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21. 发明授权

US5717113A Bioactive acetogenins and derivatives 失效
标题翻译：生物活性乙酰胆碱和衍生物
公开(公告)号：US5717113A
公开(公告)日：1998-02-10
申请号：US679005
申请日：1996-07-12
申请人： Jerry L. McLaughlin , Zhe-ming Gu , Geng-xian Zhao
发明人： Jerry L. McLaughlin , Zhe-ming Gu , Geng-xian Zhao
IPC分类号： A01N43/08 , A01N43/24 , A61K31/34 , A61K31/341 , A61K31/55 , A61P35/00 , C07D307/58 , C07D407/14 , C07D321/10 , C07D321/12 , C07D323/00
CPC分类号： C07D307/58
摘要： Novel acetogenins isolated from Asimina triloba and Goniothalamus giganteus of the family Annonaceae and derivatives of those and other acetogenins are described. Bioactive cyclic formaldehyde acetal derivatives are prepared from Annonaceous acetogenins having 1,2-, 1,4- or 1,5-diols. A non-adjacent bis-tetrahydrofuran (THF) acetogenin is prepared from an unsaturated mono-THF acetogenin earlier isolated from Goniothalamus giganteus. The substantially pure acetogenins and acetogenin derivatives of the invention exhibit cytotoxicity to human solid tumor cell lines equipotent to adriamycin or orders of magnitude more potent than adriamycin, and they exhibit effective pesticidal activities.
摘要翻译：描述了分离自家蚕科的三叶草和Goniothalamus giganteus的新型乙酰胆碱和这些和其他乙酰胆碱的衍生物。生物活性环状甲醛缩醛衍生物由具有1,2-，1,4-或1,5-二醇的洋甘草素生成素制备。不相邻的双 - 四氢呋喃（THF）乙酰头孢菌素由早前从Goniothalamus giganteus分离出的不饱和单THF乙酰头孢菌素制备。本发明的基本上纯的乙酰辅酶原和乙酰辅酶衍生物对与阿霉素相当的人类实体瘤细胞系表现出细胞毒性或比阿霉素更有效的数量级，并且它们表现出有效的杀虫活性。

22. 发明授权

US5675021A Method to produce and purify cyclic esters 失效
标题翻译：生产和纯化环酯的方法
公开(公告)号：US5675021A
公开(公告)日：1997-10-07
申请号：US417597
申请日：1995-04-05
申请人： Timothy J. Eggeman , Herman P. Benecke
发明人： Timothy J. Eggeman , Herman P. Benecke
IPC分类号： C07C51/48 , C07D319/12 , C08G63/06 , C08J5/18 , C08L67/04 , C09D167/04 , C07D321/00 , C07D321/10
CPC分类号： C07C51/48 , C07D319/12 , C08J5/18 , C08L67/04 , C09D167/04 , B01J2219/1942 , C08J2367/04
摘要： Methods are provided for the production, recovery and purification of cyclic esters. Such methods include producing a cyclic ester composition containing at least one impurity, contacting the cyclic ester composition with at least one adsorbent to remove the impurity and recovering the purified cyclic esters. Also included are methods of cyclic ester purification involving multiple adsorption operations. The methods of the present invention can produce highly purified cyclic esters. Such compositions are suitable for use in the manufacture of polymers having an average degree of polymerization in excess of about 1700.
摘要翻译：提供了环酯的生产，回收和纯化的方法。这样的方法包括制备含有至少一种杂质的环酯组合物，使环酯组合物与至少一种吸附剂接触以除去杂质并回收纯化的环酯。还包括涉及多次吸附操作的环酯纯化方法。本发明的方法可以生产高纯度的环酯。这种组合物适用于制造平均聚合度超过约1700的聚合物。

23. 发明授权

US5314878A Composition for removing or inactivating harmful components in blood or other extracellular body fluids 失效
标题翻译：用于去除或灭活血液或其他细胞外体液中的有害成分的组合物
公开(公告)号：US5314878A
公开(公告)日：1994-05-24
申请号：US806206
申请日：1991-12-13
申请人： Henry M. Christensen , Hans B. Andreasen
发明人： Henry M. Christensen , Hans B. Andreasen
IPC分类号： A61K31/335 , A61K31/00 , A61K31/075 , A61K31/357 , A61K31/715 , A61L2/00 , A61P31/12 , A61P39/02 , B01J20/32 , C07D323/00 , C08B37/02 , C07D321/00 , C07D321/10 , C08B31/10
CPC分类号： C08B37/0021 , A61L2/0088 , B01J20/3212 , B01J20/3217 , B01J20/3219 , B01J20/3248 , B01J20/3253 , B01J20/3255 , B01J2220/4825 , Y10S514/832 , Y10S514/833 , Y10S514/836
摘要： A composition for removing or inactivating harmful components including virus from blood or other extracellular liquids comprises a crownether compound substituted on a polysaccharide, preferably dextrane. The composition may be soluble in water, preferably for intraveneous application, or insoluble for extracorporeal application.
摘要翻译：用于从血液或其他细胞外液体中除去或灭活包括病毒的有害成分的组合物包括在多糖上取代的冠醚化合物，优选为葡聚糖。该组合物可溶于水，优选用于荚膜内施用，或不溶于体外应用。

24. 发明授权

US5120758A Certain benzodioxole, benzodioxane and benzodioxepin derivatives useful as 5-lipoxygenase inhibitors 失效
标题翻译：某些苯并二氧杂环戊烯，苯并二氧杂环己烷和苯并二氧杂环己酮衍生物可用作5-脂氧合酶抑制剂
公开(公告)号：US5120758A
公开(公告)日：1992-06-09
申请号：US652851
申请日：1991-07-08
申请人： Yoshitaka Satoh
发明人： Yoshitaka Satoh
IPC分类号： A61K31/335 , A61K31/357 , A61K31/36 , A61P9/00 , A61P29/00 , A61P37/08 , C07D317/46 , C07D319/20 , C07D321/10
CPC分类号： C07D319/20
摘要： The invention relates to the compounds of the formula ##STR1## wherein each R independently represents hydrogen, lower alkyl, halogen, trifluoromethyl, lower alkoxy, carbocyclic or heterocyclic aryl, carbocyclic or heterocyclic aryloxy, carbocyclic or heterocyclic aryl-lower alkyloxy, carbocyclic or heterocyclic aryl-lower alkyl, C.sub.3 -C.sub.7 -cycloalkyl-lower alkyloxy, or C.sub.3 -C.sub.7 -cycloalkyloxy; n represents 1, 2, 3 or 4; m represents 0, 1 or 2; A represents a direct bond or lower alkylene; X represents oxygen or sulfur; R.sub.1 represents hydrogen, acyl, lower alkoxycarbonyl, aminocarbonyl, mono- or di-lower alkylaminocarbonyl, lower alkenylaminocarbonyl, lower alkynylaminocarbonyl, carbocyclic or heterocyclic aryl-lower alkylaminocarbonyl, carbocyclic or heterocyclic arylaminocarbonyl, C.sub.3 -C.sub.7 -cycloalkylaminocarbonyl or C.sub.3 -C.sub.7 -cycloalkyl-lower alkylaminocarbonyl; R.sub.2 represents lower alkyl, lower alkoxycarbonyl-lower alkyl, C.sub.3 -C.sub.7 -cycloalkyl, carbocyclic or heterocyclic aryl, carbocyclic or heterocyclic aryl-lower alkyl, C.sub.3 -C.sub.7 -cycloalkyl-lower alkyl, amino, mono- or di-lower alkylamino, lower alkenylamino, lower alkynylamino, carbocyclic or heterocyclic aryl-lower alkylamino, carbocyclic or heterocyclic arylamino, C.sub.3 -C.sub.7 -cycloalkylamino, C.sub.3 -C.sub.7 -cycloalkyl-lower alkylamino, lower alkoxycarbonyl-lower alkylamino or lower alkoxy; R.sub.3 and R.sub.4 independently represent hydrogen or lower alkyl; and pharmaceutically acceptable salts thereof; which are useful as 5-lipoxygenase inhibitors.

25. 发明授权

US4431808A Tricyclic compounds 失效
标题翻译：三环化合物
公开(公告)号：US4431808A
公开(公告)日：1984-02-14
申请号：US356474
申请日：1982-03-09
申请人： Miroslav Protiva , Karel Sindelar , Antonin Dlabac , Jirina Metysova
发明人： Miroslav Protiva , Karel Sindelar , Antonin Dlabac , Jirina Metysova
IPC分类号： A61K31/00 , A61K31/455 , A61K31/55 , A61P25/00 , A61P25/24 , A61P25/26 , C07C29/147 , C07C33/46 , C07C45/00 , C07C45/29 , C07C47/575 , C07D211/22 , C07D321/10 , C07D327/02 , C07D339/00 , C07D405/02 , C07D405/04 , C07D405/06 , C07D409/02 , C07D409/04 , C07D411/02 , C07D411/04 , C07D411/06 , C07D407/04
CPC分类号： C07D411/06 , C07C29/147 , C07C323/00 , C07C33/46 , C07C45/00 , C07C45/29 , C07C47/575 , C07D211/22 , C07D321/10 , C07D327/02 , C07D339/00
摘要： A technique is described for the preparation of a wide variety of basic derivatives of linearly condensed tricyclic systems formed by two external benzene nuclei and a 7-membered central ring having 2 chalcogen atoms as hetero atoms.Derivatives of 11H-dibenzo(b,e)-1,4-dioxepin are obtained when the chalcogens are both oxygen atoms; derivatives of 11H-dibenzo(b,f)-1,4-dithiepin are obtained when the chalcogens are both sulfur atoms; derivatives of 6H-dibenz(b,e)-1,4-oxathiepin and 11H-dibenz(b,f)-1,4-oxathiepin are obtained with combinations of sulfur and oxygen atoms as chalcogens.
摘要翻译：描述了一种用于制备由两个外部苯核和具有2个硫属原子作为杂原子的7元中心环形成的线性缩合三环系统的各种各样的碱性衍生物的技术。当硫属元素都是氧原子时，得到11H-二苯并（b，e）-1,4-二氧杂环庚二烯的衍生物; 当硫属原子都是硫原子时，得到11H-二苯并（b，f）-1,4-二硫杂的衍生物; 通过硫和氧原子的组合作为硫属元素获得6H-二苯并（b，e）-1,4-氧硫杂环十二环和11H-二苯并（b，f）-1,4-氧硫杂环庚三烯的衍生物。

26. 发明授权

US4349561A 4-Substituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase 失效
标题翻译： 4-取代的3-羟基-3-吡咯啉-2,5-二酮抑制剂的乙醇酸氧化酶
公开(公告)号：US4349561A
公开(公告)日：1982-09-14
申请号：US091293
申请日：1979-11-05
申请人： Edward J. Cragoe, Jr. , Clarence S. Rooney , Haydn W. R. Williams
发明人： Edward J. Cragoe, Jr. , Clarence S. Rooney , Haydn W. R. Williams
IPC分类号： C07D207/44 , C07D207/456 , C07D321/10 , A61K31/40 , C07D207/26
CPC分类号： C07D207/456 , C07D321/10 , Y10S514/877 , Y10S514/891
摘要： Novel 4-substituted-3-hydroxy-3-pyrroline-2,5-diones are disclosed which inhibit glycolic acid oxidase and thus are useful in the treatment and prevention of calcium oxalate kidney stone formation. A novel process for their preparation is also disclosed.
摘要翻译：公开了新的4-取代-3-羟基-3-吡咯啉-2,5-二酮，其抑制乙醇酸氧化酶，因此可用于治疗和预防草酸钙肾结石形成。还公开了一种新的制备方法。

27. 发明授权

US4294761A Preparation of 7,12-dioxaspiro[5,6]dodecane-3-one 失效
标题翻译：制备7,12-二氧杂螺[5,6]十二烷-3-酮
公开(公告)号：US4294761A
公开(公告)日：1981-10-13
申请号：US121549
申请日：1980-02-14
申请人： John A. Hyatt
发明人： John A. Hyatt
IPC分类号： C07D321/10
CPC分类号： C07D321/10
摘要： Disclosed is the title compound and its preparation by the reaction of 1,4-cyclohexanedione and 1,4-butanediol. The title compound is useful as a pharmaceutical intermediate.
摘要翻译：公开了标题化合物及其通过1,4-环己二酮和1,4-丁二醇的反应制备。标题化合物可用作药物中间体。

28. 发明授权

US3944531A Phenyl derivatives 失效
标题翻译：苯基衍生物
公开(公告)号：US3944531A
公开(公告)日：1976-03-16
申请号：US30295
申请日：1970-04-20
申请人： Madhukar Subraya Chodnekar , Albert Pfiffner , Norbert Rigassi , Ulrich Schwieter , Milos Suchy
发明人： Madhukar Subraya Chodnekar , Albert Pfiffner , Norbert Rigassi , Ulrich Schwieter , Milos Suchy
IPC分类号： A01N37/40 , A01N31/08 , A01N31/14 , A01N33/20 , A01N35/04 , A01N37/18 , A01N37/34 , A01N37/36 , A01N43/02 , A01N43/20 , A01N43/24 , A01N43/32 , A01N49/00 , C07C41/00 , C07C43/14 , C07C43/20 , C07C43/205 , C07C45/00 , C07C45/71 , C07C47/52 , C07C47/575 , C07C49/84 , C07C51/00 , C07C65/21 , C07C65/28 , C07C67/00 , C07C69/78 , C07C69/88 , C07C69/92 , C07C231/00 , C07C231/02 , C07C231/12 , C07C233/12 , C07C235/46 , C07C253/00 , C07C255/53 , C07C255/54 , C07C313/00 , C07C315/02 , C07C317/00 , C07C317/14 , C07C317/22 , C07C317/24 , C07C317/44 , C07C317/50 , C07C319/14 , C07C321/28 , C07C323/09 , C07C323/20 , C07C323/22 , C07C323/52 , C07C323/62 , C07C327/20 , C07D303/02 , C07D303/22 , C07D303/34 , C07D319/18 , C07D321/10 , C07D331/02 , C07D407/12
CPC分类号： C07C317/00 , C07C317/14 , C07C317/44 , C07C321/28 , C07C323/52 , C07C323/62 , C07C43/2055 , C07C45/71 , C07C47/575 , C07C49/84 , C07C65/28 , C07D319/18 , C07D321/10 , C07D331/02
摘要： Phenyloxy, phenylsulfinyl, phenylthio, phenylsulfonyl, benzyloxy, benzylthio, benzylsulfinyl, or benzylsulfonyl, alkyl or alkenyl derivatives wherein the alkyl or alkenyl group contains at least 7 carbon atoms which are useful in killing and preventing proliferation of insects by upsetting their hormone balance.

29. 发明授权

US3769320A Phenyl alkenyl ethers 失效
标题翻译：苯乙烯酮
公开(公告)号：US3769320A
公开(公告)日：1973-10-30
申请号：US3769320D
申请日：1970-04-20
申请人： HOFFMANN LA ROCHE
发明人： CHODNEKAR M , PFIFFNER A , SUCHY M , RIGASSI N , SCHWIETER U
IPC分类号： A01N37/40 , A01N31/08 , A01N31/14 , A01N33/20 , A01N35/04 , A01N37/18 , A01N37/34 , A01N37/36 , A01N43/02 , A01N43/20 , A01N43/24 , A01N43/32 , A01N49/00 , C07C41/00 , C07C43/14 , C07C43/20 , C07C43/205 , C07C45/00 , C07C45/71 , C07C47/52 , C07C47/575 , C07C49/84 , C07C51/00 , C07C65/21 , C07C65/28 , C07C67/00 , C07C69/78 , C07C69/88 , C07C69/92 , C07C231/00 , C07C231/02 , C07C231/12 , C07C233/12 , C07C235/46 , C07C253/00 , C07C255/53 , C07C255/54 , C07C313/00 , C07C315/02 , C07C317/00 , C07C317/14 , C07C317/22 , C07C317/24 , C07C317/44 , C07C317/50 , C07C319/14 , C07C321/28 , C07C323/09 , C07C323/20 , C07C323/22 , C07C323/52 , C07C323/62 , C07C327/20 , C07D303/02 , C07D303/22 , C07D303/34 , C07D319/18 , C07D321/10 , C07D331/02 , C07D407/12
CPC分类号： C07C317/00 , C07C43/2055 , C07C45/71 , C07C47/575 , C07C49/84 , C07C65/28 , C07C317/14 , C07C317/44 , C07C321/28 , C07C323/52 , C07C323/62 , C07D319/18 , C07D321/10 , C07D331/02
摘要： PHENYL ALKENYL ETHERS WHEREIN THE ALKENYL GROUP CONTAINS A CARBON CHAIN OF 8 OR 9 CARBON ATOMS AND THE TERMINAL UNSATURATED DOUBLE BOND CAN BE EPOXIDIZED OR EPISULFIDIZED, WHICH ARE USEFUL IN UPSETTING THE HORMONE BALANCE OF PESTS SUCH AS INSECTS.

30. 发明授权

US3712913A Alkenylthiobenzoic acids 失效
标题翻译：亚硝基苯甲酸
公开(公告)号：US3712913A
公开(公告)日：1973-01-23
申请号：US3712970
申请日：1970-04-20
申请人： HOFFMANN LA ROCHE
发明人： CHODNEKAR M , PFIFFNER A , RIGASSI N , SCHWIETER U , SUCHY M
IPC分类号： A01N37/40 , A01N31/08 , A01N31/14 , A01N33/20 , A01N35/04 , A01N37/18 , A01N37/34 , A01N37/36 , A01N43/02 , A01N43/20 , A01N43/24 , A01N43/32 , A01N49/00 , C07C41/00 , C07C43/14 , C07C43/20 , C07C43/205 , C07C45/00 , C07C45/71 , C07C47/52 , C07C47/575 , C07C49/84 , C07C51/00 , C07C65/21 , C07C65/28 , C07C67/00 , C07C69/78 , C07C69/88 , C07C69/92 , C07C231/00 , C07C231/02 , C07C231/12 , C07C233/12 , C07C235/46 , C07C253/00 , C07C255/53 , C07C255/54 , C07C313/00 , C07C315/02 , C07C317/00 , C07C317/14 , C07C317/22 , C07C317/24 , C07C317/44 , C07C317/50 , C07C319/14 , C07C321/28 , C07C323/09 , C07C323/20 , C07C323/22 , C07C323/52 , C07C323/62 , C07C327/20 , C07D303/02 , C07D303/22 , C07D303/34 , C07D319/18 , C07D321/10 , C07D331/02 , C07D407/12 , C07C149/40
CPC分类号： C07C317/00 , C07C43/2055 , C07C45/71 , C07C47/575 , C07C49/84 , C07C65/28 , C07C317/14 , C07C317/44 , C07C321/28 , C07C323/52 , C07C323/62 , C07D319/18 , C07D321/10 , C07D331/02
摘要： ALKYL OR ALKENYL ETHERS OR THIOETHERS OF BENZENE OR BENZYL DERIVATIVES WHEREIN THE ALKYL OR ALKENYL RADICAL CONTAINS A CHAIN OF EIGHT OR NINE CARBON ATOMS, WHICH ARE USEFUL IN KILLING AND PREVENTING THE PROLIFERATION OF INSECTS BY UPSETTING THEIR HORMONE BALANCE.
摘要翻译：苯氧基，苯基亚磺酰基，苯硫基，苯基磺酰基，苄氧基，苄硫基，苄基亚磺酰基或苄基磺酰基，烷基或烯基衍生物，其中烷基或链烯基含有至少7个碳原子，可用于通过破坏其激素平衡来杀死和防止昆虫的增殖。

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