专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

US20030148536A1 Chemiluminescence analyzer 审中-公开
标题翻译：化学发光分析仪
公开(公告)号：US20030148536A1
公开(公告)日：2003-08-07
申请号：US10067501
申请日：2002-02-04
发明人： Chi-Wang Liang , Jeng-Fong Chiou
IPC分类号： G01N021/76
CPC分类号： G01N21/76 , G01N2201/0231 , G01N2201/0253
摘要： A chemiluminescence analyzer determines the level of chemiluminescence of a specimen. The chemiluminescence analyzer includes a light detection chamber for containing the specimen to be analyzed. The light detection chamber includes a chamber access device, for allowing the positioning of the specimen within the light detection chamber, and a shutter device. The shutter device and the chamber access device are configured to each have an open position and a closed position. A light detector is positioned behind the shutter device. When the shutter device is in the open position, the light detector detects light within the light detection chamber. An interlock assembly is interfaced with the shutter device and the chamber access device, such that the interlock assembly prevents the shutter device and the chamber access device from being simultaneously opened.
摘要翻译：化学发光分析仪确定样品的化学发光水平。化学发光分析仪包括用于容纳要分析的样品的光检测室。光检测室包括用于允许样本在光检测室内定位的室进入装置和快门装置。快门装置和室进入装置被构造成各具有打开位置和关闭位置。光检测器位于快门装置后面。当快门装置处于打开位置时，光检测器检测光检测室内的光。互锁组件与快门装置和腔室进入装置接口，使得互锁组件防止快门装置和腔室进入装置同时打开。

22. 发明申请

US20020177235A1 Method of measuring the luminescence emitted in a luminescent assay 失效
标题翻译：测量在发光测定中发出的发光的方法
公开(公告)号：US20020177235A1
公开(公告)日：2002-11-28
申请号：US10008549
申请日：2001-11-13
发明人： Michel Mabile , Gerard Mathis , Etienne Jean-Pierre Jolu , Dominique Pouyat , Christophe Dumont
IPC分类号： G01N021/76
CPC分类号： G01N21/6452 , G01N21/6428 , G01N33/54306 , G01N33/582
摘要： The present invention relates to a method of measuring the luminescence emitted in a luminescent assay, which makes it possible to correct certain perturbations due to the measuring medium. Said method comprises employing at least one luminescent tracer compound and a luminescent compound used as an internal reference, which, when exposed to the same excitation wavelength, are capable of emitting at different wavelengths, null2 and null1 respectively, either by direct luminescence or by the induction of a luminescent emission, and correcting the measurement of the luminescence emitted by the tracer compound at wavelength null2 on the basis of the measurement of the luminescence emitted by the reference compound at wavelength nulll. The invention further relates to the use of said method in a homogeneous method of detecting and/or determining an analyte, and to a device for carrying it out.
摘要翻译：本发明涉及一种测量在发光测定中发出的发光的方法，其使得可以校正由于测量介质引起的某些扰动。所述方法包括使用至少一种发光示踪剂化合物和用作内部参考的发光化合物，当暴露于相同的激发波长时，其能够分别通过直接发光或通过直接发光分别发射不同波长的lambd2和lambd1 诱导发光发射，并且基于在参考化合物在波长lambd1处发出的发光的测量来校正在波长lambd2下由示踪剂化合物发射的发光的测量。本发明还涉及所述方法在检测和/或确定分析物的均匀方法中的用途以及用于将其分离出来的装置。

23. 发明申请

US20020176895A1 Natural fluorescent dye obtained from a marine invertebrate, compositions containing the said dye and their uses 失效
标题翻译：从海洋无脊椎动物获得的天然荧光染料，含有所述染料的组合物及其用途
公开(公告)号：US20020176895A1
公开(公告)日：2002-11-28
申请号：US09820654
申请日：2001-03-30
发明人： Usha Goswami , Anutosh Ganguly
IPC分类号： A61K035/12 , C12Q001/68 , C09B001/00 , G01N021/76 , C07C205/00
CPC分类号： C09B61/00
摘要： The present invention discloses the process of extraction, purification and characterization of a fluorescent dye from a marine echinoderm Holothuria scabra, compositions containing the dye and various applications of the dye.
摘要翻译：本发明公开了从海洋棘皮动物全息血痂病提取，纯化和表征荧光染料的方法，含有染料的组合物和染料的各种应用。

24. 发明申请

US20020132364A1 Quant-screentm chemiluminescent assays 审中-公开
标题翻译：量子化学发光测定
公开(公告)号：US20020132364A1
公开(公告)日：2002-09-19
申请号：US09756209
申请日：2001-01-09
发明人： Corinne E.M. Olesen , Yu-xin Yan , Irena Y. Bronstein
IPC分类号： G01N021/76
CPC分类号： C12Q1/34 , G01N21/76
摘要： Chemiluminescent endogenous enzyme assays which provide for the rapid, simple, and sensitive quantitation of cells directly in microwell cultures by the measurement of endogenous enzyme activity. These endogenous enzyme assays provide homogeneous chemiluminescent formats for measuring cell proliferation, growth inhibition, cell adhesion, cell migration, and cell number quantitation and normalization. Methods and kits employing such assays are also provided.
摘要翻译：化学发光内源酶测定法，通过测量内源性酶活性提供直接在微孔培养物中快速，简单和灵敏地定量细胞。这些内源性酶测定提供用于测量细胞增殖，生长抑制，细胞粘附，细胞迁移和细胞数量定量和归一化的均匀的化学发光形式。还提供了使用这种测定法的方法和试剂盒。

25. 发明申请

US20020123059A1 Chemiluminescence-based microfluidic biochip 失效
标题翻译：基于化学发光的微流体生物芯片
公开(公告)号：US20020123059A1
公开(公告)日：2002-09-05
申请号：US10022007
申请日：2001-12-13
发明人： Winston Z. Ho
IPC分类号： C12Q001/68 , G01N021/76
CPC分类号： B01L3/5027 , B01L3/50273 , B01L2200/10 , B01L2200/16 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2400/0481 , B01L2400/0487 , B01L2400/0683 , C12Q2565/629 , G01N21/76 , G01N21/7703
摘要： The disclosure describes how to use luminescence detection mechanism, move microfluid, and control multiple-step biochemical reactions in closed confined microfluidic biochip platform. More particularly, a self-contained disposable biochip with patterned microchannels and compartments having storage means for storing a plurality of samples, reagents, and luminescent substrates. At least one external microactuator in the biochip system produces positive pressure and automates multiple-step reactions in microfluidic platforms for clinical chemistry, cell biology, immunoassay and nucleic acid analysis. The method comprises the steps of transferring sequentially at least one of samples, reagents, and then luminescent substrate from compartments through microchannels to reaction sites. The luminescent substrates react with probes to form a probe complex resulting into luminescence, which is detected by an optical detector.
摘要翻译：本发明描述了如何使用发光检测机制，移动微流体，并在封闭的微流体生物芯片平台中控制多步生化反应。更具体地，具有图案化微通道和隔间的独立的一次性生物芯片具有用于存储多个样品，试剂和发光基底的存储装置。生物芯片系统中的至少一个外部微致动器产生正压力并在微流体平台中自动化多步反应用于临床化学，细胞生物学，免疫分析和核酸分析。该方法包括以下步骤：将来自隔室的样品，试剂，然后将发光底物中的至少一种顺序地通过微通道转移到反应位点。发光底物与探针反应形成探针复合物，产生发光，由光学检测器检测。

26. 发明申请

US20020110919A1 Method for determining chemical reactivity 失效
标题翻译：测定化学反应性的方法
公开(公告)号：US20020110919A1
公开(公告)日：2002-08-15
申请号：US09972520
申请日：2001-10-05
发明人： Larry C. Wienkers , Michael J. Hauer , Dennis E. Epps
IPC分类号： G01N021/76
CPC分类号： G01N21/6428 , G01N21/75 , G01N33/68 , G01N2021/6417 , G01N2500/00 , Y10T436/13
摘要： A method for screening chemical compounds for electrophilic properties comprising the steps of: (a) providing an assay having one or more reaction vessels; (b) adding a predetermined amount of separate chemical compounds for screening to each reaction vessel; (c) adding a predetermined amount of a surrogate chemical marker to each reaction vessel and allowing said separate chemical compounds and surrogate chemical marker to incubate for a period of time; (d) adding a reactive chemical to each reaction vessel which is capable of reacting with residual surrogate chemical marker such that the amount of residual surrogate chemical marker present after step (c) can be quantitatively or qualitatively measured; and (e) quantitatively or qualitatively measuring said residual chemical marker is provided.
摘要翻译：一种用于筛选亲电性质的化合物的方法，包括以下步骤：（a）提供具有一个或多个反应容器的测定; （b）向每个反应容器中加入预定量的用于筛选的单独化学化合物; （c）向每个反应容器中加入预定量的替代化学标记物，并允许所述单独的化合物和替代化学品标记物孵育一段时间; （d）向能够与残留替代化学标记物反应的每个反应容器中加入反应性化学物质，使得步骤（c）之后存在的残留替代化学标记物的量可以定量或定性测量; 并提供（e）定量或定性测量所述残留化学标记物。

27. 发明申请

US20020086437A1 Functionalized thiophene oligomers and their use as fluorescent markers 失效
标题翻译：功能化噻吩低聚物及其用作荧光标记物
公开(公告)号：US20020086437A1
公开(公告)日：2002-07-04
申请号：US09871353
申请日：2001-05-30
发明人： Franco Cipriani , Giuseppe Gigli , Roberto Cingolani , Laura Favaretto , Massimo Zambianchi , Giovanna Sotgiu , Giovanna Barbarella , Gennaro Citro
IPC分类号： G01N021/76 , C12Q001/68 , G01N033/567 , C07D49/14
CPC分类号： C07D333/48 , C07D333/20 , C07F7/0814
摘要： Thiophene oligomers which are excitable in the visible and ultraviolet region and each having at least one functional group able to form a covalent bond with organic and/or biological molecules, so as not to alter either the fluorescence properties of the oligomers or the biological activity of the bound molecules, and their use as fluorescent markers in analysis techniques.
摘要翻译：噻吩低聚物，其在可见光和紫外区域是可兴奋的，并且每个具有至少一个能够与有机和/或生物分子形成共价键的官能团，以便不改变低聚物的荧光性质或生物活性结合分子，以及它们在分析技术中作为荧光标记物的用途。

28. 发明申请

US20020042079A1 METHODS AND AGENTS FOR MEASURING AND CONTROLLING MULTIDRUG RESISTANCE 无效
标题翻译：测量和控制多电阻电阻的方法和试剂
公开(公告)号：US20020042079A1
公开(公告)日：2002-04-11
申请号：US09080739
申请日：1998-05-18
发明人： SANFORD M. SIMON , MELVIN S. SCHINDLER
IPC分类号： A01N001/02 , C12Q001/00 , G01N033/53 , G01N033/567 , G01N033/574 , C12Q001/02 , G01N031/16 , G01N031/22 , G01N021/76 , C12N005/00 , C12N005/02 , C12N005/08
CPC分类号： G01N33/5011
摘要： The effect of the pH of intracellular vesicular compartments and intracellular vesicular transport on multidrug resistance (MDR) of tumor cells is examined. The invention comprises in one aspect the treatment of MDR by administering a therapeutically effective amount of a pH modulator and/or a compound that can interfere with the vesicular transport of an intracellular vesicular compartment. Diagnostic utilities are contemplated and extend to drug discovery assays and methods for measuring monitoring the status of the onset or development of MDR, as well as the measurement of intracellular drug accumulation. Therapeutic compositions include a composition comprising a pH modulator alone or in combination with the dose-limited therapeutic agent(s), and a pharmaceutically acceptable excipient, are also contemplated.
摘要翻译：检查细胞内水泡室pH和细胞内水泡运输对肿瘤细胞多药耐药（MDR）的影响。本发明在一个方面包括通过施用治疗有效量的pH调节剂和/或可以干扰细胞内小泡隔室的水泡运输的化合物来治疗MDR。诊断实用程序被考虑并且扩展到用于测量监测MDR的发作或发展的状态以及细胞内药物积累的测量的药物发现测定和方法。治疗组合物还包括包含单独或与剂量受限治疗剂组合的pH调节剂和药学上可接受的赋形剂的组合物。

29. 发明申请

US20020012923A1 Detection of binding of charged species using pH- or potential-sensitive probes 失效
标题翻译：使用pH或潜敏感探针检测电荷物质的结合
公开(公告)号：US20020012923A1
公开(公告)日：2002-01-31
申请号：US09780757
申请日：2001-02-08
发明人： Yechezkel Barenholz , Danielle Hirsch-Lerner , Rivka Cohen , Arie Dagan , Shimon Gatt
IPC分类号： C12Q001/68 , G01N033/53 , G01N021/76
CPC分类号： G01N33/92 , C12Q1/6804 , G01N33/5432 , G01N33/582 , G01N2405/04 , C12Q2563/179 , C12Q2527/119
摘要： The extent of binding of a moiety, such as a biomolecule, to a surface, where the local environment at the surface has a pH or surface potential which is altered upon binding of the moiety, is determined by stably incorporating at the surface a probe which contains a pH- or potential-sensitive fluorophore.
摘要翻译：通过在表面上稳定地并入表面，确定表面上的局部环境具有在部分结合时被改变的pH或表面电位的表面上的部分（例如生物分子）与表面结合的程度，含有pH或潜在敏感的荧光团。

30. 发明申请

US20010007772A1 CHEMILUMINESCENCE DETECTION APPARATUS 失效
标题翻译：荧光检测装置
公开(公告)号：US20010007772A1
公开(公告)日：2001-07-12
申请号：US09129003
申请日：1998-08-04
发明人： LEPING LI , JAMES A. GILHOOLY , CLIFFORD O. MORGAN III , CONG WEI , WERNER MOSER , MATTHIAS KUTTER , JOSEPH KNEE , WALTER IMFELD , BRUNO GREUTER , HEINZ STUNZI
IPC分类号： G01N021/76
CPC分类号： B24B37/013 , B24B49/12 , G01N21/766 , H01L21/30625 , Y10T436/175383
摘要： The invention discloses an apparatus for detecting the presence of a chemical in a gaseous state, having: a) a catalytic converter, having at least one input and at least one output, wherein the chemical to be detected is one of the at least one inputs; b) a reaction chamber, having at least one input and at least one output, wherein one of the at least one outputs from the catalytic converter is one of the at least one inputs; and c) a light sensor having at least one input, wherein one of the at least one outputs from the reaction chamber is one of the at least one inputs.
摘要翻译：本发明公开了一种用于检测气态化学物质的存在的装置，其具有：a）具有至少一个输入和至少一个输出的催化转化器，其中待检测的化学物质是至少一个输入中的一个 ; b）具有至少一个输入和至少一个输出的反应室，其中来自所述催化转化器的所述至少一个输出中的一个是所述至少一个输入中的一个; 以及c）具有至少一个输入的光传感器，其中来自所述反应室的所述至少一个输出中的一个是所述至少一个输入中的一个。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式