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31. 发明授权

US4279817A Method for producing dimer alkaloids 失效
标题翻译：二聚生物碱的生产方法
公开(公告)号：US4279817A
公开(公告)日：1981-07-21
申请号：US582373
申请日：1975-05-30
申请人： James P. Kutney
发明人： James P. Kutney
IPC分类号： C07D471/20 , C07D519/04
CPC分类号： C07D519/04 , Y10S514/908
摘要： A concerted process for the synthesis of a dimer consisting of an indole unit and a dihydroindole unit possessing natural stereochemistry which comprises:(a) forming an N-oxide intermediate from said indole unit;(b) treating said N-oxide indole intermediate in the presence of acetic anhydride or halogenated derivative thereof to effect a Polonovski-type fragmentation reaction;(c) without isolating the N-oxide indole intermediate and at a temperature of about -10.degree. C. to +10.degree. C., coupling said reaction product with a dihydroindole unit in the presence of acetic anhydride or a halogenated derivative thereof at a low temperature of about -10.degree. C. to +10.degree. C. under inert conditions; and(d) subsequently reducing the immonium nitrogen on the indole unit by reacting with aqueous alkali metal borohydride to produce a dimer.
摘要翻译：一种由具有天然立体化学的吲哚单元和二氢吲哚单元组成的二聚体的合成方法，其包括：（a）从所述吲哚单元形成N-氧化物中间体; （b）在乙酸酐或其卤化衍生物的存在下处理所述N-氧化物吲哚中间体以进行Polonovski型断裂反应; （c）在不分离N-氧化物吲哚中间体的情况下，在约-10℃至+ 10℃的温度下，在乙酸酐或其卤代衍生物的存在下，将所述反应产物与二氢吲哚单元偶合低温约-10℃至+10℃，在惰性条件下; 和（d）随后通过与碱金属硼氢化钠水溶液反应产生二聚体来还原吲哚单元上的亚硝酸盐。

32. 发明申请

US20130035363A1 Thalidomide Analogs 有权
标题翻译：沙利度胺类似物
公开(公告)号：US20130035363A1
公开(公告)日：2013-02-07
申请号：US13648625
申请日：2012-10-10
申请人： Nigel H. Greig , Harold Holloway , Arnold Brossi , Xiaoxiang Zhu , Tony Giordano , Qian-sheng Yu , William D. Figg
发明人： Nigel H. Greig , Harold Holloway , Arnold Brossi , Xiaoxiang Zhu , Tony Giordano , Qian-sheng Yu , William D. Figg
IPC分类号： A61K31/4035 , A61P3/04 , A61P19/02 , A61P31/04 , A61P1/00 , A61P35/00 , A61P25/00 , A61P25/28 , A61P25/16 , A61P7/04 , A61P27/02 , A61P29/00 , A61P1/04
CPC分类号： H04M1/72522 , C07D209/44 , G06F3/01 , G06F3/0346 , H04M2250/12 , H04M2250/22 , H04M2250/74
摘要： Thalidomide analogs that modulate tumor necrosis factor alpha (TNFα) activity and angiogenesis are disclosed. In particularly disclosed embodiments, the thalidomide analogs are isosteric sulfur-containing analogs. Also disclosed are methods of treating a subject with the analogs.
摘要翻译：公开了调节肿瘤坏死因子α（TNFα）活性和血管生成的沙利度胺类似物。在特别公开的实施方案中，沙利度胺类似物是等熵含硫类似物。还公开了用类似物治疗受试者的方法。

33. 发明授权

US06010905A Method for inducing monocytes to exhibit the phenotype of activated myeloid dendritic cells 失效
标题翻译：诱导单核细胞表现活化髓样树突状细胞表型的方法
公开(公告)号：US06010905A
公开(公告)日：2000-01-04
申请号：US885671
申请日：1997-06-30
申请人： Peter A. Cohen , Brian J. Czerniecki , Gary K. Koski , David E. Weng , Charles Carter , John O. Ojeifo , Gretchen N. Schwartz
发明人： Peter A. Cohen , Brian J. Czerniecki , Gary K. Koski , David E. Weng , Charles Carter , John O. Ojeifo , Gretchen N. Schwartz
IPC分类号： A61K45/00 , A61K38/00 , A61K39/00 , A61P35/00 , A61P35/02 , A61P37/04 , A61P43/00 , C12N5/0784 , C12N5/0786 , C12N5/09 , C12N5/08
CPC分类号： C12N5/0694 , A61K39/0011 , C12N5/0639 , C12N5/0645 , A61K2039/5152 , A61K2039/5154 , A61K38/00 , C12N2500/14 , C12N2501/22 , C12N2501/23
摘要： The present invention relates to methods of increasing the antigen presenting ability of monocytes by contacting them with an agent which increases the intracellular calcium level. Methods of obtaining the monocytes are also disclosed. In addition, the present invention relates to methods of inducing bone marrow progenitor cells and endothelial cells to express molecules involved in generating immune responses. Methods of modulating the expression of molecules involved in generating immune responses are also disclosed, as are methods of treating cancer and leukemia.
摘要翻译：本发明涉及通过使其与增加细胞内钙水平的试剂接触来提高单核细胞的抗原呈递能力的方法。还公开了获得单核细胞的方法。此外，本发明涉及诱导骨髓祖细胞和内皮细胞表达涉及产生免疫应答的分子的方法。还公开了调节涉及产生免疫应答的分子的表达的方法，以及治疗癌症和白血病的方法。

34. 发明授权

US5919624A Methods for detecting cervical cancer 失效
标题翻译：检测宫颈癌的方法
公开(公告)号：US5919624A
公开(公告)日：1999-07-06
申请号：US781424
申请日：1997-01-10
申请人： Thomas Ried , Gert Auer , Evelin Schrock , Kerstin Heselmeyer , Merryn Macville
发明人： Thomas Ried , Gert Auer , Evelin Schrock , Kerstin Heselmeyer , Merryn Macville
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6886 , C12Q2600/112
摘要： The invention provides a method of detecting the presence of invasive cervical carcinoma in a subject comprising detecting in a cervical cell from the subject the presence of a chromosome abnormality which is associated with invasive cervical carcinoma; the presence of the cervical cell containing the chromosome abnormality indicating the presence of invasive cervical carcinoma in the subject. The invention also provides a method of detecting the presence of advanced-stage cervical carcinoma in a subject comprising detecting in a cervical cell from the subject the presence of a chromosome abnormality associated with advanced-stage cervical carcinoma; the presence of the cervical cell containing the chromosome abnormality indicating the presence of advanced-stage cervical carcinoma in the subject. The invention also provides a method of classifying the progression of dysplastic cervical cells from a non-invasive cervical carcinoma to an invasive cervical carcinoma comprising analyzing the dysplastic cervical cells for the presence of a chromosome abnormality which is associated with invasive cervical carcinoma, and classifying the dysplastic cervical cells having the chromosome abnormality as having progressed from a non-invasive cervical carcinoma cells to an invasive cervical carcinoma. The invention further provides kits comprising nucleic acids that specifically hybridize to chromosome 3q and specifically hybridize to another chromosome, and to compositions comprising nucleic acids.
摘要翻译：本发明提供一种检测受试者侵袭性宫颈癌存在的方法，包括在受试者宫颈细胞中检测与侵入性宫颈癌相关的染色体异常的存在; 含有染色体异常的子宫颈细胞的存在表明受试者存在浸润性宫颈癌。本发明还提供一种检测受试者中晚期宫颈癌存在的方法，包括在受试者的子宫颈细胞中检测与晚期宫颈癌相关的染色体异常的存在; 含有染色体异常的子宫颈细胞的存在表明该受试者存在晚期宫颈癌。本发明还提供了将发育不良的子宫颈细胞从非侵入性宫颈癌分级到浸润性宫颈癌的方法，包括分析发育不良的宫颈细胞是否存在与侵入性宫颈癌相关的染色体异常，并将具有染色体异常的发育不良的宫颈细胞从非侵入性宫颈癌细胞进展到浸润性宫颈癌。本发明还提供了包含与染色体3q特异性杂交并与另一染色体特异性杂交的核酸以及包含核酸的组合物的试剂盒。

35. 发明授权

US5753437A Method of diagnosing cancer susceptibility or metastatic potential 失效
标题翻译：诊断癌症易感性或转移潜力的方法
公开(公告)号：US5753437A
公开(公告)日：1998-05-19
申请号：US406005
申请日：1995-02-28
申请人： Patricia S. Steeg , Lance A. Liotta , Alvaro Leone , Generoso Bevilacqua
发明人： Patricia S. Steeg , Lance A. Liotta , Alvaro Leone , Generoso Bevilacqua
IPC分类号： C12Q1/68 , C07H21/04 , C12N15/00 , C12P19/34
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118
摘要： The present invention relates, in general, to a method for diagnosing cancer susceptibility based on alterations in the nm23 gene. In particular, the present invention relates to a method of identifying individuals at risk for developing a primary cancer or at risk for suffering treatment failure, morbidity, or mortality associated with cancer. The invention further relates to a means of using genetic methods to predict individuals at increased risk for developing distant metastases.
摘要翻译：本发明一般涉及基于nm23基因改变来诊断癌症易感性的方法。特别地，本发明涉及鉴定处于发展为原发性癌症或处于与癌症相关的治疗失败，发病率或死亡风险的风险中的个体的方法。本发明还涉及使用遗传方法预测发展远处转移的风险增加的个体的方法。

36. 发明授权

US5587308A Modified adeno-associated virus vector capable of expression from a novel promoter 失效
公开(公告)号：US5587308A
公开(公告)日：1996-12-24
申请号：US891962
申请日：1992-06-02
申请人： Barrie J. Carter , Terence Flotte , Sandra Afione , Rikki Solow
发明人： Barrie J. Carter , Terence Flotte , Sandra Afione , Rikki Solow
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C12N15/12 , C12N15/864 , C12N5/10 , C07H21/04 , C12N15/86
CPC分类号： C12N15/86 , C07K14/4712 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N2750/14143
摘要： Described herein are constructions of recombinant DNA comprising modified adeno-associated virus (AAV) DNA sequences capable of functioning as a eukaryotic expression vector for expressing foreign DNA sequences using a novel transcription promoter comprising the termini of AAV DNA. It is shown that expression of a test reporter gene can be obtained from this vector in mammalian cells. It is further shown that this combination of vector and promoter can be used to introduce and express a human gene and correct a genetic defect in human cells resulting from malfunction of the mutant endogenous gene. Further, the vector can be used to correct the genetic defect by expressing a modified version of the human gene consisting of a fusion of part of the said gene and a synthetic sequence contained in the vector.

37. 发明授权

US5503995A Exchangeable template reaction 失效
标题翻译：可交换模板反应
公开(公告)号：US5503995A
公开(公告)日：1996-04-02
申请号：US261670
申请日：1994-06-17
申请人： Yury Khudyakov , Howard A. Fields
发明人： Yury Khudyakov , Howard A. Fields
IPC分类号： C12N15/09 , C07K14/02 , C07K14/18 , C12N15/10 , C12N15/36 , C12Q1/68 , C12P19/34
CPC分类号： C12N15/10 , C07K14/005 , C12Q1/6853 , C12N2730/10122 , C12N2770/24222
摘要： The invention provides a method for the synthesis of DNA based on a cyclic mechanism of combining deoxyoligonucleotides comprising combining: (a) a series of unique single-stranded deoxypolynucleotides, each having a 5' sequence which, when in double-stranded form, can be enzymatically treated to form a unique 3' single-stranded protrusion for selective cyclic hybridization with another unique single-stranded deoxypolynucleotide of the series; (b) a unique deoxypolynucleotide having a 3' sequence which can selectively hybridize with one of the unique single-stranded deoxypolynucleotides of (a); (c) a polymerase which can direct the formation of double-stranded deoxypolynucleotides from the single-stranded deoxypolynucleotides; and (d) an enzyme which can form a unique single-stranded 3' protrusion from the double-stranded deoxypolynucleotides; under conditions which hybridize the unique single-stranded deoxypolynucleotides in a cyclic manner to form the DNA. Also provided is a kit comprising a series of unique synthesized single-stranded deoxypolynucleotides, each having a 5' sequence which, when in double-stranded form, can be enzymatically treated to form a unique 3' single-stranded protrusion for selective cyclic hybridization with another unique single-stranded deoxypolynucleotide of the series.
摘要翻译：本发明提供了一种基于组合脱氧寡核苷酸的循环机制合成DNA的方法，包括组合：（a）一系列独特的单链脱氧多核苷酸，每个具有5'序列，当双链形式可以是酶处理以形成独特的3'单链突起，用于与该系列的另一种独特的单链脱氧多核苷酸进行选择性循环杂交; （b）具有3'序列的独特的脱氧多核苷酸，其可以与（a）的独特的单链脱氧核苷酸之一选择性杂交; （c）可以从单链脱氧寡核苷酸引导形成双链脱氧核苷酸的聚合酶; 和（d）可以从双链脱氧寡核苷酸形成独特的单链3'突起的酶; 在独特的单链脱氧核苷酸以循环方式杂交以形成DNA的条件下。还提供了一种试剂盒，其包含一系列独特的合成的单链脱氧核苷酸，每个具有5'序列，当以双链形式时，可以进行酶处理以形成用于选择性环状杂交的独特的3'单链突起，该系列的另一种独特的单链脱氧多核苷酸。

38. 发明授权

US5492907A Antipsychotic composition and method of treatment 失效
标题翻译：抗精神病药物组合物和治疗方法
公开(公告)号：US5492907A
公开(公告)日：1996-02-20
申请号：US987728
申请日：1992-12-09
申请人： David Pickar , Robert E. Litman , William Z. Potter
发明人： David Pickar , Robert E. Litman , William Z. Potter
IPC分类号： A61K31/415 , A61K31/445 , A61K31/475 , A61K31/495 , A61K31/535 , A61K31/54 , A61K31/55 , A61K45/06
CPC分类号： A61K45/06 , A61K31/415 , A61K31/445 , A61K31/475 , A61K31/495 , A61K31/535 , A61K31/54 , A61K31/55
摘要： A method for treating a serious psychotic mental illness includes the step of administering to a patient in need of such treatment a combination of (i) an .alpha..sub.2 -adrenergic receptor antagonist and (ii) a D.sub.2 dopamine receptor antagonist, A pharmaceutical composition useful in the novel method includes an effective amount of the combination of the foregoing two ingredients together with a pharmaceutically acceptable carrier.
摘要翻译：用于治疗严重精神病性精神疾病的方法包括向需要这种治疗的患者施用以下组合的步骤：（i）α2-肾上腺素能受体拮抗剂和（ii）D2多巴胺受体拮抗剂，可用于该新方法包括有效量的前述两种成分与药学上可接受的载体的组合。

39. 发明授权

US5459400A Method to enhance the sensitivity of MRI for magnetic susceptibility effects 失效
标题翻译：提高磁共振磁敏感性的方法
公开(公告)号：US5459400A
公开(公告)日：1995-10-17
申请号：US106372
申请日：1993-08-13
申请人： Chrit T. W. Moonen
发明人： Chrit T. W. Moonen
IPC分类号： G01R33/20 , A61B5/055 , G01R33/48 , G01R33/561 , G01R33/563 , G01R33/565 , G01V3/00
CPC分类号： G01R33/561 , G01R33/563 , G01R33/4806 , G01R33/56527
摘要： A method for enhancing the sensitivity of gradient-recalled echo imaging for T2* effects in dynamic magnetic resonance imaging which involves the step of delaying gradient-recalled echoes so that the gradient-recalled echoes are subjected to magnetic susceptibility effects for an extended period of time. The gradient-recalled echoes are delayed beyond a subsequent radio frequency pulse by applying an additional gradient which dephases any gradient-recalled echo of spins that are excited in the radio frequency repetition time period in which said gradient-recalled echoes are produced.
摘要翻译：一种提高梯度回波成像对于动态磁共振成像中T2 *效应的灵敏度的方法，其涉及延迟梯度回波回波的步骤，使得梯度回波回波在延长的时间段内经受磁化率效应。梯度回波的回波被延迟超过随后的射频脉冲，通过应用额外的梯度，该梯度去除在产生所述梯度回波回波的射频重复时间段内被激发的任何梯度回波的自旋回波。

40. 发明授权

US5300886A Method to enhance the sensitivity of MRI for magnetic susceptibility effects 失效
标题翻译：提高磁共振磁敏感性的方法
公开(公告)号：US5300886A
公开(公告)日：1994-04-05
申请号：US841994
申请日：1992-02-28
申请人： Chrit T. W. Moonen
发明人： Chrit T. W. Moonen
IPC分类号： G01R33/20 , A61B5/055 , G01R33/48 , G01R33/561 , G01R33/563 , G01R33/565
CPC分类号： G01R33/561 , G01R33/563 , G01R33/4806 , G01R33/56527
摘要： A method for enhancing the sensitivity of gradient-recalled echo imaging for T2* effects in dynamic magnetic resonance imaging which involves the step of delaying gradient-recalled echoes so that the gradient-recalled echoes are subjected to magnetic susceptibility effects for an extended period of time. The gradient-recalled echoes are delayed beyond a subsequent radio frequency pulse by applying an additional gradient which dephases any gradient-recalled echo of spins that are excited in the radio frequency repetition time period in which said gradient-recalled echoes are produced.
摘要翻译：一种提高梯度回波成像对于动态磁共振成像中T2 *效应的灵敏度的方法，其涉及延迟梯度回波回波的步骤，使得梯度回波回波在延长的时间段内经受磁化率效应。梯度回波的回波被延迟超过随后的射频脉冲，通过应用额外的梯度，该梯度去除在产生所述梯度回波回波的射频重复时间段内被激发的任何梯度回波的自旋回波。

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