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21. 发明授权

US5679557A Process of asymmetrically reducing 1-phenyl-2-oxo-propane derivatives with microorganisms 失效
标题翻译：用微生物不对称还原1-苯基-2-氧代 - 丙烷衍生物的方法
公开(公告)号：US5679557A
公开(公告)日：1997-10-21
申请号：US613946
申请日：1996-03-13
申请人： Michio Ito , Noritsugu Yamasaki , Yoshinori Kobayashi , Kiyoshi Ikura
发明人： Michio Ito , Noritsugu Yamasaki , Yoshinori Kobayashi , Kiyoshi Ikura
IPC分类号： C07C39/11 , C07C43/23 , C07C213/02 , C07C213/08 , C07C217/60 , C07C309/66 , C07C309/73 , C12P7/22 , C12P17/06 , C12P41/00
CPC分类号： C07C217/60 , C07C213/02 , C07C213/08 , C07C309/66 , C07C309/73 , C07C39/11 , C07C43/23 , C12P17/06 , C12P7/22 , Y02P20/55 , Y10S435/822 , Y10S435/832 , Y10S435/874 , Y10S435/911 , Y10S435/921 , Y10S435/93 , Y10S435/938
摘要： An (S)-1-phenyl-2-substituted propane derivative shown by the following formula (I) ##STR1## wherein R.sup.1 and R.sup.2 represent a lower alkyl group, etc., or R.sup.1 and R.sup.2 may form together an alkylene group, etc.; R.sup.3, R.sup.4 and R.sup.5 represent a hydrogen atom, etc.; and X represents a hydroxyl group which may be protected with a protective group, or a halogen atom etc., can readily be produced (i) by permitting a microorganism belonging to the genus Torulaspora, the genus Candida, the genus Pichia or the like to act on a phenylacetone derivative and asymmetrically reducing the compound, or (ii) by sterically inverting an (R)-enantiomer. (R,R)-1-phenyl-2-�(2-phenyl-1-methylethyl)amino!ethanol derivative having a high optical purity can easily be obtained from the compound of the formula (I). The ethanol derivative is useful as an anti-obesity agent and the like.
摘要翻译：由下式（I）表示的（S）-1-苯基-2-取代的丙烷衍生物其中R 1和R 2表示低级烷基等，或者R 1和R 2可以一起形成亚烷基集团等; R3，R4和R5代表氢原子等; X表示可以被保护基或卤素原子等保护的羟基，可容易地制备（i）通过使属于弧菌属，假丝酵母属，毕赤酵母属等的微生物，作用于苯基丙酮衍生物并不对称地还原化合物，或（ii）通过空间反转（R） - 对映异构体。（I）化合物可以容易地获得具有高光学纯度的（R，R）-1-苯基-2 - [（2-苯基-1-甲基乙基）氨基]乙醇衍生物。乙醇衍生物可用作抗肥胖剂等。

22. 发明授权

US5554532A Bacteria useful for production of optically active 3-phenyl-1,3-propanediol 失效
标题翻译：用于制备光学活性3-苯基-1,3-丙二醇的细菌
公开(公告)号：US5554532A
公开(公告)日：1996-09-10
申请号：US224303
申请日：1994-04-07
申请人： Akinobu Matsuyama , Michio Ito , Yoshinori Kobayashi , Naoki Kawada
发明人： Akinobu Matsuyama , Michio Ito , Yoshinori Kobayashi , Naoki Kawada
IPC分类号： C12P7/22 , C12P41/00 , C12N1/12 , C12N1/20
CPC分类号： C12P41/001 , C12P7/22 , Y10S435/822 , Y10S435/911
摘要： A microorganism or a preparation thereof is permitted to act on a mixture of enantiomers of 3-phenyl-1,3-propanediol, and the residual optically active 3-phenyl-1,3-propanediol is harvested. The genera of those microorganisms which are able to leave (R)-3-phenyl-1,3-propanediol include Candida, Hansenula, Rhodotorula, Protaminobacter, Aspergillus, Alternaria, Macrophomina, Preussia and Talaromyces. The genera of those microorganisms which are able to leave (S)-3-phenyl-1,3-propanediol include Candida, Geotrichum, Leucosporidium, Pichia, Torulaspora, Trichosporon, Escherichia, Micrococcus, Corynebacterium, Gordona, Rhodococcus, Aspergillus, Emericella, Absidia, Fusarium, Dactylium, Serratia and Pseudomonas.
摘要翻译：允许微生物或其制剂作用于3-苯基-1,3-丙二醇的对映异构体的混合物，并收获残留的光学活性3-苯基-1,3-丙二醇。能够离开（R）-3-苯基-1,3-丙二醇的那些微生物属包括假丝酵母属，汉逊酵母属，红酵母属，普氏杆菌属，曲霉属，链格孢属，大孔雀类，杜鹃和马鞭草属。能够离开（S）-3-苯基-1,3-丙二醇的那些微生物的属包括假丝酵母属（Candida），地热霉属（Geotrichum），隐孢子虫属（Bottelogporidium），毕赤酵母属（Pichia），孢子虫属（Trichosporon），丝孢杆菌属（Trichosporon），大肠杆菌属（Escherichia），微球菌属，棒状杆菌属，戈尔多纳氏菌属茜草属，镰孢属，睾丸，沙雷氏菌属和假单胞菌属。

23. 发明授权

US5508461A Optically active 1-phenyl-2-substituted propane derivatives and methods of producing the same 失效
标题翻译：光学活性的1-苯基-2-取代的丙烷衍生物及其制备方法
公开(公告)号：US5508461A
公开(公告)日：1996-04-16
申请号：US252994
申请日：1994-06-02
申请人： Michio Ito , Noritsugu Yamasaki , Yoshinori Kobayashi , Kiyoshi Ikura
发明人： Michio Ito , Noritsugu Yamasaki , Yoshinori Kobayashi , Kiyoshi Ikura
IPC分类号： C07C39/11 , C07C43/23 , C07C213/02 , C07C213/08 , C07C217/60 , C07C309/66 , C07C309/73 , C12P7/22 , C12P17/06 , C07C39/08 , C07C43/205
CPC分类号： C07C217/60 , C07C213/02 , C07C213/08 , C07C309/66 , C07C309/73 , C07C39/11 , C07C43/23 , C12P17/06 , C12P7/22 , Y02P20/55 , Y10S435/822 , Y10S435/832 , Y10S435/874 , Y10S435/911 , Y10S435/921 , Y10S435/93 , Y10S435/938
摘要： An (S)-1-phenyl-2-substituted propane derivative shown by the following formula (I) ##STR1## wherein R.sup.1 and R.sup.2 represent a lower alkyl group, etc., or R.sup.1 and R.sup.2 may form together an alkylene group, etc.; R.sup.3, R.sup.4 and R.sup.5 represent a hydrogen atom, etc.; and X represents a hydroxyl group which may be protected with a protective group, or a halogen atom etc., can readily be produced (i) by permitting a microorganism belonging to the genus Torulaspora, the genus Candida, the genus Pichia or the like to act on a phenylacetone derivative and asymmetrically reducing the compound, or (ii) by sterically inverting an (R)-enantiomer. (R,R)-1-phenyl-2-[(2-phenyl-1-methylethyl)amino]ethanol derivative having a high optical purity can easily be obtained from the compound of the formula (I). The ethanol derivative is useful as an anti-obesity agent and the like.
摘要翻译：由下式（I）表示的（S）-1-苯基-2-取代的丙烷衍生物其中R 1和R 2表示低级烷基等，或者R 1和R 2可以一起形成亚烷基集团等; R3，R4和R5代表氢原子等; X表示可以被保护基或卤素原子等保护的羟基，可容易地制备（i）通过使属于弧菌属，假丝酵母属，毕赤酵母属等的微生物，作用于苯基丙酮衍生物并不对称地还原化合物，或（ii）通过空间反转（R） - 对映异构体。（I）化合物可以容易地获得具有高光学纯度的（R，R）-1-苯基-2 - [（2-苯基-1-甲基乙基）氨基]乙醇衍生物。乙醇衍生物可用作抗肥胖剂等。

24. 发明授权

US5473239A Capstan motor drive control device 失效
标题翻译：绞盘电机驱动控制装置
公开(公告)号：US5473239A
公开(公告)日：1995-12-05
申请号：US151347
申请日：1993-11-12
申请人： Yoshinori Kobayashi , Ryuji Watanabe
发明人： Yoshinori Kobayashi , Ryuji Watanabe
IPC分类号： G11B15/46 , G11B15/467 , G11B15/48 , H02P6/06 , H02P5/28
CPC分类号： H02P6/06 , G11B15/46 , G11B15/48 , G11B15/4673
摘要： A capstan motor is controlled by a signal derived from a frequency generator that has been converted to a voltage that reflects the instantaneous change in velocity of the rotating motor. Acceleration of the motor is found by using a mean velocity obtained as a reciprocal of the pulsed signal from the frequency generator and then estimating the instantaneous velocity based on the derived acceleration. The estimated instantaneous velocity is converted to a drive voltage for the capstan motor so that the motor can be started and stopped with a respective constant acceleration and deceleration.
摘要翻译：主导马达由从频率发生器得到的信号控制，频率发生器已被转换成反映电动机速度的瞬时变化的电压。通过使用作为来自频率发生器的脉冲信号的倒数获得的平均速度，然后基于导出的加速度来估计瞬时速度来发现电动机的加速度。估计的瞬时速度被转换为主导轴马达的驱动电压，使得马达可以以相应的恒定的加速和减速启动和停止。

25. 发明授权

US5413922A Process for producing optically active 1,3-butanediol by reduction of 4-hydroxy-2-butanone 失效
标题翻译：通过还原4-羟基-2-丁酮制备光学活性1,3-丁二醇的方法
公开(公告)号：US5413922A
公开(公告)日：1995-05-09
申请号：US54276
申请日：1993-04-30
申请人： Akinobu Matsuyama , Teruyuki Nikaido , Yoshinori Kobayashi
发明人： Akinobu Matsuyama , Teruyuki Nikaido , Yoshinori Kobayashi
IPC分类号： C12P7/18 , C12P41/00
CPC分类号： C12P41/001 , C12P7/18 , Y10S435/822 , Y10S435/911 , Y10S435/921 , Y10S435/938
摘要： An optically active 1,3-butanediol can be produced by either (1) treating a mixture of 1,3-butanediol enantiomers with a microorganism, which has been optionally treated, capable of asymmetrically assimilating said mixture, or (2) preparing a microorganism, which has been optionally treated, capable of asymmetrically reducing 4-hydroxy-2-butanone, and collecting optically active 1,3-butanediol.
摘要翻译：光学活性1,3-丁二醇可以通过（1）将1,3-丁二醇对映异构体与已经任意处理的能够不对称地同化所述混合物的微生物处理，或（2）制备微生物，其可任选地处理，能够不对称地还原4-羟基-2-丁酮，并收集光学活性的1,3-丁二醇。

26. 发明授权

US5326916A Process for producing acrolein 失效
标题翻译：制备丙烯醛的方法
公开(公告)号：US5326916A
公开(公告)日：1994-07-05
申请号：US028534
申请日：1993-03-08
申请人： Yoshinori Kobayashi , Yasuo Matsumoto , Tadashi Mizuno , Masamitu Fukuda
发明人： Yoshinori Kobayashi , Yasuo Matsumoto , Tadashi Mizuno , Masamitu Fukuda
IPC分类号： C07B61/00 , B01J19/24 , C07C45/35 , C07C45/78 , C07C47/22 , C07C45/80
CPC分类号： C07C45/35 , B01J19/2465 , C07C45/783
摘要： A process for producing acrolein which comprises bringing a reaction gas resulting from a catalytic oxidation of propylene into contact in a cooling tower with a condensate which is being circulated through the cooling tower and a circulating part, thereby to cool and separate the reaction gas and discharge an effluent gas from the cooling tower, the condensate in a bottom part of the cooling tower having a temperature of from 35.degree. to 50.degree. C., the effluent gas discharged from the cooling tower having a temperature of from 35.degree. to 55.degree. C., the temperature of the effluent gas being kept nearly equal to or higher than the temperature of the condensate in the bottom part of the cooling tower, and a process for producing acrolein which comprises bringing a reaction gas resulting from the catalytic oxidation of propylene into contact in a cooling tower with a condensate which is being circulated through the cooling tower and a circulating part, thereby to cool and separate the reaction gases, the period of the residence time of the condensate in the cooling tower and the circulating part being from 0.5 to 3 hours.
摘要翻译：一种制备丙烯醛的方法，其包括使由丙烯的催化氧化产生的反应气体在冷却塔中与冷却塔中循环的冷凝物和循环部分接触，从而冷却和分离反应气体并将其排出来自冷却塔的废气，冷却塔底部的冷凝物的温度为35〜50℃，从冷却塔排出的流出气体的温度为35〜55℃ 流出气体的温度保持在冷却塔底部的冷凝水的温度近似等于或高于丙烯醛的制造方法，其特征在于，将由丙烯的催化氧化得到的反应气体在冷却塔中与通过冷却塔循环的冷凝物和循环部分接触，从而冷却和分离反应物冷凝塔和循环部分的冷凝水停留时间为0.5〜3小时。

27. 发明授权

US5194380A Process for the production of optically active 2-hydroxy-4-phenyl-3-butenoic acid 失效
标题翻译：用于生产光学活性的2-羟基-4-苯基-3-丁酮酸的方法
公开(公告)号：US5194380A
公开(公告)日：1993-03-16
申请号：US459787
申请日：1990-03-01
申请人： Akinobu Matsuyama , Ichiro Takase , Yoichiro Ueda , Yoshinori Kobayashi
发明人： Akinobu Matsuyama , Ichiro Takase , Yoichiro Ueda , Yoshinori Kobayashi
IPC分类号： C12P7/42
CPC分类号： C12P7/42 , Y10S435/822 , Y10S435/824 , Y10S435/827 , Y10S435/83 , Y10S435/836 , Y10S435/84 , Y10S435/843 , Y10S435/85 , Y10S435/852 , Y10S435/853 , Y10S435/857 , Y10S435/873 , Y10S435/874 , Y10S435/885 , Y10S435/911 , Y10S435/921 , Y10S435/93
摘要： Optically active 2-hydroxy-4-phenyl-3-butenoic acid can be obtained by treating 2-oxo-4-phenyl-3-butenoic acid with an optionally treated microorganism capable of asymmetrically reducing the 2-oxo-4-phenyl-3-butenoic acid into (R)-2-hydroxy-4-phenyl-3-butenoic acid or (S)-2-hydroxy-4-phenyl-3-butenoic acid to thereby asymmetrically reduce the same into (R)-2-hydroxy-4-phenyl-3-butenoic acid or (S)-2-hydroxy-4-phenyl-3-butenoic acid.
摘要翻译： PCT No.PCT / JP89 / 00698 Sec。 371 1990年3月1日 102（e）1990年3月1日PCT PCT 1989年7月11日PCT公布。出版物WO90 / 00613 1990年1月25日。光学活性2-羟基-4-苯基-3-丁烯酸可以通过用任选处理的微生物处理2-氧代-4-苯基-3-丁烯酸，所述微生物能够不对称地还原2- （R）-2-羟基-4-苯基-3-丁烯酸或（S）-2-羟基-4-苯基-3-丁烯酸，从而不对称地还原相同的（R）-2-羟基-4-苯基-3-丁烯酸（R）-2-羟基-4-苯基-3-丁烯酸或（S）-2-羟基-4-苯基-3-丁烯酸。

28. 发明授权

US5103575A Method for improving qualities of wood 失效
标题翻译：提高木材品质的方法
公开(公告)号：US5103575A
公开(公告)日：1992-04-14
申请号：US649840
申请日：1991-02-05
申请人： Kuniharu Yokoo , Yoshinori Kobayashi , Yasushi Kanagawa
发明人： Kuniharu Yokoo , Yoshinori Kobayashi , Yasushi Kanagawa
IPC分类号： B27K5/00 , F26B3/347
CPC分类号： F26B3/347 , F26B2210/16
摘要： Wood is preliminary dried until its moisture content is reduced to 20 to 30%, and then treated by radio frequency heating in two stages, i.e., the first stage where the radio frequency heating is carried out at a temperature of 60.degree. to 120.degree. C., and the second stage where the radio frequency heating is carried out at a temperature of not more than 60.degree. C.
摘要翻译：将木材预干燥直到其含水量降低到20〜30％，然后通过射频加热两个阶段进行处理，即在60℃至120℃的温度下进行射频加热的第一阶段在不高于60℃的温度下进行射频加热的第二阶段

29. 发明授权

US5095377A Method of driving a ferroelectric liquid crystal matrix panel 失效
标题翻译：驱动铁电液晶矩阵面板的方法
公开(公告)号：US5095377A
公开(公告)日：1992-03-10
申请号：US561576
申请日：1990-08-02
申请人： Yoshinori Kobayashi , Naohide Wakita , Yoshihiro Gohara
发明人： Yoshinori Kobayashi , Naohide Wakita , Yoshihiro Gohara
IPC分类号： G09G3/36
CPC分类号： G09G3/3629 , G09G2310/0205 , G09G2310/06 , G09G2310/061
摘要： In a method of driving a liquid crystal matrix panel, a group of voltage pulses are applied to each pixel connected to a scanning line during a reset period prior to a selection period so as to reset the state of each pixel before writing data. When the voltage pulse group contains a voltage pulse having a voltage whose absolute value is at least equal an absolute value of a threshold voltage of the liquid crystal, the group also contains, before or after the voltage pulse, a voltage pulse having a voltage whose absolute value is smaller than the absolute value of the threshold voltage and whose polarity is opposite to that of the former voltage pulse.
摘要翻译：在驱动液晶矩阵面板的方法中，在选择周期之前的复位期间，将一组电压脉冲施加到与扫描线连接的每个像素，以便在写入数据之前复位每个像素的状态。当电压脉冲群含有其绝对值至少等于液晶的阈值电压的绝对值的电压的电压脉冲时，该组还在电压脉冲之前或之后包含电压脉冲，其电压为绝对值小于阈值电压的绝对值，其极性与前一个电压脉冲的极性相反。

30. 发明授权

US4530906A Microbial rennet having increased milk coagulating activity and method and method for production thereof 失效
标题翻译：具有增加的牛奶凝固活性的微生物凝乳酶及其生产方法和方法
公开(公告)号：US4530906A
公开(公告)日：1985-07-23
申请号：US482171
申请日：1983-04-05
申请人： Toshihiko Higashi , Yoshinori Kobayashi , Shinjiro Iwasaki
发明人： Toshihiko Higashi , Yoshinori Kobayashi , Shinjiro Iwasaki
IPC分类号： A23C19/032 , C12N9/58 , C12N9/96 , C12R1/785
CPC分类号： A23C19/0326 , C12N9/58 , C12N9/96 , Y10S435/931
摘要： A method for increasing the milk coagulating activity of microbial rennet obtained from Mucor pusillus microorganisms, which comprises acylating the microbial rennet in an aqueous medium by contacting the microbial rennet with succinic anhydride at a temperature of about 0.degree. C. to about 40.degree. C. and a pH of about 4 to about 10 for a time sufficient to obtain the desired increase in milk coagulating activity; and improved microbial rennet having a low PA/MCA index and a high MCA index and obtained by the aforesaid method.
摘要翻译：一种增加从毛霉微生物获得的微生物凝乳酶的乳凝固活性的方法，其包括通过使微生物凝乳酶与琥珀酸酐在约0℃至约40℃的温度下接触来在水性介质中酰化微生物凝乳酶。和约4至约10的pH足以获得所需乳液凝固活性增加的时间; 以及通过上述方法获得的具有低PA / MCA指数和高MCA指数的改进的微生物凝乳酶。

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