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31. 发明申请

US20090220420A1 TETRACYCLIC INDOLE DERIVATIVES AS IN VIVO IMAGING AGENTS AND HAVING PERIPHERALBENZODIAZEPINE RECEPTOR AFFINITY (PBR) 有权
标题翻译：四环素衍生物作为VIVO成像剂并具有外周血胆酸受体亲和力（PBR）
公开(公告)号：US20090220420A1
公开(公告)日：2009-09-03
申请号：US12094172
申请日：2006-11-20
申请人： Erik Arstad , Ian Wilson , Sajinder Kaur Luthra , Frank Brady , Bengt Langstrom , Farhad Karimi , Edward George Robins , Bo Shan
发明人： Erik Arstad , Ian Wilson , Sajinder Kaur Luthra , Frank Brady , Bengt Langstrom , Farhad Karimi , Edward George Robins , Bo Shan
IPC分类号： A61K51/04 , C07D495/04 , A61K31/407 , A61K49/00
CPC分类号： C07D209/80 , C07D495/04
摘要： The present invention provides novel tetracyclic indole compounds of Formula (I) either as in vivo imaging agents or as therapeutic agents. A method for the preparation of the in vivo imaging agent compound is also provided by the invention, as well as a precursor for use in said method. Pharmaceutical compositions comprising the compounds of the invention are additionally provided. Where the pharmaceutical composition comprises a compound suitable for in vivo imaging, a kit is provided for the preparation of the pharmaceutical composition. In a further aspect, use of the compound for in vivo imaging or treatment of conditions associated with PBR is provided.
摘要翻译：本发明提供作为体内显像剂或治疗剂的式（I）的新型四环吲哚化合物。本发明还提供了制备体内显像剂化合物的方法，以及用于所述方法的前体。另外提供包含本发明化合物的药物组合物。当药物组合物包含适于体内成像的化合物时，提供用于制备药物组合物的试剂盒。在另一方面，提供了该化合物用于体内成像或治疗与PBR相关的病症的用途。

32. 发明申请

US20080279639A1 DEGRADABLE EROSION CONTROL BARRIER 有权
标题翻译：可降解防腐控制棒
公开(公告)号：US20080279639A1
公开(公告)日：2008-11-13
申请号：US11746869
申请日：2007-05-10
申请人： Walter van Woudenbert , Ian Wilson
发明人： Walter van Woudenbert , Ian Wilson
IPC分类号： E02D17/20 , A62D3/00
CPC分类号： E02D17/202
摘要： An erosion control barrier for installation in a drainage path in a service environment. The erosion control barrier includes a unitary permeable sheet which is bent along a longitudinal axis to provide an upslope side, a downslope side and a longitudinally extending apex. The permeable sheet is constructed of a degradable material so that the erosion control barrier has a design service life in the service environment and a design material life in the service environment. The design material life is longer than the design service life. The permeable sheet is designed to be sufficiently transversely stiff and resilient during the design service life to enable the erosion control barrier to be self-supporting. The permeable sheet is designed to substantially disintegrate within the design material life.
摘要翻译：用于安装在服务环境中的排水路径中的侵蚀控制屏障。侵蚀控制屏障包括沿着纵向轴线弯曲的单一可渗透片材，以提供上坡面，下坡面和纵向延伸的顶点。可渗透片由可降解材料构成，使得侵蚀控制屏障在使用环境中具有设计使用寿命，并且在使用环境中具有设计材料寿命。设计使用寿命长于设计使用寿命。可渗透片设计成在设计使用寿命期间具有足够的横向刚性和弹性，以使侵蚀控制屏障能够自支撑。可渗透片被设计成在设计材料寿命内基本上分解。

33. 发明申请

US20070167377A1 Inhibitors of glycinamide ribonucleotide transformylase 审中-公开
标题翻译：甘氨酰胺核糖核苷酸转化酶抑制剂
公开(公告)号：US20070167377A1
公开(公告)日：2007-07-19
申请号：US10510405
申请日：2003-04-07
申请人： Dale Boger , Ian Wilson
发明人： Dale Boger , Ian Wilson
IPC分类号： A61K38/06 , A61K38/05 , A61K38/04 , A61K31/513
CPC分类号： C07D239/48 , A61K38/00 , C07K7/06
摘要： Potent human inhibitors of human glycinamide ribonucleotide transformylase and of aminoimidazole carboxamide ribonucleotide transformylase are designed, synthesized, and characterized.
摘要翻译：人甘氨酰胺核糖核苷酸转化酶和氨基咪唑羧酰胺核糖核苷酸转化酶的强力人抑制剂被设计，合成和表征。

34. 发明申请

US20070064523A1 Mixer apparatus 有权
标题翻译：搅拌机
公开(公告)号：US20070064523A1
公开(公告)日：2007-03-22
申请号：US11527661
申请日：2006-09-22
申请人： Ian Wilson
发明人： Ian Wilson
IPC分类号： B01F7/20
CPC分类号： B01F9/12 , A47J43/0711 , B01F7/00583 , B01F7/00975
摘要： A mixer apparatus comprising a pair of counter rotating beater elements operating in a rotating bowl for the mixing of food ingredients; at least one of said beater elements provided with urging means adapted to urging small quantities of said food ingredients from a thin distributed layer into a mixable concentration of said ingredients.
摘要翻译：一种搅拌器装置，包括一对在旋转碗中操作以用于混合食物成分的反向旋转搅拌器元件; 所述搅拌器元件中的至少一个设置有推动装置，其适于将少量所述食物成分从薄的分散层推到所述成分的可混合浓度中。

35. 发明申请

US20050208587A1 Peptides that bind to broadly neutralizing anti-HIV antibody-structure of 4E10 Fab fragment complex. uses thereof, compositions therefrom 审中-公开
标题翻译：结合4E10 Fab片段复合物的广泛中和抗HIV抗体结构的肽。其用途，组合物
公开(公告)号：US20050208587A1
公开(公告)日：2005-09-22
申请号：US10946371
申请日：2004-09-20
申请人： Rosa Cardoso , Ian Wilson , Dennis Burton , Philip Dawson
发明人： Rosa Cardoso , Ian Wilson , Dennis Burton , Philip Dawson
IPC分类号： A61K38/00 , A61K38/04 , A61K39/42 , C07K20060101 , C07K14/16 , C07K14/475 , C07K16/00 , C07K16/10 , G01N33/48 , G01N33/50 , G01N33/53 , G01N33/569 , G06F15/00 , G06F17/00 , G06F19/00
CPC分类号： G01N33/56988 , A61K38/00 , C07K14/005 , C07K16/1063 , C07K2299/00 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C12N2740/16122 , G01N33/6878 , G01N2469/20 , G16B15/00 , G16B20/00 , G16C20/50
摘要： The present invention relates to the structure of Fab 4E10, e.g., as a complex with herein identified peptide KGND, herein identified as a 4E10 mimetope on gp41, as determined by crystallographic techniques, and the confirmation that peptide KGND has a functional relevant conformation, as well as the determination of key residues on 4E10, and uses thereof and compounds and compositions therefrom. Furthermore, the invention also relates to other peptides and mimetic peptides which bind to Fab 4E10.
摘要翻译：本发明涉及Fab 4E10的结构，例如，作为本文鉴定的肽KGND的复合物，本文鉴定为gp41上的4E10 mimetop，通过晶体学技术测定，以及证实肽KGND具有功能相关构象，如以及4E10上关键残基的测定及其用途及其化合物和组合物。此外，本发明还涉及结合Fab 4E10的其它肽和模拟肽。

36. 发明授权

US06885667B1 Redirection to a virtual router 有权
标题翻译：重定向到虚拟路由器
公开(公告)号：US06885667B1
公开(公告)日：2005-04-26
申请号：US09748828
申请日：2000-12-26
申请人： Ian Wilson
发明人： Ian Wilson
IPC分类号： H04L12/56 , H04L12/28
CPC分类号： H04L12/56
摘要： Methods and apparatus for sending a redirect packet to a host by a first router that supports a virtual router protocol are disclosed. Specifically, the redirect packet notifies the host that specific packets are to be redirected to a second router. First, the first router receives a packet from a host, where the packet includes a source address identifying the host and a destination address identifying a destination network. The first router ascertains the destination network of the packet from the destination address and obtains from a routing table an address of a next router that is coupled to the packet's destination network. The first router then determines whether to send a redirect packet to the host. In accordance with one embodiment, this is performed by determining whether the next router and the host identified by the source address of the packet are on the same network. When it is determined that the next router and the host are on the same network, the first router composes and sends the redirect packet to the host. The redirect packet serves to notify the host that packets addressed to the destination network are to be redirected to a virtual address of the next router.
摘要翻译：公开了由支持虚拟路由器协议的第一路由器向主机发送重定向分组的方法和装置。具体地，重定向分组通知主机特定的分组被重定向到第二路由器。首先，第一路由器从主机接收分组，其中分组包括标识主机的源地址和标识目的地网络的目的地地址。第一路由器从目的地地址确定分组的目的网络，并且从路由表中获得耦合到分组目的网络的下一个路由器的地址。然后，第一路由器确定是否向主机发送重定向分组。根据一个实施例，这是通过确定下一个路由器和由分组的源地址标识的主机是否在相同的网络上来执行的。当确定下一个路由器和主机在同一个网络上时，第一个路由器将重定向包组成并发送到主机。重定向分组用于通知主机将寻址到目的地网络的分组重定向到下一个路由器的虚拟地址。

37. 发明申请

US20050025179A1 Distributing and balancing traffic flow in a virtual gateway 有权
标题翻译：分布和平衡虚拟网关中的流量
公开(公告)号：US20050025179A1
公开(公告)日：2005-02-03
申请号：US10632704
申请日：2003-07-31
申请人： Douglas McLaggan , Ian Wilson , Mark Denny , Rick Williams
发明人： Douglas McLaggan , Ian Wilson , Mark Denny , Rick Williams
IPC分类号： H04J3/16 , H04L12/56
CPC分类号： H04L45/00 , H04L45/28 , H04L45/38 , H04L45/586 , H04L47/10 , H04L47/125
摘要： The distribution of traffic flows in a load-sharing redundancy group that includes a first gateway device and a second gateway device includes assigning a first set of forwarding addresses to the first gateway device and a second set of forwarding addresses to the second gateway device. The redundancy group distributes forwarding addresses to hosts which in turn use the distributed forwarding addresses to send packets to the redundancy group. The traffic flow for each of the assigned forwarding addresses is measured and may be compared to a target traffic flow. The traffic flow is adjusted to close in on the target traffic flow. Adjustment of the traffic flow can be accomplished either by changing the existing measured traffic flow by re-assigning a forwarding address originally assigned to one gateway device to a different gateway device or by altering future distribution of forwarding addresses so that additional traffic is sent to one or more forwarding addresses having lower measured traffic. The gateway devices can be routers using virtual MAC addresses as forwarding addresses. The redundancy group may also be configured to provide failover services in the event that one of the gateway devices ceases operation.
摘要翻译：在包括第一网关设备和第二网关设备的负载共享冗余组中的流量分配包括：向第一网关设备分配第一组转发地址，向第二网关设备分配第二组转发地址。冗余组将转发地址分配给主机，主机依次使用分布式转发地址向冗余组发送数据包。测量每个分配的转发地址的流量，并将其与目标业务流进行比较。交通流量被调整为关闭目标交通流量。可以通过将原始分配给一个网关设备的转发地址重新分配给不同的网关设备或通过改变转发地址的将来分配来改变现有的测量业务流来实现流量的调整，从而将额外的流量发送到一个或更多的具有较低测量业务量的转发地址。网关设备可以是使用虚拟MAC地址作为转发地址的路由器。冗余组还可以被配置为在其中一个网关设备停止操作的情况下提供故障转移服务。

38. 发明授权

US06412642B2 Method of applying marking to metal sheet for scrap sorting purposes 失效
标题翻译：对金属片施加标记以进行废料分选的方法
公开(公告)号：US06412642B2
公开(公告)日：2002-07-02
申请号：US09818482
申请日：2001-03-27
申请人： David F. Charles , Greg J. Courval , Michael P. Thomas , Michael J. Wheeler , Ian Wilson
发明人： David F. Charles , Greg J. Courval , Michael P. Thomas , Michael J. Wheeler , Ian Wilson
IPC分类号： B07C5342
CPC分类号： B07C5/3412 , B07C5/3427 , B07C2501/0036 , B21C51/00 , B21C51/005 , C22B7/00 , C22B7/005 , C22B21/0069 , Y02P10/212
摘要： Application of surface marking to metal stock, such as aluminum sheet, prior to or during scrap-generating manufacturing operations, to provide a detectable mark on pieces of manufacturing scrap derived from the marked sheet and commingled with scrap of other aluminum alloy sheet, so that the scrap can be sorted and the marked alloy scrap pieces separated from scrap of other alloy sheet to which the marking was not applied. Different markings, providing detectably different marks, may be respectively applied to sheet of different compositions if scrap pieces of more than two different compositions or compositional families are to be sorted and separated from each other.
摘要翻译：在废钢生产作业之前或期间，在金属坯料（例如铝板）上施加表面标记，以在来自标记的板材的碎片制造废料片上提供可检测标记，并与其他铝合金板材的废料混合，使得可以对废料进行分选，将标记的合金废料与未施加标记的其他合金板的废料分离。不同的标记，提供可检测的不同的标记，可以分别应用于不同组合的片材，如果两个以上的不同组合物或成分族的碎片彼此分离和分离。

39. 发明授权

US5639178A Vehicle barrier 失效
标题翻译：车辆障碍
公开(公告)号：US5639178A
公开(公告)日：1997-06-17
申请号：US436432
申请日：1995-05-26
申请人： Ian Wilson , Nicholas John Stewart White
发明人： Ian Wilson , Nicholas John Stewart White
IPC分类号： E01F13/08 , E01F13/00
CPC分类号： E01F13/085
摘要： A vehicle barrier in which two arms (6, 10) linked by a linking member (14) are pivoted to a base structure (1) so that they collapse into a recess (5) in the structure to "open" the barrier. To close the barrier the arms are raised and may be latched and locked in place, the arms and structure preferably forming a triangular shape when erect.
摘要翻译： PCT No.PCT / GB93 / 02371 Sec。 371日期：1995年5月26日 102（e）日期1995年5月26日PCT提交1993年11月18日PCT公布。公开号WO94 / 12731 日期1994年6月9日一种车辆阻挡物，其中通过连接构件（14）连接的两个臂（6,10）枢转到基部结构（1），使得它们折叠成结构中的凹部（5）以“打开 “屏障。为了闭合障碍物，臂被升高并且可以被锁定并锁定就位，当直立时，臂和结构优选地形成三角形形状。

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