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1. 发明授权

US5317262A Single shot magnetic resonance method to measure diffusion, flow and/or motion 失效
标题翻译：单次磁共振法测量扩散，流动和/或运动
公开(公告)号：US5317262A
公开(公告)日：1994-05-31
申请号：US926010
申请日：1992-08-05
申请人： Chrit T. W. Moonen , Peter van Gelderen
发明人： Chrit T. W. Moonen , Peter van Gelderen
IPC分类号： G01R33/561 , G01R33/563 , G01V3/00
CPC分类号： G01R33/56341 , G01R33/561
摘要： A method of obtaining an attenuation curve, and corresponding diffusion constant, from a single-shot procedure. In contrast to the conventional pulsed field-gradient spin echo (PGSE) procedures used to determine the diffusion attenuation curve of a body undergoing magnetic resonance imaging, the method uses a single-shot procedure. The procedure uses application of a single shot pulse sequence to initiate a spin-echo procedure. This procedure creates a number of gradient recalled echoes by alternating the diffusion gradient. Each subsequent gradient-recalled echo is attenuated by an additional pair of gradient pulses. This successive attenuation by the gradient pulses allows the diffusional attenuation curve to be determined accurately in a single procedure. Ratios of time symmetric echo pulses yield a value proportional to the diffusion constant.
摘要翻译：从单次过程获得衰减曲线和相应的扩散常数的方法。与用于确定经历磁共振成像的身体的扩散衰减曲线的常规脉冲场梯度自旋回波（PGSE）程序相反，该方法使用单次过程。该过程使用单次脉冲序列的应用来启动自旋回波过程。该过程通过交替扩散梯度来创建多个渐变回归回波。每个随后的梯度回波回波被另外一对梯度脉冲衰减。通过梯度脉冲的连续衰减允许在单个过程中精确地确定扩散衰减曲线。时间对称回波脉冲的比率产生与扩散常数成比例的值。

2. 发明授权

US5685305A Method and system for MRI detection of abnormal blood flow 失效
标题翻译： MRI检测异常血流的方法和系统
公开(公告)号：US5685305A
公开(公告)日：1997-11-11
申请号：US286783
申请日：1994-08-05
申请人： Chrit T. W. Moonen , Jeff Duyn , Peter van Gelderen
发明人： Chrit T. W. Moonen , Jeff Duyn , Peter van Gelderen
IPC分类号： G01R33/28 , G01R33/561 , G01R33/563 , A61B5/055
CPC分类号： G01R33/56366 , A61B5/055 , G01R33/56308 , G01R33/281 , G01R33/5617
摘要： A magnetic resonance imaging system and method for detecting blood flow abnormalities according to the time delay for the arrival of a bolus of a MR contrast agent into localized regions as observed in a temporal series magnetic resonance signals or images obtained subsequent to bolus injection. A rapid series of imaging pulse sequences acquires the time development of the signal from localized regions within the imaged field of view of a body. During the imaging period, a bolus of a MR contrast agent is injected into the cardiovascular system of the body. As the MR contrast material circulates through the imaged region, the associated field gradient which extends into the surrounding tissue results in signal losses in the acquired signal from these regions. The arrival time for the bolus into a given localized region is determined from the acquired time data, and the relative arrival time among regions in the imaged field of view indicates whether there is decreased blood flow to certain areas.
摘要翻译：一种磁共振成像系统和方法，用于根据时间序列磁共振信号或大剂量注射后获得的图像中观察到的，根据用于大量MR造影剂到达的时间延迟来检测血流异常。成像脉冲序列的快速系列从身体的成像视野内的局部区域获取信号的时间发展。在成像期间，将大量的MR造影剂注射到身体的心血管系统中。当MR对比材料循环通过成像区域时，延伸到周围组织的相关的场梯度导致从这些区域获得的信号中的信号损失。根据获取的时间数据确定推注到给定局部区域的到达时间，并且成像视场中的区域之间的相对到达时间指示是否存在到某些区域的血液流量减少。

3. 发明授权

US5459400A Method to enhance the sensitivity of MRI for magnetic susceptibility effects 失效
标题翻译：提高磁共振磁敏感性的方法
公开(公告)号：US5459400A
公开(公告)日：1995-10-17
申请号：US106372
申请日：1993-08-13
申请人： Chrit T. W. Moonen
发明人： Chrit T. W. Moonen
IPC分类号： G01R33/20 , A61B5/055 , G01R33/48 , G01R33/561 , G01R33/563 , G01R33/565 , G01V3/00
CPC分类号： G01R33/561 , G01R33/563 , G01R33/4806 , G01R33/56527
摘要： A method for enhancing the sensitivity of gradient-recalled echo imaging for T2* effects in dynamic magnetic resonance imaging which involves the step of delaying gradient-recalled echoes so that the gradient-recalled echoes are subjected to magnetic susceptibility effects for an extended period of time. The gradient-recalled echoes are delayed beyond a subsequent radio frequency pulse by applying an additional gradient which dephases any gradient-recalled echo of spins that are excited in the radio frequency repetition time period in which said gradient-recalled echoes are produced.
摘要翻译：一种提高梯度回波成像对于动态磁共振成像中T2 *效应的灵敏度的方法，其涉及延迟梯度回波回波的步骤，使得梯度回波回波在延长的时间段内经受磁化率效应。梯度回波的回波被延迟超过随后的射频脉冲，通过应用额外的梯度，该梯度去除在产生所述梯度回波回波的射频重复时间段内被激发的任何梯度回波的自旋回波。

4. 发明授权

US5300886A Method to enhance the sensitivity of MRI for magnetic susceptibility effects 失效
标题翻译：提高磁共振磁敏感性的方法
公开(公告)号：US5300886A
公开(公告)日：1994-04-05
申请号：US841994
申请日：1992-02-28
申请人： Chrit T. W. Moonen
发明人： Chrit T. W. Moonen
IPC分类号： G01R33/20 , A61B5/055 , G01R33/48 , G01R33/561 , G01R33/563 , G01R33/565
CPC分类号： G01R33/561 , G01R33/563 , G01R33/4806 , G01R33/56527
摘要： A method for enhancing the sensitivity of gradient-recalled echo imaging for T2* effects in dynamic magnetic resonance imaging which involves the step of delaying gradient-recalled echoes so that the gradient-recalled echoes are subjected to magnetic susceptibility effects for an extended period of time. The gradient-recalled echoes are delayed beyond a subsequent radio frequency pulse by applying an additional gradient which dephases any gradient-recalled echo of spins that are excited in the radio frequency repetition time period in which said gradient-recalled echoes are produced.
摘要翻译：一种提高梯度回波成像对于动态磁共振成像中T2 *效应的灵敏度的方法，其涉及延迟梯度回波回波的步骤，使得梯度回波回波在延长的时间段内经受磁化率效应。梯度回波的回波被延迟超过随后的射频脉冲，通过应用额外的梯度，该梯度去除在产生所述梯度回波回波的射频重复时间段内被激发的任何梯度回波的自旋回波。

5. 发明授权

US5570019A Method for magnetic resonance spectroscopic imaging with multiple spin-echoes 失效
标题翻译：具有多个自旋回波的磁共振光谱成像方法
公开(公告)号：US5570019A
公开(公告)日：1996-10-29
申请号：US538786
申请日：1995-10-03
申请人： Chrit T. W. Moonen , Jeff Duyn
发明人： Chrit T. W. Moonen , Jeff Duyn
IPC分类号： G01R33/483 , G01R33/485 , G01R33/561 , G01V3/00
CPC分类号： G01R33/5615 , G01R33/4833 , G01R33/485 , G01R33/5617
摘要： A nuclear magnetic resonance pulse sequence to provide spectral encoding so that the resulting series of spin-echoes each include both spatial and spectral information for spectroscopic imaging. Atoms within the object are excited and may then be spatially encoded, as by a phase encoding gradient. A series of refocusing pulses is then applied, inducing a respective series of spin-echoes. Spectral information is directly encoded in the spin-echo signals. The multiple spin-echoes may be used for sampling different points of k-space, and/or for increasing the signal-to-noise ratio by averaging. In an alternative embodiment, the present invention produces compound weighted spectroscopic images by selecting the period between refocussing pulses according to the coupling constant of a group contained in the compound; thereby, the signal of the selected compounds modulate with a known frequency different for compounds with different coupling constants.
摘要翻译：提供频谱编码的核磁共振脉冲序列，使得所得到的一系列自旋回波各自包括用于光谱成像的空间和光谱信息。物体内的原子被激发，然后可以通过相位编码梯度进行空间编码。然后施加一系列重聚焦脉冲，引起相应的一系列自旋回波。光谱信息直接在自旋回波信号中编码。多个自旋回波可用于对k空间的不同点进行采样，和/或用于通过平均来增加信噪比。在替代实施例中，本发明通过根据化合物中所含的基团的偶联常数选择重聚焦脉冲之间的周期来产生化合物加权分光图像; 因此，所选择的化合物的信号以对具有不同偶合常数的化合物不同的已知频率进行调节。

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