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31. 发明公开

US20240198037A1 CATHETER WITH VAPOR DEPOSITED FEATURES ON TIP 审中-公开
公开(公告)号：US20240198037A1
公开(公告)日：2024-06-20
申请号：US18595054
申请日：2024-03-04
申请人： Shubhayu Basu , Dustin R. Tobey , Pieter E. Van Niekerk , Cesar Fuentes-Ortega
发明人： Shubhayu Basu , Dustin R. Tobey , Pieter E. Van Niekerk , Cesar Fuentes-Ortega
IPC分类号： A61M25/00 , A61B17/00 , A61B18/00 , A61B18/14 , A61B90/00
CPC分类号： A61M25/0009 , A61B90/06 , A61B2017/00526 , A61B2018/00083 , A61B2018/00577 , A61B2018/00619 , A61B2018/00821 , A61B18/1492 , A61B2090/064 , A61B2562/0261
摘要： A method is used to manufacture a surgical instrument. The surgical instrument includes a catheter and an end effector extending distally from the catheter. The method includes forming at least one electrode, sensor, or thermocouple onto the catheter or the end effector of the surgical instrument by etching or vapor depositing a three-dimensional structure onto a non-conductive material that is layered over a super elastic material.

32. 发明授权

US08784894B2 Methods and devices for forming treatment agent carriers 有权
标题翻译：用于形成治疗剂载体的方法和装置
公开(公告)号：US08784894B2
公开(公告)日：2014-07-22
申请号：US11485934
申请日：2006-07-12
申请人： Shubhayu Basu , Eugene T. Michal
发明人： Shubhayu Basu , Eugene T. Michal
IPC分类号： A61K38/18 , A61K9/14
CPC分类号： A61K9/4833 , A61K9/145 , A61K9/5031 , A61K38/30
摘要： A method is described including passing a solution having a biodegradable polymer, a solvent and a treatment agent through an electrocharged nozzle to form particles encapsulating the treatment agent. The particles emitted from the electrocharged nozzle may be exposed to a charge opposite that of the nozzle. The particles may be deposited in a collection assembly comprising a liquid phase. A further method including combining a biodegradable polymer, a solvent and a treatment agent to form a solution, electrodepositing the solution in a particle form wherein the particles encapsulate the treatment agent in a collection assembly comprising a liquid phase and mixing the particles with a bioerodable material capable of forming a gel is described. An apparatus having an electrocharged nozzle, a grounded electrode having an opposite charge to that of the nozzle and a collection assembly comprising a liquid phase is further disclosed.
摘要翻译：描述了一种方法，包括使具有可生物降解的聚合物，溶剂和处理剂的溶液通过电荷注入喷嘴以形成包封处理剂的颗粒。从电荷喷嘴发射的颗粒可以暴露于与喷嘴相反的电荷。颗粒可以沉积在包含液相的收集组件中。另一种方法包括组合可生物降解聚合物，溶剂和处理剂以形成溶液，以颗粒形式电沉积溶液，其中颗粒将包含液相的收集组合物包封处理剂并将颗粒与可生物侵蚀的材料混合描述了形成凝胶的能力。具有电荷喷嘴的设备，具有与喷嘴相反的电荷的接地电极和包括液相的收集组件进一步被公开。

33. 发明授权

US08388948B2 Cytocompatible alginate gels 有权
标题翻译：细胞相容性藻酸盐凝胶
公开(公告)号：US08388948B2
公开(公告)日：2013-03-05
申请号：US13525158
申请日：2012-06-15
申请人： Shubhayu Basu , Gene Michal , Florian Ludwig , Jinping Wan , John Stankus
发明人： Shubhayu Basu , Gene Michal , Florian Ludwig , Jinping Wan , John Stankus
IPC分类号： A01N63/00 , C12N5/071
CPC分类号： A61L27/52 , A61L27/20 , A61L27/3604 , A61L27/3641 , A61L27/365 , A61L27/3804 , A61L27/3839 , C08L5/04
摘要： The present invention relates to a method of making cytocompatible alginate gels and their use in the treatment of cardiomyopathy.
摘要翻译：本发明涉及一种制备细胞相容性藻酸盐凝胶的方法及其在治疗心肌病中的应用。

34. 发明授权

US08293226B1 Cytocompatible alginate gels 有权
公开(公告)号：US08293226B1
公开(公告)日：2012-10-23
申请号：US13525165
申请日：2012-06-15
申请人： Shubhayu Basu , Gene Michal , Florian Ludwig , Jinping Wan , John Stankus
发明人： Shubhayu Basu , Gene Michal , Florian Ludwig , Jinping Wan , John Stankus
IPC分类号： A01N63/00
CPC分类号： A61L27/52 , A61L27/20 , A61L27/3604 , A61L27/3641 , A61L27/365 , A61L27/3804 , A61L27/3839 , C08L5/04
摘要： The present invention relates to a method of making cytocompatible alginate gels and their use in the treatment of cardiomyopathy.

35. 发明申请

US20120251508A1 CYTOCOMPATIBLE ALGINATE GELS 有权
标题翻译：可溶性胶原凝胶
公开(公告)号：US20120251508A1
公开(公告)日：2012-10-04
申请号：US13525158
申请日：2012-06-15
申请人： Shubhayu Basu , Gene Michal , Florian Ludwig , Jinping Wan , John Stankus
发明人： Shubhayu Basu , Gene Michal , Florian Ludwig , Jinping Wan , John Stankus
IPC分类号： A61K35/12 , A61K35/34 , A61P9/00 , A61K35/22 , A61K35/38 , A61K35/28 , A61K35/32
CPC分类号： A61L27/52 , A61L27/20 , A61L27/3604 , A61L27/3641 , A61L27/365 , A61L27/3804 , A61L27/3839 , C08L5/04
摘要： The present invention relates to a method of making cytocompatible alginate gels and their use in the treatment of cardiomyopathy.
摘要翻译：本发明涉及一种制备细胞相容性藻酸盐凝胶的方法及其在治疗心肌病中的应用。

36. 发明申请

US20120041257A1 APPARATUS AND METHODS FOR SUPPORTING CARDIAC ISCHEMIC TISSUE 有权
标题翻译：用于支持心脏组织化学组织的装置和方法
公开(公告)号：US20120041257A1
公开(公告)日：2012-02-16
申请号：US12855469
申请日：2010-08-12
申请人： John J. Stankus , Barbara E. Stamberg , Pamela A. Kramer-Brown , Jesus Magana , Shubhayu Basu , Yuet Mei Khong , Florian N. Ludwig
发明人： John J. Stankus , Barbara E. Stamberg , Pamela A. Kramer-Brown , Jesus Magana , Shubhayu Basu , Yuet Mei Khong , Florian N. Ludwig
IPC分类号： A61F2/00
CPC分类号： A61F2/2487 , A61B17/064 , A61B17/068 , A61B17/12122 , A61B17/12181 , A61B17/12186 , A61B17/12195 , A61B2017/0647 , A61L2430/20
摘要： Apparatus and methods are disclosed for supporting ischemic tissue of the heart using scaffolds that may be placed within the heart percutaneously. A scaffold assembly may include a layer of biocompatible material detachably secured to a placement rod, such that the placement rod may be used to urge the layer of biocompatible material through a catheter to adjacent an area of ischemic tissue. Anchors may secure the layer of material to the myocardium. Multiple layers of biocompatible material may be placed in the ventricle separately to form the scaffold. In some embodiments, a scaffold is formed or reinforced by injecting a polymer, such as a visco-elastic foam, around an inflatable member inflated within a ventricle.
摘要翻译：公开了用于支持心脏的缺血组织的装置和方法，所述支架可以经皮放置在心脏内的支架。支架组件可以包括可拆卸地固定到放置杆的生物相容性材料层，使得放置杆可以用于通过导管将生物相容性材料层推动到邻近缺血组织的区域。锚固体可以将材料层固定到心肌。可以将多层生物相容性材料分别放置在心室中以形成支架。在一些实施方案中，通过将聚合物（例如粘弹性泡沫）注射到在心室内膨胀的可充气构件的周围形成或增强支架。

37. 发明申请

US20100004627A1 NEEDLE CATHETER WITH AN ANGLED DISTAL TIP LUMEN 有权
标题翻译：带有远距离提示灯的针式导管
公开(公告)号：US20100004627A1
公开(公告)日：2010-01-07
申请号：US12167791
申请日：2008-07-03
申请人： Florian N. Ludwig , Shubhayu Basu
发明人： Florian N. Ludwig , Shubhayu Basu
IPC分类号： A61M25/00 , A61M5/32
CPC分类号： A61M25/0068 , A61M25/0074 , A61M25/0084 , A61M2025/0081 , A61M2025/009
摘要： A needle catheter configured for injecting an agent into a wall of a patient's body cavity, which directs a needle from the distal tip of the catheter into the wall of the body cavity at an angle relative to the axis of the shaft. The resulting angled injection pathway improves the retention of the agent in the body cavity wall, while keeping a distal section of the catheter substantially perpendicular to the body cavity wall for optimal push against the tissue at the injection site.
摘要翻译：一种针导管，其构造成用于将药剂注射到患者体腔的壁中，其将针从导管的远侧末端引导到相对于轴的轴线成一定角度的体腔的壁中。所产生的角度注射通道改善了药剂在体腔壁中的保留性，同时保持导管的远端部分基本上垂直于体腔壁，以最佳地推动注射部位处的组织。

38. 发明申请

US20090075933A1 CYTOCOMPATIBLE ALGINATE GELS 有权
标题翻译：可溶性胶原凝胶
公开(公告)号：US20090075933A1
公开(公告)日：2009-03-19
申请号：US11857878
申请日：2007-09-19
申请人： Shubhayu Basu , Gene Michal , Florian Ludwig , Jinping Wan , John Stankus
发明人： Shubhayu Basu , Gene Michal , Florian Ludwig , Jinping Wan , John Stankus
IPC分类号： A61K31/715 , A61P9/00 , C07H1/00 , C12P19/04
CPC分类号： A61L27/52 , A61L27/20 , A61L27/3604 , A61L27/3641 , A61L27/365 , A61L27/3804 , A61L27/3839 , C08L5/04
摘要： The present invention relates to a method of making cytocompatible alginate gels and their use in the treatment of cardiomyopathy.
摘要翻译：本发明涉及一种制备细胞相容性藻酸盐凝胶的方法及其在治疗心肌病中的应用。

39. 发明申请

US20090035381A1 ELECTROSPRAYING METHOD FOR FABRICATION OF PARTICLES AND COATINGS AND TREATMENT METHODS THEREOF 审中-公开
标题翻译：用于制备颗粒和涂层的电喷涂方法及其处理方法
公开(公告)号：US20090035381A1
公开(公告)日：2009-02-05
申请号：US11832257
申请日：2007-08-01
申请人： John J. Stankus , Shubhayu Basu
发明人： John J. Stankus , Shubhayu Basu
IPC分类号： A61K47/30 , A61K38/18 , A61K9/14 , B29B13/08 , B29B9/00
CPC分类号： A61K9/0024 , A61K9/5031 , A61K9/5073 , A61K9/5089 , B05B5/001 , B05B5/025
摘要： Electrospray systems and modified electrospray systems for the fabrication of core-shell particles for controlled-release and/or sustained-release treatment and delivery are herein disclosed. The electrospray system may include between one and a plurality of co-axially situated tubes. Each tube may be electrically connected to a power supply wherein a voltage may be applied thereto. Core-shell particles may be collected on a collection target, which may be a wet or dry collector, and electrically connected to the power supply. Core-shell particles and methods of manufacture are also disclosed. The precursors of the core-shell particles may be polymer- or biomacromolecule-based solutions and may include at least one treatment agent incorporated therein. The number of “core” particle(s) within the “shell” may vary and may provide different treatment agent release profiles depending on the material and/or chemical characteristics of the polymer and/or biomacromolecule used. Methods of treating a condition are also disclosed. A treatment may include delivery of a plurality of core-shell particles which include a treatment agent to a treatment site. Delivery may be performed by a surgical procedure or by a non-invasive procedure such as catheter delivery.
摘要翻译：本文公开了用于制备用于控制释放和/或持续释放处理和递送的核 - 壳颗粒的电喷雾系统和改进的电喷雾系统。电喷雾系统可以包括在一个和多个同轴位于的管之间。每个管可以电连接到电源，其中可以施加电压。核 - 壳颗粒可以收集在收集目标上，其可以是湿的或干的收集器，并且电连接到电源。还公开了核 - 壳颗粒和制造方法。核 - 壳颗粒的前体可以是基于聚合物或生物大分子的溶液，并且可以包括并入其中的至少一种处理剂。 “壳”内的“芯”颗粒的数量可以变化，并且可以根据所使用的聚合物和/或生物大分子的材料和/或化学特性提供不同的处理剂释放曲线。还公开了治疗病症的方法。治疗可以包括将包括治疗剂的多个核 - 壳颗粒递送到治疗部位。可以通过外科手术或非侵入性手术（例如导管递送）进行输送。

40. 发明申请

US20080014276A1 Methods and devices for forming treatment agent carriers 有权
标题翻译：用于形成治疗剂载体的方法和装置
公开(公告)号：US20080014276A1
公开(公告)日：2008-01-17
申请号：US11485934
申请日：2006-07-12
申请人： Shubhayu Basu , Eugene T. Michal
发明人： Shubhayu Basu , Eugene T. Michal
IPC分类号： A61K38/18 , A61K9/14
CPC分类号： A61K9/4833 , A61K9/145 , A61K9/5031 , A61K38/30
摘要： A method is described including passing a solution having a biodegradable polymer, a solvent and a treatment agent through an electrocharged nozzle to form particles encapsulating the treatment agent. The particles emitted from the electrocharged nozzle may be exposed to a charge opposite that of the nozzle. The particles may be deposited in a collection assembly comprising a liquid phase. A further method including combining a biodegradable polymer, a solvent and a treatment agent to form a solution, electrodepositing the solution in a particle form wherein the particles encapsulate the treatment agent in a collection assembly comprising a liquid phase and mixing the particles with a bioerodable material capable of forming a gel is described. An apparatus having an electrocharged nozzle, a grounded electrode having an opposite charge to that of the nozzle and a collection assembly comprising a liquid phase is further disclosed.
摘要翻译：描述了一种方法，包括使具有可生物降解的聚合物，溶剂和处理剂的溶液通过电荷注入喷嘴以形成包封处理剂的颗粒。从电荷喷嘴发射的颗粒可以暴露于与喷嘴相反的电荷。颗粒可以沉积在包含液相的收集组件中。另一种方法包括组合可生物降解聚合物，溶剂和处理剂以形成溶液，以颗粒形式电沉积溶液，其中颗粒将包含液相的收集组合物包封处理剂并将其与生物可蚀塑料混合描述了形成凝胶的能力。具有电荷喷嘴的设备，具有与喷嘴相反的电荷的接地电极和包括液相的收集组件进一步被公开。

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