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1. 发明授权

US07736292B2 Brachytherapy apparatus and methods of using same 有权
标题翻译：近距离放射治疗仪及其使用方法
公开(公告)号：US07736292B2
公开(公告)日：2010-06-15
申请号：US11554731
申请日：2006-10-31
申请人： George D. Hermann , Doug S. Sutton , Gail S. Lebovic , Eduardo Chi Sing , Robert R. Bowes
发明人： George D. Hermann , Doug S. Sutton , Gail S. Lebovic , Eduardo Chi Sing , Robert R. Bowes
IPC分类号： A61M36/12 , A61M36/00 , A61M36/04 , A61N5/00
CPC分类号： A61N5/1007 , A61N5/1014 , A61N5/1027 , A61N2005/1005 , A61N2005/1011 , A61N2005/1012 , A61N2005/1023 , A61N2005/1094
摘要： Apparatus, systems and methods for delivering brachytherapy to a target tissue region of a human or other mammalian body. In some embodiments, a flexible brachytherapy device is implanted that includes a therapy delivery portion having one or more radioactive sources securely retained thereto, and a tail portion extending from the therapy delivery portion. Once implanted, the tail portion may extend outside the body, where it may be folded and secured flat against the skin. The device may be removed at therapy completion. Other embodiments of the invention are directed to systems and methods for delivering brachytherapy devices to the body.
摘要翻译：用于将近距离放射治疗递送到人或其他哺乳动物身体的靶组织区域的装置，系统和方法。在一些实施例中，植入柔性近距离放射治疗装置，其包括具有一个或多个可靠地保持在其上的放射源的治疗递送部分和从治疗递送部分延伸的尾部。一旦植入，尾部可以延伸到身体的外部，在那里它可以被折叠并且平坦地固定在皮肤上。在治疗完成时可以移除该装置。本发明的其它实施例涉及用于将近距离放射治疗装置输送到身体的系统和方法。

2. 发明申请

US20100249487A1 BRACHYTHERAPY APPARATUS AND METHODS OF USING SAME 审中-公开
标题翻译： BRACHYTHERAPY装置及其使用方法
公开(公告)号：US20100249487A1
公开(公告)日：2010-09-30
申请号：US12815374
申请日：2010-06-14
申请人： George D. Hermann , Doug S. Sutton , Gail S. Lebovic , Eduardo Chi Sing , Robert R. Bowes
发明人： George D. Hermann , Doug S. Sutton , Gail S. Lebovic , Eduardo Chi Sing , Robert R. Bowes
IPC分类号： A61M36/04
CPC分类号： A61N5/1007 , A61N5/1014 , A61N5/1027 , A61N2005/1005 , A61N2005/1011 , A61N2005/1012 , A61N2005/1023 , A61N2005/1094
摘要： Apparatus, systems and methods for delivering brachytherapy to a target tissue region of a human or other mammalian body. In some embodiments, a flexible brachytherapy device is implanted that includes a therapy delivery portion having one or more radioactive sources securely retained thereto, and a tail portion extending from the therapy delivery portion. Once implanted, the tail portion may extend outside the body, where it may be folded and secured flat against the skin. The device may be removed at therapy completion. Other embodiments of the invention are directed to systems and methods for delivering brachytherapy devices to the body.
摘要翻译：用于将近距离放射治疗递送到人或其他哺乳动物身体的靶组织区域的装置，系统和方法。在一些实施例中，植入柔性近距离放射治疗装置，其包括具有一个或多个可靠地保持在其上的放射源的治疗递送部分和从治疗递送部分延伸的尾部。一旦植入，尾部可以延伸到身体的外部，在那里它可以被折叠并且平坦地固定在皮肤上。在治疗完成时可以移除该装置。本发明的其它实施例涉及用于将近距离放射治疗装置输送到身体的系统和方法。

3. 发明授权

US08858415B2 Brachytherapy apparatus and methods for using them 有权
标题翻译：近距离放射治疗仪及其使用方法
公开(公告)号：US08858415B2
公开(公告)日：2014-10-14
申请号：US12764892
申请日：2010-04-21
申请人： Eduardo Chi Sing , George D. Hermann , Mark A. Cole , Mark A. Richart , Than Nguyen , Gail S. Lebovic
发明人： Eduardo Chi Sing , George D. Hermann , Mark A. Cole , Mark A. Richart , Than Nguyen , Gail S. Lebovic
IPC分类号： A61M36/12 , A61N5/10
CPC分类号： A61N5/1015 , A61N2005/1018
摘要： Apparatus for delivering brachytherapy to a target tissue region includes an elongate body including a proximal end, a distal end sized for introduction into a tissue tract and carrying a plurality of elongate members including pathways for receiving a source of radiation. The elongate members are movable between collapsed and expanded configurations. During use, a tract is created through tissue, and the elongate body carrying the elongate members is advanced through the tract into a target location with the elongate members in the collapsed configuration. The elongate members are directed to the expanded configuration at the target location, and radiation is delivered to treat tissue at the target location, e.g., by introducing one or more radiation sources along the pathways.
摘要翻译：用于将近距离放射治疗递送到目标组织区域的装置包括细长主体，其包括近端，远端，其尺寸适于引入到组织道中并且承载多个细长构件，包括用于接收辐射源的路径。细长构件可在折叠和膨胀构型之间移动。在使用期间，通过组织产生管道，并且携带细长构件的细长体通过管道前进到目标位置，细长构件处于收缩构型。细长构件在目标位置处被引导到扩展构型，并且例如通过沿着路径引入一个或多个辐射源，传送辐射以在目标位置处理组织。

4. 发明授权

US07862496B2 Brachytherapy apparatus and methods for using them 有权
标题翻译：近距离放射治疗仪及其使用方法
公开(公告)号：US07862496B2
公开(公告)日：2011-01-04
申请号：US11276851
申请日：2006-03-16
申请人： George D. Hermann , Eduardo Chi Sing , Gail S. Lebovic , Mark A. Cole , Mark A. Ritchart , Than Nguyen
发明人： George D. Hermann , Eduardo Chi Sing , Gail S. Lebovic , Mark A. Cole , Mark A. Ritchart , Than Nguyen
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61N2005/1018
摘要： Apparatus for delivering brachytherapy to a target tissue region includes an elongate body including a proximal end, a distal end sized for introduction into a tissue tract and carrying a plurality of elongate members including pathways for receiving a source of radiation. The elongate members are movable between collapsed and expanded configurations. During use, a tract is created through tissue, and the elongate body carrying the elongate members is advanced through the tract into a target location with the elongate members in the collapsed configuration. The elongate members are directed to the expanded configuration at the target location, and radiation is delivered to treat tissue at the target location, e.g., by introducing one or more radiation sources along the pathways.
摘要翻译：用于将近距离放射治疗递送到目标组织区域的装置包括细长主体，其包括近端，远端，其尺寸适于引入到组织道中并且承载多个细长构件，包括用于接收辐射源的路径。细长构件可在折叠和膨胀构型之间移动。在使用期间，通过组织产生管道，并且携带细长构件的细长体通过管道前进到目标位置，细长构件处于收缩构型。细长构件在目标位置处被引导到扩展构型，并且例如通过沿着路径引入一个或多个辐射源，传送辐射以在目标位置处理组织。

5. 发明授权

US10201716B2 Brachytherapy apparatus and methods for using them 有权
公开(公告)号：US10201716B2
公开(公告)日：2019-02-12
申请号：US12982823
申请日：2010-12-30
申请人： George D. Hermann , Eduardo Chi Sing , Gail S. Lebovic , Mark A. Cole , Mark A. Ritchart , Than Nguyen
发明人： George D. Hermann , Eduardo Chi Sing , Gail S. Lebovic , Mark A. Cole , Mark A. Ritchart , Than Nguyen
IPC分类号： A61M36/12 , A61N5/10
摘要： Apparatus for delivering brachytherapy to a target tissue region includes an elongate body including a proximal end, a distal end sized for introduction into a tissue tract and carrying a plurality of elongate members including pathways for receiving a source of radiation. The elongate members are movable between collapsed and expanded configurations. During use, a tract is created through tissue, and the elongate body carrying the elongate members is advanced through the tract into a target location with the elongate members in the collapsed configuration. The elongate members are directed to the expanded configuration at the target location, and radiation is delivered to treat tissue at the target location, e.g., by introducing one or more radiation sources along the pathways.

6. 发明申请

US20100204537A1 BRACHYTHERAPY APPARATUS AND METHODS FOR USING THEM 有权
标题翻译： BRACHYTHERAPY设备及其使用方法
公开(公告)号：US20100204537A1
公开(公告)日：2010-08-12
申请号：US12764892
申请日：2010-04-21
申请人： George D. Hermann , Eduardo Chi Sing , Gail S. Lebovic , Mark A. Cole , Mark A. Ritchart , Than Nguyen
发明人： George D. Hermann , Eduardo Chi Sing , Gail S. Lebovic , Mark A. Cole , Mark A. Ritchart , Than Nguyen
IPC分类号： A61M36/12
CPC分类号： A61N5/1015 , A61N2005/1018
摘要： Apparatus for delivering brachytherapy to a target tissue region includes an elongate body including a proximal end, a distal end sized for introduction into a tissue tract and carrying a plurality of elongate members including pathways for receiving a source of radiation. The elongate members are movable between collapsed and expanded configurations. During use, a tract is created through tissue, and the elongate body carrying the elongate members is advanced through the tract into a target location with the elongate members in the collapsed configuration. The elongate members are directed to the expanded configuration at the target location, and radiation is delivered to treat tissue at the target location, e.g., by introducing one or more radiation sources along the pathways.
摘要翻译：用于将近距离放射治疗递送到目标组织区域的装置包括细长主体，其包括近端，远端，其尺寸适于引入到组织道中并且承载多个细长构件，包括用于接收辐射源的路径。细长构件可在折叠和膨胀构型之间移动。在使用期间，通过组织产生管道，并且携带细长构件的细长体通过管道前进到目标位置，细长构件处于收缩构型。细长构件在目标位置处被引导到扩展构型，并且例如通过沿着路径引入一个或多个辐射源，传送辐射以在目标位置处理组织。

7. 发明申请

US20110137103A1 BRACHYTHERAPY APPARATUS AND METHODS FOR USING THEM 审中-公开
标题翻译： BRACHYTHERAPY设备及其使用方法
公开(公告)号：US20110137103A1
公开(公告)日：2011-06-09
申请号：US12982823
申请日：2010-12-30
申请人： George D. Hermann , Eduardo Chi Sing , Gail S. Lebovic , Mark A. Cole , Mark A. Ritchart , Than Nguyen
发明人： George D. Hermann , Eduardo Chi Sing , Gail S. Lebovic , Mark A. Cole , Mark A. Ritchart , Than Nguyen
IPC分类号： A61M36/12
CPC分类号： A61N5/1015 , A61N2005/1018
摘要： Apparatus for delivering brachytherapy to a target tissue region includes an elongate body including a proximal end, a distal end sized for introduction into a tissue tract and carrying a plurality of elongate members including pathways for receiving a source of radiation. The elongate members are movable between collapsed and expanded configurations. During use, a tract is created through tissue, and the elongate body carrying the elongate members is advanced through the tract into a target location with the elongate members in the collapsed configuration. The elongate members are directed to the expanded configuration at the target location, and radiation is delivered to treat tissue at the target location, e.g., by introducing one or more radiation sources along the pathways.
摘要翻译：用于将近距离放射治疗递送到目标组织区域的装置包括细长主体，其包括近端，远端，其尺寸适于引入到组织道中并且承载多个细长构件，包括用于接收辐射源的路径。细长构件可在折叠和膨胀构型之间移动。在使用期间，通过组织产生管道，并且携带细长构件的细长体通过管道前进到目标位置，细长构件处于收缩构型。细长构件在目标位置处被引导到扩展构型，并且例如通过沿着路径引入一个或多个辐射源，传送辐射以在目标位置处理组织。

8. 发明授权

US09014787B2 Bioabsorbable target for diagnostic or therapeutic procedure 有权
标题翻译：用于诊断或治疗程序的生物可吸收靶标
公开(公告)号：US09014787B2
公开(公告)日：2015-04-21
申请号：US12790314
申请日：2010-05-28
申请人： James B. Stubbs , George D. Hermann , Gail S. Lebovic , Michael J. Drews
发明人： James B. Stubbs , George D. Hermann , Gail S. Lebovic , Michael J. Drews
IPC分类号： A61B5/05 , A61B19/00 , A61N5/10 , A61B17/00
CPC分类号： A61N5/1015 , A61B90/39 , A61B90/94 , A61B2017/00004 , A61B2017/00716 , A61B2090/0815 , A61B2090/3908 , A61B2090/3925 , A61B2090/3954 , A61B2090/3966 , A61N5/1049 , A61N5/1069 , A61N2005/1098
摘要： An implantable device has a body that is substantially rigid and has an imageable shape. The body is further bioabsorbable and may contain permanent metallic elements to aid in its imaging. When the device is implanted in a resected cavity in soft tissue, it can cause the cavity to conform substantially to a known imageable shape. The implantable device is further imageable due to its attenuation properties being different from those of soft tissue such that the boundaries of the tissue corresponding to the predetermined shape can be determined.
摘要翻译：可植入装置具有基本上刚性且具有可成像形状的主体。身体是进一步的生物可吸收的并且可以包含永久性金属元素以帮助其成像。当将该装置植入软组织中的切除的腔中时，其可以使空腔基本上符合已知可成像的形状。可植入装置由于其衰减特性与软组织的衰减特性不同而进一步成像，从而能够确定对应于预定形状的组织的边界。

9. 发明授权

US08512217B2 Systems and methods for delivering radiation therapy 有权
公开(公告)号：US08512217B2
公开(公告)日：2013-08-20
申请号：US12395625
申请日：2009-02-27
申请人： Gail S. Lebovic , George D. Hermann , Douglas S. Sutton
发明人： Gail S. Lebovic , George D. Hermann , Douglas S. Sutton
IPC分类号： A61M36/10
CPC分类号： A61N5/1016 , A61N2005/1004
摘要： Described here are conformable brachytherapy applicators. The conformable brachytherapy applicators generally follow the contour of tissue surfaces so that distances between radiation sources and target tissues can be precisely determined and radiation dose clouds can be readily shaped. Systems and methods for using the conformable brachytherapy applicators are also described.

10. 发明授权

US08323171B2 Brachytherapy apparatus and methods for using same 有权
标题翻译：近距离放射治疗仪及其使用方法
公开(公告)号：US08323171B2
公开(公告)日：2012-12-04
申请号：US11867625
申请日：2007-10-04
申请人： Gail S. Lebovic , George D. Hermann
发明人： Gail S. Lebovic , George D. Hermann
IPC分类号： A61N5/00
CPC分类号： A61N5/1027 , A61N2005/1011 , A61N2005/1023 , A61N2005/1094
摘要： Apparatus, systems and methods are provided for delivering brachytherapy to a target tissue region of a human or other mammalian body. In some embodiments, a flexible brachytherapy device is implanted that includes a therapy delivery portion having one or more radioactive sources securely retained thereto, and a tail portion extending from the therapy delivery portion. Once implanted, the tail portion may extend outside the body, where it may be folded and secured flat against the skin. The device may be removed at therapy completion. Other embodiments of the invention are directed to systems and methods for delivering brachytherapy devices to the body.
摘要翻译：提供装置，系统和方法用于将近距离放射治疗递送至人或其他哺乳动物身体的靶组织区域。在一些实施例中，植入柔性近距离放射治疗装置，其包括具有一个或多个可靠地保持在其上的放射源的治疗递送部分和从治疗递送部分延伸的尾部。一旦植入，尾部可以延伸到身体的外部，在那里它可以被折叠并且平坦地固定在皮肤上。在治疗完成时可以移除该装置。本发明的其它实施例涉及用于将近距离放射治疗装置输送到身体的系统和方法。

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