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    • 25. 发明申请
    • CONTROLLED SURFACE TOPOGRAPHY FOR ENHANCED PROTEIN CRYSTALLIZATION RATES
    • 用于增强蛋白质结晶率的控制表面形貌
    • US20080119642A1
    • 2008-05-22
    • US11943134
    • 2007-11-20
    • Matthew HALL
    • Matthew HALL
    • C07K1/00
    • C30B29/58C30B7/00C30B7/005
    • A method for accelerating protein crystallization on a substrate is provided, including the steps of providing a coating layer comprising a colloidal solution containing inert particles on at least one discrete testing portion of a testing substrate to provide at least one coated portion, and drying the coated portion so that the coated portion has an enhanced surface topography defined by the characteristics of the coating layer. A supersaturated protein solution is applied to the coated portion, and the testing substrate is placed in an incubator for crystallization, and the growth rate of the protein crystals is accelerated during incubation due to the enhanced surface topography of the at least one coated portion. The testing substrate is evaluated to determine the degree of protein crystallization until crystallization in complete, and the protein crystals are subsequently removed from the testing substrate subjected to specific characterization testing.
    • 提供了一种用于加速基质上的蛋白质结晶的方法,包括以下步骤:在测试基材的至少一个离散的测试部分上提供包含惰性颗粒的胶体溶液的涂层,以提供至少一个涂布部分, 使得涂覆部分具有由涂层的特性限定的增强的表面形貌。 将过饱和蛋白质溶液施加到涂布部分,并且将测试底物置于培养箱中用于结晶,并且由于至少一个涂布部分的增强的表面形貌,蛋白质晶体的生长速率在孵育期间被加速。 评估测试底物以确定蛋白质结晶的程度,直到完全结晶,随后将蛋白质晶体从经过特异性表征测试的测试底物中除去。
    • 27. 发明申请
    • Selection and deposition of nanoparticles using CO2-expanded liquids
    • 使用二氧化碳膨胀液体选择和沉积纳米颗粒
    • US20070243716A1
    • 2007-10-18
    • US11237601
    • 2005-09-27
    • Christopher RobertsMarshall McLeodMadhu Anand
    • Christopher RobertsMarshall McLeodMadhu Anand
    • H01L21/31
    • C30B7/00B05D1/18B05D2401/32B05D2401/90B82Y30/00C30B7/005C30B29/605Y10S977/70Y10S977/773
    • A method for size selection of nanostructures comprising utilizing a gas-expanded liquids (GEL) and controlled pressure to precipitate desired size populations of nanostructures, e.g., monodisperse. The GEL can comprise CO2 antisolvent and an organic solvent. The method can be carried out in an apparatus comprising a first open vessel configured to allow movement of a liquid/particle solution to specific desired locations within the vessel, a second pressure vessel, a location controller for controlling location of the particles and solution within the first vessel, a inlet for addition of antisolvent to the first vessel, and a device for measuring the amount of antisolvent added. Also disclosed is a method for forming nanoparticle thin films comprising utilizing a GEL containing a substrate, pressurizing the solution to precipitate and deposit nanoparticles onto the substrate, removing the solvent thereby leaving a thin nanoparticle film, removing the solvent and antisolvent, and drying the film.
    • 纳米结构尺寸选择的方法包括利用气体膨胀液体(GEL)和受控压力来沉淀所需尺寸的纳米结构体,例如单分散。 GEL可以包含CO 2反溶剂和有机溶剂。 该方法可以在包括构造成允许液体/颗粒溶液移动到容器内的特定所需位置的第一开放容器的设备中进行,第二压力容器,位置控制器,用于控制颗粒和溶液的位置 第一容器,用于向第一容器添加抗溶剂的入口,以及用于测量加入的抗溶剂量的装置。 还公开了一种用于形成纳米颗粒薄膜的方法,其包括使用含有底物的GEL,将溶液加压沉淀并将纳米颗粒沉积到基底上,除去溶剂从而留下薄的纳米颗粒膜,除去溶剂和反溶剂,并干燥该膜 。
    • 28. 发明授权
    • Thick porous anodic alumina films and nanowire arrays grown on a solid substrate
    • 在固体基底上生长的厚多孔阳极氧化铝膜和纳米线阵列
    • US07267859B1
    • 2007-09-11
    • US10303653
    • 2002-11-25
    • Oded RabinPaul R. HerzMildred S. DresselhausAkintunde I. AkinwandeYu-Ming Lin
    • Oded RabinPaul R. HerzMildred S. DresselhausAkintunde I. AkinwandeYu-Ming Lin
    • B32B3/10B32B9/00B32B15/00G03C5/00C23C28/00
    • C23C14/024B82Y30/00C23C14/16C23C14/5873C30B7/00C30B7/005C30B29/605H01L35/32H01L35/34Y10T156/10Y10T428/12486Y10T428/1259Y10T428/24273Y10T428/24322Y10T428/24917
    • The presently disclosed invention provides for the fabrication of porous anodic alumina (PAA) films on a wide variety of substrates. The substrate comprises a wafer layer and may further include an adhesion layer deposited on the wafer layer. An anodic alumina template is formed on the substrate. When a rigid substrate such as Si is used, the resulting anodic alumina film is more tractable, easily grown on extensive areas in a uniform manner, and manipulated without danger of cracking. The substrate can be manipulated to obtain free-standing alumina templates of high optical quality and substantially flat surfaces PAA films can also be grown this way on patterned and non-planar surfaces. Furthermore, under certain conditions the resulting PAA is missing the barrier layer (partially or completely) and the bottom of the pores can be readily accessed electrically. The resultant film can be used as a template for forming an array of nanowires wherein the nanowires are deposited electrochemically into the pores of the template. By patterning the electrically conducting adhesion layer, pores in different areas of the template can be addressed independently, and can be filled electrochemically by different materials. Single-stage and multi-stage nanowire-based thermoelectric devices, consisting of both n-type and p-type nanowires, can be assembled on a silicon substrate by this method.
    • 目前公开的发明提供了在各种基底上制造多孔阳极氧化铝(PAA)膜。 衬底包括晶片层,并且还可以包括沉积在晶片层上的粘附层。 在基板上形成阳极氧化铝模板。 当使用诸如Si的刚性基材时,所得的阳极氧化铝膜更易于处理,容易在均匀的方式在广泛的区域生长,并且操作而没有开裂的危险。 可以操作基底以获得高光学质量的自立式氧化铝模板和基本平坦的表面。也可以在图案化和非平面表面上生长PAA膜。 此外,在某些条件下,所得PAA缺少阻挡层(部分或完全),并且孔的底部可以容易地电接触。 所得膜可以用作形成纳米线阵列的模板,其中纳米线电化学沉积到模板的孔中。 通过图案化导电粘合层,可以独立地解决模板的不同区域中的孔,并且可以通过不同的材料电化学填充。 通过这种方法,可以在硅衬底上组装由n型和p型纳米线组成的单级和多级纳米线型热电装置。