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1. 发明授权

US09005672B2 Methods of modifying myocardial infarction expansion 有权
标题翻译：改变心肌梗死扩张的方法
公开(公告)号：US09005672B2
公开(公告)日：2015-04-14
申请号：US12016180
申请日：2008-01-17
申请人： Eugene T. Michal , Shubhayu Basu , Alexander J. Sheehy , Francis G. Spinale , Rupak Mukherjee
发明人： Eugene T. Michal , Shubhayu Basu , Alexander J. Sheehy , Francis G. Spinale , Rupak Mukherjee
IPC分类号： A61K33/06 , A61L27/52 , A61L27/20 , A61L27/22 , A61L27/26 , A61L27/50
CPC分类号： A61L27/26 , A61L27/20 , A61L27/22 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L2300/418 , A61L2300/64 , A61L2400/06 , A61L2430/20 , C08L5/04 , C08L89/00
摘要： A bioscaffolding can be formed within a post-myocardial infarct region sufficient to cause attenuation of a rate of myocardial infarct expansion. A bioscaffolding may further be formed in the post-myocardial infarct region to cause an increase in posterior left ventricular wall thickness. The gel or bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture.
摘要翻译：可以在足以引起心肌梗死扩张速率衰减的后心肌梗死区域中形成生物支架。在心肌梗死后区域可进一步形成生物支架，引起左后壁壁厚度增加。凝胶或生物支架可以由不同凝胶化系统的凝胶组分的混合物形成。例如，生物支架可以通过混合至少两种不同的双组分凝胶化体系的至少两种不同组分形成第一混合物并通过混合至少两种不同组分（构成第一混合物的组分）的至少两种不同的双组分凝胶化体系以形成第二混合物。

2. 发明申请

US20090022817A1 METHODS OF MODIFYING MYOCARDIAL INFARCTION EXPANSION 有权
标题翻译：改善心肌梗塞扩张的方法
公开(公告)号：US20090022817A1
公开(公告)日：2009-01-22
申请号：US12016180
申请日：2008-01-17
申请人： Eugene T. Michal , Shubhayu Basu , Alexander J. Sheehy , Francis G. Spinale , Rupak Mukherjee
发明人： Eugene T. Michal , Shubhayu Basu , Alexander J. Sheehy , Francis G. Spinale , Rupak Mukherjee
IPC分类号： A61K33/14 , C12N5/06 , A61P9/00
CPC分类号： A61L27/26 , A61L27/20 , A61L27/22 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L2300/418 , A61L2300/64 , A61L2400/06 , A61L2430/20 , C08L5/04 , C08L89/00
摘要： A bioscaffolding can be formed within a post-myocardial infarct region sufficient to cause attenuation of a rate of myocardial infarct expansion. A bioscaffolding may further be formed in the post-myocardial infarct region to cause an increase in posterior left ventricular wall thickness. The gel or bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture.
摘要翻译：可以在足以引起心肌梗死扩张速率衰减的后心肌梗死区域中形成生物支架。在心肌梗死后区域可进一步形成生物支架，引起左后壁壁厚度增加。凝胶或生物支架可以由不同凝胶化系统的凝胶组分的混合物形成。例如，生物支架可以通过混合至少两种不同的双组分凝胶化体系的至少两种不同组分形成第一混合物并通过混合至少两种不同组分（构成第一混合物的组分）的至少两种不同的双组分凝胶化体系以形成第二混合物。

3. 发明申请

US20150017265A9 METHODS OF MODIFYING MYOCARDIAL INFARCTION EXPANSION 有权
公开(公告)号：US20150017265A9
公开(公告)日：2015-01-15
申请号：US12016180
申请日：2008-01-17
申请人： Eugene T. Michal , Shubhayu Basu , Alexander J. Sheehy , Francis G. Spinale , Rupak Mukherjee
发明人： Eugene T. Michal , Shubhayu Basu , Alexander J. Sheehy , Francis G. Spinale , Rupak Mukherjee
IPC分类号： A61K33/14 , A61P9/00 , C12N5/06
CPC分类号： A61L27/26 , A61L27/20 , A61L27/22 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L2300/418 , A61L2300/64 , A61L2400/06 , A61L2430/20 , C08L5/04 , C08L89/00
摘要： A bioscaffolding can be formed within a post-myocardial infarct region sufficient to cause attenuation of a rate of myocardial infarct expansion. A bioscaffolding may further be formed in the post-myocardial infarct region to cause an increase in posterior left ventricular wall thickness. The gel or bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture.

4. 发明授权

US08784894B2 Methods and devices for forming treatment agent carriers 有权
标题翻译：用于形成治疗剂载体的方法和装置
公开(公告)号：US08784894B2
公开(公告)日：2014-07-22
申请号：US11485934
申请日：2006-07-12
申请人： Shubhayu Basu , Eugene T. Michal
发明人： Shubhayu Basu , Eugene T. Michal
IPC分类号： A61K38/18 , A61K9/14
CPC分类号： A61K9/4833 , A61K9/145 , A61K9/5031 , A61K38/30
摘要： A method is described including passing a solution having a biodegradable polymer, a solvent and a treatment agent through an electrocharged nozzle to form particles encapsulating the treatment agent. The particles emitted from the electrocharged nozzle may be exposed to a charge opposite that of the nozzle. The particles may be deposited in a collection assembly comprising a liquid phase. A further method including combining a biodegradable polymer, a solvent and a treatment agent to form a solution, electrodepositing the solution in a particle form wherein the particles encapsulate the treatment agent in a collection assembly comprising a liquid phase and mixing the particles with a bioerodable material capable of forming a gel is described. An apparatus having an electrocharged nozzle, a grounded electrode having an opposite charge to that of the nozzle and a collection assembly comprising a liquid phase is further disclosed.
摘要翻译：描述了一种方法，包括使具有可生物降解的聚合物，溶剂和处理剂的溶液通过电荷注入喷嘴以形成包封处理剂的颗粒。从电荷喷嘴发射的颗粒可以暴露于与喷嘴相反的电荷。颗粒可以沉积在包含液相的收集组件中。另一种方法包括组合可生物降解聚合物，溶剂和处理剂以形成溶液，以颗粒形式电沉积溶液，其中颗粒将包含液相的收集组合物包封处理剂并将颗粒与可生物侵蚀的材料混合描述了形成凝胶的能力。具有电荷喷嘴的设备，具有与喷嘴相反的电荷的接地电极和包括液相的收集组件进一步被公开。

5. 发明申请

US20080014276A1 Methods and devices for forming treatment agent carriers 有权
标题翻译：用于形成治疗剂载体的方法和装置
公开(公告)号：US20080014276A1
公开(公告)日：2008-01-17
申请号：US11485934
申请日：2006-07-12
申请人： Shubhayu Basu , Eugene T. Michal
发明人： Shubhayu Basu , Eugene T. Michal
IPC分类号： A61K38/18 , A61K9/14
CPC分类号： A61K9/4833 , A61K9/145 , A61K9/5031 , A61K38/30
摘要： A method is described including passing a solution having a biodegradable polymer, a solvent and a treatment agent through an electrocharged nozzle to form particles encapsulating the treatment agent. The particles emitted from the electrocharged nozzle may be exposed to a charge opposite that of the nozzle. The particles may be deposited in a collection assembly comprising a liquid phase. A further method including combining a biodegradable polymer, a solvent and a treatment agent to form a solution, electrodepositing the solution in a particle form wherein the particles encapsulate the treatment agent in a collection assembly comprising a liquid phase and mixing the particles with a bioerodable material capable of forming a gel is described. An apparatus having an electrocharged nozzle, a grounded electrode having an opposite charge to that of the nozzle and a collection assembly comprising a liquid phase is further disclosed.
摘要翻译：描述了一种方法，包括使具有可生物降解的聚合物，溶剂和处理剂的溶液通过电荷注入喷嘴以形成包封处理剂的颗粒。从电荷喷嘴发射的颗粒可以暴露于与喷嘴相反的电荷。颗粒可以沉积在包含液相的收集组件中。另一种方法包括组合可生物降解聚合物，溶剂和处理剂以形成溶液，以颗粒形式电沉积溶液，其中颗粒将包含液相的收集组合物包封处理剂并将其与生物可蚀塑料混合描述了形成凝胶的能力。具有电荷喷嘴的设备，具有与喷嘴相反的电荷的接地电极和包括液相的收集组件进一步被公开。

6. 发明授权

US08747385B2 Methods and compositions to treat myocardial conditions 失效
公开(公告)号：US08747385B2
公开(公告)日：2014-06-10
申请号：US13468956
申请日：2012-05-10
申请人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
发明人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
IPC分类号： A61M31/00
CPC分类号： A61K9/0019 , A61K9/0024 , A61K31/7088
摘要： Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.

7. 发明授权

US08673332B2 Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens 有权
标题翻译：将水溶性或水不溶性治疗剂局部输送到体腔表面
公开(公告)号：US08673332B2
公开(公告)日：2014-03-18
申请号：US13560538
申请日：2012-07-27
申请人： Eugene T. Michal , Daniel J. Lerner , Matthew J. Pollman
发明人： Eugene T. Michal , Daniel J. Lerner , Matthew J. Pollman
IPC分类号： A61F13/00 , A61K9/00
CPC分类号： A61L29/085 , A61K9/0024 , A61L29/141 , A61L29/16 , A61L2300/216 , A61L2420/02 , A61L2420/06 , A61M25/104 , A61M2025/105 , A61M2025/1075
摘要： A method and device for local delivery of water-soluble or water-insoluble therapeutic agents to the surface of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with an amphiphilic polymer coating comprising a therapeutic agent and an amphiphilic polymer or co-polymer. The medical disposable device is inserted into a body lumen, and expanded to contact the amphiphilic polymer coating against the body lumen. The total solubility of the polymer or co-polymer in vivo prevents any embolic hazard associated with the amphiphilic polymer coating.
摘要翻译：公开了一种将水溶性或水不溶性治疗剂局部递送到正常或患病体腔表面的方法和装置。医疗一次性装置（例如球囊导管的球囊）的可膨胀结构用包含治疗剂和两亲性聚合物或共聚物的两亲性聚合物涂层涂覆。将医疗一次性装置插入体腔中，并膨胀以使两亲性聚合物涂层抵靠体腔接触。聚合物或共聚物在体内的总溶解度可防止与两亲性聚合物涂层相关的任何栓塞危险。

8. 发明授权

US08658194B2 Coatings for implantable medical devices comprising hydrophilic substances and methods for fabricating the same 有权
标题翻译：包含亲水物质的可植入医疗装置用涂料及其制造方法
公开(公告)号：US08658194B2
公开(公告)日：2014-02-25
申请号：US12909668
申请日：2010-10-21
申请人： Thierry Glauser , Connie S. Kwok , Charles D. Claude , Eugene T. Michal , Yiwen Tang , Irina Astafieva , John Whatley , Stephen D. Pacetti , Ashok Shah
发明人： Thierry Glauser , Connie S. Kwok , Charles D. Claude , Eugene T. Michal , Yiwen Tang , Irina Astafieva , John Whatley , Stephen D. Pacetti , Ashok Shah
IPC分类号： A61F13/00
CPC分类号： A61L31/16 , A61F2250/0067 , A61L31/10 , A61L2300/252 , A61L2300/606 , C08L75/04
摘要： A segmented polyurethane and an amphiphilic random or block copolymer are disclosed. The segmented polyurethane and the amphiphilic random or block copolymer can be used for fabricating a coating for an implantable medical device such as a stent.
摘要翻译：公开了一种分段聚氨酯和两亲无规或嵌段共聚物。分段聚氨酯和两亲无规或嵌段共聚物可用于制造可植入医疗装置例如支架的涂层。

9. 发明授权

US08608661B1 Method for intravascular delivery of a treatment agent beyond a blood vessel wall 有权
标题翻译：血管内递送治疗剂超过血管壁的方法
公开(公告)号：US08608661B1
公开(公告)日：2013-12-17
申请号：US10792960
申请日：2004-03-03
申请人： Evgenia Mandrusov , Eugene T. Michal
发明人： Evgenia Mandrusov , Eugene T. Michal
IPC分类号： A61B8/00
CPC分类号： A61B5/6852 , A61B5/0066 , A61B5/02007 , A61B5/4839 , A61B17/3478 , A61B2017/00247 , A61B2017/22082 , A61B2090/3735 , Y10S977/905 , Y10S977/915
摘要： A method including positioning a delivery device at a location in a blood vessel; advancing the delivery device a distance into a wall of the blood vessel to a treatment site beyond an external elastic lamina of the blood vessel; and after advancing the delivery device, introducing a treatment agent including a cellular component through the delivery device. A composition including a treatment agent comprising a cellular component associated with a matrix material, wherein the composition is suitable for percutaneous delivery. Also an apparatus suitable for delivering a treatment agent. Also, a kit including a treatment agent.
摘要翻译：一种包括将输送装置定位在血管中的位置的方法; 将输送装置推进到血管壁的距离超过血管的外部弹性层的治疗部位; 并且在推进传送装置之后，通过传送装置引入包括蜂窝部件的处理剂。一种组合物，其包含包含与基质材料相关的细胞成分的处理剂，其中所述组合物适于经皮递送。也是适用于递送治疗剂的装置。另外，还可以使用包含处理剂的试剂盒。

10. 发明授权

US08563023B2 Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens 有权
标题翻译：将水溶性或水不溶性治疗剂局部输送到体腔表面
公开(公告)号：US08563023B2
公开(公告)日：2013-10-22
申请号：US13310320
申请日：2011-12-02
申请人： Eugene T. Michal , Daniel J. Lerner , Matthew J. Pollman
发明人： Eugene T. Michal , Daniel J. Lerner , Matthew J. Pollman
IPC分类号： A61F13/00 , A61L31/12
CPC分类号： A61L31/128 , A61K9/70 , A61K31/337 , A61K47/02 , A61L29/085 , A61L29/10 , A61L29/141 , A61L29/148 , A61L29/16 , A61L2300/106 , A61L2300/416 , A61L2300/42 , A61L2300/606
摘要： A method and device for local delivery of water-soluble or water-insoluble therapeutic agents to the tissue of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with a non-durable coating which is complexed with iodine and has a substantially water-insoluble therapeutic agent dispersed therein. The medical disposable device is inserted into a body lumen, and expanded to contact the non-durable coating against the body lumen and deliver the substantially water-insoluble therapeutic agent to the body lumen tissue.
摘要翻译：公开了将水溶性或水不溶性治疗剂局部递送至正常或患病体腔组织的方法和装置。医疗一次性装置（例如球囊导管的球囊）的可膨胀结构涂覆有与碘络合的非耐久涂层，并且其中分散有基本上不溶于水的治疗剂。将医疗一次性装置插入体腔中，并且膨胀以将非耐久涂层接触体腔，并将基本上不溶于水的治疗剂输送到体腔组织。

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