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31. 发明授权

US06383214B1 Encapsulated stent 有权
标题翻译：封装支架
公开(公告)号：US06383214B1
公开(公告)日：2002-05-07
申请号：US09531833
申请日：2000-03-21
申请人： Christopher E. Banas , Tarun J. Edwin
发明人： Christopher E. Banas , Tarun J. Edwin
IPC分类号： A61F206
CPC分类号： A61F2/07 , A61F2/90 , A61F2002/072
摘要： An encapsulated stent having a stent or structural support layer sandwiched between two biocompatible flexible layers. One preferred embodiment has a stent cover which includes a tubular shaped stent that is concentrically retained between two tubular shaped grafts comprised of expanded polytetrafluoroethylene. Another preferred embodiment has a stent graft which includes at least one stent sandwiched between the ends of two tubular shaped grafts wherein at least a portion of the grafts are unsupported by the stent. Still another embodiment includes an articulating stented graft which includes a plurality of stents spaced apart from one another at a predetermined distance wherein each stent is contained between two elongated biocompatible tubular members. The graft/stent/graft assemblies all have inseparable layers.
摘要翻译：具有夹在两个生物相容性柔性层之间的支架或结构支撑层的胶囊化支架。一个优选实施例具有支架盖，其包括同心地保持在由膨胀聚四氟乙烯构成的两个管状移植物之间的管状支架。另一优选实施例具有支架移植物，其包括夹在两个管状移植物的端部之间的至少一个支架，其中移植物的至少一部分不被支架支撑。另一个实施例包括铰接式支架移植物，其包括以预定距离彼此间隔开的多个支架，其中每个支架包含在两个细长的生物相容性管状构件之间。移植物/支架/移植物组件都具有不可分离的层。

32. 发明授权

US06245099B1 Selective adherence of stent-graft coverings, mandrel and method of making stent-graft device 有权
公开(公告)号：US06245099B1
公开(公告)日：2001-06-12
申请号：US09409209
申请日：1999-09-30
申请人： Tarun J. Edwin , Scott L. Randall , Brendan J. McCrea , Christopher E. Banas
发明人： Tarun J. Edwin , Scott L. Randall , Brendan J. McCrea , Christopher E. Banas
IPC分类号： A61F206
CPC分类号： A61F2/07 , A61F2/90 , A61F2002/072 , A61F2230/0013 , A61F2230/005 , A61F2240/004 , A61F2250/0014 , A61F2250/0067
摘要： A method for selectively bonding layers of polymeric material, especially expanded polytetrafluoroethylene (ePTFE), to create endoluminal vascular devices. In a preferred method the selective bonding is achieved by applying pressure to selected areas using a textured mandrel. This permits a stent device to be encapsulated between two layers of ePTFE with unbonded slip pockets to accommodate movement of the structural members of the stent. This allows stent compression with minimal force and promotes a low profile of the compressed device. Unbonded regions of ePTFE allow enhanced cellular penetration for rapid healing and can also contain bioactive substance that will diffuse through the ePTFE to treat the vessel wall.

33. 发明授权

US6039755A Radially expandable tubular polytetrafluoroethylene grafts and method of making same 失效
标题翻译：径向可膨胀管状聚四氟乙烯移植物及其制备方法
公开(公告)号：US6039755A
公开(公告)日：2000-03-21
申请号：US794871
申请日：1997-02-05
申请人： Tarun J. Edwin , Fariba Hurry , Christopher E. Banas
发明人： Tarun J. Edwin , Fariba Hurry , Christopher E. Banas
IPC分类号： A61F2/06 , A61L27/16 , A61L27/50 , A61L31/04 , B29C47/00 , B29C55/00 , B29C55/22 , B32B27/28 , A61F2/04
CPC分类号： A61L27/507 , A61F2/06 , A61F2/07 , A61L27/16 , A61L31/048 , B29C47/0004 , B29C47/0023 , B29C55/005 , B29C55/24 , B32B1/08 , B32B27/08 , B32B27/322 , A61F2/90 , A61F2002/072 , B29K2027/18 , B32B2262/0253 , B32B2535/00
摘要： Tubular ePTFE materials which are capable of being radially expanded under the influence of a radially outward force applied from the lumen of the ePTFE tubular material to substantially uniformly radially deform the ePTFE material. The ePTFE material is radially expandable to a diameter 700% its unexpanded diameter under the influence of pressures less than 6 atm while retaining the structural integrity of the ePTFE microstructure. Conservation of the structural integrity of the ePTFE material is determined by conservation of the ePTFE microstructure structural integrity.
摘要翻译：管状ePTFE材料，其能够在从ePTFE管状材料的内腔施加的径向向外的力的作用下径向膨胀，以使ePTFE材料基本均匀地径向变形。在保持ePTFE微观结构的结构完整性的同时，ePTFE材料在小于6atm的压力的影响下可径向扩张至其未膨胀直径的700％直径。 ePTFE材料的结构完整性的保护由ePTFE微观结构完整性的保护决定。

34. 发明授权

US6004348A Endoluminal encapsulated stent and methods of manufacture and endoluminal delivery 失效
标题翻译：腔内胶囊支架及其制造方法和腔内输送
公开(公告)号：US6004348A
公开(公告)日：1999-12-21
申请号：US67158
申请日：1998-04-27
申请人： Christopher E. Banas , Tarun J. Edwin , David Dalessandro
发明人： Christopher E. Banas , Tarun J. Edwin , David Dalessandro
IPC分类号： A61F2/82 , A61F2/06
CPC分类号： A61F2/07 , A61F2/90 , A61F2002/072 , A61F2002/075
摘要： An radially expandable stent-graft and method of making the same, including at least one a stent member encapsulated between at least two longitudinally expanded polytetrafluoroethylene (ePTFE) coverings. The at least one stent member has openings through wall surfaces of the stent to permit radial expansion. The at least two longitudinally expanded ePTFE coverings are circumferentially applied over the at least one stent member in their unsintered state, and sintered during application of a circumferential pressure to bond the ePTFE around and through the wall surfaces of the stent. The sintered ePTFE forms a substantially continuous, monolithic and integral encapsulation of the at least one stent. Upon radial expansion of the stent-graft, the stent and the ePTFE node-fibril microstructure radially deform. Radial deformation of the ePTFE encapsulation results in nodal elongation in the axis of radial expansion. After radial expansion of the stent-graft, a substantial bonded area remains intact and maintains the encapsulation of the stent in vivo.
摘要翻译：一种可径向扩张的支架移植物及其制造方法，包括至少一个封装在至少两个纵向膨胀的聚四氟乙烯（ePTFE）覆盖物之间的支架构件。至少一个支架构件具有通过支架的壁表面的开口以允许径向膨胀。所述至少两个纵向膨胀的ePTFE覆盖物在其未烧结状态下周向地施加在所述至少一个支架构件上，并且在施加周向压力下烧结以将ePTFE结合在支架的壁表面上并通过支架的壁表面。烧结的ePTFE形成至少一个支架的基本上连续的，整体的和整体的包封。在支架移植物的径向膨胀时，支架和ePTFE节点 - 原纤维微结构径向变形。 ePTFE封装的径向变形导致径向膨胀轴的节点伸长。在支架移植物的径向膨胀之后，实质的结合区域保持完整并且将体内的支架保持在囊内。

35. 发明授权

US08313524B2 Self-sealing PTFE graft with kink resistance 有权
标题翻译：具有扭结阻力的自密封PTFE接枝
公开(公告)号：US08313524B2
公开(公告)日：2012-11-20
申请号：US11661250
申请日：2005-08-30
申请人： Tarun J. Edwin , Jamie Abbott , Heidi R. Cole , Chandrashekhar P. Pathak , David L. Bogert , Richard Elton , Fitzroy Brown , Kereshmeh Shahriari
发明人： Tarun J. Edwin , Jamie Abbott , Heidi R. Cole , Chandrashekhar P. Pathak , David L. Bogert , Richard Elton , Fitzroy Brown , Kereshmeh Shahriari
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/94 , A61F2002/072 , A61L27/16 , A61L27/34 , A61L27/507 , A61L27/56 , A61L2300/44 , A61L2300/442 , A61L2420/08 , C08L27/18 , C08L75/04
摘要： A self-sealing vascular graft, including a substrate with a sealant layer and several optional additional layers, is described. The substrate can be ePTFE and the material used for the sealant and additional layers can be polyurethane. The sealant layer and additional layers may include one or more base layers, one or more foam layers, beading of different sizes and shapes, and ePTFE tape. A flared cuff may be integral to one or both ends of the substrate or may be attached to one or both ends. Various methods of making a self-sealing vascular graft are also described, including methods of disposition, methods of forming, methods of bonding and methods of attaching.
摘要翻译：描述了一种自密封血管移植物，其包括具有密封层和几个任选附加层的基底。基材可以是ePTFE，用于密封剂和附加层的材料可以是聚氨酯。密封剂层和附加层可以包括一个或多个基层，一个或多个泡沫层，不同尺寸和形状的珠饰以及ePTFE胶带。喇叭形袖带可以与衬底的一端或两端成一体，或者可以连接到一端或两端。还描述了制造自密封血管移植物的各种方法，包括处置方法，形成方法，粘合方法和附着方法。

36. 发明授权

US06358276B1 Fluid containing endoluminal stent 有权
公开(公告)号：US06358276B1
公开(公告)日：2002-03-19
申请号：US09321496
申请日：1999-05-27
申请人： Tarun J. Edwin
发明人： Tarun J. Edwin
IPC分类号： A61F206
CPC分类号： A61F2/82 , A61F2/88 , A61F2210/0042 , A61F2250/0067
摘要： An endoluminal stent contains a hollow passageway for the circulation of fluids to treat vascular walls affected with malignant growths or experiencing restenosis. The hollow passageway stent can have one or a plurality of passageways and is configured in a tubular shape with numerous coils, providing an empty tubular lumen through the center of the stent to allow blood flow. The stent is connected to a removable catheter that conducts fluid to the stent. Fluid flow may be regulated by valves incorporated in either the stent and/or the catheter. The stent and catheter are connected to avoid leakage of the fluid. Cryogenic, heated or radioactive fluids are circulated through the stent to treat the affected sites. A method of delivering drugs to the vascular wall is also provided by creating a stent with porous outer walls to allow diffusion of the drug.

37. 发明授权

US07083640B2 Covered stent with encapsulated ends 失效
标题翻译：具有封装端的覆盖支架
公开(公告)号：US07083640B2
公开(公告)日：2006-08-01
申请号：US10836492
申请日：2004-04-30
申请人： Sylvie Lombardi , Guido Koch , Richard Layne , Tarun J. Edwin , Wolfgang Supper , Walter Gamer , Thomas Kirchhoff
发明人： Sylvie Lombardi , Guido Koch , Richard Layne , Tarun J. Edwin , Wolfgang Supper , Walter Gamer , Thomas Kirchhoff
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/848 , A61F2/89 , A61F2/915 , A61F2002/072 , A61F2002/075 , A61F2230/005 , A61F2230/0054 , A61L31/048 , C08L27/18
摘要： A flexible covered stent having a stent covered on a first surface by a first layer of biocompatible material and on a second surface by both a second and third layer of biocompatible material, the first and second layers and the first and third layers of biocompatible material being bonded to one another through openings in a wall in the stent. The first layer of biocompatible material is longer than both the second and third layers of biocompatible material such that at least a portion of the second surface of the stent is not covered by either second or third layer, imparting flexibility to the stent.
摘要翻译：一种柔性覆盖的支架，其具有通过第一生物相容性材料层在第一表面上覆盖的支架，并且通过第二和第三层生物相容性材料在第二表面上，第一和第二层以及第一和第三层生物相容性材料是通过支架的壁中的开口彼此粘合。生物相容性材料的第一层比第二层和第三层生物相容性材料长，使得支架的第二表面的至少一部分不被第二层或第三层覆盖，赋予支架灵活性。

38. 发明授权

US06203735B1 Method of making expanded polytetrafluoroethylene products 失效
标题翻译：制造膨胀聚四氟乙烯产品的方法
公开(公告)号：US06203735B1
公开(公告)日：2001-03-20
申请号：US08792780
申请日：1997-02-03
申请人： Tarun J. Edwin , Scott Randall
发明人： Tarun J. Edwin , Scott Randall
IPC分类号： B29C6902
CPC分类号： A61F2/06 , A61F2/07 , A61F2002/061 , A61F2002/065 , A61F2002/075 , B29C55/26 , B29C61/025 , B29K2027/18 , B29L2031/7534
摘要： A method of shaping three-dimensional products by manipulating an expanded polytetrafluoroethylene tubular body into a desired three-dimensional conformation. The present invention entails radially expanding a longitudinally expanded polytetrafluoroethylene (ePTFE) tube to form a radially expanded ePTFE (rePTFE) tube, engaging the rePTFE tube circumferentially about a shaping mandrel, heating the assembly to a temperature below the crystalline melt point temperature, or sintering temperature, of polytetrafluoroethylene to radially shrink the diameter of the rePTFE tube into intimate contact with the shaping mandrel, and heating the assembly to a temperature above the crystalline melt point temperature of polytetrafluoroethylene to amorphously lock the microstructure of the shaped polytetrafluoroethylene body.
摘要翻译：通过将膨胀的聚四氟乙烯管体操纵成所需的三维构象来形成三维产品的方法。本发明需要径向膨胀纵向膨胀的聚四氟乙烯（ePTFE）管，以形成径向膨胀的ePTFE（rePTFE）管，其在成形心轴周围接合rePTFE管，将组件加热到低于结晶熔点温度的温度，或烧结聚四氟乙烯的温度以径向收缩rePTFE管的直径与成形心轴紧密接触，并将组件加热到高于聚四氟乙烯的结晶熔点温度的温度，以非晶态地锁定成形聚四氟乙烯体的微观结构。

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