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1. 发明授权

US06861001B2 Methods for removal, purification, and concentration of viruses, and methods of therapy based thereupon 失效
标题翻译：病毒的去除，纯化和浓缩方法及其治疗方法
公开(公告)号：US06861001B2
公开(公告)日：2005-03-01
申请号：US09728882
申请日：2000-12-01
申请人： William Lee , Jeffrey R. Morgan , Martin L. Yarmush
发明人： William Lee , Jeffrey R. Morgan , Martin L. Yarmush
IPC分类号： A61L2/00 , C12N7/02 , B01D61/00
CPC分类号： C12N7/00 , A61L2/0017 , A61L2/0082 , C12N2740/10051
摘要： The invention is based on the discovery that certain membranes, which include side chains or molecular “brushes” having, for example, tertiary amino functional groups, can be used as highly effective filters to capture viruses/virus particles from liquids without removal of proteins. New methods based on this discovery include removing viruses from liquids such as blood or plasma, removing viruses from pharmaceuticals, concentrating and/or purifying viruses, e.g., for use in gene therapy, and producing recombinant viruses in new bioreactors. The invention also includes new methods of therapy or adjunct therapy for viral infections, in which a patient's blood or plasma is filtered through the membranes to remove viruses to reduce the viral load. The invention also includes new bioreactors and viral filters containing the membranes.
摘要翻译：本发明基于以下发现：包括侧链的某些膜或具有例如叔氨基官能团的分子“刷”可用作高效过滤器，以从液体中捕获病毒/病毒颗粒而不除去蛋白质。基于该发现的新方法包括从诸如血液或血浆的液体中除去病毒，从药物中除去病毒，浓缩和/或纯化病毒，例如用于基因治疗，以及在新的生物反应器中产生重组病毒。本发明还包括用于病毒感染的新的治疗方法或辅助治疗方法，其中通过膜过滤患者的血液或血浆以除去病毒以减少病毒载量。本发明还包括含有膜的新的生物反应器和病毒过滤器。

2. 发明授权

US06884613B2 Selective precipitation of viruses 有权
标题翻译：选择性降解病毒
公开(公告)号：US06884613B2
公开(公告)日：2005-04-26
申请号：US09939065
申请日：2001-08-24
申请人： Joseph M. Le Doux , Martin L. Yarmush , Jeffrey R. Morgan
发明人： Joseph M. Le Doux , Martin L. Yarmush , Jeffrey R. Morgan
IPC分类号： A61K48/00 , C12N7/02 , C12N15/867
CPC分类号： C12N15/86 , A61K48/0091 , C12N7/00 , C12N2740/13043 , C12N2740/13051
摘要： The invention provides new methods for purifying and concentrating viruses. The inventors have discovered that high molecular weight proteoglycans present in retroviral stocks are co-concentrated with the retroviruses, and can inhibit retroviral transduction. The new purification and concentration methods feature treatment of virus stock with an anionic polyelectrolyte and a cationic polyelectrolyte, followed by centrifugation. The new methods minimize the amount of proteoglycan co-precipitated with the infectious virus.
摘要翻译：本发明提供了用于纯化和浓缩病毒的新方法。发明人已经发现存在于逆转录病毒原液中的高分子量蛋白聚糖与逆转录病毒共同浓缩，并且可以抑制逆转录病毒转导。新的纯化和浓缩方法特征是用阴离子聚电解质和阳离子聚电解质处理病毒原液，然后离心。新方法使与感染性病毒共沉淀的蛋白多糖的量最小化。

3. 发明授权

US4980286A In vivo introduction and expression of foreign genetic material in epithelial cells 失效
标题翻译：外源遗传物质在上皮细胞中的体内引入和表达
公开(公告)号：US4980286A
公开(公告)日：1990-12-25
申请号：US292885
申请日：1989-01-03
申请人： Jeffrey R. Morgan , Richard C. Mulligan
发明人： Jeffrey R. Morgan , Richard C. Mulligan
IPC分类号： A61K38/00 , A61L27/54 , A61L27/60 , C07K14/61 , C07K14/635 , C12N15/85 , C12N15/867 , C12N15/90
CPC分类号： C12N15/86 , A61L27/54 , A61L27/60 , C07K14/61 , C07K14/635 , C12N15/85 , C12N15/90 , A61K38/00 , A61L2300/258 , A61L2300/602 , A61L2300/64 , C12N2740/13043
摘要： Epithelial cells expressing foreign genetic material are described. The foreign genetic material can be DNA or RNA which does not occur in epithelial cells; DNA or RNA which occurs in epithelial cells but is not expressed in them at levels which are biologically significant; DNA or RNA which occurs in epithelial and has been modified so that it is expressed in epithelial cells; and any DNA or RNA which can be modified to be expressed in epithelial cells, alone or in any combination thereof. In addition, epithelial cells of the present invention can express genetic material encoding a selectable marker by which cells expressing the foreign genetic material can be expressed.
摘要翻译：描述表达外源遗传物质的上皮细胞。外来遗传物质可以是不发生在上皮细胞中的DNA或RNA; 发生在上皮细胞中但不具有生物学意义的水平的DNA或RNA; DNA或RNA，其在上皮中发生并被修饰，使其在上皮细胞中表达; 以及可以修饰以在上皮细胞中单独或以任何组合表达的任何DNA或RNA。此外，本发明的上皮细胞可以表达编码可以表达外源遗传物质的细胞的选择标记的遗传物质。

4. 发明授权

US4868116A Introduction and expression of foreign genetic material in epithelial cells 失效
标题翻译：外源遗传物质在上皮细胞中的引入和表达
公开(公告)号：US4868116A
公开(公告)日：1989-09-19
申请号：US883590
申请日：1986-07-09
申请人： Jeffrey R. Morgan , Richard C. Mulligan
发明人： Jeffrey R. Morgan , Richard C. Mulligan
IPC分类号： C12N15/09 , A61F2/10 , A61K35/12 , A61K35/36 , A61K38/00 , A61K38/22 , A61K38/28 , A61K38/43 , A61K47/00 , A61L27/54 , A61L27/60 , C07K14/61 , C07K14/635 , C12N5/00 , C12N5/06 , C12N5/08 , C12N5/10 , C12N15/00 , C12N15/56 , C12N15/85 , C12N15/867 , C12N15/90
CPC分类号： C07K14/61 , A61K35/36 , A61L27/54 , A61L27/60 , C07K14/635 , C12N15/85 , C12N15/86 , C12N15/90 , A61K38/00 , A61L2300/254 , A61L2300/258 , A61L2300/43 , A61L2300/64 , C12N2740/13041 , C12N2740/13043 , Y10S435/948
摘要： Epithelial cells expressing foreign genetic material are described. The foreign genetic material can be DNA or RNA which does not occur in epithelial cells; DNA or RNA which occurs in epithelial cells but is not expressed in them at levels which are biologically significant; DNA or RNA which occurs in epithelial and has been modified so that it is expressed in epithelial cells; and any DNA or RNA which can be modified to be expressed in epithelial cells, alone or in any combination thereof. In addition, epithelial cells of the present invention can express genetic material encoding a selectable marker by which cells expressing the foreign genetic material can be expressed.
摘要翻译：描述表达外源遗传物质的上皮细胞。外来遗传物质可以是不发生在上皮细胞中的DNA或RNA; 发生在上皮细胞中但不具有生物学意义的水平的DNA或RNA; DNA或RNA，其在上皮中发生并被修饰，使其在上皮细胞中表达; 以及可以修饰以在上皮细胞中单独或以任何组合表达的任何DNA或RNA。此外，本发明的上皮细胞可以表达编码可以表达外源遗传物质的细胞的选择标记的遗传物质。

5. 发明授权

US08501476B2 Assays and methods for fusing cell aggregates to form proto-tissues 有权
标题翻译：用于融合细胞聚集体以形成原组织的测定和方法
公开(公告)号：US08501476B2
公开(公告)日：2013-08-06
申请号：US12896173
申请日：2010-10-01
申请人： Jeffrey R. Morgan , Dylan Dean , Adam Rago
发明人： Jeffrey R. Morgan , Dylan Dean , Adam Rago
IPC分类号： C12N5/02
CPC分类号： C12N5/0062 , B33Y80/00 , C12N2533/76 , G01N33/5005
摘要： Provided are assays and methods for creating proto-tissues from aggregates of cells. The invention concerns assays and methods useful in tissue engineering and reconstruction techniques, specifically in the formation of macrotissues from microtissues using microtissue pre-culture time as a controlling parameter.
摘要翻译：提供了用于从细胞聚集体产生原组织的测定和方法。本发明涉及在组织工程和重建技术中有用的测定和方法，特别是使用微组织培养前时间作为控制参数从微组织形成宏观组织。

6. 发明申请

US20110212481A1 ASSAYS AND METHODS FOR FUSING CELL AGGREGATES TO FORM PROTO-TISSUES 有权
标题翻译：用于融合细胞聚集体以形成原型组织的测定和方法
公开(公告)号：US20110212481A1
公开(公告)日：2011-09-01
申请号：US12896173
申请日：2010-10-01
申请人： Jeffrey R. Morgan , Dylan Dean , Adam Rago
发明人： Jeffrey R. Morgan , Dylan Dean , Adam Rago
IPC分类号： C12N5/071 , C12Q1/02
CPC分类号： C12N5/0062 , B33Y80/00 , C12N2533/76 , G01N33/5005
摘要： Provided are assays and methods for creating proto-tissues from aggregates of cells. The invention concerns assays and methods useful in tissue engineering and reconstruction techniques, specifically in the formation of macrotissues from microtissues using microtissue pre-culture time as a controlling parameter.
摘要翻译：提供了用于从细胞聚集体产生原组织的测定和方法。本发明涉及在组织工程和重建技术中有用的测定和方法，特别是使用微组织培养前时间作为控制参数从微组织形成宏观组织。

7. 发明授权

US07592170B2 Selective precipitation of viruses using polyectrolytes 有权
标题翻译：使用聚电解质选择性沉淀病毒
公开(公告)号：US07592170B2
公开(公告)日：2009-09-22
申请号：US11104161
申请日：2005-04-12
申请人： Joseph M. Le Doux , Martin L. Yarmush , Jeffrey R. Morgan
发明人： Joseph M. Le Doux , Martin L. Yarmush , Jeffrey R. Morgan
IPC分类号： C12N9/00
CPC分类号： C12N15/86 , A61K48/0091 , C12N7/00 , C12N2740/13043 , C12N2740/13051
摘要： The invention provides new methods for purifying and concentrating viruses. The inventors have discovered that high molecular weight proteoglycans present in retroviral stocks are co-concentrated with the retroviruses, and can inhibit retroviral transduction. The new purification and concentration methods feature treatment of virus stock with an anionic polyelectrolyte and a cationic polyelectrolyte, followed by centrifugation. The new methods minimize the amount of proteoglycan co-precipitated with the infectious virus.
摘要翻译：本发明提供了用于纯化和浓缩病毒的新方法。发明人已经发现存在于逆转录病毒原液中的高分子量蛋白聚糖与逆转录病毒共同浓缩，并且可以抑制逆转录病毒转导。新的纯化和浓缩方法特征是用阴离子聚电解质和阳离子聚电解质处理病毒原液，然后离心。新方法使与感染性病毒共沉淀的蛋白多糖的量最小化。

8. 发明申请

US20090104095A1 NOVEL COMPOSITIONS AND RELATED METHODS, COATINGS, AND ARTICLES 有权
公开(公告)号：US20090104095A1
公开(公告)日：2009-04-23
申请号：US12253530
申请日：2008-10-17
申请人： Jeffrey R. Morgan , John D. Jarrell
发明人： Jeffrey R. Morgan , John D. Jarrell
IPC分类号： C01G5/00 , C01G23/04 , C01G31/02 , C01G35/00 , C01G1/02 , C01G9/02
CPC分类号： C01G1/02 , C01G5/00 , C01G9/02 , C01G23/047 , C01G23/053 , C01G25/02 , C01G31/02 , C01G35/00 , Y10T428/31504 , Y10T428/31598
摘要： Novel compositions, as well as related methods, coatings, and articles, are disclosed.

9. 发明授权

US07160464B2 Methods for removal, purification, and concentration of viruses and methods of therapy based thereupon 有权
标题翻译：病毒的去除，纯化和浓缩方法及其治疗方法
公开(公告)号：US07160464B2
公开(公告)日：2007-01-09
申请号：US11018939
申请日：2004-12-21
申请人： William Lee , Jeffrey R. Morgan , Martin L. Yarmush
发明人： William Lee , Jeffrey R. Morgan , Martin L. Yarmush
IPC分类号： B01D61/00 , B01D63/00 , B01D15/04
CPC分类号： C12N7/00 , A61L2/0017 , A61L2/0082 , C12N2740/10051
摘要： The invention is based on the discovery that certain membranes, which include side chains or molecular “brushes” having, for example, tertiary amino functional groups, can be used as highly effective filters to capture viruses/virus particles from liquids without removal of proteins. New methods based on this discovery include removing viruses from liquids such as blood or plasma, removing viruses from pharmaceuticals, concentrating and/or purifying viruses, e.g., for use in gene therapy, and producing recombinant viruses in new bioreactors. The invention also includes new methods of therapy or adjunct therapy for viral infections, in which a patient's blood or plasma is filtered through the membranes to remove viruses to reduce the viral load. The invention also includes new bioreactors and viral filters containing the membranes.
摘要翻译：本发明基于以下发现：包括侧链的某些膜或具有例如叔氨基官能团的分子“刷”可用作高效过滤器，以从液体中捕获病毒/病毒颗粒而不除去蛋白质。基于该发现的新方法包括从诸如血液或血浆的液体中除去病毒，从药物中除去病毒，浓缩和/或纯化病毒，例如用于基因治疗，以及在新的生物反应器中产生重组病毒。本发明还包括用于病毒感染的新的治疗方法或辅助治疗方法，其中通过膜过滤患者的血液或血浆以除去病毒以减少病毒载量。本发明还包括含有膜的新的生物反应器和病毒过滤器。

10. 发明申请

US20090105384A1 NOVEL COMPOSITIONS AND RELATED METHODS, COATINGS, AND ARTICLES 有权
标题翻译：新型组合物和相关方法，涂料和文章
公开(公告)号：US20090105384A1
公开(公告)日：2009-04-23
申请号：US12253555
申请日：2008-10-17
申请人： Jeffrey R. Morgan , John D. Jarrell
发明人： Jeffrey R. Morgan , John D. Jarrell
IPC分类号： C09D5/00 , C08K3/22 , A61L27/28
CPC分类号： C01G1/02 , C01G5/00 , C01G9/02 , C01G23/047 , C01G23/053 , C01G25/02 , C01G31/02 , C01G35/00 , Y10T428/31504 , Y10T428/31598
摘要： Novel compositions, as well as related methods, coatings, and articles, are disclosed.
摘要翻译：公开了新型组合物，以及相关方法，涂料和制品。

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