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31. 发明申请

US20100249487A1 BRACHYTHERAPY APPARATUS AND METHODS OF USING SAME 审中-公开
标题翻译： BRACHYTHERAPY装置及其使用方法
公开(公告)号：US20100249487A1
公开(公告)日：2010-09-30
申请号：US12815374
申请日：2010-06-14
申请人： George D. Hermann , Doug S. Sutton , Gail S. Lebovic , Eduardo Chi Sing , Robert R. Bowes
发明人： George D. Hermann , Doug S. Sutton , Gail S. Lebovic , Eduardo Chi Sing , Robert R. Bowes
IPC分类号： A61M36/04
CPC分类号： A61N5/1007 , A61N5/1014 , A61N5/1027 , A61N2005/1005 , A61N2005/1011 , A61N2005/1012 , A61N2005/1023 , A61N2005/1094
摘要： Apparatus, systems and methods for delivering brachytherapy to a target tissue region of a human or other mammalian body. In some embodiments, a flexible brachytherapy device is implanted that includes a therapy delivery portion having one or more radioactive sources securely retained thereto, and a tail portion extending from the therapy delivery portion. Once implanted, the tail portion may extend outside the body, where it may be folded and secured flat against the skin. The device may be removed at therapy completion. Other embodiments of the invention are directed to systems and methods for delivering brachytherapy devices to the body.
摘要翻译：用于将近距离放射治疗递送到人或其他哺乳动物身体的靶组织区域的装置，系统和方法。在一些实施例中，植入柔性近距离放射治疗装置，其包括具有一个或多个可靠地保持在其上的放射源的治疗递送部分和从治疗递送部分延伸的尾部。一旦植入，尾部可以延伸到身体的外部，在那里它可以被折叠并且平坦地固定在皮肤上。在治疗完成时可以移除该装置。本发明的其它实施例涉及用于将近距离放射治疗装置输送到身体的系统和方法。

32. 发明申请

US20100048978A1 BRACHYTHERAPY APPARATUS, SYSTEMS, AND METHODS FOR USING THEM 有权
标题翻译： BRACHYTHERAPY设备，系统和使用它们的方法
公开(公告)号：US20100048978A1
公开(公告)日：2010-02-25
申请号：US12543469
申请日：2009-08-18
申请人： Eduardo Chi Sing , Tommy G. Nguyen
发明人： Eduardo Chi Sing , Tommy G. Nguyen
IPC分类号： A61M36/10 , A61M36/12
CPC分类号： A61N5/1015 , A61N5/1016
摘要： An applicator for delivering brachytherapy includes elongate members movable between collapsed and expanded configurations for delivering brachytherapy within a lumpectomy cavity, a vaginal cavity, or other target region. The elongate members may be expandable into a symmetrical or asymmetrical expanded configuration, e.g., into a generally spherical, pear-shaped, or planar configuration. A system for delivering brachytherapy includes the applicator and an access device for lining and/or dilating a body cavity and/or for receiving the applicator therein. The access device is advanced into a body cavity, an expandable member on the access device is inflated, the applicator is advanced into the access device, and the elongate members are expanded to deliver radiation to the target region. Alternatively, the access device carries an expandable device into the target region, the expandable device is removed after dilating the target region, and the applicator is introduced through the access device to deliver radiation.
摘要翻译：用于递送近距离放射治疗的施放器包括可在塌陷和膨胀构型之间移动的细长构件，用于在乳房切除腔，阴道腔或其它目标区域内输送近距离放射治疗。细长构件可以可扩展成对称或不对称的膨胀构型，例如，变成大致球形的梨形或平面构型。用于递送近距离放射治疗的系统包括施用器和用于衬里和/或扩张体腔和/或用于在其中接收施用器的进入装置。进入装置前进到体腔中，进入装置上的可膨胀构件被充气，施加器前进到进入装置中，并且细长构件被扩张以将辐射传递到目标区域。或者，接入设备将可扩展设备携带到目标区域中，在扩大目标区域之后移除可扩展设备，并且通过接入设备引入施加器以传送辐射。

33. 发明申请

US20220386890A1 IMPEDANCE REFLECTOR DETECTION SYSTEMS AND METHODS FOR USING THEM 有权
公开(公告)号：US20220386890A1
公开(公告)日：2022-12-08
申请号：US17805617
申请日：2022-06-06
申请人： Cianna Medical, Inc.
发明人： Nikolai Rulkov , John E. Greene
IPC分类号： A61B5/06 , A61B90/00 , A61B5/00
摘要： An impedance reflector apparatus, systems, and methods are provided for detecting a marker implanted within tissue that includes a switch for changing a configuration of an antenna of the marker. The apparatus includes a set of transmit electrodes coupled to a signal generator for transmitting a drive current into tissue to generate an electromagnetic field around the marker, a set of receive electrodes configured to detect voltage signals within the tissue corresponding to the electromagnetic field, and a light source for delivering light pulses into the body to open and close the switch to change the configuration of the antenna of the marker. A processor coupled to the receive electrodes processes the detected voltage signals to identify changes in the electromagnetic field that are synchronized with the light pulses to determine whether the marker is operating properly.

34. 发明申请

US20220151726A1 APPARATUS, SYSTEMS, AND METHODS FOR LOCALIZING MARKERS OR TISSUE STRUCTURES WITHIN A BODY 有权
公开(公告)号：US20220151726A1
公开(公告)日：2022-05-19
申请号：US17456134
申请日：2021-11-22
申请人： Cianna Medical, Inc.
发明人： Eduardo Chi Sing , Tommy G. Nguyen , Luis Urquidi
IPC分类号： A61B90/00 , A61B5/0507 , A61B5/06 , A61B5/00 , A61B8/08 , A61B10/00 , A61B17/34
摘要： Apparatus, systems, and methods are provided for localizing lesions within a patient's body, e.g., within a breast. The system may include one or more markers implantable within or around the target tissue region, and a probe for transmitting and receiving electromagnetic signals to detect the one or more markers. During use, the marker(s) are into a target tissue region, and the probe is placed against the patient's skin to detect and localize the marker(s). A tissue specimen, including the lesion and the marker(s), is then removed from the target tissue region based at least in part on the localization information from the probe.

35. 发明授权

US11298045B2 Microwave antenna apparatus, systems, and methods for localizing markers or tissue structures within a body 有权
公开(公告)号：US11298045B2
公开(公告)日：2022-04-12
申请号：US16544765
申请日：2019-08-19
申请人： Cianna Medical, Inc.
发明人： Larry W Fullerton , John E. Greene , Tommy G. Nguyen , Eduardo Chi Sing
IPC分类号： A61B5/06 , A61B90/00 , A61B5/00 , A61B5/0507 , A61B34/20
摘要： Apparatus, systems, and methods are provided for localizing lesions within a patient's body, e.g., within a breast. The system includes a microwave antenna probe for transmitting and receiving electromagnetic signals to detect one or more markers that are implanted within or around the target tissue region. During use, the marker(s) are implanted into a target tissue region, and the microwave antenna probe is placed against the patient's skin to transmit a signal to the marker(s) and to receive the reflected signal from the marker(s) in order to determine the location of the marker(s). A tissue specimen, including the lesion and the marker(s), is then removed from the target tissue region based at least in part on the location information from the microwave antenna probe.

36. 发明申请

US20210068705A1 REFLECTOR MARKERS AND SYSTEMS AND METHODS FOR IDENTIFYING AND LOCATING THEM 有权
公开(公告)号：US20210068705A1
公开(公告)日：2021-03-11
申请号：US17093464
申请日：2020-11-09
申请人： Cianna Medical, Inc.
发明人： John E. Greene , Nikolai Rullkov , Jonathan White
IPC分类号： A61B5/06 , H01Q1/27 , A61B34/20 , A61B90/00 , H01L23/60 , A61B90/98 , G01S7/35 , G01S13/88 , A61B5/00 , H01Q1/00
摘要： Markers and related systems and methods are provided for localizing lesions within a patient's body, e.g., within a breast. The marker includes one or more photosensitive diodes for transforming light pulses striking the marker into electrical energy, one or more antennas, and a switch coupled to the photodiodes and antennas such that the light pulses cause the switch to open and close and modulate radar signals reflected by the marker back to a source of the signals. The antenna(s) may include one or more wire elements extending from a housing, one or more antenna elements printed on a substrate, or one or more chip antennas. Optionally, the marker may include a processor coupled to the photodiodes for identifying signals in the light pulses or one or more coatings or filters to allow selective activation of the marker.

37. 发明授权

US10827949B2 Reflector markers and systems and methods for identifying and locating them 有权
公开(公告)号：US10827949B2
公开(公告)日：2020-11-10
申请号：US15928085
申请日：2018-03-21
申请人： CIANNA MEDICAL, INC.
发明人： John E. Greene , Nikolai Rulkov , Jonathan White
IPC分类号： A61B5/06 , H01Q1/27 , A61B34/20 , A61B90/00 , H01L23/60 , A61B90/98 , G01S7/35 , G01S13/88 , A61B5/00 , H01Q1/00 , G01S13/75 , H01Q9/16 , H01Q1/22 , G01S13/84 , H01Q15/02 , G01S7/41 , H01Q1/38 , A61B17/00 , G01S7/02 , H01Q9/28 , H01Q9/26 , H01L23/00 , H01L23/48 , G01S13/36
摘要： Markers and related systems and methods are provided for localizing lesions within a patient's body, e.g., within a breast. The marker includes one or more photosensitive diodes for transforming light pulses striking the marker into electrical energy, one or more antennas, and a switch coupled to the photodiodes and antennas such that the light pulses cause the switch to open and close and modulate radar signals reflected by the marker back to a source of the signals. The antenna(s) may include one or more wire elements extending from a housing, one or more antenna elements printed on a substrate, or one or more chip antennas. Optionally, the marker may include a processor coupled to the photodiodes for identifying signals in the light pulses or one or more coatings or filters to allow selective activation of the marker.

38. 发明授权

US10499832B2 Reflector markers and systems and methods for identifying and locating them 有权
公开(公告)号：US10499832B2
公开(公告)日：2019-12-10
申请号：US15481431
申请日：2017-04-06
申请人： CIANNA MEDICAL, INC.
发明人： John E. Greene , Nikolai Rulkov , Jonathan White
IPC分类号： A61B5/06 , A61B34/20 , A61B90/00 , A61B90/98 , H01L23/60 , H01L25/16 , A61B17/00 , A61B90/30 , A61B34/30 , H01L23/00
CPC分类号： A61B5/064 , A61B34/20 , A61B90/04 , A61B90/39 , A61B90/98 , H01L23/60 , H01L25/167 , A61B5/062 , A61B2017/008 , A61B2017/0088 , A61B2017/00212 , A61B2017/00411 , A61B2017/00867 , A61B2034/2051 , A61B2034/306 , A61B2090/306 , A61B2090/397 , A61B2090/3908 , A61B2090/3975 , A61B2090/3979 , A61B2090/3987 , H01L24/48 , H01L2224/48091 , H01L2224/48227 , H01L2224/48465 , H01L2924/00014 , H01L2224/48091 , H01L2924/00014 , H01L2924/00014 , H01L2224/45099 , H01L2224/48465 , H01L2224/48227 , H01L2924/00012 , H01L2224/48465 , H01L2224/48227 , H01L2924/00
摘要： Markers and related systems and methods are provided for localizing lesions within a patient's body, e.g., within a breast. The marker includes one or more photosensitive diodes for transforming light pulses striking the marker into electrical energy, one or more antennas, and a switch coupled to the photodiodes and antennas such that the light pulses cause the switch to open and close and modulate radar signals reflected by the marker back to a source of the signals. The antenna(s) may include one or more wire elements extending from a housing, one or more antenna elements printed on a substrate, or one or more chip antennas. Optionally, the marker may include a processor coupled to the photodiodes for identifying signals in the light pulses or one or more coatings or filters to allow selective activation of the marker.

39. 发明授权

US09067063B2 Expandable brachytherapy apparatus and methods for using them 有权
标题翻译：可扩展近距离放射治疗仪及其使用方法
公开(公告)号：US09067063B2
公开(公告)日：2015-06-30
申请号：US12939121
申请日：2010-11-03
申请人： Eduardo Chi Sing , Tommy G. Nguyen
发明人： Eduardo Chi Sing , Tommy G. Nguyen
IPC分类号： A61M36/04 , A61M36/12 , A61N5/10 , A61M25/10
CPC分类号： A61N5/1015 , A61M25/10 , A61N5/1001 , A61N5/1002 , A61N5/1007 , A61N5/1014 , A61N2005/1004
摘要： Brachytherapy treatment apparatus are provided that include an elongate core member, a plurality of expandable catheters or other elongate members and a balloon or other expandable member on a distal portion adjacent the core member. Each catheter includes a distal end coupled to the core member distal end, a proximal end movable relative to the core member, and a lumen extending between the proximal and distal ends for receiving a source of radiation therealong. The balloon is expandable independently of the catheters such that the balloon may be expanded after expanding the catheters, e.g., to facilitate imaging and/or dose planning. Optionally, a working channel may be provided for receiving an aspiration catheter or other instrument or at least one of the catheters may include an aspiration lumen and one or more ports, e.g., for aspirating material from a region surrounding the distal portion.
摘要翻译：提供了近距离放射疗法治疗装置，其包括细长芯部件，多个可膨胀导管或其它细长部件以及邻近该芯部件的远侧部分上的球囊或其它可扩张部件。每个导管包括联接到芯构件远端的远端，可相对于芯构件移动的近端，以及在近端和远端之间延伸的腔，用于在其周围接收辐射源。气囊可以独立于导管扩张，使得气囊可以在扩张导管之后膨胀，例如以便于成像和/或剂量计划。可选地，可以提供工作通道用于接收抽吸导管或其他器械，或者至少一个导管可以包括抽吸腔和一个或多个端口，例如用于从围绕远端部分的区域抽吸材料。

40. 发明授权

US08892185B2 Apparatus, systems, and methods for localizing markers or tissue structures within a body 有权
标题翻译：用于在身体内定位标记物或组织结构的装置，系统和方法
公开(公告)号：US08892185B2
公开(公告)日：2014-11-18
申请号：US12824139
申请日：2010-06-25
申请人： Eduardo Chi Sing , Mark A. Cole , Tommy G. Nguyen
发明人： Eduardo Chi Sing , Mark A. Cole , Tommy G. Nguyen
IPC分类号： A61B5/06 , A61B5/05 , A61B17/00 , A61B19/00
CPC分类号： A61B5/061 , A61B5/0507 , A61B5/06 , A61B5/064 , A61B90/37 , A61B90/39 , A61B2017/00438 , A61B2017/00442 , A61B2034/2051 , A61B2034/2072 , A61B2090/3908 , A61B2090/397 , A61B2090/3975 , A61B2090/3987
摘要： Apparatus, systems, and methods are provided for localizing lesions within a patient's body, e.g., within a breast. The system may include one or more markers implantable within or around the target tissue region, and a probe for transmitting and receiving electromagnetic signals to detect the one or more markers. During use, the marker(s) are into a target tissue region, and the probe is placed against the patient's skin to detect and localize the marker(s). A tissue specimen, including the lesion and the marker(s), is then removed from the target tissue region based at least in part on the localization information from the probe.
摘要翻译：提供了设备，系统和方法，用于定位患者身体内的损伤，例如在乳房内。系统可以包括可植入在目标组织区域内或周围的一个或多个标记，以及用于发送和接收电磁信号以检测一个或多个标记的探针。在使用期间，标记物进入目标组织区域，并将探针放置在患者皮肤上以检测和定位标记物。然后至少部分地基于来自探针的定位信息从靶组织区域中移除包括病变和标记物的组织标本。

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