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31. 发明申请

US20100292550A1 IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：可植入医疗器械
公开(公告)号：US20100292550A1
公开(公告)日：2010-11-18
申请号：US12809304
申请日：2007-12-21
申请人： Hans Abrahamson , Anders Björling , Tomas Snitting , Nils Holmström
发明人： Hans Abrahamson , Anders Björling , Tomas Snitting , Nils Holmström
IPC分类号： A61N1/365 , A61B5/1473 , A61N1/39
CPC分类号： A61B5/053 , A61B5/14546 , A61N1/36557
摘要： An analyte measuring system has an implantable medical device having a signal source arranged for generating a current signal and electrodes for applying the current signal to a surrounding tissue in a subject body. The device measures a resulting voltage signal with the electrodes and calculates an impedance signal therefrom. The system comprises a signal processor arranged for generating an estimate of a concentration of an analyte in the tissue based on a spectrum analysis of the determined impedance signal.
摘要翻译：分析物测量系统具有植入式医疗装置，其具有布置成产生电流信号的信号源和用于将电流信号施加到被检体内的周围组织的电极。该装置用电极测量得到的电压信号并从其计算阻抗信号。该系统包括信号处理器，其被布置为基于所确定的阻抗信号的频谱分析来生成组织中的分析物的浓度的估计。

32. 发明授权

US07569020B2 Method for extracting timing parameters using a cardio-mechanical sensor 有权
标题翻译：使用心机械传感器提取定时参数的方法
公开(公告)号：US07569020B2
公开(公告)日：2009-08-04
申请号：US11455518
申请日：2006-06-19
申请人： Kjell Norén , Nils Holmström
发明人： Kjell Norén , Nils Holmström
IPC分类号： A61B5/026
CPC分类号： A61B5/02416 , A61B5/0031 , A61B5/0452 , A61B5/083 , A61B5/1116 , A61B5/686 , A61B5/7239 , A61N1/36514 , A61N1/36578
摘要： In a method and apparatus for measuring the ejection fraction in a mammalian heart, the opening and closing of a heart valve is sensed with an implanted sensor, and a pre-ejection period is measured as a function of the sensed opening and closing of the heart valve. The ventricular ejection time also is measured, and the ejection fraction is determined as a function of the measured pre-ejection period and the ejection time.
摘要翻译：在用于测量哺乳动物心脏中的射血分数的方法和装置中，用植入的传感器感测心脏瓣膜的打开和关闭，并且根据检测到的心脏的开启和关闭来测量预喷射周期阀。也测量心室射血时间，并且将射血分数确定为所测量的预喷射时间和喷射时间的函数。

33. 发明授权

US06447670B1 Method and apparatus for compensating for drift in potential of a reference electrode in electrochemical measurements 失效
标题翻译：用于补偿电化学测量中参考电极电位漂移的方法和装置
公开(公告)号：US06447670B1
公开(公告)日：2002-09-10
申请号：US09530295
申请日：2000-07-11
申请人： Nils Holmström
发明人： Nils Holmström
IPC分类号： G01N2726
CPC分类号： G01N27/4163 , A61N1/36557 , G01N33/4925
摘要： In a method and an apparatus for measuring a concentration of at least one dissolved chemical entity in a liquid medium, employing a counter electrode, a working electrode and a reference electrode immersed in the liquid medium, at least one measurement potential is applied to the working electrode relative to the reference electrode, corresponding to a measurement voltage during at least a part of a measurement period, thereby causing the dissolved chemical entity to participate in an electrochemical reaction at the working electrode, the chemical reaction resulting in a measurement evoked current. Compensation for potential drift at the reference electrode is achieved by comparing the measurement evoked current with a predetermined value, and decreasing or increasing the measurement voltage by an incremental value, in a negative or a positive incremental step, so that the measurement current approaches a predetermined value. After each increment, a new comparison is made and the next increment is determined dependent on that most recent comparison.
摘要翻译：在液体介质中测量至少一个溶解化学物质的浓度的方法和装置中，使用浸在液体介质中的对电极，工作电极和参比电极，至少一个测量电位施加到工作电极相对于参考电极，对应于在测量周期的至少一部分期间的测量电压，从而使溶解的化学实体参与在工作电极处的电化学反应，导致测量诱发电流的化学反应。通过将测量诱发电流与预定值进行比较，以及在负增量或正增量步长中将测量电压减小或增加增量值来实现对参考电极的电位漂移的补偿，使得测量电流接近预定的值。在每个增量之后，进行新的比较，并根据最近的比较确定下一个增量。

34. 发明授权

US06188931B1 Electrode lead with temporary increased stiffness during ingrowth 失效
标题翻译：电极导线在向内生长期间具有临时增加的刚度
公开(公告)号：US06188931B1
公开(公告)日：2001-02-13
申请号：US09319403
申请日：1999-07-26
申请人： Nils Holmström , Martin Obel
发明人： Nils Holmström , Martin Obel
IPC分类号： A61N105
CPC分类号： A61N1/056
摘要： An implantable lead for an implantable active device, such as a pacemaker, has at least two electrodes, and a proximal end adapted for electrical and mechanical connection to the active device and a distal end opposite the proximal end. A ventricular electrode is carried at the distal end of the lead for sensing and/or electrical interaction with the ventricle, and an atrial electrode is carried on the lead for sensing and/or electrical interaction with the atrium, the atrial electrode being disposed between the proximal end and the ventricular electrode. The lead at its distal end has a first part with a first predetermined length, which is between 9 and 13 cm, and which exhibits a first stiffness. Adjacent to this first part is a second part, having a second predetermined length, which exceeds 15 cm, and which exhibits a second stiffness. The first stiffness of the first part provides the overall lead with a stiffness so as to force the atrial electrode in contact with the atrial wall when the lead is implanted. The second stiffness is greater then the first stiffness. The lead has a transition point between the first part and the second part, disposed at the proximal end of the second part.
摘要翻译：用于可植入有源装置（例如起搏器）的可植入导线具有至少两个电极，以及适于与主动装置电连接和机械连接的近端以及与近端相对的远端。在电极的远端承载心室电极，用于与心室的感应和/或电相互作用，并且心房电极承载在引线上，用于与心房的感应和/或电相互作用，心房电极设置在心室近端和心室电极。其远端处的引线具有第一部分，其具有第一预定长度，其在9和13cm之间，并且其具有第一刚度。与第一部分相邻的是第二部分，具有超过15cm的第二预定长度，并且具有第二刚度。第一部分的第一刚度提供了具有刚度的整体引线，以便当植入引线时迫使心房电极与心房壁接触。第二刚度大于第一刚度。引线在第一部分和第二部分之间具有设置在第二部分的近端处的转变点。

35. 发明授权

US08135455B2 System and method for monitoring synchrony between chambers of a heart by volume measurements and analysis 有权
标题翻译：通过体积测量和分析来监测心脏室之间的同步的系统和方法
公开(公告)号：US08135455B2
公开(公告)日：2012-03-13
申请号：US11916463
申请日：2005-06-16
申请人： Nils Holmström
发明人： Nils Holmström
IPC分类号： A61B5/04
CPC分类号： A61N1/36521 , A61B5/029 , A61B5/0295 , A61N1/3627 , A61N1/3682 , A61N1/3702
摘要： An implantable heart monitoring system includes a housing configured for implantation in a subject, at least one sensor member implanted relative to the heart of the subject to detect an electrical signal related to cardiac activity of the heart, a control circuit in the housing, and a memory accessible by the control circuit. The control circuit, from said electrical signal, derives a first value related to the volume of a first part of the heart and derives a second value related to the volume of a second part of the heart, and monitors variation of said first value over time in at least a substantial portion of a heart cycle, and monitors variation of said second value over time in said substantial portion of said heart cycle, and stores in the memory information representing the monitoring of said first and second values that represents a relationship between the first and second values in the substantial portion of the heart cycle and variation of the relationship in the substantial portion of the heart cycle.
摘要翻译：可植入心脏监测系统包括构造成用于植入对象的壳体，相对于对象的心脏植入的至少一个传感器构件，以检测与心脏的心脏活动相关的电信号，壳体中的控制电路和存储器可由控制电路访问。来自所述电信号的控制电路导出与心脏的第一部分的体积相关的第一值，并且导出与心脏的第二部分的体积相关的第二值，并且监视所述第一值随时间的变化在心脏周期的至少大部分中，并且监视所述心脏周期的所述实质部分中随时间推移的所述第二值的变化，并且存储在表示所述第一和第二值的监视的存储器信息中，所述第一和第二值表示在心脏周期的实质部分中的第一和第二值以及心脏周期的实质部分中关系的变化。

36. 发明授权

US08133187B2 Implantable medical device with heart condition detection 有权
标题翻译：具有心脏状态检测的可植入医疗器械
公开(公告)号：US08133187B2
公开(公告)日：2012-03-13
申请号：US12095216
申请日：2005-12-16
申请人： Nils Holmström , Kjell Noren
发明人： Nils Holmström , Kjell Noren
IPC分类号： A61B5/0255
CPC分类号： A61B7/00 , A61B7/04 , A61N1/36514 , A61N1/36578
摘要： A method for detecting a condition of a heart of a patient using an implantable medical device, including the steps of sensing acoustic signals indicative of heart sounds of the heart of the patient; extracting signals corresponding to a first heart sound (S1) and a second heart sound (S2) from sensed signals; calculating an energy value corresponding to a signal corresponding to the first heart sound (S1) and an energy value corresponding to the second heart sound (S2); calculating a relation between the energy value corresponding to the first heart sound and the energy value corresponding to the second heart sound for successive cardiac cycles; and using at least one relation to detect the condition or a change of the condition. A medical device for determining the posture of a patient and a computer readable medium encoded with instructions are used to perform the inventive method.
摘要翻译：一种用于使用可植入医疗装置检测患者心脏状态的方法，包括以下步骤：感测指示患者心脏的心脏声音的声学信号; 从感测信号中提取对应于第一心音（S1）和第二心音（S2）的信号; 计算对应于对应于第一心音（S1）的信号的能量值和对应于第二心音（S2）的能量值; 计算对应于第一心音的能量值与对应于第二心音的能量值之间的关系，用于连续的心动周期; 并使用至少一个关系来检测条件或条件的变化。用于确定患者姿势的医疗装置和用指令编码的计算机可读介质用于执行本发明的方法。

37. 发明申请

US20110166614A1 IMPLANTABLE ANALYTE RF SPECTROSCOPY MEASURING SYSTEM 审中-公开
标题翻译：可伸缩分析仪射频光谱测量系统
公开(公告)号：US20110166614A1
公开(公告)日：2011-07-07
申请号：US12809282
申请日：2007-12-21
申请人： Hans Abrahamson , Anders Björling , Tomas Snitting , Nils Holmström , Tom Eriksson
发明人： Hans Abrahamson , Anders Björling , Tomas Snitting , Nils Holmström , Tom Eriksson
IPC分类号： A61N1/39 , A61B5/1455 , A61N1/362
CPC分类号： A61B5/05 , A61B5/14546 , A61B5/7253 , A61N1/36557 , A61N1/3702 , A61N1/37252
摘要： An analyte measuring system includes implantable medical device having a RF signal source arranged for generating a RF signal and a transmitting antenna for transmitting the RF signal into a surrounding tissue in a subject body. The system has a receiving RF antenna for receiving the RF signal from the tissue and a signal processor arranged for generating an estimate of a concentration of an analyte in the tissue based on a spectral analysis of the received RF signal.
摘要翻译：分析物测量系统包括具有设置用于产生RF信号的RF信号源的可植入医疗装置和用于将RF信号发送到被检体内的周围组织的发射天线。该系统具有用于从组织接收RF信号的接收RF天线和布置成基于所接收的RF信号的频谱分析产生组织中分析物的浓度的估计的信号处理器。

38. 发明申请

US20090216291A1 SYSTEM AND METHOD FOR DETECTING ELECTRIC EVENTS IN CHAMBERS OF A HEART 审中-公开
标题翻译：用于检测心脏中的电活动的系统和方法
公开(公告)号：US20090216291A1
公开(公告)日：2009-08-27
申请号：US12160908
申请日：2006-01-31
申请人： Nils Holmström , Anders Björling
发明人： Nils Holmström , Anders Björling
IPC分类号： A61N1/368 , A61B5/0402
CPC分类号： A61N1/3627 , A61N1/368 , A61N1/3684 , A61N1/371 , A61N1/3714
摘要： In a system and method for detecting electrical cardiac events, and a heart stimulator embodying such a system, cardiac events are detected in respective chambers of a heart by sensing electrical signals in at least two different chambers of the heart and forming a difference signal from the sensed signals, and using the difference signal to automatically distinguish between events originating from one of the chambers and events originating in another of the chambers. At least one of the sensed signals is sensed in a coronary vein on the left atrium or the left ventricle.
摘要翻译：在用于检测电心脏事件的系统和方法以及体现这种系统的心脏刺激器中，通过感测心脏的至少两个不同腔室中的电信号并在心脏的相应腔室中形成差异信号，从而在心脏的相应腔室中检测心脏事件并且使用差分信号来自动区分源自一个室的事件和源自另一个室的事件。感测到的信号中的至少一个在左心房或左心室的冠状静脉中被感测。

39. 发明授权

US07397166B1 Electroactive polymer-actuated peristaltic pump and medical lead incorporating such a pump 失效
标题翻译：电动聚合物致动的蠕动泵和包含这种泵的医用引线
公开(公告)号：US07397166B1
公开(公告)日：2008-07-08
申请号：US11404268
申请日：2006-04-12
申请人： Kevin L. Morgan , Anne M. Shelchuk , Jeffery D. Snell , Nils Holmström , John R. Helland
发明人： Kevin L. Morgan , Anne M. Shelchuk , Jeffery D. Snell , Nils Holmström , John R. Helland
IPC分类号： H01L41/08
CPC分类号： F04B43/1223 , A61M5/14228 , A61M2205/0283 , F04B43/095 , F04B43/12 , Y10S310/80
摘要： A peristaltic pump for conveying a fluid comprises a flexible tube having an outer surface and a lumen for carrying the fluid such as a therapeutic agent. The tube has a length defined by opposed ends of the tube, the outer surface of the body carrying a plurality of longitudinally spaced-apart electroactive polymer actuators. The plurality of actuators are adapted to be responsive to electrical signals for energizing the actuators sequentially along the length of the tube to move a lumen pinch-off along the length of the tube to thereby convey the fluid from one end of the tube to the other end by means of a peristaltic pumping action. The peristaltic pump may be incorporated into a medical lead, such as an endocardial pacing lead, carrying at least one electrode.
摘要翻译：用于输送流体的蠕动泵包括具有用于承载诸如治疗剂的流体的外表面和内腔的柔性管。管具有由管的相对端限定的长度，本体的外表面承载多个纵向间隔开的电活性聚合物致动器。多个致动器适于响应于电信号，以沿着管的长度依次致动致动器，以沿着管的长度移动管腔夹紧，从而将流体从管的一端传送到另一端通过蠕动泵送动作结束。蠕动泵可以并入到携带至少一个电极的医疗引线（例如心内膜起搏引线）中。

40. 发明授权

US07389142B2 Heart monitoring device, system and method 失效
标题翻译：心脏监护装置，系统及方法
公开(公告)号：US07389142B2
公开(公告)日：2008-06-17
申请号：US10630468
申请日：2003-07-30
申请人： Nils Holmström
发明人： Nils Holmström
IPC分类号： A61N1/00
CPC分类号： A61N1/36557 , A61N1/365
摘要： In an implantable heart-monitoring device and system, and a heart-monitoring method, a control circuit is connected to one or more sensors, a first of which is positionable in the coronary sinus region of a heart and senses at least one blood constituent, and at least one other of the sensors supplying a signal to the control circuit indicative of the activity of the heart. In response to signals from the first sensor and with information about the activity of the heart from the other sensor, the control circuit determines a first value of the blood constituent during a first portion of a heart cycle, and determines a second value of the blood constituent during a second portion of the heart cycle.
摘要翻译：在可植入心脏监测装置和系统以及心脏监测方法中，控制电路连接到一个或多个传感器，其中第一个传感器可定位在心脏的冠状窦区域并且感测至少一种血液成分，并且至少另一个传感器向控制电路提供指示心脏活动的信号。响应于来自第一传感器的信号和关于来自另一传感器的心脏的活动的信息，控制电路在心脏周期的第一部分期间确定血液成分的第一值，并且确定血液的第二值在心脏周期的第二部分期间成分。

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