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21. 发明申请

US20090180989A1 Compositions and methods for delivering nucleotide sequences to vertebrates 审中-公开
标题翻译：将核苷酸序列递送给脊椎动物的组合物和方法
公开(公告)号：US20090180989A1
公开(公告)日：2009-07-16
申请号：US12380475
申请日：2009-02-27
申请人： Alex J. Harvey
发明人： Alex J. Harvey
IPC分类号： A61K48/00 , C12N15/867 , C12P21/00 , A61K35/76
CPC分类号： C07K14/505 , A01K67/0275 , A01K2217/05 , A01K2227/30 , A01K2267/01 , C07K14/56 , C12N15/8509 , C12N15/86 , C12N2740/11043
摘要： The invention includes methods of producing viral particles which include introducing into avian cells a nucleotide sequence encoding a replication deficient retroviral vector and introducing into the avian cells nucleotide sequence encoding products required for replication of the replication deficient retroviral vector, harvesting the viral particles and can include administering the viral particles to vertebrate cells.
摘要翻译：本发明包括产生病毒颗粒的方法，其包括向禽类细胞中引入编码复制缺陷型逆转录病毒载体的核苷酸序列，并将编码复制缺陷型逆转录病毒载体复制所需产物的核苷酸序列引入禽类细胞，收获病毒颗粒，并且可以包括将病毒颗粒施用于脊椎动物细胞。

22. 发明申请

US20090105462A1 Glycosylated erythropoietin 审中-公开
标题翻译：糖基化促红细胞生成素
公开(公告)号：US20090105462A1
公开(公告)日：2009-04-23
申请号：US12218079
申请日：2008-07-11
申请人： Robert D. Ivarie , Alex J. Harvey , Julie A. Morris , Guodong Liu , Jeffrey C. Rapp
发明人： Robert D. Ivarie , Alex J. Harvey , Julie A. Morris , Guodong Liu , Jeffrey C. Rapp
IPC分类号： C07K14/505
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/30 , A01K2267/01 , A61K38/00 , C07K14/505 , C07K14/535 , C07K14/70521 , C07K2319/30 , C12N15/8509 , C12N2799/027 , C12N2830/008 , C12N2830/15
摘要： The invention relates to erythropoietin having certain O-linked and/or N-linked oligosaccharide structures.
摘要翻译：本发明涉及具有某些O-连接和/或N-连接的寡糖结构的促红细胞生成素。

23. 发明授权

US07507873B2 Transgenic avians containing recombinant ovomucoid promoters 有权
标题翻译：含有重组卵巢粘蛋白启动子的转基因鸟类
公开(公告)号：US07507873B2
公开(公告)日：2009-03-24
申请号：US11649543
申请日：2007-01-04
申请人： Alex J. Harvey , Markley C. Leavitt , Youliang Wang
发明人： Alex J. Harvey , Markley C. Leavitt , Youliang Wang
IPC分类号： A01K67/027 , A01K67/00 , A01K67/033
CPC分类号： C07K16/02 , A01K67/0275 , A01K2217/05 , A01K2227/30 , A01K2267/01 , C07K16/2809 , C07K16/44 , C07K2317/21 , C07K2317/732 , C07K2317/734 , C07K2319/30 , C12N15/8509 , C12N2800/204 , C12N2800/30 , C12N2830/008
摘要： Transgenic avians having a recombinant ovomucoid gene expression controlling region operably linked to one or more useful amino acid coding sequences.
摘要翻译：具有与一个或多个有用的氨基酸编码序列可操作地连接的重组卵巢粘蛋白基因表达控制区的转基因鸟类。

24. 发明申请

US20090042299A1 Vectors and methods for tissue specific synthesis of proteins in eggs of transgenic hens 审中-公开
标题翻译：转基因鸡蛋中蛋白质组织特异性合成的载体和方法
公开(公告)号：US20090042299A1
公开(公告)日：2009-02-12
申请号：US12008399
申请日：2008-01-09
申请人： William C. MacArthur
发明人： William C. MacArthur
IPC分类号： C12N15/63 , C12N15/79
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2217/20 , A01K2227/30 , A01K2267/01 , C12N15/86 , C12N2740/10043
摘要： Vectors and methods are provided for introducing genetic material into cells of a chicken or other avian species. More particularly, vectors and methods are provided for transferring a transgene to an embryonic chicken cell, so as to create a transgenic hen wherein the transgene is expressed in the hen's oviduct and the transgene product is secreted in the hen's eggs and/or those of her offspring. In a preferred embodiment, the transgene product is secreted in the egg white.
摘要翻译：提供载体和方法用于将遗传物质引入鸡或其他禽类物种的细胞中。更具体地，提供载体和方法用于将转基因转移到胚胎鸡细胞，以便产生转基因母鸡，其中转基因在母鸡的输卵管中表达，转基因产物分泌在母鸡的卵和/或其中后代。在优选的实施方案中，转基因产物分泌在蛋清中。

25. 发明申请

US20080222743A1 RNA interference and disease resistance in avians 审中-公开
标题翻译：鸟类中的RNA干扰和抗病性
公开(公告)号：US20080222743A1
公开(公告)日：2008-09-11
申请号：US11799253
申请日：2007-05-01
申请人： Leandro Christmann , Jeffrey C. Rapp
发明人： Leandro Christmann , Jeffrey C. Rapp
IPC分类号： C12N15/87 , A01K67/027
CPC分类号： C12N15/1133 , A01K67/0275 , A01K2217/058 , A01K2227/30 , A01K2267/02 , A01K2267/0337 , C12N15/1131 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2799/027
摘要： The invention relates to transgenic avians whose genome contains nucleotide sequences which encode therapeutic polynucleotides that correspond to one or more certain sequences in the genome of an avian pathogen.
摘要翻译：本发明涉及转基因鸟类，其基因组包含编码对应于禽类病原体基因组中的一个或多个特定序列的治疗性多核苷酸的核苷酸序列。

26. 发明授权

US07399848B2 Polynucleotides encoding growth differentiation factor-8 有权
标题翻译：编码生长分化因子-8的多核苷酸
公开(公告)号：US07399848B2
公开(公告)日：2008-07-15
申请号：US10997809
申请日：2004-11-23
申请人： Se-Jin Lee , Alexandra C. McPherron
发明人： Se-Jin Lee , Alexandra C. McPherron
IPC分类号： C12N1/13 , C12N1/15 , C12N1/21 , C12N15/12 , C12N15/63
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2207/15 , A01K2217/00 , A01K2217/075 , A01K2227/10 , A01K2227/105 , A01K2227/30 , A01K2267/02 , A01K2267/03 , A01K2267/0331 , A01K2267/035 , A01K2267/0362 , A61K38/00 , C07K14/475 , C07K14/495 , C07K2319/00
摘要： Disclosed are polynucleotides encoding growth differentiation factor-8 (GDF-8) useful for increasing the muscle mass in chickens.
摘要翻译：公开了编码可用于增加鸡的肌肉质量的生长分化因子-8（GDF-8）的多核苷酸。

27. 发明授权

US07378086B2 Retroviral vector having an ovalbumin promoter 有权
标题翻译：具有卵清蛋白启动子的逆转录病毒载体
公开(公告)号：US07378086B2
公开(公告)日：2008-05-27
申请号：US10935905
申请日：2004-09-08
申请人： William C. MacArthur
发明人： William C. MacArthur
IPC分类号： C12N15/00 , A01N65/00 , A01N63/00
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2217/20 , A01K2227/30 , A01K2267/01 , C12N15/86 , C12N2740/10043
摘要： Vectors and methods are provided for introducing genetic material into cells of a chicken or other avian species. More particularly, vectors and methods are provided for transferring a transgene to an embryonic chicken cell, so as to create a transgenic hen wherein the transgene is expressed in the hen's oviduct and the transgene product is secreted in the hen's eggs and/or those of her offspring. In a preferred embodiment, the transgene product is secreted in the egg white.
摘要翻译：提供载体和方法用于将遗传物质引入鸡或其他禽类物种的细胞中。更具体地，提供载体和方法用于将转基因转移到胚胎鸡细胞，以便产生转基因母鸡，其中转基因在母鸡的输卵管中表达，转基因产物分泌在母鸡的卵和/或其中后代。在优选的实施方案中，转基因产物分泌在蛋清中。

28. 发明申请

US20080069941A1 Animals for Conserving N-3 Highly Unsaturated Fatty Acids 审中-公开
标题翻译：用于保护N-3高度不饱和脂肪酸的动物
公开(公告)号：US20080069941A1
公开(公告)日：2008-03-20
申请号：US11662413
申请日：2005-09-13
申请人： Karl Geiringer
发明人： Karl Geiringer
IPC分类号： A23C9/00 , A01K67/00 , A23D7/00 , C12N15/63 , C12N5/00
CPC分类号： A01K67/00 , A01K67/02 , A01K67/027 , A01K2227/101 , A01K2227/30 , A01K2267/02
摘要： Food-providing animals for providing human food rich in at least one of the health-promoting n-3 HUFAs (omega-3 highly unsaturated fatty acids) are selected and then bred so that a greater proportion of dietary n-3 HUFAs and/or their metabolic precursors provided to the animals is conserved in the animals food tissue as n-3 HUFA and transferred into human food. Evidence of heritability, methods for phenotypic or genotypic identification and selection of animals genetically adapted for that function are provided. Animals include farmed mammals and birds, and marine or fresh water animals including fish, crustaceans and molluscs.
摘要翻译：选择用于提供富含至少一种健康促进的n-3HFFA（ω-3高度不饱和脂肪酸）的人类食物的供食动物，然后繁殖，使得更大比例的膳食n-3 HUFA和/或向动物提供的代谢前体在动物食物组织中被保存为n-3 HUFA并转移到人类食物中。提供遗传性遗传学证据，遗传上适应该功能的表型或基因型鉴定和动物选择方法。动物包括养殖的哺乳动物和鸟类，以及海洋或淡水动物，包括鱼类，甲壳类和软体动物。

29. 发明授权

US07323619B2 Method for producing transgenic birds and fish 有权
标题翻译：转基因鸟类和鱼类的生产方法
公开(公告)号：US07323619B2
公开(公告)日：2008-01-29
申请号：US10243820
申请日：2002-09-13
申请人： David Baltimore , Elizabeth J. Hong , Carlos Lois-Caballe , Shirley Pease
发明人： David Baltimore , Elizabeth J. Hong , Carlos Lois-Caballe , Shirley Pease
IPC分类号： C12N15/00 , C12N15/86 , C12N15/02 , A01K67/027 , C07H21/04
CPC分类号： C12N15/86 , A01K2217/05 , A01K2227/30 , A01K2227/40 , A61K38/00 , A61K48/00 , C12N15/1132 , C12N15/1138 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/30 , C12N2740/16043 , C12N2800/60 , C12N2830/003 , C12N2830/006 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12N2840/20 , C12N2840/203 , C12N2840/44 , Y02A50/463 , Y02A50/465
摘要： The present invention relates to methods for producing transgenic animals, particularly transgenic birds and fish, using retroviral constructs engineered to carry the transgene(s) of interest.
摘要翻译：本发明涉及用转基因动物，特别是转基因鸟类和鱼来生产转基因动物的方法，所述方法使用工程改造来携带感兴趣的转基因的逆转录病毒构建体。

30. 发明申请

US20070214511A1 Transgenic Bird And Method Of Constructing The Same 审中-公开
标题翻译：转基因鸟及其构建方法
公开(公告)号：US20070214511A1
公开(公告)日：2007-09-13
申请号：US10585693
申请日：2004-11-05
申请人： Takashi Yamashita , Takuya Shindo , Shinji Iijima , Masamichi Kamihira , Kenichi Nishijima
发明人： Takashi Yamashita , Takuya Shindo , Shinji Iijima , Masamichi Kamihira , Kenichi Nishijima
IPC分类号： A01K67/027 , C12N15/89 , C12N5/16 , C12P21/00 , C12Q1/68
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/30 , A01K2267/01
摘要： The present invention provides a G1 transgenic bird or an offspring thereof by: incubating a fertilized avian egg, microinjecting, into the early embryo thereof at a stage except for and after the blastodermic stage just after egg laying, a replication-deficient retroviral vector coding for a useful protein, allowing the egg to hatch out to thereby obtain a G0 transgenic chimeric bird, and mating the G0 transgenic chimeric bird with another G0 transgenic chimeric bird or an offspring thereof or with a wild-type bird. The present invention is a G1 transgenic bird or an offspring thereof by: incubating a fertilized avian egg, microinjecting, into the early embryo thereof at a stage except for and after the blastodermic stage just after egg laying, a replication-deficient retroviral vector coding for a useful protein, allowing the egg to hatch out to thereby obtain a G0 transgenic chimeric bird, and mating the G0 transgenic chimeric bird with another G0 transgenic chimeric bird or an offspring thereof or with a wild-type bird.
摘要翻译：本发明通过以下方式提供G1转基因鸟或其后代：在产卵后的胚根期以外的阶段将受精禽卵孵育至其早期胚胎，将其编码为复制缺陷型逆转录病毒载体一种有用的蛋白质，允许卵孵出，从而获得G0转基因嵌合鸟，并将G0转基因嵌合鸟与另一种G0转基因嵌合鸟或其后代或野生型鸟交配。本发明是一种G1转基因鸟或其后代，其特征在于：在产卵后的胚根期以外的阶段将受精禽卵孵化至其早期胚胎，将其编码为复制缺陷型逆转录病毒载体一种有用的蛋白质，允许卵孵出，从而获得G0转基因嵌合鸟，并将G0转基因嵌合鸟与另一种G0转基因嵌合鸟或其后代或野生型鸟交配。

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