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21. 发明申请

US20160139394A1 MICROSCOPE, FOCUSING UNIT, FLUID HOLDING UNIT, AND OPTICAL UNIT 有权
标题翻译：显微镜，聚焦单元，流体控制单元和光学单元
公开(公告)号：US20160139394A1
公开(公告)日：2016-05-19
申请号：US14781625
申请日：2014-04-03
申请人： RIKEN
发明人： Yuichi TANIGUCHI , Kazuya NISHIMURA
IPC分类号： G02B21/16 , G02B21/08 , G02B21/33 , G02B21/26 , G02B21/00
CPC分类号： G02B21/16 , G01N21/6458 , G02B21/0076 , G02B21/0088 , G02B21/08 , G02B21/10 , G02B21/24 , G02B21/26 , G02B21/33
摘要： A microscope includes: a sample placement part having a placement surface on which to place a sample and a bottom face opposite to the placement surface; an observation lens; and an optical unit for generating sheet light and use of the microscope. The microscope of an embodiment is arranged such that the sheet light enters the sample placement part from the bottom face and passing through the sample placement part to irradiate the sample, and fluorescence from the sample passes through the sample placement part toward the bottom face to be received by the observation lens. The microscope can, with this arrangement, utilize the advantages of a SPIM, and allows observation of a sample which observation is free from a restriction of the size of a sample.
摘要翻译：显微镜包括：具有放置表面的样品放置部分，其上放置样品和底面与放置表面相对; 观察镜头; 以及用于产生薄片光并使用显微镜的光学单元。实施例的显微镜被布置成使得片材光从底面进入样品放置部分并且通过样品放置部分以照射样品，并且来自样品的荧光通过样品放置部分朝向底面以成为由观察镜接收。通过这种布置，显微镜可以利用SPIM的优点，并且允许观察样品，观察不受样本尺寸的限制。

22. 发明授权

US09323036B2 Immersion microscope objective and microscope using the same 有权
标题翻译：浸液显微镜物镜和显微镜使用相同
公开(公告)号：US09323036B2
公开(公告)日：2016-04-26
申请号：US13845041
申请日：2013-03-17
申请人： OLYMPUS CORPORATION
发明人： Takashi Kasahara
IPC分类号： G02B21/02 , G02B21/06 , G02B21/33 , G02B27/00 , G01N21/64
CPC分类号： G02B21/02 , G01N21/6458 , G01N21/648 , G02B21/06 , G02B21/33 , G02B27/0068
摘要： A microscope objective comprises in order from an object side, a first lens group, a second lens group, and a third lens group. The first lens group includes a first cemented lens, and at least one positive single lens, the second lens group includes a second cemented lens, and the third lens group includes a first lens component and a second lens component. A positive lens and a meniscus lens are cemented in the first cemented lens. A surface nearest to an image side of the first lens component is a concave surface, and a surface nearest to the object side of the second lens component is a concave surface. The first lens component and the second lens component are disposed such that the both concave surfaces are face-to-face, and the following conditional expression (1) is satisfied. 0.5
摘要翻译：显微镜物镜从物体侧依次包括第一透镜组，第二透镜组和第三透镜组。第一透镜组包括第一胶合透镜和至少一个正单透镜，第二透镜组包括第二胶合透镜，并且第三透镜组包括第一透镜部件和第二透镜部件。在第一胶合透镜中胶合正透镜和弯月透镜。最靠近第一透镜部件的像侧的表面是凹面，并且最靠近第二透镜部件的物体侧的表面是凹面。第一透镜部件和第二透镜部件被布置成使得两个凹面是面对面的，并且满足以下条件表达式（1）。 0.5 <（n0 / n1o）/ NAob <0.65（1）

23. 发明授权

US09291546B2 Observed portion fixing apparatus and microscope 有权
标题翻译：观察部分定影装置和显微镜
公开(公告)号：US09291546B2
公开(公告)日：2016-03-22
申请号：US13893084
申请日：2013-05-13
申请人： OLYMPUS CORPORATION
发明人： Eiji Nakasho
IPC分类号： G02B21/26 , G01N21/01 , G02B21/33
CPC分类号： G01N21/01 , G02B21/33
摘要： An immersion liquid retainer is an immersion liquid retainer used for an observation made with a microscope including an immersion objective. The immersion liquid retainer includes a fixing part in which a first penetration hole for viewing an observed portion of a specimen is formed and which is fixed to the specimen, and an immersion liquid retaining part where a concave part that has a bottom surface configured with a transparent flat plate and is intended to retain an immersion liquid is formed. The immersion liquid retaining part is joined to the fixing part or formed integrally with the fixing part so that the transparent flat plate covers the first penetration hole.
摘要翻译：浸没液体保持器是用于使用具有浸没物镜的显微镜进行的观察的浸液保持器。浸渍液保持器包括：固定部，在该固定部中形成有用于观察被检体的观察部的第一贯通孔，并固定在试样上;浸渍液保持部，其中，具有底面的凹部透明平板，旨在保持形成浸液。浸渍液保持部与固定部接合或与固定部一体形成，透明平板覆盖第一贯通孔。

24. 发明申请

US20150277094A1 CASSETTE FOR FACILITATING OPTICAL SECTIONING OF A RETAINED TISSUE SPECIMEN 有权
标题翻译：用于促进保留的组织样本的光学部分
公开(公告)号：US20150277094A1
公开(公告)日：2015-10-01
申请号：US14730799
申请日：2015-06-04
申请人： Caliber Imaging & Diagnostics, Inc.
发明人： Jay M. Eastman , William J. Fox , Roger J. Greenwald , Kevin P. Roesser , James M. Zavislan
IPC分类号： G02B21/36 , G02B21/00 , G02B21/33 , G02B21/34 , G02B21/26
CPC分类号： G02B21/368 , B01L3/508 , B01L2200/0642 , B01L2300/021 , B01L2300/043 , B01L2300/044 , B01L2300/0609 , B01L2300/0822 , B01L2300/123 , G01N2001/315 , G02B21/0012 , G02B21/26 , G02B21/33 , G02B21/34
摘要： A cassette for retaining a specimen of surgically exposed tissue from a patient in an orientation that facilitates optical sectioning of the tissue by a confocal microscopic or other optical imaging microscope. The cassette includes a base member having a rigid optically transparent window upon which a tissue specimen is situated, a pliable membrane locatable over a substantial portion of the base member including the window, and an upper member, having an aperture therethrough, which can cover the base member to provide an enclosed cavity between the membrane and the window sealing the tissue specimen therein. The edges of the tissue specimen may be positioned planar against the window and retained in that position by bonds formed between the membrane and window at multiple points or locations around the tissue specimen. The specimen retained in the cavity is imagible by a microscope through the window of the base member.
摘要翻译：用于通过共聚焦显微镜或其他光学成像显微镜以方便光学切片的方向从患者保持外科手术曝光的组织的样本的盒。盒包括具有刚性光学透明窗口的基部构件，组织样本位于该基部构件上，柔性膜可定位在包括窗口的基部构件的主要部分上方，以及具有穿过其的孔的上部构件，其可覆盖在膜和窗户之间提供封闭的腔，密封组织样本。组织样本的边缘可以相对于窗户定位，并且通过在组织样本周围的多个点或位置处形成在膜和窗之间的结合保持在该位置。通过显微镜通过基底构件的窗口可以保持保留在空腔中的样品。

25. 发明申请

US20150248002A1 COOLING SYSTEMS AND METHODS FOR CRYO SUPER-RESOLUTION FLOURESCENCE LIGHT MICROSCOPY AND OTHER APPLICATIONS 有权
标题翻译：冷冻超声波清洗系统及其应用方法
公开(公告)号：US20150248002A1
公开(公告)日：2015-09-03
申请号：US14428271
申请日：2013-09-13
申请人： Charles G. INGERSOLL , BRANDEIS UNIVERSITY
发明人： Charles G. Ingersoll , David J. Derosier , Gina Turrigiano , Marc Nahmani
IPC分类号： G02B21/28 , G02B21/26
CPC分类号： G02B21/28 , G02B21/26 , G02B21/32 , G02B21/33
摘要： New systems and methods are described for maintaining a desired steady state temperature differential between two objects that may otherwise undergo heat transfer to restore thermal steady state. In one application, a cooling microscope assembly and its use with conventional optical microscopes are described for achieving super-resolution imaging. The assembly allows for the high resolution imaging of samples at cryogenic temperatures while maintaining the temperature of the objective lens above freezing by employing circulation systems and a coupling fluid between the sample and objective lens.
摘要翻译：描述了用于在两个物体之间保持期望的稳态温差的新系统和方法，否则可能会经历热传递以恢复热稳定状态。在一个应用中，描述了用于实现超分辨率成像的冷却显微镜组件及其与常规光学显微镜的用途。组件允许在低温下对样品进行高分辨率成像，同时通过采用循环系统和样品与物镜之间的耦合流体，将物镜的温度保持在高于冻结状态。

26. 发明申请

US20150146304A1 IMMERSION MICROSCOPE OBJECTIVE AND MICROSCOPE USING THE SAME 审中-公开
标题翻译：使用相同的显微镜目标和显微镜
公开(公告)号：US20150146304A1
公开(公告)日：2015-05-28
申请号：US14504112
申请日：2014-10-01
申请人： OLYMPUS CORPORATION
发明人： Yasuhiro YAMAWAKI
IPC分类号： G02B21/33 , G02B21/00 , G02B21/02
CPC分类号： G02B21/33 , G02B21/0076 , G02B21/02 , G02B21/32 , G02B27/0068
摘要： An immersion microscope objective includes, a first lens group having a positive refractive power, a second lens group having a positive refractive power, and a third lens group having a negative refractive power, wherein the first lens group includes a first lens surface and a second lens surface, the first lens surface is positioned nearest to the object side and the second lens surface is positioned on an image side of the first lens surface and nearest to the first lens surface, and the following conditional expression (1) is satisfied: −3≦(rG12/f)×(NAob/ndimm)2−1.7 (1) where rG12 denotes a radius of curvature at the second lens surface, f denotes a focal length of an entire system of the immersion microscope objective, NAob denotes an object-side numerical aperture of the immersion microscope objective, and ndimm denotes a refractive index of an immersion liquid for a d-line.
摘要翻译：浸没式显微镜物镜包括具有正折光力的第一透镜组，具有正折光力的第二透镜组和具有负屈光力的第三透镜组，其中第一透镜组包括第一透镜表面和第二透镜组第一透镜表面最靠近物体侧定位，第二透镜表面位于第一透镜表面的最靠近第一透镜表面的像侧，并满足以下条件表达式（1）： - 3＆nlE;（rG12 / f）×（NAob / ndimm）2-1.7（1）其中rG12表示第二透镜表面的曲率半径，f表示浸没显微镜物镜的整个系统的焦距，NAob表示浸渍显微镜物镜的物体侧数值孔径，ndimm表示d线浸渍液体的折射率。

27. 发明授权

US08854601B2 Projection optical system, exposure apparatus, and exposure method 有权
标题翻译：投影光学系统，曝光装置和曝光方法
公开(公告)号：US08854601B2
公开(公告)日：2014-10-07
申请号：US13229589
申请日：2011-09-09
申请人： Yasuhiro Omura , Takaya Okada , Hiroyuki Nagasaka
发明人： Yasuhiro Omura , Takaya Okada , Hiroyuki Nagasaka
IPC分类号： G03B27/42 , G03F7/20 , G02B17/08 , G02B1/06 , G02B21/33
CPC分类号： G03F7/70725 , G02B1/06 , G02B17/08 , G02B17/0892 , G02B21/33 , G03F7/702 , G03F7/70225 , G03F7/70341
摘要： An immersion projection optical system having, for example, a catadioptric and off-axis structure, reduces the portion of an image space filled with liquid (immersion liquid). The projection optical system, which projects a reduced image of a first plane onto a second plane through the liquid, includes a refractive optical element (Lp) arranged nearest to the second plane. The refractive optical element includes a light emitting surface (Lpb) shaped to be substantially symmetric with respect to two axial directions (XY-axes) perpendicular to each other on the second plane. The light emitting surface has a central axis (Lpba) that substantially coincides with a central axis (40a) of a circle (40) corresponding to a circumference of a light entering surface (Lpa) of the refractive optical element. The central axis of the light emitting surface is decentered in one of the two axial directions (Y-axis) from an optical axis (AX).
摘要翻译：具有例如反射折射和离轴结构的浸没投影光学系统减少了填充有液体（浸没液体）的图像空间的部分。通过液体将第一平面的缩小图像投影到第二平面上的投影光学系统包括最靠近第二平面布置的折射光学元件（Lp）。折射光学元件包括成形为在第二平面上相对于彼此垂直的两个轴向（XY轴）基本对称的发光表面（Lpb）。发光表面具有与对应于折射光学元件的光入射表面（Lpa）的圆周的圆（40）的中心轴线（40a）基本重合的中心轴线（Lpba）。发光面的中心轴线从光轴（AX）的两个轴向（Y轴）的一方偏心。

28. 发明授权

US08767199B2 Inspection system utilizing solid immersion lenses 有权
标题翻译：使用固体浸没透镜的检查系统
公开(公告)号：US08767199B2
公开(公告)日：2014-07-01
申请号：US12905472
申请日：2010-10-15
申请人： David M. Dozor , Yullin Kim , Kris Tumidajski , Gary Fancher , Ken Salvestrini , Douglas Holt , Ron DeWitt, Jr.
发明人： David M. Dozor , Yullin Kim , Kris Tumidajski , Gary Fancher , Ken Salvestrini , Douglas Holt , Ron DeWitt, Jr.
IPC分类号： G11B7/12 , G02B7/02
CPC分类号： G02B21/33
摘要： An inspection system including a lens. In one instance, the lens is a solid immersion lens. The inspection system includes a component or components for providing a self aligning solid immersion lens arrangement in order to allow at most a small distance between the solid immersion lens and a device under test and components or components for constraining a force exerted on the device under test. The inspection system may include a “purge” port, or a thermal isolation configuration or an anti-contamination component. The inspection system may include software and hardware to prevent crashing of the lens. The inspection system may also include a method for ensuring that various objective lenses can be replaced while maintaining the intended spacing between lenses.
摘要翻译：包括透镜的检查系统。在一种情况下，透镜是固体浸没透镜。检查系统包括用于提供自对准固体浸没透镜布置的部件或部件，以便允许固体浸没透镜和被测器件之间的至少一定距离，以及用于约束施加在被测器件上的力的部件或部件。检查系统可以包括“吹扫”端口，或热隔离构造或抗污染部件。检查系统可以包括软件和硬件，以防止镜头的撞击。检查系统还可以包括一种用于确保在保持透镜之间的预定间隔的同时更换各种物镜的方法。

29. 发明授权

US08582202B2 Observing device and method 有权
标题翻译：观察装置和方法
公开(公告)号：US08582202B2
公开(公告)日：2013-11-12
申请号：US12665588
申请日：2008-06-13
申请人： Hirotoshi Terada , Hiroshi Tanabe
发明人： Hirotoshi Terada , Hiroshi Tanabe
IPC分类号： G02B21/00
CPC分类号： G02B21/0016 , G01N21/9501 , G02B7/022 , G02B21/248 , G02B21/33
摘要： When it is detected that a solid immersion lens comes into contact with the semiconductor device, the lens is caused to vibrate by a vibration generator unit. Next, a reflected light image from the lens is input to calculate a reflected light quantity of the reflected light image, and it is judged whether a ratio of the reflected light quantity to an incident light quantity is not greater than a threshold value. When the ratio is greater than the threshold value, it is judged that optical close contact between the lens and the semiconductor device is not achieved, and the lens is again caused to vibrate. When the ratio is not greater than the threshold value, it is judged that optical close contact between the lens and the semiconductor device is achieved, and an observed image of the semiconductor device is acquired.
摘要翻译：当检测到固体浸没透镜与半导体器件接触时，透镜被振动发生器单元振动。接下来，输入来自透镜的反射光图像以计算反射光图像的反射光量，并且判断反射光量与入射光量的比率是否不大于阈值。当比率大于阈值时，判断透镜和半导体器件之间的光学紧密接触没有实现，并且再次使透镜振动。当比率不大于阈值时，判断透镜和半导体器件之间的光学紧密接触是实现的，并且获得了半导体器件的观察图像。

30. 发明申请

US20130278742A1 METHOD OF OBSERVATION OF THE EMISSION OF LIGHT FROM A SAMPLE BY DYNAMIC OPTICAL MICROSCOPY 有权
标题翻译：通过动态光学显微镜观察样品中的光的发射方法
公开(公告)号：US20130278742A1
公开(公告)日：2013-10-24
申请号：US13881707
申请日：2011-10-25
申请人： Emmanuel Fort , Sandrine Leveque Fort , Karla Balaa , Thomas Barocca
发明人： Emmanuel Fort , Sandrine Leveque Fort , Karla Balaa , Thomas Barocca
IPC分类号： G02B21/36
CPC分类号： G01N21/6458 , G01N21/648 , G01N2021/6465 , G01N2201/12 , G02B5/005 , G02B21/0088 , G02B21/16 , G02B21/33 , G02B21/361 , G02B21/367 , H04N5/23232 , H04N5/265
摘要： Method for observing an emission of light from a sample in a medium of refractive index nL disposed against a surface of a transparent support of refractive index nS, greater than nL, the emission of light comprising luminous components oriented toward the support and forming an angle θ and including supercritical luminous components and critical or subcritical luminous components, implementing an observation device applying filters to the signal; and transforming the signal into an image zone of the sample Modulation of the signal is carried out, in which components of the emission of light are allowed to pass through so as to obtain image zones, the modulation pertaining to all or some of the collected signals; and at least one useful image zone of the sample is produced by combining image zones, the combination evidencing differences between the image zones related to the modulation.
摘要翻译：用于观察来自折射率为nL的介质中的样品的光的发射的方法，所述介质的折射率为nS的透明支撑体的表面，大于nL，所述发光包括朝向所述支撑件定向的发光部件，并且形成角度θ 并且包括超临界发光部件和临界或亚临界发光部件，实现向信号施加滤波器的观察装置; 并且将信号变换成样本的图像区域进行信号的调制，其中允许发射光的分量通过以获得图像区域，与所有或一些所收集的信号相关的调制 ; 并且通过组合图像区域，证明与调制相关的图像区域之间的差异的组合来产生样本的至少一个有用图像区域。

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