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21. 发明授权

US08877458B2 Method of detecting bacterial contamination using dynamic light scattering 有权
标题翻译：使用动态光散射检测细菌污染的方法
公开(公告)号：US08877458B2
公开(公告)日：2014-11-04
申请号：US12525467
申请日：2008-02-01
申请人： Elisabeth Maurer
发明人： Elisabeth Maurer
IPC分类号： C12Q1/04 , G01N15/02 , G01N15/00
CPC分类号： C12Q1/04 , G01N15/0211 , G01N15/1429 , G01N15/1456 , G01N2015/0084 , G01N2015/0088 , G01N2015/0092 , G01N2015/0222 , G01N2015/03 , G01N2015/1402
摘要： Methods of detecting bacterial contamination in a platelet concentrate are performed using a dynamic light scattering (DLS) instrument and a sample holder. A sample of platelet concentrate can be held vertically or horizontally in a capillary in the sample holder. Alternatively, novel platelet storage bags modified to include an optically translucent window can be held within another variant of the sample holder. Still alternatively, platelet storage bags having one or more tubes detachably appended to the bag can be used. A sample is drawn off into an appended tube for placement directly into the sample holder. This method provides a number of related, non-invasive techniques for detecting whether bacteria has contaminated a platelet concentrate. Contamination indicators include a population of particles different from platelets, microparticles or proteins, bad-quality platelets, i.e. low DLS score, and very high or very low scattering intensity.
摘要翻译：使用动态光散射（DLS）仪器和样品架进行血小板浓缩物中细菌污染检测的方法。血小板浓缩物的样品可以垂直或水平地保持在样品架中的毛细管中。或者，修改为包括光学半透明窗口的新颖血小板储存袋可以保持在样品保持器的另一个变体中。或者，可以使用具有可拆卸地附接到袋的一个或多个管的血小板储存袋。将样品抽出到附加的管中以直接放置在样品架中。该方法提供了许多相关的非侵入性技术来检测细菌是否已经污染了血小板浓缩物。污染指标包括与血小板，微粒或蛋白质不同的颗粒群，不良质量的血小板，即低DLS评分，以及非常高或非常低的散射强度。

22. 发明授权

US08673566B2 Method for detection of Staphylococcus epidermidis 失效
标题翻译：检测表皮葡萄球菌的方法
公开(公告)号：US08673566B2
公开(公告)日：2014-03-18
申请号：US11584871
申请日：2006-10-23
申请人： Sandra M. Ramirez-Arcos , Cherie Cameron
发明人： Sandra M. Ramirez-Arcos , Cherie Cameron
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/689 , C12Q2600/16
摘要： A method for detecting the bacteria Staphylococcus epidermidis includes isolating DNA from a biological sample suspected of containing the bacteria. The method further includes subjecting the DNA to a Polymerase Chain Reaction (PCR) amplification method utilizing at least one primer derived from a cell division gene. The method may further include characterizing an indicator of a Staphylococcus epidermidis phenotype of interest. The method additionally includes detecting the bacterium Staphylococcus epidermidis by visualizing the product of the polymerase chain reaction. Amplification products of cell division genes and virulence genes are also provided.
摘要翻译：用于检测细菌表皮葡萄球菌的方法包括从怀疑含有细菌的生物样品中分离DNA。该方法还包括使用至少一种衍生自细胞分裂基因的引物的DNA进行聚合酶链式反应（PCR）扩增方法。该方法还可以包括表征感兴趣的表皮葡萄球菌表型的指标。该方法还包括通过使聚合酶链反应的产物可视化来检测表皮葡萄球菌。还提供了细胞分裂基因和毒力基因的扩增产物。

23. 发明申请

US20130122538A1 Dynamic Light Scattering for in vitro Testing of Bodily Fluids 有权
标题翻译：动态光散射用于体液检测体液
公开(公告)号：US20130122538A1
公开(公告)日：2013-05-16
申请号：US13692039
申请日：2012-12-03
申请人： Canadian Blood Services
发明人： Elisabeth Maurer , Cheryl Pittendreigh
IPC分类号： G01N21/49
CPC分类号： G01N21/49 , G01N15/0211 , G01N15/05 , G01N21/51 , G01N2015/0084
摘要： A method of diagnosing a pathological condition by detecting microparticles in a sample of bodily fluid using dynamic light scattering (DLS) is disclosed. The detection of microparticles in the bodily fluid by DLS may be used as an indicator of existing disease, to evaluate a risk of disease, as well, as to monitor the efficacy of a treatment for disease.
摘要翻译：公开了一种通过使用动态光散射（DLS）检测体液样品中的微粒来诊断病理状况的方法。通过DLS检测体液中的微粒可以用作现有疾病的指标，以评估疾病的风险，以及监测治疗疾病的功效。

24. 发明授权

US08323652B2 Antibodies against GPIbα 有权
标题翻译： GPIbα抗体
公开(公告)号：US08323652B2
公开(公告)日：2012-12-04
申请号：US12618224
申请日：2009-11-13
申请人： Heyu Ni , Guangheng Zhu
发明人： Heyu Ni , Guangheng Zhu
IPC分类号： A61K39/395
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/33 , C07K2317/76
摘要： This application relates to agents capable of specifically recognizing GPIbα, a key receptor required for platelet adhesion and aggregation. More specifically, this application relates to monoclonal antibodies and derivatives thereof capable of specifically recognizing both the murine and the human GPIbα. These monoclonal antibodies and derivatives are particularly useful in the treatment or prevention of thrombosis as well as research tools.
摘要翻译：本申请涉及能够特异性识别血小板粘附和聚集所需的关键受体GPIbα的药剂。更具体地，本申请涉及能够特异性识别鼠和人GPIbα的单克隆抗体及其衍生物。这些单克隆抗体和衍生物特别可用于治疗或预防血栓形成以及研究工具。

25. 发明授权

US07964339B2 Cold storage of modified platelets 有权
标题翻译：改良血小板的冷藏
公开(公告)号：US07964339B2
公开(公告)日：2011-06-21
申请号：US11673287
申请日：2007-02-09
申请人： Mark D. Scott , Elisabeth Maurer
发明人： Mark D. Scott , Elisabeth Maurer
IPC分类号： A01N1/02
CPC分类号： A01N1/02 , A01N1/0215 , A61K35/19 , A61K47/6901
摘要： A method for storing and using platelets and an associated platelet structure. At least one modified platelet is formed. Each modified platelet includes a platelet and at least one polymerated chemical. Each polymerated chemical includes a polymer covalently bonded directly to the platelet or includes the polymer and a linker molecule such that the linker molecule is covalently bonded to the platelet and the polymer is covalently attached to the linker molecule. The polymer of each polymerated chemical of each modified platelet is polyethylene glycol (PEG) or a PEG derivative. Forming each modified platelet does not include modifying the platelet membrane of each platelet with a glycan-modifying agent. The at least one modified platelet is stored in a temperature range below 20° C. for at least one hour. After being stored, the at least one modified platelet may be introduced into a mammal.
摘要翻译：一种用于储存和使用血小板和相关血小板结构的方法。至少形成一个改良的血小板。每个改性的血小板包括血小板和至少一种聚合化学品。每种聚合化学品包括直接共价键合到血小板上的聚合物，或包括聚合物和连接分子，使得连接体分子与血小板共价结合，并且聚合物共价连接到连接分子上。每个改性血小板的每种聚合化学品的聚合物是聚乙二醇（PEG）或PEG衍生物。形成每个修饰的血小板不包括用聚糖修饰剂修饰每个血小板的血小板膜。将至少一种修饰的血小板在低于20℃的温度范围内储存至少1小时。储存后，可将至少一种改良的血小板引入哺乳动物。

26. 发明申请

US20100137214A1 CHIMERIC HIRUDIN PROTEINS 失效
标题翻译： CHIMERIC HIRUDIN蛋白质
公开(公告)号：US20100137214A1
公开(公告)日：2010-06-03
申请号：US12619919
申请日：2009-11-17
申请人： William P. Sheffield
发明人： William P. Sheffield
IPC分类号： A61K38/17 , C07K14/435 , C07H21/04 , C12N15/63 , C12N5/00
CPC分类号： C07K14/815 , C07K2319/31 , C07K2319/50
摘要： The present invention relates to a chimeric hirudin protein comprising a carrier attached to the N-terminus of hirudin, with an intervening plasmin cleavage site. The chimeric hirudin protein contains a relatively inactive form of hirudin. However, when such chimeric hirudin protein being cleaved by plasmin in the vicinity of a clot and, ultimately causing the release of active hirudin and the reduction of the size of the clot. The chimeric hirudin protein exhibited much slower clearance in mice than unfused wild-type hirudin.
摘要翻译：本发明涉及一种嵌合水蛭素蛋白，其包含连接于水蛭素N末端的载体，以及介入的纤溶酶切割位点。嵌合水蛭素蛋白含有相对无活性的水蛭素。然而，当这种嵌合水蛭素蛋白质在凝块附近被纤溶酶切割并且最终导致活性水蛭素的释放和凝块尺寸的减小时。嵌合水蛭素蛋白在小鼠中的表现比未使用的野生型水蛭蛋白显着更慢。

27. 发明申请

US20080213369A1 SYNTHETIC PLATELETS 审中-公开
标题翻译：合成胶片
公开(公告)号：US20080213369A1
公开(公告)日：2008-09-04
申请号：US11851718
申请日：2007-09-07
申请人： Maria I.C. Gyongyossy-Issa , Jayachandran N. Kizhakkedathu , Iren Constantinescu , William Campbell , Carlos A. Del Carpio Munoz
发明人： Maria I.C. Gyongyossy-Issa , Jayachandran N. Kizhakkedathu , Iren Constantinescu , William Campbell , Carlos A. Del Carpio Munoz
IPC分类号： A61K9/14 , A61K38/00 , A61P9/00
CPC分类号： A61K9/1271 , A61K9/1277 , A61K35/19 , A61K47/6911
摘要： A synthetic platelet substitute that interacts with platelets and the (sub)endothelium, comprising: (a) a carrier molecule comprising lipidic particles with a cross-linked surface mesh, the lipidic particles comprising: an inner lipidic particle of pharmaceutically acceptable particle-forming lipids; hydrophilic polymer chains linked to the surface of the lipidic particle, the hydrophilic polymer chains comprising a crosslinkable end group at free ends thereof; and cross-linker groups linking the end groups of the hydrophilic polymer chains to form the cross-linked surface mesh; and (b) at least one receptor molecule attached to the surface of the carrier molecule. The receptor molecule can be a peptide moiety specific for ligands involved in platelet function.
摘要翻译：一种与血小板和（亚）内皮相互作用的合成血小板替代物，其包含：（a）包含具有交联表面网的脂质颗粒的载体分子，所述脂质颗粒包含：药学上可接受的形成颗粒的脂质的内脂质颗粒 ; 亲水性聚合物链与脂质颗粒的表面连接，亲水性聚合物链在其自由端包含可交联端基; 和连接亲水性聚合物链的端基以形成交联表面网的交联剂基团; 和（b）至少一个连接于载体分子表面的受体分子。受体分子可以是特异于参与血小板功能的配体的肽部分。

28. 发明申请

US20070025979A1 Coagulation proteins, coagulation-anticoagulation protein complexes, derivatives thereof and their uses 有权
标题翻译：凝血蛋白，凝血 - 抗凝蛋白复合物，其衍生物及其用途
公开(公告)号：US20070025979A1
公开(公告)日：2007-02-01
申请号：US11451959
申请日：2006-06-13
申请人： Edward Pryzdial
发明人： Edward Pryzdial
IPC分类号： A61K38/48 , A61K38/36
CPC分类号： A61K31/727 , A61K38/166 , A61K38/4846 , A61K38/49 , A61K38/58 , A61K45/06 , C12Q1/37 , G01N33/6893 , G01N33/86 , G01N2333/96463 , G01N2800/224 , A61K2300/00
摘要： The present invention relates to the use of coagulation proteins and complexes thereof with anticoagulation proteins for the lysis of blood clots or other applications affected by accelerated plasmin production. More specifically, the present invention provides a method for accelerating the dissolution of a blood clot through the administration of at least one coagulation protein, with or without being in complex with a serpin, comprising a basic C-terminal amino acid, wherein the coagulation protein may be a derivative of Factor X or Factor V or a combination thereof. Pharmaceutical compositions for the treatment and prophylaxis of blood clots are also provided, wherein, the methods and products of the present invention advantageously accelerate clot dissolution while potentially minimizing the adverse side-effects, such as hemorrhaging, seen with other clot dissolving agents. The present invention also provides a method for detecting a fibrinolytic potential in a subject.
摘要翻译：本发明涉及凝血蛋白及其与抗凝蛋白的复合物在凝血酶或其它受加速纤溶酶生成影响的应用中的应用。更具体地，本发明提供了一种通过施用包含碱性C末端氨基酸的丝氨酸蛋白酶引起的至少一种凝血蛋白加速血块溶解的方法，其中所述凝血蛋白可以是因子X或因子V的衍生物或其组合。还提供了用于治疗和预防血凝块的药物组合物，其中，本发明的方法和产品有利地加速凝块溶解，同时潜在地最小化与其它凝块溶解剂一起观察到的不良副作用，例如出血。本发明还提供了一种用于检测受试者中的纤维蛋白溶解电位的方法。

29. 发明授权

US11007221B2 Acellular pro-inflammatory compositions, process for making same and methods of using same 有权
公开(公告)号：US11007221B2
公开(公告)日：2021-05-18
申请号：US14904347
申请日：2013-12-13
申请人： CANADIAN BLOOD SERVICES
发明人： Mark D. Scott , Duncheng Wang , Wendy M. Toyofuku
IPC分类号： C12N15/11 , A61K35/17 , A61K31/7105 , A61K35/15 , A61K35/26 , C12N5/0783 , C12N5/078 , C12N15/113
摘要： This invention relates to acellular-based therapies for decreasing the level of regulatory T cells (Treg) and/or increasing the level of pro-inflammatory T cells (Th17) to favor immune stimulation. To provide these therapeutic effects, an allogeneic leukocyte population is contacted with another leukocyte population and the acellular components produced are isolated. The leukocyte populations are contacted so as to allow pro-inflammatory allo-recognition. Acellular-based preparations and processes for achieving therapy are also provided.

30. 发明申请

US20180305453A1 Monovalent Chimeras 审中-公开
公开(公告)号：US20180305453A1
公开(公告)日：2018-10-25
申请号：US15769697
申请日：2016-10-20
申请人： CANADIAN BLOOD SERVICES
发明人： Alan H. Lazarus , Xiaojie Yu , William Peter Sheffield
IPC分类号： C07K16/28 , A61P37/06
CPC分类号： C07K16/283 , A61K2039/505 , A61P37/06 , C07K2317/24 , C07K2317/35 , C07K2317/52 , C07K2317/55 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/31
摘要： The present disclosure relates to monovalent antibodies and chimeric proteins (comprising the monovalent antibodies) for the treatment of an auto-immune inflammatory disorder or condition. The monovalent antibody moiety lacks a Fc region, is specific for an activating Fc receptor and is for limiting or avoiding the activation of an immune cell induced in the presence and upon the binding of a ligand of the activating Fc receptor to the activating Fc receptor. The monovalent antibodies and chimeric proteins are especially useful for the prevention, treatment or alleviation of symptoms associated with an auto-immune inflammatory disorder caused or maintained by the engagement of an auto-antibody having a Fc region capable of engaging the activating Fc receptor to mediate the pathological destructions of cells or tissues.

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