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21. 发明授权

US09856457B2 Use of cellular extracts for obtaining pluripotent stem cells 有权
公开(公告)号：US09856457B2
公开(公告)日：2018-01-02
申请号：US14234192
申请日：2012-07-19
申请人： Marcel Mechali , Olivier Ganier
发明人： Marcel Mechali , Olivier Ganier
IPC分类号： C12N5/074 , C12N5/16
CPC分类号： C12N5/0696 , C12N5/16 , C12N2502/04
摘要： The use of a composition including at least one permeabilized nucleus of a first cell, or at least one permeabilized first cell including the nucleus and an extract of female germinal cells, or eggs, of a multicellular organism, the eggs being blocked in the metaphase II of meiosis, the extract including EGTA, for carrying out a method for obtaining pluripotent stem cells, or tissues derived from the pluripotent stem cells, or of cloning, provided that the process is not for cloning human beings.

22. 发明申请

US20130337431A1 COMPOSITIONS AND METHODS FOR IMPROVING THE QUALITY OF PROCESSED SPERM 有权
标题翻译：用于改善加工质量的组合物和方法
公开(公告)号：US20130337431A1
公开(公告)日：2013-12-19
申请号：US13844273
申请日：2013-03-15
申请人： INGURAN, LLC
发明人： Richard Lenz , Juan Moreno , Ramakrishnan Vishwanath
IPC分类号： C12N5/076
CPC分类号： C12N5/0609 , A01N1/0226 , A01N1/0284 , C12N5/061 , C12N5/0612 , C12N2500/30 , C12N2500/38 , C12N2502/04 , G01N15/1459 , G01N2015/149
摘要： Generally, compositions and methods for handling processed sperm populations including samples that are freshly collected, transported as fresh samples, as well as samples that are frozen and thawed, those sorted into one or more subpopulations, and those that are otherwise processed or handled that impose trauma on the sperm cell. Such trauma can reduce the motility, fertility, viability and overall integrity of the sperm and reduce the sperm's ability to fertilize an egg, grow into a healthy embryo and produce a healthy offspring. The novel compounds described can be added to the sperm cell sample to reduce the traumatic effects of physical stress during mild as well as extensive sperm cell processing, methods of using the compounds in standard sperm processing procedures, the end products made from these methods including sperm and embryos, as well as methods of using those end products in assisted reproductive biology techniques in animals.
摘要翻译：一般来说，用于处理加工的精子群体的组合物和方法，包括新鲜收集的样品，作为新鲜样品运输的样品以及被冷冻和解冻的样品，被分类到一个或多个亚种群中的那些，以及另外加工或处理的那些对精子细胞的创伤。这种创伤可以降低精子的运动力，生育能力，活力和整体完整性，并降低精子施用卵子的能力，生长成健康的胚胎并产生健康的后代。所描述的新化合物可以添加到精子细胞样品中以减轻轻度和广泛的精子细胞处理期间身体应激的创伤作用，在标准精子加工程序中使用化合物的方法，由这些方法制成的最终产物，包括精子和胚胎，以及在动物的辅助生殖生物学技术中使用这些终产物的方法。

23. 发明申请

US20130236428A1 Reprogramming of Aged Adult Stem Cells 审中-公开
标题翻译：老年成人干细胞重编程
公开(公告)号：US20130236428A1
公开(公告)日：2013-09-12
申请号：US13785691
申请日：2013-03-05
申请人： Vincent C. Giampapa
发明人： Vincent C. Giampapa
IPC分类号： C12N5/071
CPC分类号： C12N5/0696 , C12N2502/04 , C12N2506/11 , C12N2506/1369
摘要： Reprogramming of mammalian stem cells including aged human adult stem cells of all types with young adult stem cell's supernatant-intracellular matrix, bioactive lipids and or microvesicules in a single step or as a secondary two step process using oocyte supernatant, its intracellular matrix and/or cellular components are disclosed to accomplish a gene erasure and reprogramming. This invention focuses on reprogramming and/or reactivating genes that are active and involved in youthful adult stem cell function, within aged adult stem cells that have been previously collected by and/or stored for patients who are 40 years and older. The process is accomplished by using the natural unaltered young adult stem cell fluid and its cellular components.
摘要翻译：将哺乳动物干细胞（包括所有类型的老年人成体干细胞）重编程为具有年轻成体干细胞的上清 - 细胞内基质，生物活性脂质和/或微囊泡在单一步骤中或作为使用卵母细胞上清液，其细胞内基质和/或公开了细胞组分以实现基因删除和重编程。本发明的重点是重新编程和/或重新激活已经在年龄成年干细胞中活跃并参与年轻成体干细胞功能的基因，这些成年干细胞先前已被40岁及以上的患者收集和/或储存。该过程通过使用天然未改变的年轻成体干细胞流体及其细胞组分来实现。

24. 发明申请

US20130183656A1 COMPOSITIONS AND METHODS FOR IMPROVING THE QUALITY OF PROCESSED SPERM 有权
标题翻译：用于改善加工质量的组合物和方法
公开(公告)号：US20130183656A1
公开(公告)日：2013-07-18
申请号：US13823843
申请日：2012-06-01
申请人： Richard Lenz , Juan Moreno , Ramakrishnan Vishwanath
发明人： Richard Lenz , Juan Moreno , Ramakrishnan Vishwanath
IPC分类号： A01N1/02
CPC分类号： C12N5/0609 , A01N1/0226 , A01N1/0284 , C12N5/061 , C12N5/0612 , C12N2500/30 , C12N2500/38 , C12N2502/04 , G01N15/1459 , G01N2015/149
摘要： The present invention relates to compositions and methods for the handling of processed sperm including samples that are freshly collected, those transported as fresh samples, samples that are frozen and thawed, those sorted into one or more subpopulations, and those that are otherwise processed or handled that impose trauma on the cell. Trauma can reduce the motility, fertility, viability and overall integrity of the sperm and reduce the ability to fertilize, produce an embryo and a healthy offspring. The present invention relates to novel compounds that can be added to the sperm cell sample to reduce the traumatic effects of physical stress during mild as well as extensive sperm cell processing, methods of using the compounds in standard sperm processing procedures, the end products made from these methods including sperm and embryos, as well as methods of using those end products in assisted reproductive biology techniques in animals.
摘要翻译：本发明涉及用于处理加工精子的组合物和方法，包括新鲜收集的样品，作为新鲜样品运输的样品，被冷冻和解冻的样品，分为一个或多个亚种群的样品，以及另外处理或处理的样品对细胞造成创伤。创伤可以降低精子的活力，生育力，生存力和整体完整性，降低受精，产生胚胎和健康后代的能力。本发明涉及可以添加到精子细胞样品中以减轻轻度和广泛精子细胞处理期间物理应激的创伤作用的新型化合物，在标准精子加工程序中使用化合物的方法，由这些方法包括精子和胚胎，以及在动物的辅助生殖生物学技术中使用这些终产物的方法。

25. 发明授权

US08426200B2 Neuronal differentiation of stem cells 有权
标题翻译：干细胞的神经元分化
公开(公告)号：US08426200B2
公开(公告)日：2013-04-23
申请号：US10561826
申请日：2004-07-02
申请人： Catherine Verfaillie , Yuehua Jiang
发明人： Catherine Verfaillie , Yuehua Jiang
IPC分类号： C12N5/071 , C12N5/0793 , C12N5/0797 , C12N5/0735 , C12N5/0789 , C12N5/077 , C12N5/0775 , C12N5/074 , C12N5/00 , C12N5/079 , G01N33/567 , A01N1/00
CPC分类号： C12N5/0619 , C12N2500/25 , C12N2500/46 , C12N2501/115 , C12N2501/119 , C12N2501/13 , C12N2501/41 , C12N2502/02 , C12N2502/04 , C12N2502/08 , C12N2506/03
摘要： The present invention relates to compositions and methods for culturing stem cells, such that neuronal differentiation can be achieved.
摘要翻译：本发明涉及用于培养干细胞的组合物和方法，从而可以实现神经元分化。

26. 发明申请

US20080274963A1 Modulation of Granulosa Cell Apoptosis 有权
标题翻译：颗粒细胞凋亡的调节
公开(公告)号：US20080274963A1
公开(公告)日：2008-11-06
申请号：US11988949
申请日：2006-07-18
申请人： Robert B. Gilchrist , Jeremy Thompson , Tamer Hussein
发明人： Robert B. Gilchrist , Jeremy Thompson , Tamer Hussein
IPC分类号： A61K38/17 , C12N5/02 , A61P15/00 , C12Q1/02
CPC分类号： C12N5/0609 , A61K38/1841 , A61K38/1875 , C12N5/0604 , C12N2501/155 , C12N2501/19 , C12N2502/04
摘要： The present invention relates to a method of modulating apoptosis of a granulosa cell. The method includes one or more of the following steps: (i) modulating the concentration and/or activity of BMP-15 and/or BMP-6 that the granulosa cell is exposed to; (ii) modulating activity of a BMP-15 dependent signalling pathway in the granulosa cell; and (iii) modulating activity of a BMP-6 dependent signalling pathway in a granulosa cell.
摘要翻译：本发明涉及一种调节颗粒细胞凋亡的方法。该方法包括一个或多个以下步骤：（i）调节颗粒细胞暴露于BMP-15和/或BMP-6的浓度和/或活性; （ii）调节颗粒细胞中BMP-15依赖性信号通路的活性; 和（iii）调节颗粒细胞中BMP-6依赖性信号通路的活性。

27. 发明申请

US20080166804A1 Compostions and methods for growing human embryonic stem cells 审中-公开
标题翻译：用于培养人胚胎干细胞的组合物和方法
公开(公告)号：US20080166804A1
公开(公告)日：2008-07-10
申请号：US11826539
申请日：2007-07-16
申请人： Michael J. Shamblott , Michael Cohen
发明人： Michael J. Shamblott , Michael Cohen
IPC分类号： C12N5/06
CPC分类号： C12N5/0606 , C12N2502/04 , C12N2533/54
摘要： Methods for deriving and cultivating human embryonic stem (ES) cells and maintaining their pluripotency in culture is provided by utilizing secreted products obtained from the culture medium of human embryonic germ (EG) cell derivatives, such as embryoid body-derived cells. Substrates include compounds such as collagen I, fibronectin, or superfibronectin, or extracellular matrix, typically human derived.
摘要翻译：通过利用从人类胚胎（EG）细胞衍生物（例如胚状体衍生细胞）的培养基获得的分泌产物，提供用于诱导和培养人胚胎干（ES）细胞并保持其培养多能性的方法。底物包括诸如胶原I，纤连蛋白或超纤连蛋白的化合物，或通常人衍生的细胞外基质。

28. 发明申请

US20070059823A1 Neuronal differentiation of stem cells 有权
标题翻译：干细胞的神经元分化
公开(公告)号：US20070059823A1
公开(公告)日：2007-03-15
申请号：US10561826
申请日：2004-07-02
申请人： Catherine Verfaillie , Yuehua Jiang
发明人： Catherine Verfaillie , Yuehua Jiang
IPC分类号： C12N5/08
CPC分类号： C12N5/0619 , C12N2500/25 , C12N2500/46 , C12N2501/115 , C12N2501/119 , C12N2501/13 , C12N2501/41 , C12N2502/02 , C12N2502/04 , C12N2502/08 , C12N2506/03
摘要： The present invention relates to compositions and methods for culturing stem cells, such that neuronal differentiation can be achieved.
摘要翻译：本发明涉及用于培养干细胞的组合物和方法，从而可以实现神经元分化。

29. 发明授权

US07135336B1 Use of Xenopus laevis oocytes a microincubators 有权
标题翻译：使用非洲爪蟾卵母细胞微量培养基
公开(公告)号：US07135336B1
公开(公告)日：2006-11-14
申请号：US11109311
申请日：2005-04-19
申请人： Sergei Paylian
发明人： Sergei Paylian
IPC分类号： C12N5/00 , C12N5/06
CPC分类号： C12N5/16 , A01K67/0271 , A01K2227/50 , A01K2267/025 , C12N2502/04 , C12N2502/1358 , C12N2506/1353
摘要： The present invention concerns methods for de-differentiation and stabilize cells, such as progenitor cells, by introducing the cells into the cytoplasm of host oocytes, such as Xenopus laevis oocytes. Advantageously, this method obviates the need for any nuclear transfer procedure, which is known to disrupt the chromosomal architecture of donor and recipient cells. The present invention also concerns host oocytes encapsulating cells that have been introduced into their cytoplasm. The present invention also concerns cells that have been removed from the host oocytes.
摘要翻译：本发明涉及通过将细胞导入宿主卵母细胞如非洲爪蟾卵母细胞的细胞质来去分化和稳定细胞如祖细胞的方法。有利地，该方法不需要已知破坏供体和受体细胞的染色体结构的任何核转移过程。本发明还涉及封装已经被引入其细胞质中的细胞的宿主卵母细胞。本发明还涉及从宿主卵母细胞中除去的细胞。

30. 发明申请

US20060112438A1 Novel culture systems for ex vivo development 审中-公开
标题翻译：用于体外发育的新型文化系统
公开(公告)号：US20060112438A1
公开(公告)日：2006-05-25
申请号：US11028345
申请日：2005-01-03
申请人： Michael West , Karen Chapman , Irina Klimanskaya
发明人： Michael West , Karen Chapman , Irina Klimanskaya
IPC分类号： A01K67/027 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0606 , C12N15/873 , C12N2502/04
摘要： The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.
摘要翻译：本发明提供了用于培养动物多能干细胞及其分化的后代细胞，组织和器官以及非人动物胚胎和胎儿的方法。

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