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    • 37. 发明授权
    • Method for the production of β-aminopropionic acid derivatives
    • 生产氨基丙酸衍生物的方法
    • US07674929B2
    • 2010-03-09
    • US12066681
    • 2006-09-13
    • Holger EversJohann-Peter MelderThomas PreissHarald Meissner
    • Holger EversJohann-Peter MelderThomas PreissHarald Meissner
    • C07C255/00
    • C07C253/30C07B43/04C07C227/06C07C2601/14C07C255/24
    • The invention relates to a process for preparing β-aminopropionic acid derivatives by reacting a primary or secondary amine with an acrylic acid derivative, wherein comprises (i) a first primary or secondary amine is provided as an amine of value and reacted with the acrylic acid derivative, to obtain a reaction mixture comprising a first β-aminopropionic acid derivative as a product of value and additionally unconverted acrylic acid derivative, (ii) the unconverted acrylic acid derivative present in the reaction mixture is reacted with a second secondary amine as a scavenger amine virtually fully to give a second β-aminopropionic acid derivative to obtain a reaction mixture comprising the first β-aminopropionic acid derivative as a product of value, the second β-aminopropionic acid derivative and unconverted secondary amine.
    • 本发明涉及一种通过使伯胺或仲胺与丙烯酸衍生物反应来制备β-氨基丙酸衍生物的方法,其中包括(i)第一伯胺或仲胺作为有价值的胺并与丙烯酸反应 酸衍生物,得到包含第一和次氨基丙酸衍生物作为值的产物和另外未转化的丙烯酸衍生物的反应混合物,(ii)将存在于反应混合物中的未转化的丙烯酸衍生物与第二仲胺反应, 一种清除剂胺实际上完全可以得到第二种 - 氨基丙酸衍生物,以获得包含第一种和第二种 - 氨基丙酸衍生物和未转化的仲胺的第一种 - 氨基丙酸衍生物的反应混合物。