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21. 发明申请

US20100317567A1 DIAGNOSING AND PROTECTING HORSES AGAINST PAPILLOMAVIRUS 审中-公开
标题翻译：诊断和保护马尾TING虫
公开(公告)号：US20100317567A1
公开(公告)日：2010-12-16
申请号：US12861409
申请日：2010-08-23
申请人： A. Bennett Jenson , Shin-je Ghim , Victoria B. Kyle , Joongho Joh
发明人： A. Bennett Jenson , Shin-je Ghim , Victoria B. Kyle , Joongho Joh
IPC分类号： A61K38/02 , C12Q1/70 , A61P31/20
CPC分类号： C12Q1/708 , A61K38/162 , A61K39/12 , A61K2039/5258 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034 , G01N33/6854 , G01N2333/025
摘要： Compositions for conferring protection against Equus caballus papillomavirus (EcPV) and Bovine papillomavirus (BPV) infection in a subject are provided and include a virus-like particle assembled from an EcPV L1 protein and virus like particle assembled from a BPV L1 protein. Methods for protecting a subject against EcPV and BPV infection are further provided and include administering to the subject a composition comprised of a virus-like particle assembled from an EcPV L1 protein and virus like particle assembled from a BPV L1 protein. Methods of diagnosing EcPV and/or BPV infection in a subject are also provided and include providing a virus-like particle assembled from a papillomavirus L1 protein selected from an EcPV L1 protein and a BPV L1 protein; contacting the virus-like particle with serum from the subject; and identifying the subject as having an infection if an antibody capable of binding the virus-like particle is detected in the serum.
摘要翻译：提供了在受试者中赋予对马尾猴乳头瘤病毒（EcPV）和牛乳头瘤病毒（BPV）感染的保护作用的组合物，包括由EcPV L1蛋白组装的病毒样颗粒和由BPV L1蛋白组装的病毒样颗粒。还提供了保护受试者免受EcPV和BPV感染的方法，包括向受试者施用由EcPV L1蛋白组装的病毒样颗粒和由BPV L1蛋白组装的病毒样颗粒组成的组合物。还提供了诊断受试者中EcPV和/或BPV感染的方法，包括提供从选自EcPV L1蛋白和BPV L1蛋白的乳头瘤病毒L1蛋白组装的病毒样颗粒; 使病毒样颗粒与受试者的血清接触; 并且如果在血清中检测到能够结合病毒样颗粒的抗体，则将受试者识别为感染。

22. 发明授权

US07838215B2 Advanced cervical cell screening methods 失效
标题翻译：先进的宫颈细胞筛选方法
公开(公告)号：US07838215B2
公开(公告)日：2010-11-23
申请号：US12211547
申请日：2008-09-16
申请人： Peter Gombrich , Mitchell Golbus
发明人： Peter Gombrich , Mitchell Golbus
IPC分类号： C12Q1/70
CPC分类号： G01N33/57411 , C07K14/005 , C07K16/084 , C12N7/00 , C12N2710/20022 , G01N33/56983 , G01N2333/025
摘要： Advanced cervical cancer screening methods that provide a molecular based process of detecting HPV-integration. The disclosed methods allow for a streamlined approach of conducting a Pap test and immunohistochemical test on the same slide. The disclosed methods provides an inexpensive, highly sensitive, specific, and detailed test that is easy to evaluate and follow-up.
摘要翻译：先进的宫颈癌筛查方法，提供检测HPV整合的基于分子的过程。所公开的方法允许在同一载玻片上进行Pap测试和免疫组织化学测试的流线型方法。所公开的方法提供了便宜的，高度灵敏的，特定的和详细的测试，其易于评估和跟踪。

23. 发明申请

US20100267009A1 METHOD FOR THE IN VITRO DIAGNOSIS AND/OR IN VITRO THERAPY MONITORING OF INFECTIONS 审中-公开
标题翻译：用于体外诊断和/或体外监测感染的方法
公开(公告)号：US20100267009A1
公开(公告)日：2010-10-21
申请号：US12740049
申请日：2008-10-29
申请人： Volkmar Schollhorn
发明人： Volkmar Schollhorn
IPC分类号： C12Q1/70 , G01N33/53
CPC分类号： G01N33/5091 , G01N33/569 , G01N2333/025 , G01N2333/35 , Y02A50/54 , Y02A50/57
摘要： A method for in-vitro diagnosis and/or in-vitro therapy monitoring of infections and/or infectious diseases and differentiation between acute infections and latent or overcome infections comprising incubating eukaryotic cells with an antigen; and testing for cells (ASCs) secreting antigen-specific antibodies, the secreted antibodies of which are directed specifically against the antigen.
摘要翻译：用于体外诊断和/或体外治疗监测感染和/或感染性疾病以及急性感染与潜伏或克服感染之间的分化的方法，包括用真菌孵育真核细胞与抗原; 以及检测分泌抗原特异性抗体的细胞（ASC），其分泌的抗体特异性针对抗原。

24. 发明申请

US20090312527A1 Novel monoclonal antibodies against HPV proteins 有权
标题翻译：针对HPV蛋白的新型单克隆抗体
公开(公告)号：US20090312527A1
公开(公告)日：2009-12-17
申请号：US12456053
申请日：2009-06-10
申请人： Shuling Cheng
发明人： Shuling Cheng
IPC分类号： C07K16/08 , C12Q1/70
CPC分类号： G01N33/56983 , C07K16/084 , C12Q1/708 , G01N33/571 , G01N2333/025 , G01N2469/10
摘要： Embodiments of the invention provide methods, monoclonal antibodies, polyclonal antibodies, assays, and kits for detecting HPV infection and HPV related cancer diagnosis, including infection by various HPV genotypes, early and/or late stage HPV-associated or HPV-specific cancers. Various monoclonal antibodies recognizing specific epitope for specific HPV protein or HPV type, common epitope for various HPV proteins or HPV types are obtained. These obtained monoclonal antibodies are useful tools in early clinical detection of HPV infection and general detection of HPV related diseases, specific detection of invasive cervical cancer, detection of other HPV related cancers, early stage precancerous lesions as well as late stage cancer progression.
摘要翻译：本发明的实施方案提供用于检测HPV感染和HPV相关癌症诊断的方法，单克隆抗体，多克隆抗体，测定和试剂盒，包括各种HPV基因型，早期和/或晚期HPV相关或HPV特异性癌症的感染。获得识别特定HPV蛋白或HPV型特异性表位的各种单克隆抗体，各种HPV蛋白或HPV类型的常见表位。这些获得的单克隆抗体是早期临床检测HPV感染和HPV相关疾病的一般检测，侵袭性宫颈癌的特异性检测，其他HPV相关癌症的检测，早期癌前期病变以及晚期癌症进展的有用工具。

25. 发明申请

US20090269732A1 Methods for Diagnosing Oncogenic Human Papillomavirus (HPV) 有权
标题翻译：诊断致癌人乳头瘤病毒（HPV）的方法
公开(公告)号：US20090269732A1
公开(公告)日：2009-10-29
申请号：US12108550
申请日：2008-04-24
申请人： Richard Ivey , Stephen J. Lovell , Robert Rosenstein , Thomas Gentle , Song Shi
发明人： Richard Ivey , Stephen J. Lovell , Robert Rosenstein , Thomas Gentle , Song Shi
IPC分类号： C12Q1/70
CPC分类号： G01N33/56983 , G01N2333/025
摘要： Methods for diagnosis of HPV infection in a subject are provided. HPV infection in a subject can be determined by generating mass profile data for a biological sample from the subject and correlating the mass profile data with reference mass profiles to detect the presence or absence, and/or quantity of at least one biomarker associated with HPV infection. Methods for detecting at least one biomarker associated with HPV infection in a biological sample are also provided.
摘要翻译：提供了一种用于诊断受试者HPV感染的方法。可以通过产生来自受试者的生物样品的质量分布数据来确定受试者中的HPV感染，并将质量分布数据与参考质量分布相关联，以检测与HPV感染有关的至少一种生物标志物的存在或不存在和/或数量。还提供了用于检测生物样品中与HPV感染相关联的至少一种生物标志物的方法。

26. 发明申请

US20090148864A1 METHODS AND COMPOSITIONS FOR THE DETECTION OF CERVICAL DISEASE 审中-公开
公开(公告)号：US20090148864A1
公开(公告)日：2009-06-11
申请号：US12263942
申请日：2008-11-03
申请人： Timothy J. Fischer , Douglas P. Malinowski , Adriann J. Taylor , Margaret R. Parker
发明人： Timothy J. Fischer , Douglas P. Malinowski , Adriann J. Taylor , Margaret R. Parker
IPC分类号： G01N33/53
CPC分类号： G01N33/57411 , C07K16/3069 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/6875 , G01N2333/025
摘要： Methods and compositions for identifying high-grade cervical disease in a patient sample are provided. The methods of the invention comprise detecting overexpression of at least one biomarker in a body sample, wherein the biomarker is selectively overexpressed in high-grade cervical disease. In particular claims, the body sample is a cervical smear or monolayer of cervical cells. The biomarkers of the invention include genes and proteins that are involved in cell cycle regulation, signal transduction, and DNA replication and transcription. In particular claims, the biomarker is an S-phase gene. In some aspects of the invention, overexpression of a biomarker of interest is detected at the protein level using biomarker-specific antibodies or at the nucleic acid level using nucleic acid hybridization techniques. Kits for practicing the methods of the invention are further provided.

27. 发明申请

US20090136531A1 HPV E6 protein T cell epitopes and uses thereof 有权
标题翻译： HPV E6蛋白T细胞表位及其用途
公开(公告)号：US20090136531A1
公开(公告)日：2009-05-28
申请号：US12286822
申请日：2008-10-02
申请人： Mayumi Nakagawa
发明人： Mayumi Nakagawa
IPC分类号： A61K39/12 , C12Q1/02 , A61K35/12 , A61K39/00 , A61K31/7088
CPC分类号： C07K14/005 , A61K39/00 , C12N7/00 , C12N2710/20022 , C12N2710/24143 , G01N33/56983 , G01N2333/025
摘要： The present invention is directed to the examination of the pattern of immunodominant T cell epitopes in the E6 protein of Human Papilloma virus and its further characterization in terms of its amino acid sequence and Human Leukocyte Antigen restriction. These epitopes are identified based on their ability to induce specific T cell responses and therefore, are important as sources of antigens for immunotherapies to treat cervical and other cancers. The present invention contemplates identifying a number of similar epitopes restricted by a wide variety of Human Leukocyte Antigen types so that they can be used together to develop preventative or therapeutic vaccines, which can be used for the general human population.
摘要翻译：本发明涉及人乳头状瘤病毒的E6蛋白中免疫优势T细胞表位的模式的检查及其在氨基酸序列和人白细胞抗原限制方面的进一步表征。基于它们诱导特异性T细胞应答的能力来鉴定这些表位，因此，作为用于治疗子宫颈癌和其他癌症的免疫治疗的抗原的来源是重要的。本发明考虑了鉴定由多种人白细胞抗原类型限制的许多类似表位，以便它们可以一起用于开发可用于一般人群的预防性或治疗性疫苗。

28. 发明申请

US20090075300A1 METHODS AND COMPOSITIONS FOR THE DETECTION OF CERVICAL DISEASE 审中-公开
标题翻译：检测宫颈疾病的方法和组成
公开(公告)号：US20090075300A1
公开(公告)日：2009-03-19
申请号：US12263139
申请日：2008-10-31
申请人： Timothy J. Fischer , Douglas P. Malinowski , Adriann J. Taylor , Margaret R. Parker
发明人： Timothy J. Fischer , Douglas P. Malinowski , Adriann J. Taylor , Margaret R. Parker
IPC分类号： G01N33/53
CPC分类号： G01N33/57411 , C07K16/3069 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/6875 , G01N2333/025
摘要： Methods and compositions for identifying high-grade cervical disease in a patient sample are provided. The methods of the invention comprise detecting overexpression of at least one biomarker in a body sample, wherein the biomarker is selectively overexpressed in high-grade cervical disease. In particular claims, the body sample is a cervical smear or monolayer of cervical cells. The biomarkers of the invention include genes and proteins that are involved in cell cycle regulation, signal transduction, and DNA replication and transcription. In particular claims, the biomarker is an S-phase gene. In some aspects of the invention, overexpression of a biomarker of interest is detected at the protein level using biomarker-specific antibodies or at the nucleic acid level using nucleic acid hybridization techniques. Kits for practicing the methods of the invention are further provided.
摘要翻译：提供了用于鉴定患者样品中高级别宫颈疾病的方法和组合物。本发明的方法包括检测身体样品中至少一种生物标志物的过表达，其中生物标志物在高级子宫颈疾病中选择性地过度表达。在具体的权利要求中，身体样品是宫颈涂片或宫颈细胞单层。本发明的生物标志物包括参与细胞周期调节，信号转导和DNA复制和转录的基因和蛋白质。在具体的权利要求中，生物标志物是S期基因。在本发明的一些方面，使用生物标志物特异性抗体或在核酸水平使用核酸杂交技术在蛋白质水平上检测目标生物标志物的过表达。还提供了用于实施本发明的方法的试剂盒。

29. 发明授权

US07501235B2 Methods of collecting and transporting vaginal discharge for detection of infectious organisms and to facilitate cervical cancer screening 有权
标题翻译：收集和运输阴道分泌物以检测感染性生物体并促进子宫颈癌筛查的方法
公开(公告)号：US07501235B2
公开(公告)日：2009-03-10
申请号：US10538954
申请日：2003-12-24
申请人： Sun-Wing Tong , Olivia Wai-Hing Chan , Tat-Chong Chow , Vivian Yu
发明人： Sun-Wing Tong , Olivia Wai-Hing Chan , Tat-Chong Chow , Vivian Yu
IPC分类号： C12Q1/70
CPC分类号： C12Q1/6886 , A61B2010/0074 , C12Q1/708 , G01N33/528 , G01N2333/025
摘要： The present invention provides a method of testing for the presence of infectious disease agents or host genetic markers comprising applying a device comprising an absorbent and porous material onto the introitus of a female patient; encouraging air drying of at least a portion of the collected vaginal discharge while the device is proximate to the introitus; and determining the presence of infectious disease agents or host genetic markers in the at least partially dried vaginal discharge.
摘要翻译：本发明提供一种测试传染病病原体或宿主遗传标记物的存在的方法，包括将包含吸收剂和多孔材料的装置施用到女性患者的口腔上; 鼓励收集的阴道排泄物的至少一部分的空气干燥，同时装置接近口腔; 以及确定所述至少部分干燥的阴道分泌物中感染性疾病剂或宿主遗传标记的存在。

30. 发明授权

US07422859B2 Method for discrimination of metaplasias from neoplastic or preneoplastic lesions 有权
标题翻译：从肿瘤或肿瘤前病变中鉴别化生的方法
公开(公告)号：US07422859B2
公开(公告)日：2008-09-09
申请号：US10511108
申请日：2003-04-08
申请人： Ruediger Ridder , Magnus Von Knebel Doeberitz , Peter Martin
发明人： Ruediger Ridder , Magnus Von Knebel Doeberitz , Peter Martin
IPC分类号： G01N33/53
CPC分类号： C12Q1/6886 , C12Q1/708 , C12Q2600/112 , C12Q2600/158 , G01N33/57411 , G01N2333/025
摘要： The present invention relates to a method for discrimination of p16INK4a overexpressing metaplasias from neoplastic or preneoplastic p16INK4a overexpressing lesions by determination of the level of high risk HPV encoded gene-products such as e.g. HPV E2 and/or HPV E7 molecules in biological samples in the course of cytological testing procedures. The method thus enables for reduction of false positive results in the p16INK4a based detection of anogenital lesions in cytological testing procedures.
摘要翻译：本发明涉及通过测定高风险HPV编码的基因产物的水平来鉴定过表达p16 INK4a过表达病毒的p16，INK4a，p16，INK4a，例如 HPV E2和/或HPV E7分子在生物样品中的细胞学检测过程中。因此，该方法能够在细胞学检测程序中基于p16 INK4a 的检测肛门生殖器损伤中减少假阳性结果。

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