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21. 发明授权

US06455519B1 Use of substituted N, N-disubstituted fused-heterocyclo amino compounds for inhibiting cholesteryl ester transfer protein activity 失效
标题翻译：使用取代的N，N-二取代的稠合 - 杂环氨基化合物来抑制胆固醇酯转移蛋白活性
公开(公告)号：US06455519B1
公开(公告)日：2002-09-24
申请号：US09991116
申请日：2001-11-15
申请人： James A. Sikorski , Richard C. Durley , Deborah A. Mischke , Emily J. Reinhard , Yvette M. Fobian , Michael B. Tollefson , Lijuan Wang , Margaret L. Grapperhaus , Brian S. Hickory , Mark A. Massa , Monica B. Norton , William F. Vernier , Barry L. Parnas , Michele A. Promo , Ashton T. Hamme , Dale P. Spangler , Melvin L. Rueppel
发明人： James A. Sikorski , Richard C. Durley , Deborah A. Mischke , Emily J. Reinhard , Yvette M. Fobian , Michael B. Tollefson , Lijuan Wang , Margaret L. Grapperhaus , Brian S. Hickory , Mark A. Massa , Monica B. Norton , William F. Vernier , Barry L. Parnas , Michele A. Promo , Ashton T. Hamme , Dale P. Spangler , Melvin L. Rueppel
IPC分类号： A61K31536
CPC分类号： C07C323/25 , B01D2201/345 , C07B2200/07 , C07C215/08 , C07C215/16 , C07C217/58 , C07C217/84 , C07C217/88 , C07C217/90 , C07C217/92 , C07C219/06 , C07C219/28 , C07C219/34 , C07C225/22 , C07C229/38 , C07C229/52 , C07C229/60 , C07C233/25 , C07C233/43 , C07C233/69 , C07C233/80 , C07C235/20 , C07C235/24 , C07C235/56 , C07C237/30 , C07C237/38 , C07C255/13 , C07C255/21 , C07C255/24 , C07C255/54 , C07C255/58 , C07C271/28 , C07C275/34 , C07C275/40 , C07C311/21 , C07C311/58 , C07C317/32 , C07C317/36 , C07C323/19 , C07C323/20 , C07C323/31 , C07C323/32 , C07C323/37 , C07C323/44 , C07C323/65 , C07C327/30 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2603/18 , C07D207/335 , C07D209/82 , C07D213/38 , C07D213/62 , C07D225/08 , C07D239/26 , C07D239/34 , C07D251/46 , C07D257/04 , C07D263/04 , C07D265/14 , C07D295/088 , C07D295/108 , C07D295/135 , C07D295/192 , C07D307/04 , C07D307/38 , C07D333/20 , C07D333/28 , C07D491/10
摘要： The invention relates to use of substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Preferred tertiary-heteroalkylamine compounds are substituted N,N- disubstituted fused-heterocyclo amines. A preferred specific N,N-disubstituted fused-heterocyclo amine is the compound:
摘要翻译：本发明涉及可用作胆固醇酯转移蛋白（CETP;血浆脂质转移蛋白-1）的抑制剂的取代多环芳基和杂芳基叔杂烷基胺化合物的用途以及用于治疗动脉粥样硬化和其它冠状动脉疾病的化合物，组合物和方法。优选的叔杂烷基胺化合物是取代的N，N-二取代稠合 - 杂环胺。优选的具体的N，N-二取代稠合 - 杂环胺是化合物：

22. 发明授权

US5278341A N-acylaminoalkyl 2-hydroxyethyl sulfides and a process for their preparation 失效
标题翻译： N-酰基氨基烷基2-羟乙基硫化物及其制备方法
公开(公告)号：US5278341A
公开(公告)日：1994-01-11
申请号：US923956
申请日：1992-09-04
申请人： Michael Meier , Heinrich Angenendt , Peter Mischke
发明人： Michael Meier , Heinrich Angenendt , Peter Mischke
IPC分类号： C07C319/18 , C07C323/31 , C07C323/41 , C07C235/08
CPC分类号： C07C323/31 , C07C323/41
摘要： The invention relates to N-acyl-aminoalkyl-2-hydroxyethylsulfides of formula R--CONH--(CH.sub.2).sub.n --S--CH.sub.2 --CH.sub.2 --OH, where R is a hydrogen atom or a (C.sub.1 -C.sub.4) alkyl group and n is an integer between 3 and 6, and to a method for preparing them. The method consists in reacting compounds of formula R--CONH--(CH.sub.2).sub.m --CH.dbd.CH.sub.2, where R has the above-mentioned meaning and m is an integer between 1 and 4, with the equivalent quantity of mercaptoethanol at approximately 15.degree. to approximately 150.degree. C. in the presence of a radical starter and in the presence or in the absence of a solvent which is inert to the reactants and to radical reactions.
摘要翻译： PCT No.PCT / EP91 / 00360 Sec。 371日期：1992年9月4日 102（e）日期1992年9月4日PCT 1991年2月27日提交PCT公布。公开号WO91 / 13867 1991年9月19日，本发明涉及式R-CONH-（CH2）nS-CH2-CH2-OH的N-酰基 - 氨基烷基-2-羟乙基硫醚，其中R是氢原子或（C1-C4）烷基，n为3〜6的整数，以及其制备方法。该方法包括使式R-CONH-（CH 2）m -CH = CH 2的化合物反应，其中R具有上述含义，m为1至4之间的整数，巯基乙醇的当量为约15度至约150℃，在自由基引发剂的存在下，并且在存在或不存在对反应物是惰性的溶剂和自由基反应的情况下。

23. 发明授权

US5107026A Fluorinated acetylene-containing aromatic amines and diamines 失效
标题翻译：含氟乙炔的芳香胺和二胺
公开(公告)号：US5107026A
公开(公告)日：1992-04-21
申请号：US631132
申请日：1990-12-20
申请人： Steven P. Fenelli
发明人： Steven P. Fenelli
IPC分类号： C07C211/43 , C07C211/52 , C07C211/53 , C07C217/80 , C07C217/84 , C07C323/31 , C07C323/35 , C07C323/36 , C08G73/10
CPC分类号： C07C211/52 , C07C211/53 , C07C217/80 , C07C323/31
摘要： A class of fluorinated phenylethynylaniline compounds is disclosed, said compounds having a use as capping reagents in high temperature stable polyimides or other polymers having a functionality which can undergo reaction with the amine to form a stable adduct. The diamine compounds of the invention are useful as step-growth monomers in the preparation of polymers containing reactive acetylene groups in the polymer backbone.

25. 发明申请

US20170145121A1 NOVEL POLYMERIZATION INITIATOR AND RADICALLY POLYMERIZABLE COMPOSITION CONTAINING SAME 有权
公开(公告)号：US20170145121A1
公开(公告)日：2017-05-25
申请号：US15318780
申请日：2015-07-24
申请人： ADEKA CORPORATION
发明人： Yukiko KANEHARA , Tomoya TAMACHI , Tomoyuki ARIYOSHI
IPC分类号： C08F2/50 , C07F7/18 , C07D295/116 , C07C323/31 , C07D295/10 , C07C323/32
CPC分类号： C08F2/50 , C07C323/31 , C07C323/32 , C07D295/10 , C07D295/116 , C07F7/1804 , C08F2/38 , C08F20/00
摘要： Provided is an α-aminoalkylphenone compound that has good stability and low sublimability, efficiently generates radicals when irradiated with a bright line at 365 nm (I line) or the like, and is useful as a polymerization initiator to be used in a radically polymerizable composition. The α-aminoalkylphenone compound is represented by Formula (I) mentioned below. In Formula (I) mentioned above, it is preferable that R11 is a nitro group, an alkoxy group having 1 to 12 carbon atoms, or an alkoxycarbonyl group having 1 to 12 carbon atoms. The α-aminoalkylphenone compound can be preferably used in a polymerization initiator.

26. 发明授权

US09585850B2 Methods of treatment using arylcyclopropylamine compounds 有权
标题翻译：使用芳基环丙胺化合物的处理方法
公开(公告)号：US09585850B2
公开(公告)日：2017-03-07
申请号：US14513488
申请日：2014-10-14
申请人： Duke University
发明人： Dewey G. McCafferty , Julie A. Pollock , David M. Gooden , Marc G. Caron , Raul R. Gainetdinov , Tatyana D. Sotnikova
IPC分类号： A61K31/135 , C07D317/58 , C07C217/74 , C07C211/40 , C07C323/31 , C07C211/42 , A61K31/343 , A61K31/198
CPC分类号： A61K31/135 , A61K31/198 , A61K31/343 , C07C211/40 , C07C211/42 , C07C217/74 , C07C323/31 , C07D317/58 , A61K2300/00
摘要： The present invention is directed to a method of treating Parkinson's disease using arylcyclopropylamine compounds. The arylcyclopropylamine compounds have the following formula wherein R1, R2, R3, R4, R5 and R6 are described herein.
摘要翻译：本文描述的是使用芳基环丙胺化合物治疗帕金森病的方法。

27. 发明授权

US09238660B1 Synthesis of 4-(pentafluorosulfanyl)benzenediazonium tetrafluoroborate and analogs and their application for the preparation of SF5-aromatics 有权
标题翻译： 4-（五氟硫烷基）苯并氮鎓四氟硼酸盐及其类似物的合成及其在制备SF5-芳烃中的应用
公开(公告)号：US09238660B1
公开(公告)日：2016-01-19
申请号：US14465257
申请日：2014-08-21
申请人： Kenneth K. Laali
发明人： Kenneth K. Laali
IPC分类号： C07C323/31 , C07F5/02 , C07C67/00 , C07C57/60 , C07C381/00 , C07D249/06 , C07C245/08
CPC分类号： C07F5/022 , B01J31/0204 , B01J31/0275 , B01J31/1805 , B01J2231/4283 , C07C67/00 , C07C323/31 , C07C381/00 , C07D249/06
摘要： 4-(pentafluorosulfanyl)benzenediazonium tetrafluoroborate salt was synthesized and isolated. The pentafluorosulfanyl salt was examined in a wide assortment of reactions to form novel SF5-bearing alkenes, alkynes, and biaryl derivatives using Heck-Matsuda, Sonogashira, and Suzuki coupling protocols. Dediazoniation of the salt furnished the corresponding p-SF5—C6H4X,C6H4OS(O)(CF3)═NSO2CF3, and p-SF5—C6H4-NTf2 derivatives. The azide derivative p-SF5—C6H4N3 entered into click chemistry with phenylacetylenes to furnish the corresponding triazoles. Various SF5-bearing alkenes were synthesized by coupling reactions using a metal catalyst. Fluorodediazoniation selectively furnished the fluoro derivative p-SF5—C6H4F. Homolytic dediazoniation gave the unsymmetrical biaryls, thus demonstrating the broad utility of pentafluorosulfanyl diazonium salts as building blocks of SF5-aromatics that are in high demand in many branches of chemistry including biomedicine and materials chemistry.
摘要翻译：合成并分离出4-（五氟硫烷基）苯二氮鎓四氟硼酸盐。使用Heck-Matsuda，Sonogashira和Suzuki偶联方案，在各种各样的反应中检查五氟硫烷基盐以形成新的含SF5的烯烃，炔烃和联芳基衍生物。盐的淡化提供相应的对应的SF-C6H4X，C6H4OS（O）（CF3）= NO2O2CF3和p-SF5-C6H4-NTf2衍生物。叠氮衍生物p-SF5-C6H4N3与苯乙炔进行点击化学反应，得到相应的三唑。通过使用金属催化剂的偶联反应合成了各种含SF5的烯烃。氟代氮化选择性提供氟衍生物p-SF5-C6H4F。均相脱氮化得到不对称的联芳基，从而证明五氟硫烷基重氮盐作为SF5芳族化合物的结构单元的广泛用途，其在包括生物医学和材料化学在内的许多化学分支中具有高需求。

28. 发明授权

US07253189B2 Cannabinoid receptor ligands 失效
标题翻译：大麻素受体配体
公开(公告)号：US07253189B2
公开(公告)日：2007-08-07
申请号：US10721015
申请日：2003-11-21
申请人： Ling Tong , Lei Chen , Bandarpalle B. Shankar , Joseph A. Kozlowski , Neng-Yang Shih
发明人： Ling Tong , Lei Chen , Bandarpalle B. Shankar , Joseph A. Kozlowski , Neng-Yang Shih
IPC分类号： C07D401/02 , A61K31/44
CPC分类号： C07D401/12 , C07C317/32 , C07C323/31 , C07C323/41 , C07C323/49 , C07C2601/02 , C07C2601/08 , C07C2602/08 , C07D213/71
摘要： A compound of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein: R1, R2, L1, L2, M1, M2, n, p, q, A, D, X, Y and Z are as described in the specification; pharmaceutical compositions thereof, methods of making said pharmaceutical compositions; and methods of use thereof.
摘要翻译：下式的化合物或其药学上可接受的盐或溶剂化物，其中：R 1，R 2，L 1，L 2， 2，M 1，M 2，n，p，q，A，D，X，Y和Z如说明书中所述; 药物组合物，制备所述药物组合物的方法; 及其使用方法。

29. 发明授权

US06723753B2 Substituted n-benzyl-n-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity 失效
标题翻译：用于抑制胆固醇酯转移蛋白活性的取代的正苄基 - 正 - 苯基氨基醇化合物
公开(公告)号：US06723753B2
公开(公告)日：2004-04-20
申请号：US10071518
申请日：2002-02-07
申请人： James A. Sikorski , Richard C. Durley , Deborah A. Mischke , Emily J. Reinhard , Yvette M. Fobian , Michael B. Tollefson , Lijuan Wang , Margaret L. Grapperhaus , Brian S. Hickory , Mark A. Massa , Monica B. Norton , William F. Vernier , Barry L. Parnas , Michele A. Promo , Ashton T. Hamme , Dale P. Spangler , Melvin L. Rueppel
发明人： James A. Sikorski , Richard C. Durley , Deborah A. Mischke , Emily J. Reinhard , Yvette M. Fobian , Michael B. Tollefson , Lijuan Wang , Margaret L. Grapperhaus , Brian S. Hickory , Mark A. Massa , Monica B. Norton , William F. Vernier , Barry L. Parnas , Michele A. Promo , Ashton T. Hamme , Dale P. Spangler , Melvin L. Rueppel
IPC分类号： A61K3137
CPC分类号： C07C323/25 , B01D2201/345 , C07B2200/07 , C07C215/08 , C07C215/16 , C07C217/58 , C07C217/84 , C07C217/88 , C07C217/90 , C07C217/92 , C07C219/06 , C07C219/28 , C07C219/34 , C07C225/22 , C07C229/38 , C07C229/52 , C07C229/60 , C07C233/25 , C07C233/43 , C07C233/69 , C07C233/80 , C07C235/20 , C07C235/24 , C07C235/56 , C07C237/30 , C07C237/38 , C07C255/13 , C07C255/21 , C07C255/24 , C07C255/54 , C07C255/58 , C07C271/28 , C07C275/34 , C07C275/40 , C07C311/21 , C07C311/58 , C07C317/32 , C07C317/36 , C07C323/19 , C07C323/20 , C07C323/31 , C07C323/32 , C07C323/37 , C07C323/44 , C07C323/65 , C07C327/30 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2603/18 , C07D207/335 , C07D209/82 , C07D213/38 , C07D213/62 , C07D225/08 , C07D239/26 , C07D239/34 , C07D251/46 , C07D257/04 , C07D263/04 , C07D265/14 , C07D295/088 , C07D295/108 , C07D295/135 , C07D295/192 , C07D307/04 , C07D307/38 , C07D333/20 , C07D333/28 , C07D491/10
摘要： The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Preferred tertiary-heteroalkylamine compounds are substituted N-benzyl-N-phenyl aminoalcohols. A preferred specific N-benzyl-N-phenyl aminoalcohol is the compound:
摘要翻译：本发明涉及可用作胆固醇酯转移蛋白（CETP;血浆脂质转移蛋白-I）抑制剂的取代多环芳基和杂芳基叔杂烷基胺化合物以及用于治疗动脉粥样硬化和其它冠状动脉疾病的化合物，组合物和方法。优选的叔杂烷基胺化合物是取代的N-苄基-N-苯基氨基醇。优选的特定N-苄基-N-苯基氨基醇是化合物：

30. 发明授权

US06696435B2 Substituted N,N-disubstituted fused-heterocyclo amino compounds useful for inhibiting cholesteryl ester transfer protein activity 失效
标题翻译：用于抑制胆固醇酯转移蛋白活性的取代的N，N-二取代的稠合 - 杂环氨基化合物
公开(公告)号：US06696435B2
公开(公告)日：2004-02-24
申请号：US10154861
申请日：2002-05-23
申请人： James A. Sikorski , Richard C. Durley , Deborah A. Mischke , Emily J. Reinhard , Yvette M. Fobian , Michael B. Tollefson , Lijuan Wang , Margaret L. Grapperhaus , Brian S. Hickory , Mark A. Massa , Monica B. Norton , William F. Vernier , Barry L. Parnas , Michele A. Promo , Ashton T. Hamme , Dale P. Spangler , Melvin L. Rueppel
发明人： James A. Sikorski , Richard C. Durley , Deborah A. Mischke , Emily J. Reinhard , Yvette M. Fobian , Michael B. Tollefson , Lijuan Wang , Margaret L. Grapperhaus , Brian S. Hickory , Mark A. Massa , Monica B. Norton , William F. Vernier , Barry L. Parnas , Michele A. Promo , Ashton T. Hamme , Dale P. Spangler , Melvin L. Rueppel
IPC分类号： A61K31536
CPC分类号： C07C323/25 , B01D2201/345 , C07B2200/07 , C07C215/08 , C07C215/16 , C07C217/58 , C07C217/84 , C07C217/88 , C07C217/90 , C07C217/92 , C07C219/06 , C07C219/28 , C07C219/34 , C07C225/22 , C07C229/38 , C07C229/52 , C07C229/60 , C07C233/25 , C07C233/43 , C07C233/69 , C07C233/80 , C07C235/20 , C07C235/24 , C07C235/56 , C07C237/30 , C07C237/38 , C07C255/13 , C07C255/21 , C07C255/24 , C07C255/54 , C07C255/58 , C07C271/28 , C07C275/34 , C07C275/40 , C07C311/21 , C07C311/58 , C07C317/32 , C07C317/36 , C07C323/19 , C07C323/20 , C07C323/31 , C07C323/32 , C07C323/37 , C07C323/44 , C07C323/65 , C07C327/30 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2603/18 , C07D207/335 , C07D209/82 , C07D213/38 , C07D213/62 , C07D225/08 , C07D239/26 , C07D239/34 , C07D251/46 , C07D257/04 , C07D263/04 , C07D265/14 , C07D295/088 , C07D295/108 , C07D295/135 , C07D295/192 , C07D307/04 , C07D307/38 , C07D333/20 , C07D333/28 , C07D491/10
摘要： The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Preferred tertiary-heteroalkylamine compounds are substituted N,N-disubstituted fused-heterocyclo amines. A preferred specific N,N-disubstituted fused-heterocyclo amine is the compound:
摘要翻译：本发明涉及可用作胆固醇酯转移蛋白（CETP;血浆脂质转移蛋白-I）抑制剂的取代多环芳基和杂芳基叔杂烷基胺化合物以及用于治疗动脉粥样硬化和其它冠状动脉疾病的化合物，组合物和方法。优选的叔杂烷基胺化合物是取代的N，N-二取代的稠合 - 杂环胺。优选的具体的N，N-二取代稠合 - 杂环胺是化合物：

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