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31. 发明授权

US07396915B2 Monoclonal antibody and gene encoding the same, hybridoma, pharmaceutical composition, and diagnostic reagent 失效
标题翻译：单克隆抗体和编码相同的基因，杂交瘤，药物组合物和诊断试剂
公开(公告)号：US07396915B2
公开(公告)日：2008-07-08
申请号：US10546594
申请日：2004-02-27
申请人： Saiko Hosokawa , Masahiko Aoki , Yoko Hirakawa , Seima Itami , Hiroe Umeki , Yoshiro Saikawa , Koichiro Kumai , Kazumasa Fukuda
发明人： Saiko Hosokawa , Masahiko Aoki , Yoko Hirakawa , Seima Itami , Hiroe Umeki , Yoshiro Saikawa , Koichiro Kumai , Kazumasa Fukuda
IPC分类号： C07K16/00
CPC分类号： G01N33/57442 , A61K47/6857 , A61K47/6913 , C07K16/30 , C07K2317/73 , G01N33/57423
摘要： A novel human monoclonal antibody specifically recognizing cancer cells such as non-small cell lung cancer, pancreatic cancer and gastric cancer cells is produced by hybridomas which are obtained by fusing lymphocytes derived from a cancer tissue of a cancer patient with mouse myeloma cells. An anti-cancer drug is obtained by using the antibody alone or anchoring the antibody on the surface of a liposome containing a toxin or an anti-cancer drug encapsulated therein. More specifically, an anti-cancer drug is obtained by using an antibody, in which variable region of its heavy chain comprises the amino acid sequence of SEQ ID NO: 115 and variable region of the light chain comprises the amino acid sequence of SEQ ID NO: 117, alone or anchoring the antibody on the surface of a liposome containing a toxin or an anti-cancer drug encapsulated therein.
摘要翻译：通过将衍生自癌症患者的癌症组织的淋巴细胞与小鼠骨髓瘤细胞融合获得的杂交瘤产生特异性识别癌细胞例如非小细胞肺癌，胰腺癌和胃癌细胞的新型人单克隆抗体。通过单独使用抗体或将抗体锚定在包含毒素或其中的抗癌药物的脂质体的表面上来获得抗癌药物。更具体地，通过使用抗体，其重链的可变区包含SEQ ID NO：115的氨基酸序列并且轻链的可变区包含SEQ ID NO的氨基酸序列：117单独或将抗体锚定在包含其中的毒素或抗癌药物的脂质体的表面上。

32. 发明申请

US20060088538A1 Monoclonal antibody and gene encoding the same, hybridoma, pharmaceutical composition, and diagnostic reagent 失效
标题翻译：单克隆抗体和编码相同的基因，杂交瘤，药物组合物和诊断试剂
公开(公告)号：US20060088538A1
公开(公告)日：2006-04-27
申请号：US10546594
申请日：2004-02-27
申请人： Saiko Hosokawa , Masahiko Aoki , Yoko Hirakawa , Seima Itami , Hiroe Umeki , Yoshiro Saikawa , Koichiro Kumai , Kazumasa Fukuda
发明人： Saiko Hosokawa , Masahiko Aoki , Yoko Hirakawa , Seima Itami , Hiroe Umeki , Yoshiro Saikawa , Koichiro Kumai , Kazumasa Fukuda
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K16/30
CPC分类号： G01N33/57442 , A61K47/6857 , A61K47/6913 , C07K16/30 , C07K2317/73 , G01N33/57423
摘要： A novel human monoclonal antibody specifically recognizing cancer cells such as non-small cell lung cancer, pancreatic cancer and gastric cancer cells is produced by hybridomas which are obtained by fusing lymphocytes derived from a cancer tissue of a cancer patient with mouse myeloma cells. An anti-cancer drug is obtained by using the antibody alone or anchoring the antibody on the surface of a liposome containing a toxin or an anti-cancer drug encapsulated therein. More specifically, an anti-cancer drug is obtained by using an antibody, in which variable region of its heavy chain comprises the amino acid sequence of SEQ ID NO: 115 and variable region of the light chain comprises the amino acid sequence of SEQ ID NO: 117, alone or anchoring the antibody on the surface of a liposome containing a toxin or an anti-cancer drug encapsulated therein.
摘要翻译：通过将衍生自癌症患者的癌症组织的淋巴细胞与小鼠骨髓瘤细胞融合获得的杂交瘤产生特异性识别癌细胞例如非小细胞肺癌，胰腺癌和胃癌细胞的新型人单克隆抗体。通过单独使用抗体或将抗体锚定在包含毒素或其中的抗癌药物的脂质体的表面上来获得抗癌药物。更具体地，通过使用抗体，其重链的可变区包含SEQ ID NO：115的氨基酸序列并且轻链的可变区包含SEQ ID NO的氨基酸序列：117单独或将抗体锚定在包含其中的毒素或抗癌药物的脂质体的表面上。

33. 发明授权

US06810578B1 Method of manufacturing thin film magnetic head with improved performance 失效
标题翻译：具有改进性能的薄膜磁头制造方法
公开(公告)号：US06810578B1
公开(公告)日：2004-11-02
申请号：US09650690
申请日：2000-08-30
申请人： Yoshitaka Sasaki , Atsushi Iijima , Kazumasa Fukuda
发明人： Yoshitaka Sasaki , Atsushi Iijima , Kazumasa Fukuda
IPC分类号： G11B5127
CPC分类号： G11B5/3967 , G11B5/3116 , G11B5/313 , G11B5/3163 , Y10T29/49021 , Y10T29/49032 , Y10T29/49034 , Y10T29/49044 , Y10T29/49046 , Y10T29/4906
摘要： A method of manufacturing a thin film magnetic head. The method includes forming, near a pole portion: a first magnetic layer supported by a base substrate; a first insulating layer on the first magnetic layer with an end edge which forms a reference position for an air bearing surface; a gap layer on the pole portion of the first magnetic layer and the first insulation layer; a second magnetic layer that extends to a region beyond the pole portion; a thin film coil isolated by a second insulation layer located above the first insulation layer; a third magnetic layer on the second insulation layer. The air bearing surface is formed by grinding in part an end face of the pole portion of the first magnetic layer and an end face of the pole portion of the second magnetic layer and the gap layer placed therebetween.
摘要翻译：一种制造薄膜磁头的方法。该方法包括在极部附近形成由基底基板支撑的第一磁性层; 在第一磁性层上的第一绝缘层，其端边缘形成空气轴承表面的基准位置; 第一磁性层的极部和第一绝缘层的间隙层; 第二磁性层，延伸到超过极部分的区域; 由位于第一绝缘层上方的第二绝缘层隔离的薄膜线圈; 在第二绝缘层上的第三磁性层。空气轴承表面通过部分地研磨第一磁性层的极部的端面和第二磁性层的极部的端面以及间隔层而形成。

34. 发明授权

US06609291B1 Method of manufacturing a thin film magnetic head 失效
标题翻译：制造薄膜磁头的方法
公开(公告)号：US06609291B1
公开(公告)日：2003-08-26
申请号：US09592918
申请日：2000-06-13
申请人： Yoshitaka Sasaki , Atsushi Iijima , Kazumasa Fukuda
发明人： Yoshitaka Sasaki , Atsushi Iijima , Kazumasa Fukuda
IPC分类号： G11B5127
CPC分类号： G11B5/3967 , G11B5/3116 , G11B5/313 , Y10T29/49032 , Y10T29/49044 , Y10T29/49046 , Y10T29/4906
摘要： A method of manufacturing a thin film magnetic head including the steps of forming a first magnetic layer, a band-shaped insulating layer, a gap layer, a second magnetic layer, a thin film coil, a third magnetic layer wherein the substrate, pole portions of the first and second magnetic layers and gap layer sandwiched by the magnetic layers to form the air bearing surface which is to be opposed to a magnetic record medium is polished.
摘要翻译：一种制造薄膜磁头的方法，包括以下步骤：形成第一磁性层，带状绝缘层，间隙层，第二磁性层，薄膜线圈，第三磁性层，其中基底，极部分的第一和第二磁性层以及被磁性层夹持形成与磁记录介质相对的空气轴承表面的间隙层被抛光。

35. 发明授权

US06252748B1 Thin film magnetic head with widening outer layer of multi-layer pole 有权
标题翻译：薄膜磁头，多层极扩展外层
公开(公告)号：US06252748B1
公开(公告)日：2001-06-26
申请号：US09169983
申请日：1998-10-13
申请人： Noboru Yamanaka , Kazumasa Fukuda , Yuzuru Iwai
发明人： Noboru Yamanaka , Kazumasa Fukuda , Yuzuru Iwai
IPC分类号： G11B539
CPC分类号： G11B5/3967 , G11B5/3116 , G11B5/312
摘要： A gap film of a write element is provided between a first pole portion and a second pole portion. The second pole portion includes a third magnetic film and a fourth magnetic film. The third magnetic film is provided adjacent to the gap film and the fourth magnetic film is provided adjacent to the third magnetic film. The surface of the fourth magnetic film facing opposite the medium includes a first side adjacent to the third magnetic film and a second sides extending outward from the first side. The second sides each inclines toward the opposite side from the third magnetic film at an angle of less than 90° relative to an extended line of the first side to eliminate recording bleed occurring due to leaked magnetic field.
摘要翻译：写元件的间隙膜设置在第一极部分和第二极部分之间。第二极部包括第三磁性膜和第四磁性膜。第三磁性膜被设置成与间隙膜相邻，并且第四磁性膜设置成与第三磁性膜相邻。第四磁性膜的与介质相对的表面包括与第三磁性膜相邻的第一侧和从第一侧向外延伸的第二侧。第二面各自相对于第一侧的延长线以相对于第三磁性膜的相反侧倾斜90度以消除由于泄漏的磁场而产生的记录渗漏。

36. 发明授权

US6144533A Thin film magnetic head 有权
标题翻译：薄膜磁头
公开(公告)号：US6144533A
公开(公告)日：2000-11-07
申请号：US215301
申请日：1998-12-18
申请人： Kazumasa Fukuda , Noboru Yamanaka , Yuzuru Iwai
发明人： Kazumasa Fukuda , Noboru Yamanaka , Yuzuru Iwai
IPC分类号： G11B5/09 , G11B5/31 , G11B5/39 , G11B5/127
CPC分类号： G11B5/3967 , G11B5/31 , G11B5/3116 , G11B5/313 , G11B5/09
摘要： The present invention relates to a thin film magnetic head that achieves low NLTS and demonstrates outstanding O/W characteristics in a high frequency range. A first magnetic film and a second magnetic film face opposite each other over a gap film at a side where a surface facing opposite the medium is present. A first yoke and a second yoke, which extend rearward on the opposite side from the surface facing opposite the medium, are linked to each other at a rear linking portion. A coil film, which is supported by an insulating film, is provided in a coil around the rear linking portion. N/YL.gtoreq.0.2 (turns/.mu.m) is satisfied, with YL (.mu.m) representing the distance from the surface facing opposite the medium to the rear linking portion and N (turns) representing the number of turns of the coil film.
摘要翻译：薄膜磁头技术领域本发明涉及一种实现低NLTS并在高频范围内表现出优异的O / W特性的薄膜磁头。第一磁性膜和第二磁性膜表面在与存在介质相反的一侧的间隙膜上彼此相对。在与相对介质相对的表面的相反侧向后延伸的第一轭和第二轭在后连接部处彼此连接。由绝缘膜支撑的线圈膜围绕后连接部设置在线圈中。 N / YL> / = 0.2（匝/μm），其中YL（μm）表示与介质相对于后连接部分的表面的距离，N（匝数）表示线圈匝数电影。

37. 发明授权

US5991110A Thin film magnetic head and magnetic recording and reproducing apparatus 有权
标题翻译：薄膜磁头和磁记录和重放装置
公开(公告)号：US5991110A
公开(公告)日：1999-11-23
申请号：US159562
申请日：1998-09-24
申请人： Masanori Sakai , Makoto Yoshida , Kazumasa Fukuda , Mikio Matsuzaki
发明人： Masanori Sakai , Makoto Yoshida , Kazumasa Fukuda , Mikio Matsuzaki
IPC分类号： G11B5/31 , G11B5/09 , G11B5/187 , G11B5/48 , G11B5/60 , G11B5/035
CPC分类号： G11B5/09 , G11B5/1872 , G11B5/3106 , G11B5/3116 , G11B5/4886 , G11B5/6005
摘要： In the thin film magnetic transducer element, the front end portions of the upper pole piece and the lower pole piece are partially removed in such a manner that they align non parallel to the gap film on the opposite sides of the gap film. The condition .DELTA.P1>.DELTA.P2 is satisfied when the difference between the maximum pole length P1max and the minimum pole length P1min of the lower pole piece is .DELTA.P1 and the difference between the maximum pole length P2max and the minimum pole length P2min of the upper pole piece is .DELTA.P2. The sub pulse is reduced and so the partial response method can be employed.
摘要翻译：在薄膜磁换能器元件中，上极片和下极片的前端部分被部分地移除，使得它们在间隙膜的相对侧上与间隙膜不平行地对准。当下极点的最大极长度P1max和最小极长度P1min之间的差为DELTA P1，并且上极的最大极长度P2max与最小极长度P2min之间的差值满足条件DELTA P1> DELTA P2 极片是DELTA P2。子脉冲减少，因此可以采用部分响应方法。

38. 发明授权

US5844749A Thin film magnetic head with an induction type magnetic transducer for suppressing sub-pulses 失效
标题翻译：具有用于抑制子脉冲的感应式磁换能器的薄膜磁头
公开(公告)号：US5844749A
公开(公告)日：1998-12-01
申请号：US774317
申请日：1996-12-24
申请人： Masanori Sakai , Makoto Yoshida , Kazumasa Fukuda , Mikio Matsuzaki
发明人： Masanori Sakai , Makoto Yoshida , Kazumasa Fukuda , Mikio Matsuzaki
IPC分类号： G11B5/31 , G11B5/09 , G11B5/187 , G11B5/48 , G11B5/60
CPC分类号： G11B5/09 , G11B5/1872 , G11B5/3106 , G11B5/3116 , G11B5/4886 , G11B5/6005
摘要： In the thin film magnetic transducer element, the front end portions of the upper pole piece and the lower pole piece are partially removed in such a manner that they align non parallel to the gap film on he opposite sides of the gap film. The condition .DELTA.P1>.DELTA.P2 is satisfied when the difference between the maximum pole length P1max and the minimum pole length P1min of the lower pole piece is .DELTA.P1 and the difference between the maximum pole length P2max and the minimum pole length P2min of the upper pole piece is .DELTA.P2. The sub pulse is reduced and so the partial response method can be employed.
摘要翻译：在薄膜磁换能器元件中，上极片和下极片的前端部分被部分地移除，使得它们与间隙膜的相对侧上的间隙膜不平行地对准。当下极点的最大极长度P1max和最小极长度P1min之间的差为DELTA P1，并且上极的最大极长度P2max与最小极长度P2min之间的差值满足条件DELTA P1> DELTA P2 极片是DELTA P2。子脉冲减少，因此可以采用部分响应方法。

39. 发明授权

US5812349A Magnetic head apparatus including separation features 失效
标题翻译：磁头设备包括分离特征
公开(公告)号：US5812349A
公开(公告)日：1998-09-22
申请号：US797626
申请日：1997-02-07
申请人： Jun Shouji , Masanori Sakai , Kazumasa Fukuda
发明人： Jun Shouji , Masanori Sakai , Kazumasa Fukuda
IPC分类号： G11B5/39 , G11B5/17 , G11B5/40 , G11B5/48 , G11B5/56 , G11B5/60 , H05K1/02 , H05K1/11 , G11B5/127
CPC分类号： G11B5/4853 , G11B5/40 , G11B5/48 , G11B5/39 , H05K1/0254 , H05K1/117
摘要： The present invention is directed to prevention of breakdown caused by electrostatic discharge in an MR element. An MR element constitutes a read element. A head support device 2 supports a magnetic head 1. A lead wire 3 is constituted with at least a pair of lead wires 31 and 32 and each of the pair of lead wires 31 and 32 is connected to the read element at one end. A terminal board 5 is provided with at least one pair of terminal conductors 52 and 53 on top of a hard substrate 51. The pair of terminal conductors 52 and 53 are provided with connecting areas 54 and 55 respectively on the same side, to which one end of which are connected the other ends of the lead wires 31 and 32 respectively. The pair of terminal conductors 52 and 53 are electrically shorted from each other by a shorting portion 56 at a rearward position which is away from the connecting areas 54 and 55 over a distance. The substrate 51 is provided with grooves or perforations 57 which facilitate the cutting operation between the shorting portion 56 and the connecting areas 54 and 55.
摘要翻译：本发明涉及防止由MR元件中的静电放电引起的击穿。 MR元件构成读取元件。头支撑装置2支撑磁头1.引线3由至少一对引线31和32构成，并且一对引线31和32中的每一个在一端连接到读取元件。端子板5在硬质基板51的上面设置有至少一对端子导体52和53.一对端子导体52和53分别在同一侧设置有连接区域54和55，其中一个其端部分别连接到引线31和32的另一端。一对端子导体52和53通过远离连接区域54和55的后方位置处的短路部分56彼此电短路。基板51设置有槽或穿孔57，其有利于短路部分56和连接区域54和55之间的切割操作。

40. 发明授权

US5416656A Magnetic recording and reproducing head having a flat surface with round front ridge 失效
标题翻译：具有圆形前缘的平坦表面的磁记录和再现头
公开(公告)号：US5416656A
公开(公告)日：1995-05-16
申请号：US801626
申请日：1991-12-04
申请人： Kazumasa Fukuda , Monjiro Momoi , Takamitsu Tsuna , Mikio Matsuzaki
发明人： Kazumasa Fukuda , Monjiro Momoi , Takamitsu Tsuna , Mikio Matsuzaki
IPC分类号： G11B5/82 , G11B5/012 , G11B5/02 , G11B5/127 , G11B5/187 , G11B5/60 , G11B19/20 , G11B21/21
CPC分类号： G11B5/012 , G11B19/20 , G11B5/6005
摘要： A magnetic recording and reproducing apparatus having a magnetic disk, a magnetic head and a magnetic head supporting device. The surface roughness R.sub.max of the magnetic disk is at most 10 nm, and the magnetic head has a slider on which reading and writing elements are mounted. The slider is of a generally rectangular prism shape with the entire area of a medium opposing surface which opposes the magnetic disk being flat. The surface area of the medium opposing surface is 2 mm.sup.2 or less. The apparatus has a first relative speed at which the frictional coefficient between the magnetic disk and the magnetic head is changed from a high value to a low value when the speed increases, and a second relative speed at which the frictional coefficient is changed from a low value to a high value when the speed decreases. A ridge portion between the front surface and the medium opposing surface has a round corner, wherein the length of the round corner in the direction of the medium opposing surface is larger than the length of the round corner in the direction of the front surface.
摘要翻译：具有磁盘，磁头和磁头支撑装置的磁记录和重放装置。磁盘的表面粗糙度Rmax为10nm以下，磁头具有安装有读取和写入元件的滑块。滑块是大致矩形的棱镜形状，其中与磁盘相对的介质相对表面的整个区域是平坦的。介质相对表面的表面积为2mm 2以下。该装置具有第一相对速度，在该速度增加时，磁盘和磁头之间的摩擦系数从高值变为低值，摩擦系数从低的角度变化的第二相对速度当速度降低时，值变为高值。前表面和介质相对表面之间的脊部具有圆角，其中圆形在介质相对表面方向上的长度大于前表面方向上圆角的长度。

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