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1. 发明授权

US5919624A Methods for detecting cervical cancer 失效
标题翻译：检测宫颈癌的方法
公开(公告)号：US5919624A
公开(公告)日：1999-07-06
申请号：US781424
申请日：1997-01-10
申请人： Thomas Ried , Gert Auer , Evelin Schrock , Kerstin Heselmeyer , Merryn Macville
发明人： Thomas Ried , Gert Auer , Evelin Schrock , Kerstin Heselmeyer , Merryn Macville
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6886 , C12Q2600/112
摘要： The invention provides a method of detecting the presence of invasive cervical carcinoma in a subject comprising detecting in a cervical cell from the subject the presence of a chromosome abnormality which is associated with invasive cervical carcinoma; the presence of the cervical cell containing the chromosome abnormality indicating the presence of invasive cervical carcinoma in the subject. The invention also provides a method of detecting the presence of advanced-stage cervical carcinoma in a subject comprising detecting in a cervical cell from the subject the presence of a chromosome abnormality associated with advanced-stage cervical carcinoma; the presence of the cervical cell containing the chromosome abnormality indicating the presence of advanced-stage cervical carcinoma in the subject. The invention also provides a method of classifying the progression of dysplastic cervical cells from a non-invasive cervical carcinoma to an invasive cervical carcinoma comprising analyzing the dysplastic cervical cells for the presence of a chromosome abnormality which is associated with invasive cervical carcinoma, and classifying the dysplastic cervical cells having the chromosome abnormality as having progressed from a non-invasive cervical carcinoma cells to an invasive cervical carcinoma. The invention further provides kits comprising nucleic acids that specifically hybridize to chromosome 3q and specifically hybridize to another chromosome, and to compositions comprising nucleic acids.
摘要翻译：本发明提供一种检测受试者侵袭性宫颈癌存在的方法，包括在受试者宫颈细胞中检测与侵入性宫颈癌相关的染色体异常的存在; 含有染色体异常的子宫颈细胞的存在表明受试者存在浸润性宫颈癌。本发明还提供一种检测受试者中晚期宫颈癌存在的方法，包括在受试者的子宫颈细胞中检测与晚期宫颈癌相关的染色体异常的存在; 含有染色体异常的子宫颈细胞的存在表明该受试者存在晚期宫颈癌。本发明还提供了将发育不良的子宫颈细胞从非侵入性宫颈癌分级到浸润性宫颈癌的方法，包括分析发育不良的宫颈细胞是否存在与侵入性宫颈癌相关的染色体异常，并将具有染色体异常的发育不良的宫颈细胞从非侵入性宫颈癌细胞进展到浸润性宫颈癌。本发明还提供了包含与染色体3q特异性杂交并与另一染色体特异性杂交的核酸以及包含核酸的组合物的试剂盒。

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