20070243176A1
公开(公告)日：2007-10-18
申请号：US10615618
申请日：2003-07-07
申请人： Jaime Escobedo , Pablo Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Filippo Randazzo , George Lamson , Elizabeth Scott , Guozhong Zhang , Altaf Kassam , David Pot , Radoje Drmanac , Ivan Labat , Birgit Stache-Crain
发明人： Jaime Escobedo , Pablo Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Filippo Randazzo , George Lamson , Elizabeth Scott , Guozhong Zhang , Altaf Kassam , David Pot , Radoje Drmanac , Ivan Labat , Birgit Stache-Crain
IPC分类号： A61K48/00 , C07H21/02 , C07H21/04 , C07K14/47 , C07K16/18 , C12N15/85 , C12N5/10 , C12P21/00 , C12Q1/68
CPC分类号： C07K14/47
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
摘要翻译：本发明涉及对应于这些多核苷酸的基因和由该基因表达的蛋白质的新型人多核苷酸及其变体，其编码的多肽及其变体。本发明还涉及使用这种新型人多核苷酸的诊断和治疗剂，其相应的基因或基因产物，例如这些基因和蛋白质，包括探针，反义构建体和抗体。

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