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31. 发明授权

US07223419B2 Production process for polymeric micelle charged therein with drug and polymeric micelle composition 有权
标题翻译：用药物和聚合物胶束组合物填充聚合物胶束的生产方法
公开(公告)号：US07223419B2
公开(公告)日：2007-05-29
申请号：US10666384
申请日：2003-09-22
申请人： Masayuki Yokoyama , Eiichi Honzawa , Yasuaki Ogawa
发明人： Masayuki Yokoyama , Eiichi Honzawa , Yasuaki Ogawa
IPC分类号： A61K9/14
CPC分类号： A61K9/1075
摘要： Provided are a production process for a polymeric micelle which is stable and has a high drug content and a composition containing such polymeric micelle. Disclosed are a production process for a polymeric micelle, comprising the steps of dissolving a drug and a specific copolymer in a water non-miscible organic solvent to prepare a solution, mixing the resulting solution with water to form an O/W type emulsion and then slowly volatilizing the organic solvent from the solution, and a polymeric micelle composition charged therein with a water-scarcely soluble drug, which can be obtained by the above production process.
摘要翻译：提供稳定且具有高药物含量的聚合胶束的生产方法和含有这种聚合胶束的组合物。公开了一种聚合物胶束的制备方法，包括以下步骤：将药物和特定共聚物溶解在水不混溶的有机溶剂中以制备溶液，将所得溶液与水混合以形成O / W型乳液，然后从溶液中缓慢挥发有机溶剂，以及在其中装入难溶于水的药物的聚合胶束组合物，其可以通过上述制备方法获得。

32. 发明申请

US20060153930A1 Drug-containing sustained release microparticle, process for producing the same and preparation containing the microparticle 审中-公开
标题翻译：含药缓释微粒，其制造方法和含有微粒的制剂
公开(公告)号：US20060153930A1
公开(公告)日：2006-07-13
申请号：US10559512
申请日：2004-06-11
申请人： Yutaka Mizushima , Yasuaki Ogawa , Junzo Tanaka , Toshiyuki Ikoma
发明人： Yutaka Mizushima , Yasuaki Ogawa , Junzo Tanaka , Toshiyuki Ikoma
IPC分类号： A61K33/42
CPC分类号： A61K31/00 , A61K9/1611 , A61K33/30 , A61K33/42 , A61K45/06 , A61K2300/00
摘要： Sustained release microparticles suitable for various types of drugs, or drug-containing sustained release microparticles capable of sustained release of drugs over a period of three days or more and capable of inhibiting initial burst release; a process for producing the same; and preparations containing the microparticles are disclosed. The drug-containing sustained release microparticles comprise a drug other than human growth hormone and a porous apatite derivative, and optionally include a water-soluble bivalent metal compound. The drug-containing sustained release microparticles can be produced by dispersing under agitation microparticles of a porous apatite derivative in an aqueous solution containing a drug so that the aqueous solution infiltrates into the porous apatite derivative; optionally adding an aqueous solution containing a water-soluble bivalent metal compound that may infiltrate into the porous apatite derivative; further adding additives such as a stabilizer to the mixture; and effecting lyophilization or vacuum drying.
摘要翻译：适用于各种类型药物的持续释放微粒，或能够在三天或更长时间内持续释放药物并且能够抑制初始爆发释放的药物持续释放微粒; 其制造方法; 并且公开了含有微粒的制剂。含药物的缓释微粒包含除人生长激素以外的药物和多孔磷灰石衍生物，任选地包含水溶性二价金属化合物。含药缓释微粒可以通过将多孔磷灰石衍生物的微粒分散在含有药物的水溶液中分散而制成，使得水溶液渗透到多孔磷灰石衍生物中; 任选地加入含有可渗透到多孔磷灰石衍生物中的水溶性二价金属化合物的水溶液; 进一步向混合物中加入稳定剂等添加剂; 并进行冻干或真空干燥。

33. 发明授权

US5094854A Liposome composition useful for hypertheria therapy 失效
标题翻译：脂质体组合物可用于治疗高血压
公开(公告)号：US5094854A
公开(公告)日：1992-03-10
申请号：US607647
申请日：1990-10-31
申请人： Yasuaki Ogawa , Katsumi Iga , Yasutaka Igari
发明人： Yasuaki Ogawa , Katsumi Iga , Yasutaka Igari
IPC分类号： A61K9/127 , A61K9/133
CPC分类号： A61K9/1277 , A61K9/127 , A61K9/1272 , Y10S514/963 , Y10T428/2984
摘要： This invention relates to the liposome compositions which are characterized in that the phase transition temperature of the membrane is in the range of 40.degree. to 45.degree. C. and the osmotic pressure of a drug-containing solution to be entrapped in liposomes is 1.2 to 2.5 times higher than that of body fluid of warm-blooded animals. The compositions are useful for treatment of solid tumors in hyperthermia therapy.

34. 发明授权

US4954298A Method for producing microcapsule 失效
标题翻译：微胶囊生产方法
公开(公告)号：US4954298A
公开(公告)日：1990-09-04
申请号：US249198
申请日：1988-09-23
申请人： Masaki Yamamoto , Shigeyuki Takada , Yasuaki Ogawa
发明人： Masaki Yamamoto , Shigeyuki Takada , Yasuaki Ogawa
IPC分类号： A61K9/56 , A61K9/16 , A61K9/50 , A61K9/52 , A61K9/58 , A61K9/62 , B01J13/02 , B01J13/12
CPC分类号： A61K9/5031 , A61K9/1647 , A61K9/1652 , A61K9/1658 , A61K9/1694 , B01J13/02 , Y10S514/80 , Y10S514/885 , Y10S514/963 , Y10T428/2984 , Y10T428/2985 , Y10T428/2987
摘要： Microcapsules are advantageously produced with high take-up of a water-soluble drug by preparing a W/O emulsion composed of a water-soluble drug-containing solution as the inner aqueous phase and a polymer-containing solution as the oil phase, dispersing said emulsion in an aqueous phase and subjecting the resulting W/O/W emulsion to an in-water drying, wherein the viscosity of the W/O emulsion used in preparing the W/O/W emulsion is adjusted to about 150 to about 10,000 centipoises.
摘要翻译：通过制备由作为内部水相的水溶性药物溶液和作为油相的含有聚合物的溶液组成的W / O乳液，有利地生产水溶性药物的高吸收性的微胶囊，将所述在水相中的乳液，并将所得W / O / W乳液进行水中干燥，其中用于制备W / O / W乳液的W / O乳液的粘度调节至约150至约10,000厘泊。

35. 发明授权

US4283389A Novel antibiotic, BN-183B substance 失效
标题翻译：新型抗生素，BN-183B物质
公开(公告)号：US4283389A
公开(公告)日：1981-08-11
申请号：US105442
申请日：1979-12-19
申请人： Norio Ezaki , Shinji Miyadoh , Yasuaki Ogawa , Takashi Hisamatsu , Harumi Fukuyashu , Yujiro Yamada
发明人： Norio Ezaki , Shinji Miyadoh , Yasuaki Ogawa , Takashi Hisamatsu , Harumi Fukuyashu , Yujiro Yamada
IPC分类号： C07G11/00 , A61K35/74 , A61P31/00 , A61P31/04 , C12P1/04 , C12R1/38 , A61K35/00
CPC分类号： C12P1/04
摘要： A novel antibiotic designated BN-183B substance is disclosed which is produced by cultivating a strain of the genus Pseudomonas. The antibiotic has a strong action against Gram-positive and Gram-negative bacteria.
摘要翻译：公开了一种称为BN-183B物质的新型抗生素，其通过培养假单胞菌属的菌株产生。抗生素对革兰氏阳性和革兰氏阴性菌具有很强的作用。

36. 发明授权

US4103083A Novel antibiotics derivatives and process for preparing the same 失效
标题翻译：新型抗生素衍生物及其制备方法
公开(公告)号：US4103083A
公开(公告)日：1978-07-25
申请号：US751877
申请日：1976-12-17
申请人： Yasuaki Ogawa , Yasumitsu Kondo , Takashi Shomura , Takashi Tsuruoka , Shigeharu Inouye , Taro Niida
发明人： Yasuaki Ogawa , Yasumitsu Kondo , Takashi Shomura , Takashi Tsuruoka , Shigeharu Inouye , Taro Niida
IPC分类号： C07D501/20 , C07D501/57
CPC分类号： C07D501/57 , Y10S435/886
摘要： Novel antibiotics derivatives 7-(5-acylamido-5-carboxyvaleramido)-3-(.alpha.-methoxy-p-acyloxycinnamoyloxymethyl)-7-methoxy-3-cephem-4-carboxylic acids and the salts thereof which are useful as antibiotics and intermediates for the preparation of cephamycin derivatives, a process for preparing the same, and a process for recovering the cephamycin derivatives effectively and stably from the fermentation broth in the form of an N-acyl derivative.
摘要翻译：新型抗生素衍生物7-（5-酰氨基-5-羧基戊酰氨基）-3-（α-甲氧基 - 对酰氧基肉桂酰氧基甲基）-7-甲氧基-3-头孢烯-4-羧酸及其盐，可用作抗生素和中间体用于制备头孢霉素衍生物，其制备方法，以及以N-酰基衍生物的形式从发酵液中有效稳定地回收头孢霉素衍生物的方法。

37. 发明授权

US4010155A Antibiotic SF-1623 substance 失效
标题翻译：抗生素SF-1623物质
公开(公告)号：US4010155A
公开(公告)日：1977-03-01
申请号：US526731
申请日：1974-11-25
申请人： Shigeharu Inouye , Takashi Shomura , Michio Kojima , Yasuaki Ogawa , Hiroshi Watanabe , Yasumitsu Kondo , Kazuo Saito, deceased , Yujiro Yamada , Taro Niida
发明人： Shigeharu Inouye , Takashi Shomura , Michio Kojima , Yasuaki Ogawa , Hiroshi Watanabe , Yasumitsu Kondo , Kazuo Saito, deceased , Yujiro Yamada , Taro Niida
IPC分类号： A61K35/74 , C07D501/36 , C07D501/57 , C12P1/06 , C12P35/08 , C12D9/00
CPC分类号： C12P35/08 , Y10S435/803 , Y10S435/893 , Y10S435/929
摘要： A new antibiotic designated as SF-1623 substance exhibiting a useful antibacterial activity against gram-negative bacteria is now produced by cultivating a new strain ATCC 21999 of the known species Streptomyces chartreusis. The SF-1623 substance in the form of its an alkali metal salt may be recovered from the culture when the cultivation is effected under aerobic conditions in the presence of an alkali metal thiosulfate.
摘要翻译：现在通过培育已知种类的链霉菌Streptomyces chartreusis的新菌株ATCC 21999，产生一种被指定为对革兰氏阴性细菌有用的抗菌活性的SF-1623物质的新抗生素。当在有氧条件下在碱金属硫代硫酸盐存在下进行培养时，可以从培养物中回收其碱金属盐形式的SF-1623物质。

38. 发明申请

US20120248190A1 CODE READING APPARATUS AND COMPUTER PROGRAM PRODUCT 有权
标题翻译：代码阅读器和计算机程序产品
公开(公告)号：US20120248190A1
公开(公告)日：2012-10-04
申请号：US13434246
申请日：2012-03-29
申请人： Yasuaki OGAWA , Keiichi Tanioka
发明人： Yasuaki OGAWA , Keiichi Tanioka
IPC分类号： G06K7/10
CPC分类号： G06K7/10811 , G02B7/36 , G02B26/10 , G03B3/10
摘要： Disclosed is a code reading apparatus including: a storage section storing an applied voltage table showing a relationship between a focal distance of a liquid lens and an applied voltage to the liquid lens; a laser focus section performing laser focus adjustment; a contrast focus section performing contrast focus adjustment; and a correction section correcting a content of the applied voltage table based on a distance from the liquid lens to a subject found by the laser focus section and a corresponding applied voltage with which the subject is brought into focus by the contrast focus section.
摘要翻译：一种代码读取装置，包括：存储部，其存储施加的电压表，其表示液体透镜的焦距与施加的电压对液体透镜的关系; 进行激光聚焦调整的激光对焦部; 执行对比度聚焦调整的对比度焦点部分; 以及校正部，其基于从所述激光聚焦部发现的从所述液体透镜到所述被摄体的距离，以及由所述对比度聚焦部使所述被摄体对焦的对应的施加电压来校正所施加的电压表的内容。

39. 发明申请

US20120141556A1 LYOPHILIZING COMPOSITION OF DRUG-ENCAPSULATING POLYMER MICELLE AND METHOD FOR PREPARATION THEREOF 审中-公开
标题翻译：杀虫胶囊组合物的制备及其制备方法
公开(公告)号：US20120141556A1
公开(公告)日：2012-06-07
申请号：US13358025
申请日：2012-01-25
申请人： Yasuaki OGAWA , Shoko Nagasaki , Yoshihiko Nogata , Katsuhiko Sagawa , Chieko Tsuchiya
发明人： Yasuaki OGAWA , Shoko Nagasaki , Yoshihiko Nogata , Katsuhiko Sagawa , Chieko Tsuchiya
IPC分类号： A61K9/00
CPC分类号： A61K47/36 , A61K9/1075 , A61K9/127 , A61K9/19 , A61K31/337 , A61K31/343 , A61K33/24 , A61K47/10 , A61K47/26
摘要： Provided are a composition for preparing a lyophilized preparation, comprising a drug-encapsulating polymer micelle and saccharides and/or polyethylene glycol as a stabilizing agent, a lyophilized preparation and a process for producing them. The lyophilized preparation thus provided is easily restructured to an aqueous preparation using an aqueous medium.
摘要翻译：提供一种用于制备冻干制剂的组合物，其包含药物包封的聚合物胶束和作为稳定剂的糖和/或聚乙二醇，冻干制剂及其制备方法。由此提供的冻干制剂使用水性介质容易地重组成含水制剂。

40. 发明申请

US20110220719A1 BARCODE READING APPARATUS AND COMPUTER PROGRAM PRODUCT 有权
标题翻译：条形码读取装置和计算机程序产品
公开(公告)号：US20110220719A1
公开(公告)日：2011-09-15
申请号：US13038595
申请日：2011-03-02
申请人： Yasuaki Ogawa , Keiichi Tanioka
发明人： Yasuaki Ogawa , Keiichi Tanioka
IPC分类号： G06K7/14 , G06K5/00 , G06K7/01
CPC分类号： G06K7/10811 , G02B3/14 , G06K7/10712 , G06K7/10861
摘要： Disclosed is a barcode reading apparatus including: a variable focus lens in which a focus position can be adjusted at a high speed according to applied voltage; an imaging section to generate image data by imaging a barcode through the variable focus lens; a control section to change a focus position of the variable focus lens and to obtain image data of a plurality of image areas with different focus positions in one frame from the imaging section when image data of one frame is obtained from the imaging section; and a decoding section to decode a barcode image included in the image data of the plurality of image areas obtained by the control section.
摘要翻译：公开了一种条形码读取装置，包括：可变焦距透镜，其中聚焦位置可以根据施加的电压高速调节; 成像部分，用于通过可变焦距透镜对条形码进行成像来产生图像数据; 控制部分，当从所述成像部分获得一帧的图像数据时，改变所述可变焦距透镜的焦点位置并从所述成像部分获得具有不同焦点位置的多个图像区域的图像数据; 以及解码部，对由所述控制部获得的所述多个图像区域的图像数据中包含的条形码图像进行解码。

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