专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明申请

US20170308679A1 BIOSECURITY SCREENING SYSTEM AND METHOD 审中-公开
公开(公告)号：US20170308679A1
公开(公告)日：2017-10-26
申请号：US15518735
申请日：2015-10-12
申请人： Cepheid
发明人： William E Murray
IPC分类号： G06F19/00 , G01N33/487 , B01L3/00 , A61B10/00 , C12Q1/68 , G01N35/02 , C12Q1/70
CPC分类号： G16H50/80 , A61B10/0096 , B01L3/502 , B01L2300/0627 , B01L2300/087 , C12Q1/6888 , C12Q1/701 , G01N33/48792 , G01N35/021 , G06Q50/22 , Y02A90/22 , Y02A90/24
摘要： The present invention provides systems and methods for rapid screening of individuals who may have been exposed to and carrying biological agents potentially contagious or otherwise harmful to the general public.

32. 发明申请

US20170252742A1 FLUID PROCESSING AND CONTROL 审中-公开
公开(公告)号：US20170252742A1
公开(公告)日：2017-09-07
申请号：US15601725
申请日：2017-05-22
申请人： Cepheid
发明人： Douglas B. DORITY , Ronald Chang
IPC分类号： B01L3/00 , G01N1/18 , G01N1/28 , G01N1/40
摘要： A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region. The body includes at least one external port. The fluid processing region is fluidicly coupled with the at least one external port. The fluid displacement region is fluidicly coupled with at least one external port of the body. The body is adjustable with respect to the plurality of chambers to place the at least one external port selectively in fluidic communication with the plurality of chambers. One or more of the chambers may be a processing chamber which includes two ports configured to selectively engage the at least one external port of the body, and a fluid processing material such as an enrichment material or a depletion material. In some embodiments, one or more chambers may include a separation channel, and an electric field may be applied across the separation channel.

33. 发明申请

US20170137871A1 INTEGRATED PURIFICATION AND MEASUREMENT OF DNA METHYLATION AND CO-MEASUREMENT OF MUTATIONS AND/OR MRNA EXPRESSION LEVELS IN AN AUTOMATED REACTION CARTRIDGE 审中-公开
公开(公告)号：US20170137871A1
公开(公告)日：2017-05-18
申请号：US15182394
申请日：2016-06-14
申请人： Cepheid
发明人： EDWIN W. LAI , ANDREW KOHLWAY , REUEL VANATTA , RUSSELL HIGUCHI , ALEXANDER GALL , KRISZTEN KOCMOND
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , B01L7/52 , B01L2300/0864 , B01L2300/087 , C12N15/1006 , C12N15/1017 , C12Q1/6806 , C12Q1/6886 , C12Q2600/154 , C12Q2523/125 , C12Q2537/164 , C12Q2565/629
摘要： In various embodiments methods of determining methylation of DNA are provided. In one illustrative, but non-limiting embodiment the method comprises i) contacting a biological sample comprising a nucleic acid to a first matrix material comprising a first column or filter where said matrix material binds and/or filters nucleic acids in said sample and thereby purifies the DNA; ii) eluting the bound DNA from the first matrix material and denaturing the DNA to produce eluted denatured DNA; iii) heating the eluted DNA in the presence of bisulfite ions to produce a deaminated nucleic acid; iv) contacting said deaminated nucleic acid to a second matrix material comprising a second column to bind said deaminated nucleic acid to said second matrix material; v) desulfonating the bound deaminated nucleic acid and/or simultaneously eluting and desulfonating the nucleic acid by contacting the deaminated nucleic acid with an alkaline solution to produce a bisulfite converted nucleic acid; vi) eluting said bisulfite converted nucleic acid from said second matrix material; and vii) performing methylation specific PCR and/or nucleic acid sequencing, and/or high resolution melting analysis (HRM) on said bisulfite-converted nucleic acid to determine the methylation of said nucleic acid, wherein at least steps iv) through vi) are performed in a single reaction cartridge.

34. 发明申请

US20170023281A1 THERMAL CONTROL DEVICE AND METHODS OF USE 审中-公开
标题翻译：热控制装置及其使用方法
公开(公告)号：US20170023281A1
公开(公告)日：2017-01-26
申请号：US15217902
申请日：2016-07-22
申请人： Cepheid
发明人： David FROMM , Tien PHAN , Matthew PICCINI
IPC分类号： F25B21/04 , B01L7/00
CPC分类号： F25B21/04 , B01L7/52 , B01L2200/025 , B01L2300/1822 , F25B2321/0212 , F25B2321/0251
摘要： Thermal control devices adapted to provide improved control and efficiency in temperature cycling are provided herein. Such thermal control device can include a thermoelectric cooler controlled in coordination with another thermal manipulation device to control an opposing face of the thermoelectric cooler and/or a microenvironment. Some such thermal control devices include a first and second thermoelectric cooler separated by a thermal capacitor. The thermal control devices can be configured in a planar configuration with a means for thermally coupling with a planar reaction vessel of a sample analyzer for use in thermal cycling in a polymerase chain reaction of the fluid sample in the reaction vessel. Methods of thermal cycling using such a thermal control devices are also provided.
摘要翻译：本文提供了适于提供改进的温度循环控制和效率的热控制装置。这种热控制装置可以包括与另一个热操纵装置配合控制的热电冷却器，以控制热电冷却器和/或微环境的相对面。一些这样的热控制装置包括由热电容器分离的第一和第二热电冷却器。热控制装置可以被配置成具有用于与样品分析器的平面反应容器热耦合的装置的平面配置，以用于在反应容器中的流体样品的聚合酶链式反应中的热循环。还提供了使用这种热控制装置的热循环方法。

35. 发明授权

US09446409B2 Method and apparatus for storing and dispensing reagent beads 有权
公开(公告)号：US09446409B2
公开(公告)日：2016-09-20
申请号：US14268682
申请日：2014-05-02
申请人： Cepheid
发明人： Ronald Chang , Douglas B. Dority , Steven Montgomery
IPC分类号： B01L9/00 , B23Q7/04 , G07F11/16 , B65H5/00 , B65H1/08 , B65H3/00 , B01L3/00 , B01J19/00 , B01L3/02 , G01N35/00
CPC分类号： B01L3/527 , B01J19/0046 , B01J2219/00468 , B01J2219/005 , B01J2219/00657 , B01L3/0289 , B01L2200/0647 , B01L2200/16 , G01N2035/00574 , Y10T436/25
摘要： Embodiments of the invention provide an efficient and effective technique for storing and dispensing reagent beads. In some embodiments, an apparatus is provided for dispensing reagent beads contained in a bead storage device which includes a bead carrier having a plurality of wells; a plurality of reagent beads disposed in the wells; and a cover tape releasably attached to the bead carrier to cover the wells and retain the reagent beads in the wells. The apparatus comprises a channel in which to place the bead storage device with the bead carrier facing a support wall of the channel and the cover tape facing a stripping wall of the channel. The stripping wall includes a stripping gap disposed between a stripping edge and an opposite edge, and a dispense opening provided adjacent the opposite edge on a side of the stripping wall opposite from the stripping edge. The cover tape is insertable through the stripping gap to be pulled against the stripping edge to peel the cover tape from the bead carrier to move the wells of the bead carrier inside the channel toward the dispense opening and expose the wells individually to dispense the reagent beads.

36. 发明授权

US09394086B2 Multi-chambered lid apparatus 有权
标题翻译：多层盖装置
公开(公告)号：US09394086B2
公开(公告)日：2016-07-19
申请号：US14214668
申请日：2014-03-15
申请人： Cepheid
发明人： Paul Jordan
IPC分类号： B65D47/00 , B65D51/18 , B65D3/26 , B01L3/00
CPC分类号： B65D47/0857 , B01L3/50853 , B01L2300/043 , B65D25/04 , B65D43/0204 , B65D47/00 , B65D51/18
摘要： A lid apparatus for a multi-chambered container. The lid apparatus has a top-lid that is hingedly attached to a bottom-cap. The top-lid includes one or more openings for fluid filling multiple passages that extend from the bottom-cap. A lower bottom-cap includes welding features for welding to the multi-chambered container.
摘要翻译：一种用于多室容器的盖装置。盖装置具有铰接地附接到底盖的顶盖。顶盖包括用于流体填充从底盖延伸的多个通道的一个或多个开口。下底盖包括用于焊接到多室容器的焊接特征。

37. 发明授权

US09322052B2 Cartridge for conducting a chemical reaction 有权
标题翻译：用于进行化学反应的墨盒
公开(公告)号：US09322052B2
公开(公告)日：2016-04-26
申请号：US14218517
申请日：2014-03-18
申请人： Cepheid
发明人： Kurt E. Petersen , William McMillan , Farzad Pourahmadi , Ronald Chang , Douglas B. Dority
IPC分类号： C12Q1/68 , G01N33/53 , B01L3/00 , B01L7/00
CPC分类号： B01L7/52 , B01L3/502 , B01L2200/10 , B01L2300/0654 , B01L2300/0681 , B01L2300/0858 , B01L2300/087 , B01L2300/123 , B01L2300/14 , B01L2300/168 , B01L2300/18 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , C12Q1/6844 , G01N33/5302 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： A cartridge for conducting a chemical reaction includes a body having at least one flow path formed therein. The cartridge also includes a reaction vessel extending from the body for holding a reaction mixture for chemical reaction and optical detection. The vessel comprises a rigid frame defining the side walls of a reaction chamber. The frame includes at least one channel connecting the flow path to the chamber. The vessel also includes flexible films or sheets attached to opposite sides of the rigid frame to form opposing major walls of the chamber. In addition, at least two of the side walls are optically transmissive and angularly offset from each to permit real-time optical detection of analyte in the reaction chamber.
摘要翻译：用于进行化学反应的药筒包括具有形成在其中的至少一个流路的主体。药筒还包括从身体延伸的反应容器，用于保持用于化学反应和光学检测的反应混合物。容器包括限定反应室侧壁的刚性框架。该框架包括连接到该腔室的流动路径的至少一个通道。容器还包括附接到刚性框架的相对侧的柔性膜或片，以形成腔室的相对的主壁。此外，至少两个侧壁是光学透射的并且与每个侧壁成角度地偏移以允许对反应室中的分析物的实时光学检测。

38. 发明申请

US20160024586A1 METHODS OF DETECTING CANCER 审中-公开
标题翻译：检测癌症的方法
公开(公告)号：US20160024586A1
公开(公告)日：2016-01-28
申请号：US14773060
申请日：2014-03-10
申请人： CEPHEID
发明人： Olivier Delfour , David Vilanova
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178
摘要： Methods of detecting cancer are provided. Methods of detecting changes in the levels of one or more small RNAs associated with cancer are also provided. Compositions and kits are also provided.
摘要翻译：提供了检测癌症的方法。还提供了检测与癌症相关的一种或多种小RNA水平变化的方法。还提供了组合和成套工具。

39. 发明申请

US20150322510A1 TWO-PRIMER PCR FOR MICRORNA MULTIPLEX ASSAY 审中-公开
标题翻译：用于MICRORNA多重测定的两次PCR
公开(公告)号：US20150322510A1
公开(公告)日：2015-11-12
申请号：US14431257
申请日：2013-09-25
申请人： CEPHEID
发明人： Russell HIGUCHI , Edwin Wei-Lung LAI , Sergey LOKHOV
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12N15/111 , C12N2310/141 , C12N2320/10 , C12Q1/6853 , C12Q2600/16 , C12Q2600/178 , C12Q2525/207 , C12Q2537/143 , C12Q2521/131 , C12Q2525/173 , C12Q2525/301 , C12Q2565/1015
摘要： The present invention provides method for amplifying a specific RNA molecule in a sample, the method comprising: (a) adding a poly(ribonucleotide) sequence to RNA molecules in the sample; (b) reverse transcribing the poly-adenylated RNA molecules using a reverse primer comprising a sequence that anneals to said poly(ribonucleotide) sequence; and (c) amplifying and detecting the cDNA molecule(s) using the same reverse primer and using a forward primer specific for the RNA molecule to be detected; wherein at least one of the forward and reverse primers comprises a hairpin primer. The invention also provides kits useful for practicing this method.
摘要翻译：本发明提供扩增样品中特异性RNA分子的方法，所述方法包括：（a）向样品中的RNA分子加入聚（核糖核苷酸）序列; （b）使用包含与所述多核苷酸核苷酸序列退火的序列的反向引物逆转录多聚腺苷酸化的RNA分子; 和（c）使用相同的反向引物扩增和检测cDNA分子，并使用对待检测的RNA分子特异性的正向引物; 其中所述正向引物和反向引物中的至少一个包含发夹引物。本发明还提供了用于实施该方法的试剂盒。

40. 发明申请

US20150133325A1 METHODS OF DETECTING BLADDER CANCER 审中-公开
标题翻译：检测乳腺癌的方法
公开(公告)号：US20150133325A1
公开(公告)日：2015-05-14
申请号：US14394352
申请日：2013-04-19
申请人： Cepheid
发明人： Russell Higuchi , Stacey Ellen Wallace , Edwin Wei-Lung Lai
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/158 , C12Q2600/16 , C12Q2600/166
摘要： Compositions and methods for detecting bladder cancer are provided. In some embodiments, methods of monitoring recurrence of bladder cancer are provided. In some embodiments, the methods comprise detecting a set of markers consisting of CRH, IGF2, KRT20, and ANXA10.
摘要翻译：提供了检测膀胱癌的组合物和方法。在一些实施方案中，提供了监测膀胱癌复发的方法。在一些实施方案中，所述方法包括检测由CRH，IGF2，KRT20和ANXA10组成的一组标志物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式