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31. 发明授权

US10893813B2 Heart failure management 有权
公开(公告)号：US10893813B2
公开(公告)日：2021-01-19
申请号：US15879139
申请日：2018-01-24
申请人： Cardiac Pacemakers, Inc.
发明人： Imad Libbus , Krzysztof Z. Siejko , Marina V. Brockway , Robert J. Sweeney
IPC分类号： A61B5/0205 , A61N1/36 , A61N1/365 , A61B7/00 , A61N1/362 , A61B5/00 , A61B5/0215 , A61B5/0402 , A61B5/0488 , A61N1/372 , A61B7/04
摘要： Various system embodiments comprise a stimulator adapted to deliver a stimulation signal for a heart failure therapy, a number of sensors adapted to provide at least a first measurement of a heart failure status and a second measurement of the heart failure status, and a controller. The controller is connected to the stimulator and to the number of sensors. The controller is adapted to use the first and second measurements to create a heart failure status index, and control the stimulator to modulate the signal using the index. Other aspects and embodiments are provided herein.

32. 发明授权

US10251563B2 Methods and apparatus for detecting heart failure event using patient chronic conditions 有权
公开(公告)号：US10251563B2
公开(公告)日：2019-04-09
申请号：US14282283
申请日：2014-05-20
申请人： Cardiac Pacemakers, Inc.
发明人： Robert J. Sweeney , Yi Zhang , Qi An , Pramodsingh Hirasingh Thakur
IPC分类号： A61B5/08 , A61B5/0205 , A61B5/145 , A61B5/00 , A61B5/1455 , A61B5/11 , A61B5/024 , A61B5/0245 , G06F19/00
摘要： Devices and methods for detecting physiological target event such as events indicative of HF decompensation status are described. A medical device is configured to receive at least a first and a second chronic condition indictors of a patient, receive one or more physiologic signals from the patient, and generate a plurality of signal metrics when the first and the second chronic condition indicators meet their respective criterion. The medical device can detect the target event or condition using one or more patient-specific signal metrics selected from a group including both the first and the second set of the signal metrics. The medical device and the methods can be configured to detect an event indicative of HF decompensation.

33. 发明授权

US09629548B2 Within-patient algorithm to predict heart failure decompensation 有权
公开(公告)号：US09629548B2
公开(公告)日：2017-04-25
申请号：US13870382
申请日：2013-04-25
申请人： Cardiac Pacemakers, Inc.
发明人： Haresh G. Sachanandani , Jon Peterson , Shelley M. Cazares , Robert J. Sweeney , Kevin John Stalsberg
IPC分类号： G08B21/00 , A61B5/00 , A61B5/0205 , A61B5/0245 , A61B5/07 , A61N1/362 , A61N1/372 , A61B5/0402 , A61B5/08 , A61B5/145
CPC分类号： A61B5/0031 , A61B5/0205 , A61B5/02455 , A61B5/0402 , A61B5/076 , A61B5/0816 , A61B5/145 , A61B5/14532 , A61B5/7275 , A61B5/746 , A61B2560/0242 , A61N1/3627 , A61N1/37252 , G06F19/00
摘要： This document discusses, among other things, systems and methods for predicting heart failure decompensation using within-patient diagnostics. A method comprises detecting an alert status of each of one or more sensors; calculating an alert score by combining the detected alerts; and calculating a composite alert score, the composite alert score being indicative of a physiological condition and comprising a combination of two or more alert scores.

34. 发明申请

US20150327776A1 SYSTEM AND METHODS FOR AUTOMATIC DIFFERENTIAL DIAGNOSIS OF WORSENING HEART FAILURE 审中-公开
标题翻译：自动差异诊断心脏失败的系统与方法
公开(公告)号：US20150327776A1
公开(公告)日：2015-11-19
申请号：US14698178
申请日：2015-04-28
申请人： Cardiac Pacemakers, Inc.
发明人： Yi Zhang , Ramesh Wariar , Pramodsingh Hirasingh Thakur , Viktoria A. Averina , Qi An , Robert J. Sweeney , Julie A. Thompson
IPC分类号： A61B5/0205 , A61B5/0452 , A61B7/04 , A61B5/00 , A61B5/08
CPC分类号： A61B5/0205 , A61B5/0452 , A61B5/0809 , A61B5/4818 , A61B5/4842 , A61B5/7264 , A61B5/7275 , A61B5/74 , A61B7/04 , G16H50/20 , G16H50/30
摘要： Devices and methods for differentially diagnosing between worsening heart failure (HF) and other diseases or medical conditions are described. A medical system can receive patient information including one or more physiologic signals, and detect a respective physiologic feature from each of the one or more received physiologic signals. The medical system can include a differential diagnosis circuit that generates one or more signal metrics, receive two or more candidate conditions associated with the change in patient physical or physiological status, and determine a respective diagnostic score for each of the candidate conditions. The diagnostic score can indicate likelihood the change in the patient physical or physiologic status being caused by the corresponding candidate condition. A user interface can be provided to generate a presentation of the detected physiologic features and the diagnostic scores associated with the candidate conditions.
摘要翻译：描述了在恶化心力衰竭（HF）与其他疾病或医疗条件之间差异诊断的装置和方法。医疗系统可以接收包括一个或多个生理信号的患者信息，并从所述一个或多个所接收的生理信号中的每一个检测相应的生理特征。医疗系统可以包括产生一个或多个信号量度的差分诊断电路，接收与患者物理或生理状态的变化相关联的两个或更多候选条件，并且确定每个候选条件的相应诊断分数。诊断分数可以指示患者身体或生理状态由相应的候选病症引起的变化的可能性。可以提供用户界面以生成检测到的生理特征和与候选条件相关联的诊断分数的呈现。

35. 发明申请

US20150250428A1 HEART FAILURE EVENT DETECTION USING MULTI-LEVEL CATEGORICAL FUSION 有权
标题翻译：使用多级分类融合的故障事件检测
公开(公告)号：US20150250428A1
公开(公告)日：2015-09-10
申请号：US14637447
申请日：2015-03-04
申请人： Cardiac Pacemakers, Inc.
发明人： Yi Zhang , Pramodsingh Hirasingh Thakur , Qi An , Julie A. Thompson , Ramesh Wariar , Robert J. Sweeney
IPC分类号： A61B5/00 , A61B5/0205
CPC分类号： A61B5/7275 , A61B5/0205 , A61B5/4842 , A61B5/686 , A61B7/00 , G06F19/00 , G16H50/20 , G16H50/30
摘要： Systems and methods for detecting a present, or predicting a future, target physiologic event such as worsening heart failure (HF) are described. A system can comprise a patient information receiver circuit, at least two categorical risk analyzer circuits, and a categorical fusion circuit. The patient information receiver circuit receives physiologic signals and generates signal trends. The categorical risk analyzer circuit receives a category-specific input selected from the signal trends according to an associative physiologic condition indicative or correlative of the target event. The categorical risk analyzer circuit produces a signal trend metric indicating relative change in signal strength over time. The categorical risk analyzer circuit calculates a categorical risk index that indicates likelihood of the patient developing or presenting the associative physiologic condition. The categorical fusion circuit uses the categorical risk indices to generate a composite risk indicator indicating likelihood of the patient developing the target physiologic event.
摘要翻译：描述了用于检测目前或预测未来的目标生理事件（例如恶化的心力衰竭（HF））的系统和方法。系统可以包括患者信息接收器电路，至少两个分类风险分析器电路和分类融合电路。患者信息接收电路接收生理信号并产生信号趋势。分类风险分析器电路根据指示或相关于目标事件的关联生理条件接收从信号趋势中选择的类别特定输入。分类风险分析仪电路产生信号趋势指标，指示信号强度随时间的相对变化。分类风险分析器电路计算出指示患者发展或呈现关联生理状况的可能性的分类风险指数。分类融合电路使用分类风险指数来产生指示患者发展目标生理事件的可能性的综合风险指标。

36. 发明申请

US20150182750A1 HEART FAILURE MANAGEMENT 审中-公开
标题翻译：心脏失败管理
公开(公告)号：US20150182750A1
公开(公告)日：2015-07-02
申请号：US14644841
申请日：2015-03-11
申请人： Cardiac Pacemakers, Inc.
发明人： Imad Libbus , Krzysztof Z. Siejko , Marina V. Brockway , Robert J. Sweeney
IPC分类号： A61N1/36 , A61N1/362
CPC分类号： A61B5/0205 , A61B5/0031 , A61B5/0215 , A61B5/02158 , A61B5/0402 , A61B5/0488 , A61N1/36114 , A61N1/36117 , A61N1/36128 , A61N1/36139 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36542 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/36592 , A61N1/372 , A61N1/37288
摘要： Various system embodiments comprise a stimulator adapted to deliver a stimulation signal for a heart failure therapy, a number of sensors adapted to provide at least a first measurement of a heart failure status and a second measurement of the heart failure status, and a controller. The controller is connected to the stimulator and to the number of sensors. The controller is adapted to use the first and second measurements to create a heart failure status index, and control the stimulator to modulate the signal using the index. Other aspects and embodiments are provided herein.
摘要翻译：各种系统实施例包括适于递送用于心力衰竭治疗的刺激信号的刺激器，适于提供心力衰竭状态的至少第一测量和心力衰竭状态的第二测量的多个传感器以及控制器。控制器连接到刺激器和传感器的数量。控制器适于使用第一和第二测量来创建心力衰竭状态指数，并且使用该索引来控制刺激器来调制信号。本文提供了其它方面和实施例。

37. 发明申请

US20140343439A1 METHODS AND APPARATUS FOR STRATIFYING RISK OF HEART FAILURE DECOMPENSATION 审中-公开
标题翻译：分解心脏衰竭风险的方法和装置
公开(公告)号：US20140343439A1
公开(公告)日：2014-11-20
申请号：US14282353
申请日：2014-05-20
申请人： Cardiac Pacemakers, Inc.
发明人： Robert J. Sweeney , Yi Zhang , Qi An , Pramodsingh Hirasingh Thakur
IPC分类号： A61B5/0205 , A61B5/20 , A61B5/00 , A61B5/02 , A61B5/08 , A61B5/145
CPC分类号： A61B5/0205 , A61B5/0031 , A61B5/02028 , A61B5/024 , A61B5/0245 , A61B5/08 , A61B5/0826 , A61B5/14532 , A61B5/201 , A61B5/4818 , A61B5/7275 , A61B5/7282 , G06F19/00
摘要： Devices and methods for identifying patient at elevated risk of developing future heart failure (HF) events, such as events indicative of HF decompensation status, are described. The devices and methods can stratify the risk using sensor signals or signal metrics selected in accordance with patient chronic conditions. A medical device can receive a patient status input including at least a first and a second chronic condition indicators, sense one or more physiologic signals from the patient, and generate a plurality of signal metrics from the physiologic signals when the first chronic condition indicator and the second chronic condition indicator meets respective criterion. One or more patient-specific signal metrics can be selected from a group including the signal metrics selected for both the first and the second chronic conditions. A risk stratification algorithm can use the selected one or more patient-specific signal metrics to compute a composite risk index indicative of the probability of the patient later developing an event indicative of worsening of HF.
摘要翻译：描述了用于识别患有发展未来心力衰竭（HF）事件的高风险的患者的装置和方法，例如指示HF失代偿状态的事件。设备和方法可以使用根据患者慢性病选择的传感器信号或信号度量来分级风险。医疗设备可以接收包括至少第一和第二慢性病症指示符的患者状态输入，感测来自患者的一个或多个生理信号，并且当第一慢性病症指示符和第二项慢性病指标符合相应标准。可以从包括为第一和第二慢性疾病两者选择的信号度量的组中选择一个或多个患者特异性信号度量。风险分层算法可以使用所选择的一个或多个患者特异性信号度量来计算指示患者随后发展指示HF恶化的事件的概率的复合风险指数。

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