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21. 发明授权

US09102943B2 Method for producing virus vector 有权
标题翻译：生产病毒载体的方法
公开(公告)号：US09102943B2
公开(公告)日：2015-08-11
申请号：US13823805
申请日：2011-10-04
申请人： Kazuhisa Shinmura , Yoshinori Katayama , Kensuke Sakai , Toshihiro Shodai , Hirofumi Yoshioka , Junichi Mineno
发明人： Kazuhisa Shinmura , Yoshinori Katayama , Kensuke Sakai , Toshihiro Shodai , Hirofumi Yoshioka , Junichi Mineno
IPC分类号： C12N5/00 , C12N15/00 , A61K39/21 , C12N15/64 , C12N7/00
CPC分类号： C12N15/64 , C12N7/00 , C12N2500/36 , C12N2501/065 , C12N2501/39 , C12N2740/10051
摘要： The present invention provides a method for producing a virus vector, which comprises a step wherein cells that are capable of producing a virus vector are cultured in a culture medium that contains, as active components, a retinoic acid and a histone deacetylase inhibiting substance; and a culture medium for the production of a virus vector, which is characterized by containing, as active components, a retinoic acid and a histone deacetylase inhibiting substance.
摘要翻译：本发明提供一种病毒载体的制造方法，其特征在于，包括能够产生病毒载体的细胞在含有视黄酸和组蛋白脱乙酰酶抑制物质作为活性成分的培养基中培养的步骤。以及用于生产病毒载体的培养基，其特征在于含有视黄酸和组蛋白脱乙酰酶抑制物质作为活性成分。

22. 发明申请

US20150079050A1 METHOD FOR PRODUCING VIRAL VECTOR 有权
标题翻译：生产病毒载体的方法
公开(公告)号：US20150079050A1
公开(公告)日：2015-03-19
申请号：US14381721
申请日：2013-03-14
申请人： TAKARA BIO INC.
发明人： Kazuhisa Shinmura , Hirofumi Yoshioka , Hikaru Takakura , Junichi Mineno
IPC分类号： C12N15/86 , C12N5/00 , A61K35/00 , C12N7/00
CPC分类号： C12N15/86 , A61K35/13 , A61K48/00 , C12N5/0018 , C12N7/00 , C12N2740/10041 , C12N2740/10051 , C12N2740/10052
摘要： The present invention provides a method for producing a virus vector, which involves a step of culturing a cell capable of producing the virus vector in a culture medium containing a retinoic acid compound, a histone deacetylase-inhibiting substance and a substance capable of forming a chelate; and a culture medium for use in the production of a virus vector, which is characterized by containing a retinoic acid compound, a histone deacetylase-inhibiting substance and a substance capable of forming a chelate as active ingredients.
摘要翻译：本发明提供一种病毒载体的制备方法，其包括在含有维甲酸化合物，组蛋白脱乙酰酶抑制物质和能够形成螯合物的培养基中培养能够产生病毒载体的细胞的步骤 ; 以及用于生产病毒载体的培养基，其特征在于含有视黄酸化合物，组蛋白脱乙酰酶抑制物质和能够形成螯合物的物质作为活性成分。

23. 发明申请

US20140315294A1 SCALABLE LENTIVIRAL VECTOR PRODUCTION SYSTEM COMPATIBLE WITH INDUSTRIAL PHARMACEUTICAL APPLICATIONS 审中-公开
标题翻译：可扩展的生物体系生产系统兼容工业药品应用
公开(公告)号：US20140315294A1
公开(公告)日：2014-10-23
申请号：US14359960
申请日：2012-11-26
申请人： GENETHON
发明人： Nicolas Marceau , Mehdi Gasmi
IPC分类号： C12N15/86 , C12N7/00
CPC分类号： C12N15/86 , C12N7/00 , C12N7/02 , C12N2740/10051 , C12N2740/15011 , C12N2740/16051
摘要： The present invention relates to the industrialization of the production of recombinant lentiviral vectors in order to manufacture sufficient materials for therapeutic applications such as gene therapy and/or DNA vaccination, for use in clinical trials and/or commercial use.
摘要翻译：本发明涉及生产重组慢病毒载体的工业化，以便制备用于治疗应用的足够材料，例如用于临床试验和/或商业用途的基因治疗和/或DNA疫苗接种。

24. 发明申请

US20120028358A1 METHOD FOR INCREASING RETROVIRAL INFECTIVITY 审中-公开
标题翻译：增加退行性感染的方法
公开(公告)号：US20120028358A1
公开(公告)日：2012-02-02
申请号：US13170836
申请日：2011-06-28
申请人： Victor Solodushko , Brian Fouty
发明人： Victor Solodushko , Brian Fouty
IPC分类号： C12N15/867 , C12N5/071
CPC分类号： C12N15/86 , C12N2740/10043 , C12N2740/10051 , C12N2740/13043 , C12N2740/13051
摘要： The present invention is directed to methods for enhanced retroviral delivery of a nucleic acid to a target cell in vitro, ex vivo or in vivo, which involves increasing infectivity of a retrovirus carrying a transgene of interest to a target cell. In one particular aspect the invention relates to a method for increasing retroviral infectivity of target cells comprising culturing packaging cells transfected with retroviral vector containing a transgene of interest in medium containing a glucocorticoid receptor agonist or analog or derivative thereof present in the medium in an amount effective to increase titer of propagated retrovirus; and subsequently culturing a target cell in medium comprising the propagated retrovirus from a) and a glucocorticoid receptor antagonist or analog or derivative thereof present in the medium in an amount effective to increase target cell sensitivity to infection by the propagated retrovirus.
摘要翻译：本发明涉及用于在体外，体外或体内增强核酸向靶细胞的逆转录病毒递送的方法，其涉及将携带感兴趣的转基因的逆转录病毒的感染性增加至靶细胞。在一个特定方面，本发明涉及一种用于增加靶细胞的逆转录病毒感染性的方法，所述方法包括用存在于培养基中的培养含有目的转基因的逆转录病毒载体转染培养包含细胞的培养基，所述培养基含有存在于培养基中的糖皮质激素受体激动剂或其类似物或衍生物增加传播逆转录病毒的滴度; 并且随后在来自a）的培养基中培养包含增殖的逆转录病毒的靶细胞，并且以有效增加靶细胞对传播的逆转录病毒感染的敏感性的量存在于培养基中的糖皮质激素受体拮抗剂或其类似物或衍生物。

25. 发明授权

US07674888B2 Viral material and nucleotide fragments associated with multiple sclerosis, for diagnostic, prophylactic and therapeutic purposes 有权
标题翻译：与多发性硬化相关的病毒材料和核苷酸片段，用于诊断，预防和治疗目的
公开(公告)号：US07674888B2
公开(公告)日：2010-03-09
申请号：US11581030
申请日：2006-10-16
申请人： Herve Perron , Frederic Beseme , Frederic Bedin , Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Colette Jolivet-Reynaud , Bernard Mandrand , Jeremy Alexander Garson , Philip William Tuke
发明人： Herve Perron , Frederic Beseme , Frederic Bedin , Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Colette Jolivet-Reynaud , Bernard Mandrand , Jeremy Alexander Garson , Philip William Tuke
IPC分类号： C07H21/02
CPC分类号： C07K14/005 , A61K38/00 , C12N7/00 , C12N9/1241 , C12N2740/10022 , C12N2740/10051 , C12Q1/702
摘要： The invention provides viral material and nucleotide fragments associated with multiple sclerosis and/or rheumatoid arthritis for use in method of diagnosis, prophylaxis, and therapy.
摘要翻译：本发明提供了用于诊断，预防和治疗方法的与多发性硬化和/或类风湿性关节炎有关的病毒物质和核苷酸片段。

26. 发明授权

US07449562B2 PERV screening method and use thereof 失效
标题翻译： PERV筛选方法及其用途
公开(公告)号：US07449562B2
公开(公告)日：2008-11-11
申请号：US10481160
申请日：2002-06-28
申请人： Christopher Herring , Gillian Langford , Gary Quinn , Linda Scobie
发明人： Christopher Herring , Gillian Langford , Gary Quinn , Linda Scobie
IPC分类号： C07H21/04 , C12P19/34
CPC分类号： C12N15/8509 , A01K2207/15 , A01K2217/00 , A01K2217/075 , A01K2227/108 , A01K2267/02 , A01K2267/025 , C07K14/005 , C12N7/00 , C12N2740/10022 , C12N2740/10051 , C12Q1/702
摘要： The invention relates to porcine endogenous retrovirus (PERV) and novel methods of identification, isolation and screening via polynucleotide sequences. It also relates to use of said methods in providing a pig that does not express porcine endogenous retrovirus. The organs, tissues and cells of said pig being capable of use for xenotransplantaion.
摘要翻译：本发明涉及猪内源性逆转录病毒（PERV）和通过多核苷酸序列鉴定，分离和筛选的新方法。它还涉及所述方法在提供不表达猪内源性逆转录病毒的猪中的用途。所述猪的器官，组织和细胞能够用于异种转移。

27. 发明授权

US07186559B2 Apparatus and method for electroporation of biological samples 有权
标题翻译：生物样品电穿孔装置及方法
公开(公告)号：US07186559B2
公开(公告)日：2007-03-06
申请号：US10751586
申请日：2004-01-05
申请人： Sergey M. Dzekunov , Linhong Li , Vininder Singh , Linda Liu , John W. Holaday , Hyung J. Lee
发明人： Sergey M. Dzekunov , Linhong Li , Vininder Singh , Linda Liu , John W. Holaday , Hyung J. Lee
IPC分类号： C12N15/64
CPC分类号： A61N1/0412 , A61K9/5068 , A61K48/0091 , A61N1/327 , C12M35/02 , C12N15/87 , C12N2740/10051 , C12N2840/203
摘要： The present invention relates to methods and apparatus for the encapsulation of biologically-active substances in various cell populations. More particularly, the present invention relates to a method and apparatus for the encapsulation of biologically-active substances in various cell populations in blood by electroporation to achieve therapeutically desirable changes in the physical characteristics of the various cell populations in blood.
摘要翻译：本发明涉及将生物活性物质包封在各种细胞群中的方法和装置。更具体地，本发明涉及通过电穿孔将生物活性物质包封在血液中的各种细胞群体中以实现血液中各种细胞群体的物理特性的理想上的改变的方法和装置。

28. 发明授权

US07160464B2 Methods for removal, purification, and concentration of viruses and methods of therapy based thereupon 有权
标题翻译：病毒的去除，纯化和浓缩方法及其治疗方法
公开(公告)号：US07160464B2
公开(公告)日：2007-01-09
申请号：US11018939
申请日：2004-12-21
申请人： William Lee , Jeffrey R. Morgan , Martin L. Yarmush
发明人： William Lee , Jeffrey R. Morgan , Martin L. Yarmush
IPC分类号： B01D61/00 , B01D63/00 , B01D15/04
CPC分类号： C12N7/00 , A61L2/0017 , A61L2/0082 , C12N2740/10051
摘要： The invention is based on the discovery that certain membranes, which include side chains or molecular “brushes” having, for example, tertiary amino functional groups, can be used as highly effective filters to capture viruses/virus particles from liquids without removal of proteins. New methods based on this discovery include removing viruses from liquids such as blood or plasma, removing viruses from pharmaceuticals, concentrating and/or purifying viruses, e.g., for use in gene therapy, and producing recombinant viruses in new bioreactors. The invention also includes new methods of therapy or adjunct therapy for viral infections, in which a patient's blood or plasma is filtered through the membranes to remove viruses to reduce the viral load. The invention also includes new bioreactors and viral filters containing the membranes.
摘要翻译：本发明基于以下发现：包括侧链的某些膜或具有例如叔氨基官能团的分子“刷”可用作高效过滤器，以从液体中捕获病毒/病毒颗粒而不除去蛋白质。基于该发现的新方法包括从诸如血液或血浆的液体中除去病毒，从药物中除去病毒，浓缩和/或纯化病毒，例如用于基因治疗，以及在新的生物反应器中产生重组病毒。本发明还包括用于病毒感染的新的治疗方法或辅助治疗方法，其中通过膜过滤患者的血液或血浆以除去病毒以减少病毒载量。本发明还包括含有膜的新的生物反应器和病毒过滤器。

29. 发明申请

US20050066380A1 Perv screening method and use thereof 失效
标题翻译： Perv筛选方法及其用途
公开(公告)号：US20050066380A1
公开(公告)日：2005-03-24
申请号：US10481160
申请日：2002-06-28
申请人： Christopher Herring , Gillian Langford , Gary Quinn , Linda Scobie
发明人： Christopher Herring , Gillian Langford , Gary Quinn , Linda Scobie
IPC分类号： A01K67/027 , C07H21/04 , C07K14/15 , C12N7/02 , C12N15/09 , C12N15/53 , C12N15/85 , C12N15/867 , C12Q1/68 , C12Q1/70
CPC分类号： C12N15/8509 , A01K2207/15 , A01K2217/00 , A01K2217/075 , A01K2227/108 , A01K2267/02 , A01K2267/025 , C07K14/005 , C12N7/00 , C12N2740/10022 , C12N2740/10051 , C12Q1/702
摘要： The invention relates to porcine endogenous retrovirus (PERV) and novel methods of identification, isolation and screening via polynucleotides sequences. It also relates to use of said methods in providing a pig that does not express porcine endogenous retrovirus. The organs, tissues and cells of said pig being capable of use for xenotransplantation.
摘要翻译：本发明涉及猪内源性逆转录病毒（PERV）以及通过多核苷酸序列鉴定，分离和筛选的新方法。它还涉及所述方法在提供不表达猪内源性逆转录病毒的猪中的用途。所述猪的器官，组织和细胞能够用于异种移植。

30. 发明申请

US20010034055A1 Methods for removal, purification, and concentration of viruses, and methods of therapy based thereupon 失效
标题翻译：病毒的去除，纯化和浓缩方法及其治疗方法
公开(公告)号：US20010034055A1
公开(公告)日：2001-10-25
申请号：US09728882
申请日：2000-12-01
发明人： William Lee , Jeffrey R. Morgan , Martin L. Yarmush
IPC分类号： A61K039/00 , C12N007/02 , C12M001/00 , B01D035/16
CPC分类号： C12N7/00 , A61L2/0017 , A61L2/0082 , C12N2740/10051
摘要： The invention is based on the discovery that certain membranes, which include side chains or molecular nullbrushesnull having, for example, tertiary amino functional groups, can be used as highly effective filters to capture viruses/virus particles from liquids without removal of proteins. New methods based on this discovery include removing viruses from liquids such as blood or plasma, removing viruses from pharmaceuticals, concentrating and/or purifying viruses, e.g., for use in gene therapy, and producing recombinant viruses in new bioreactors. The invention also includes new methods of therapy or adjunct therapy for viral infections, in which a patient's blood or plasma is filtered through the membranes to remove viruses to reduce the viral load. The invention also includes new bioreactors and viral filters containing the membranes.
摘要翻译：本发明基于以下发现：包括侧链的某些膜或具有例如叔氨基官能团的分子“刷”可用作高效过滤器，以从液体中捕获病毒/病毒颗粒而不除去蛋白质。基于该发现的新方法包括从诸如血液或血浆的液体中除去病毒，从药物中除去病毒，浓缩和/或纯化病毒，例如用于基因治疗，以及在新的生物反应器中产生重组病毒。本发明还包括用于病毒感染的新的治疗方法或辅助治疗方法，其中通过膜过滤患者的血液或血浆以除去病毒以减少病毒载量。本发明还包括含有膜的新的生物反应器和病毒过滤器。

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