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21. 发明申请

US20170051310A1 METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION 审中-公开
公开(公告)号：US20170051310A1
公开(公告)日：2017-02-23
申请号：US15138604
申请日：2016-04-26
申请人： Emmanuelle Charpentier , The Regents of the University of California , University of Vienna
发明人： Jennifer A. Doudna , Martin Jinek , Krzysztof Chylinski , James Harrison Doudna Cate , Wendell Lim , Lei Qi , Emmanuelle Charpentier
IPC分类号： C12N15/90
CPC分类号： C12N15/907 , A01H6/4684 , A01K67/027 , A61K38/465 , A61K48/00 , C12N9/22 , C12N15/102 , C12N15/111 , C12N15/113 , C12N15/63 , C12N15/70 , C12N15/746 , C12N15/90 , C12N15/902 , C12N2310/11 , C12N2310/13 , C12N2310/14 , C12N2310/20 , C12N2310/31 , C12N2310/32 , C12N2310/33 , C12N2310/3519 , C12N2310/531 , C12N2800/80 , C12Y301/04
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.

22. 发明授权

US09549956B2 Agent for inducing interferon production containing lactic acid bacteria 有权
标题翻译：用于诱导含有乳酸菌的干扰素生产的试剂
公开(公告)号：US09549956B2
公开(公告)日：2017-01-24
申请号：US14263306
申请日：2014-04-28
申请人： KIRIN HOLDINGS KABUSHIKI KAISHA
发明人： Daisuke Fujiwara , Kenta Jonai , Tetsu Sugimura
IPC分类号： A61K35/74 , A61K35/744 , A23C9/123 , A61K35/747 , C12N1/20 , A23C19/06 , A61K31/711 , C12N15/74 , C12Q1/68 , G01N33/68 , A23C19/032
CPC分类号： A61K35/744 , A23C9/123 , A23C9/1236 , A23C19/0323 , A23C19/062 , A23L33/135 , A23Y2240/41 , A61K9/0053 , A61K31/711 , A61K35/747 , C12N1/20 , C12N15/746 , C12Q1/6809 , C12R1/01 , G01N33/6866
摘要： This invention provides an IFN inducer comprising, as an active ingredient, lactic acid bacteria and capable of inducing IFN production, an immunopotentiating agent or prophylactic agent against virus infection comprising such inducer, and a food or drink product comprising such IFN inducer and having IFN-inducing activity, immunopotentiating activity, or prophylactic activity against virus infection. The agent for inducing IFN production comprises, as active ingredients, lactic acid bacteria that can activate plasmacytoid dendritic cells (pDCs) and promote IFN production, such as Lactococcus garvieae NBRC100934, Lactococcus lactis subsp. cremoris JCM16167, Lactococcus lactis subsp. cremoris NBRC100676, Lactococcus lactis subsp. hordniae JCM1180, Lactococcus lactis subsp. hordniae JCM11040, Lactococcus lactis subsp. lactis NBRC12007, Lactococcus lactis subsp. lactis NRIC1150, Lactococcus lactis subsp. lactis JCM5805, Lactococcus lactis subsp. lactis JCM20101, Leuconostoc lactis NBRC12455, Leuconostoc lactis NRIC1540, Pediococcus damnosus JCM5886, or Streptococcus thermophilus TA-45.
摘要翻译：本发明提供一种IFN诱导剂，其包含作为活性成分的乳酸菌并能够诱导IFN产生，包含该诱导剂的免疫增强剂或抗病毒感染的预防剂，以及包含该IFN诱导剂的食品或饮品，诱导活性，免疫增强活性或针对病毒感染的预防活性。用于诱导IFN产生的药物包括作为活性成分的可激活浆细胞样树突状细胞（pDC）并促进IFN产生的乳酸菌，例如乳球乳杆菌NBRC100934，乳酸乳球菌亚种。 cremoris JCM16167，乳酸乳球菌亚种 cremoris NBRC100676，乳酸乳球菌亚种大麦草JCM1180，乳酸乳球菌亚种大麦草JCM11040，乳酸乳球菌亚种乳酸菌NBRC12007，乳酸乳球菌亚种乳酸菌NRIC1150，乳酸乳球菌亚种乳酸菌JCM5805，乳酸乳球菌亚种乳酸菌JCM20101，乳酸列表克鲁维酵母NBRC12455，乳酸列表氨酸亮氨酸NRIC1540，侏儒球菌JCM5886或嗜热链球菌TA-45。

23. 发明授权

US09453232B2 Topical composition comprising transformed bacteria expressing a compound of interest 有权
标题翻译：包含表达目的化合物的转化细菌的局部组合物
公开(公告)号：US09453232B2
公开(公告)日：2016-09-27
申请号：US14863236
申请日：2015-09-23
申请人： TOPGENIX, INC.
发明人： Noga Qvit-Raz , Tahel Altman
IPC分类号： A61K8/18 , C12N15/74 , A61Q17/04 , A61Q17/00 , A61K8/99 , A61Q19/00 , A61Q19/08 , A61K35/744 , A61K8/27 , A61K8/40 , C12N1/20 , C12P21/04 , C12P21/06
CPC分类号： C12N15/746 , A61K8/27 , A61K8/40 , A61K8/99 , A61K35/744 , A61K2800/592 , A61Q17/00 , A61Q17/04 , A61Q19/007 , A61Q19/08
摘要： Compositions comprised of a population of transformed bacteria formulated for topical application to a subject are described. The population of transformed bacteria are created from a non-pathogenic bacteria and transformed to express a compound of interest for a therapeutic or a cosmetic purpose. In one embodiment, the composition is for protection of the skin from ultraviolet rays.
摘要翻译：描述了由配制用于局部施用于受试者的转化细菌群组成的组合物。转化细菌的群体是由非致病细菌产生并转化以表达用于治疗或美容目的的目标化合物。在一个实施方案中，组合物用于保护皮肤免受紫外线的影响。

24. 发明授权

US09228191B2 Transfection vector 有权
标题翻译：转染载体
公开(公告)号：US09228191B2
公开(公告)日：2016-01-05
申请号：US13015918
申请日：2011-01-28
申请人： Yuko Shimatani-Shibata , Hitomi Shimizu-Matsuhashi , Takayuki Sasaki
发明人： Yuko Shimatani-Shibata , Hitomi Shimizu-Matsuhashi , Takayuki Sasaki
IPC分类号： C07K2/00 , C07H21/04 , C12N15/74
CPC分类号： C12N15/746
摘要： The present invention relates to a novel secretory signal, a novel plasmid containing the secretory signal, a transformed anaerobic bacterium transformed with said plasmid, a gene transfer carrier consisting of said anaerobic bacterium, and a pharmaceutical composition containing said carrier.
摘要翻译：本发明涉及新型分泌信号，含有分泌信号的新型质粒，用所述质粒转化的转化的厌氧细菌，由所述厌氧细菌组成的基因转移载体和含有所述载体的药物组合物。

25. 发明授权

US09228190B2 Vector for constitutive high-level expression containing REPe mutant gene 有权
标题翻译：含有REPe突变基因的组成型高水平表达载体
公开(公告)号：US09228190B2
公开(公告)日：2016-01-05
申请号：US13143918
申请日：2010-01-07
申请人： Moon-Hee Sung , Seung Pyo Hong , A Ri Jang
发明人： Moon-Hee Sung , Seung Pyo Hong , A Ri Jang
IPC分类号： C12N15/00 , C12P21/06 , C12N1/20 , C12N15/70 , C07K14/195 , C12N15/74
CPC分类号： C12N15/70 , C07K14/195 , C12N15/746
摘要： A vector for constitutively expressing a high level of a target protein, and more particularly a RepE mutant protein containing a deletion of 21 amino acids in the C-terminal region of a RepE protein and a vector for constitutively expressing a high level of a target protein, which comprises a gene encoding the mutant protein. The constitutive high-level expression vector can stably express a high level of a target protein. Also, the surface expression vector can express a target protein on the surface of recombinant microorganisms while constitutively expressing a high level of the target protein, and thus will be useful for construction of an antigen for vaccines.
摘要翻译：用于组成型表达高水平靶蛋白的载体，更具体地，在RepE蛋白的C-末端区域中含有21个氨基酸缺失的RepE突变蛋白和用于组成型表达高水平靶蛋白的载体，其包含编码突变蛋白的基因。组成型高水平表达载体可稳定表达高水平的靶蛋白。此外，表面表达载体可以在重组微生物的表面上表达靶蛋白，同时组成型表达高水平的靶蛋白，因此可用于构建疫苗抗原。

26. 发明申请

US20150265660A1 METHODS FOR MAKING AND USING ANTIMICROBIAL PEPTIDES 有权
标题翻译：制备和使用抗微生物肽的方法
公开(公告)号：US20150265660A1
公开(公告)日：2015-09-24
申请号：US14431044
申请日：2013-09-25
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA
发明人： Yiannis J. Kaznessis , Katherine G. Volzing , Juan Borrero Del Pino , Gary Dunny
IPC分类号： A61K35/744 , A61K38/10 , C07K14/00 , A61K38/16 , C12N15/74 , C07K7/08
CPC分类号： A61K35/744 , A01N63/00 , A61K38/10 , A61K38/16 , A61K2035/11 , C07K7/08 , C07K14/001 , C12N15/746
摘要： Provided herein are genetically modified microbes. In one embodiment, a genetically modified microbe includes an exogenous polynucleotide comprising a pheromone-responsive region. In one embodiment, the pheromone-responsive region is derived from a conjugative plasmid from a member of the genus Enterococcus spp. The pheromone-responsive region includes a pheromone-responsive promoter and an operably linked coding region encoding an antimicrobial peptide. In one embodiment, a genetically modified microbe includes an exogenous polynucleotide comprising a promoter and an operably linked coding sequence encoding an antimicrobial peptide, where expression of the coding region is controlled by a modulator polypeptide and is altered by a modulating agent, and where the coding region encodes an antimicrobial peptide. Also provided herein are methods of using the genetically modified microbes, including methods for inhibiting growth of an Enterococcus spp., a pathogenic E. coli, or a pathogenic Salmonella spp., for treating a subject, and for modifying a subject's gastrointestinal microflora.
摘要翻译：本文提供了转基因微生物。在一个实施方案中，遗传修饰的微生物包括包含信息素反应区的外源多核苷酸。在一个实施方案中，信息素反应性区域衍生自来自肠球菌属的成员的共轭质粒。信息素反应区包括信息素反应启动子和编码抗微生物肽的可操作连接的编码区。在一个实施方案中，遗传修饰的微生物包括外源多核苷酸，其包含启动子和编码抗微生物肽的可操作地连接的编码序列，其中编码区的表达由调节多肽控制并被调节剂改变，并且其中编码区域编码抗微生物肽。本文还提供了使用遗传修饰的微生物的方法，包括用于抑制肠球菌属，致病性大肠杆菌或致病性沙门氏菌的生长用于治疗受试者和修饰受试者的胃肠微生物群落的方法。

27. 发明申请

US20150247169A1 FERMENTIVE PRODUCTION OF FOUR CARBON ALCOHOLS 审中-公开
标题翻译：四碳醇的生产生产
公开(公告)号：US20150247169A1
公开(公告)日：2015-09-03
申请号：US14715992
申请日：2015-05-19
申请人： Butamax Advanced Biofuels LLC
发明人： Gail K. DONALDSON , Andrew C. Eliot , Dennis Flint , Lori Ann Maggio-Hall , Vasantha Nagarajan
IPC分类号： C12P7/16 , C12N9/88 , C12N9/10
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/0008 , C12N9/0016 , C12N9/1022 , C12N9/1096 , C12N9/88 , C12N15/52 , C12N15/70 , C12N15/74 , C12N15/746 , C12N15/75 , C12N15/81 , C12Y101/01001 , C12Y101/01002 , C12Y101/01086 , C12Y102/00 , C12Y102/01003 , C12Y102/04004 , C12Y202/01006 , C12Y401/01072 , C12Y402/01009 , Y02E50/10 , Y02E50/343 , Y02P20/52
摘要： Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.
摘要翻译：提供了发酵生产四种碳醇的方法。具体地，通过表达异丁醇生物合成途径的重组细菌的发酵生长来生产丁醇，优选异丁醇。

28. 发明申请

US20150119608A1 Fermentive Production of Four Carbon Alcohols 审中-公开
标题翻译：四种酒精的发酵生产
公开(公告)号：US20150119608A1
公开(公告)日：2015-04-30
申请号：US14585261
申请日：2014-12-30
申请人： BUTAMAX ADVANCED BIOFUELS LLC
发明人： Gail K. Donaldson , Andrew C. Eliot , Dennis Flint , Lori Ann Maggio-Hall , Vasantha Nagarajan
IPC分类号： C12P7/16 , C12N15/70 , C12N15/81 , C12N15/74 , C12N15/75
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/0008 , C12N9/0016 , C12N9/1022 , C12N9/1096 , C12N9/88 , C12N15/52 , C12N15/70 , C12N15/74 , C12N15/746 , C12N15/75 , C12N15/81 , C12Y101/01001 , C12Y101/01002 , C12Y101/01086 , C12Y102/00 , C12Y102/01003 , C12Y102/04004 , C12Y202/01006 , C12Y401/01072 , C12Y402/01009 , Y02E50/10 , Y02E50/343 , Y02P20/52
摘要： Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.
摘要翻译：提供了发酵生产四种碳醇的方法。具体地，通过表达异丁醇生物合成途径的重组细菌的发酵生长来生产丁醇，优选异丁醇。

29. 发明申请

US20150093473A1 CULTURES WITH IMPROVED PHAGE RESISTANCE 有权
标题翻译：具有改善抗药性的文化
公开(公告)号：US20150093473A1
公开(公告)日：2015-04-02
申请号：US14570994
申请日：2014-12-15
申请人： Rodolphe Barrangou , Christophe Fremaux , Phillippe Horvath , Dennis Romero , Patrick Boyaval
发明人： Rodolphe Barrangou , Christophe Fremaux , Phillippe Horvath , Dennis Romero , Patrick Boyaval
IPC分类号： C12N15/74 , A23C9/123
CPC分类号： C12N15/746 , A23C9/123 , A23C9/1238 , A23C2220/202 , A23Y2240/75 , C12N1/20 , C12N2795/00011 , C12Q1/70 , C12Q2525/151
摘要： The present invention provides methods and compositions related to modulating the resistance of a cell against a target nucleic acid or a transcription product thereof. In some preferred embodiments, the present invention provides compositions and methods for the use of one or more cas genes or proteins for modulating the resistance of a cell against a target nucleic acid or a transcription product thereof. In some embodiments, the present invention provides methods and compositions that find use in the development and use of strain combinations and starter culture rotations. In additional embodiments, the present invention provides methods for labelling and/or identifying bacteria. In some preferred embodiments, the present invention provides methods for the use of CRISPR loci to determine the potential virulence of a phage against a cell and the use of CRISPR-cas to modulate the genetic sequence of a phage for increased virulence level. In still further embodiments, the present invention provides means and compositions for the development and use of phages as biocontrol agents.
摘要翻译：本发明提供了与调节细胞对靶核酸或其转录产物的抗性相关的方法和组合物。在一些优选实施方案中，本发明提供了使用一种或多种cas基因或蛋白质调节细胞对靶核酸或其转录产物的抗性的组合物和方法。在一些实施方案中，本发明提供了用于开发和使用菌株组合和起始培养旋转的方法和组合物。在另外的实施方案中，本发明提供用于标记和/或鉴定细菌的方法。在一些优选的实施方案中，本发明提供了使用CRISPR基因座确定噬菌体对细胞的潜在毒力的方法，以及使用CRISPR-cas调节噬菌体的遗传序列以增加毒力水平。在另外的实施方案中，本发明提供用于开发和使用噬菌体作为生物防治剂的方法和组合物。

30. 发明申请

US20150079236A1 LACTOBACILLUS RHAMNOSUS FOOD GRADE BACTERIA 有权
标题翻译： LACTOBACILLUS RHAMNOSUS食品级细菌菌株
公开(公告)号：US20150079236A1
公开(公告)日：2015-03-19
申请号：US14390018
申请日：2013-04-05
申请人： Compagnie Gervais Danone
发明人： Jeremy Burton , Marc Monaches , Gregor Reid , Tamara Smokvina , Johan Van Hylckama Vlieg
IPC分类号： A23C9/123 , C12N15/74 , C12N1/20 , C12R1/225
CPC分类号： C12N1/20 , A23C9/1234 , A23K10/18 , A23K20/00 , A23K20/10 , A23Y2220/73 , A61K35/74 , A61K35/747 , A61K38/00 , A62D3/02 , C12N15/102 , C12N15/70 , C12N15/746 , C12N15/86 , C12R1/225
摘要： The present invention relates to food-grade bacteria strain being capable of removing mercury from an aqueous environment.
摘要翻译：本发明涉及能够从水性环境中除去汞的食品级菌株。

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