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21. 发明授权

US07336390B2 Method and apparatus for reducing multi-bit image data 失效
标题翻译：用于减少多位图像数据的方法和装置
公开(公告)号：US07336390B2
公开(公告)日：2008-02-26
申请号：US10424908
申请日：2003-04-29
申请人： Nobuo Ogawa
发明人： Nobuo Ogawa
IPC分类号： G06F15/00
CPC分类号： G06K15/02 , G06K15/1871 , G06K2215/0074
摘要： Input pixels are input to a thinning processing circuit. When thinning is performed at the thinning processing circuit, minimum values are selected in order to reduce the pixel data, whereby loss of thin lines is prevented. The thinned image data are input to a binarization processing circuit. Although the image having been thinned through selection of minimum values becomes dark as a whole, collapse of characters can be suppressed, because the binarization processing circuit dynamically changes a binarization threshold by employing, as the binarization threshold, the average of maximum and minimum values in each local region. In a density flat portion, the local maximum value and the local minimum value assume the same value. Therefore, when the difference between the local maximum value and the local minimum value is not greater than a predetermined range, binarization is performed by use of a fixed threshold value. Instead of local maximum and minimum values, a local average value may be used as a binarization threshold value.
摘要翻译：输入像素被输入到细化处理电路。当在稀化处理电路中进行稀疏化时，选择最小值以减少像素数据，从而防止细线的损失。减薄的图像数据被输入到二值化处理电路。虽然通过选择最小值而变薄的图像整体变暗，但是由于二值化处理电路通过采用二值化阈值来动态地改变二值化阈值，因此可以抑制字符的折叠每个地方区域。在密度平坦部分中，局部最大值和局部最小值采用相同的值。因此，当局部最大值与局部最小值之差不大于预定范围时，通过使用固定阈值进行二值化。代替局部最大值和最小值，可以将局部平均值用作二值化阈值。

22. 发明授权

US06462036B1 Tricyclic pyrazole derivatives 有权
标题翻译：三环吡唑衍生物
公开(公告)号：US06462036B1
公开(公告)日：2002-10-08
申请号：US09573366
申请日：2000-05-17
申请人： Kevin J. Doyle , Paul Rafferty , Robert W. Steele , David J. Wilkins , Lee D. Arnold , Michael Hockley , Anna M. Ericsson , Nobuhiko Iwasaki , Nobuo Ogawa
发明人： Kevin J. Doyle , Paul Rafferty , Robert W. Steele , David J. Wilkins , Lee D. Arnold , Michael Hockley , Anna M. Ericsson , Nobuhiko Iwasaki , Nobuo Ogawa
IPC分类号： A61K3155
CPC分类号： C07D401/04 , C07D231/54 , C07D401/06 , C07D401/12 , C07D403/10 , C07D403/12 , C07D409/04 , C07D409/14 , C07D417/12 , C07D451/04 , C07D491/04 , C07D495/04
摘要： This invention relates to certain 3-aryl or 3-heteroaryl pyrazoles with 4,5(3,4)-bicyclic ring fusion which are inhibitors of protein kinase activity, of which some are novel compounds, to pharmaceutical compositions containing these pyrazoles and to processes for preparing these pyrazoles.
摘要翻译：本发明涉及某些3-芳基或3-杂芳基吡唑与具有蛋白激酶活性的抑制剂4,5（3,4） - 双环融合，其中一些是新化合物，含有这些吡唑的药物组合物和方法用于制备这些吡唑。

23. 发明授权

US5422735A Image processing method and image processing apparatus 失效
标题翻译：图像处理方法和图像处理装置
公开(公告)号：US5422735A
公开(公告)日：1995-06-06
申请号：US250506
申请日：1994-05-27
申请人： Nobuo Ogawa
发明人： Nobuo Ogawa
IPC分类号： H04N1/403 , H04N1/405
CPC分类号： H04N1/403
摘要： The invention provides an image processing method and an image processing apparatus suitably applied to an image reading apparatus such as an OCR or a facsimile, by which a drop or a break of a thin line which is caused by a little inclination of an original can be prevented with certainty by a simple processing procedure without emphasizing noise and besides sharp binary digitization processing which does not cause blurring or distortion can be performed even where color characters are present discretely in the original. When a density value of a noticed picture element upon binary processing is lower than a predetermined threshold level, a binary value error of a picture element on the opposite side to the noticed picture element in a main scanning direction or a sub scanning direction is added to the density value of the noticed picture element to obtain a sum value, and the sum value is compared with the predetermined threshold level. When the sum value is equal to or higher than the predetermined threshold level, binary digitization is performed for the noticed picture element.
摘要翻译：本发明提供一种图像处理方法和图像处理装置，其适用于诸如OCR或传真机的图像读取装置，由原稿的一点倾斜引起的细线的下降或断裂可以是通过简单的处理程序确定地防止了噪声，并且即使在颜色字符离散地存在于原件中的情况下，也可以执行不会引起模糊或失真的尖锐的二进制数字化处理。当二进制处理中注意到的像素的浓度值低于预定阈值电平时，将与主扫描方向或副扫描方向上的注意像素相反的像素的二进制值误差加到将获得和值的注意到的像素的浓度值和和值与预定阈值水平进行比较。当和值等于或高于预定阈值电平时，对于注意到的像素执行二进制数字化。

24. 发明授权

US4971990A Phenoxyethylamine derivatives, for preparing the same and composition for exhibiting excellent .alpha..sub.1 -blocking activity containing the same 失效
标题翻译：苯氧基乙胺衍生物，其制备方法和用于表现出优异的α1-阻断活性的组合物
公开(公告)号：US4971990A
公开(公告)日：1990-11-20
申请号：US301354
申请日：1989-01-24
申请人： Yasuo Itoh , Hideo Kato , Eiichi Koshinaka , Nobuo Ogawa , Kazuya Mitani , Shunichiro Sakurai
发明人： Yasuo Itoh , Hideo Kato , Eiichi Koshinaka , Nobuo Ogawa , Kazuya Mitani , Shunichiro Sakurai
IPC分类号： C07C311/27 , C07D295/26
CPC分类号： C07D295/26 , C07C311/27
摘要： Phenoxyethylamine derivatives represented by the general formula (I): ##STR1## wherein R.sub.1 and R.sub.5 represent lower-alkyl, R.sub.2 and R.sub.3, which may be the same or different, each represents hydrogen or lower-alkyl, or ##STR2## represents a 5- or 6-membered ring system which may include nitrogen, oxygen or sulfur as a ring membered atom, R.sub.4 represents hydrogen or lower-alkyl, and n represents an integer selected from 1 to 3, their optical isomers and pharmacologically-acceptable acid addition salts, which exhibit excellent .alpha..sub.1 -blocking activity, a process for their preparation, pharmaceutical compositions thereof, and a method for the treatment of a subject afflicted with hypertension or dysuria by administrating such a compound, are all disclosed.

25. 发明授权

US4638009A Derivatives of 3-pyrrolidinopropiophenone and a process for preparation thereof 失效
标题翻译： 3-吡咯烷基苯丙酮的衍生物及其制备方法
公开(公告)号：US4638009A
公开(公告)日：1987-01-20
申请号：US573862
申请日：1984-01-25
申请人： Yasuo Itho , Hideo Kato , Nobuo Ogawa , Kagari Yamagishi , Eiichi Koshinaka , Hiroyuki Nishino
发明人： Yasuo Itho , Hideo Kato , Nobuo Ogawa , Kagari Yamagishi , Eiichi Koshinaka , Hiroyuki Nishino
IPC分类号： C07D295/108 , A61K31/41 , C07D207/06
CPC分类号： C07D295/108
摘要： Certain 4'-alkyl-2-methyl-3-pyrrolidinopropiophenones, acid addition salts thereof, their method of preparation, pharmaceutical compositions embodying the same, and a method of muscle relaxation therewith, are disclosed.
摘要翻译：公开了某些4'-烷基-2-甲基-3-吡咯烷基苯丙酮，其酸加成盐，其制备方法，含有其的药物组合物及其与肌肉松弛的方法。

26. 发明授权

US4612329A Pharmaceutical alpha-aminoalkyl-alpha-alkylphenylacetonitriles 失效
标题翻译：药物α-氨基烷基-α-烷基苯基乙腈
公开(公告)号：US4612329A
公开(公告)日：1986-09-16
申请号：US786742
申请日：1985-10-11
申请人： Yasuo Itoh , Hideo Kato , Eiichi Koshinaka , Nobuo Ogawa , Sakae Kurata , Hiroyuki Nishino , Toshihiko Yoshida
发明人： Yasuo Itoh , Hideo Kato , Eiichi Koshinaka , Nobuo Ogawa , Sakae Kurata , Hiroyuki Nishino , Toshihiko Yoshida
IPC分类号： A61K31/275 , A61K31/445 , C07C20060101 , C07C255/58 , C07D20060101 , C07D211/08 , C07D295/08 , C07C121/78
CPC分类号： C07C255/00
摘要： Novel alpha-aminoalkyl-alpha-alkylphenylacetonitrile derivatives useful for treatment of cartino vaso diseases, a peripheral circulatory insufficiency and cerebral circulation failure are disclosed.
摘要翻译：公开了用于治疗纸浆血管疾病，外周循环功能不全和脑循环衰竭的新型α-氨基烷基-α-烷基苯基乙腈衍生物。

27. 发明授权

US4478838A 1-(3,4,5-Trimethoxycinnamoyl)-4-alkylaminocarbonylethyl piperazines 失效
标题翻译： 1-（3,4,5-三甲氧基肉桂酰基）-4-烷基氨基羰基乙基哌嗪
公开(公告)号：US4478838A
公开(公告)日：1984-10-23
申请号：US441635
申请日：1982-11-15
申请人： Yasuo Itho , Hideo Kato , Eiichi Koshinaka , Nobuo Ogawa , Sakae Kurata , Kagari Yamagishi
发明人： Yasuo Itho , Hideo Kato , Eiichi Koshinaka , Nobuo Ogawa , Sakae Kurata , Kagari Yamagishi
IPC分类号： C07D243/08 , A61K31/55 , A61P9/08 , C07D295/18 , C07D295/185 , A61K31/495 , C07D241/04
CPC分类号： C07D295/185 , Y10S514/929
摘要： 1-(3,4,5-Trimethoxycinnamoyl)-4-aminocarbonylethyl-substituted piperazine derivatives represented by general formula (I): ##STR1## wherein R is a straight- or branched-chain alkyl group having 1 to 6 carbon atoms or a cycloalkyl group having 5 to 7 carbon atoms, and pharmaceutically acceptable acid addition salts thereof are disclosed.The 1-(3,4,5-trimethoxycinnamoyl)-4-aminocarbonylethyl-substituted piperazine derivatives are useful as vasodilator agents.
摘要翻译：由通式（I）表示的1-（3,4,5-三甲氧基肉桂酰基）-4-氨基羰基乙基取代的哌嗪衍生物：其中R是具有1至6个碳原子的直链或支链烷基或公开了具有5至7个碳原子的环烷基基团及其药学上可接受的酸加成盐。 1-（3,4,5-三甲氧基肉桂酰基）-4-氨基羰基乙基取代的哌嗪衍生物可用作血管舒张剂。

28. 发明授权

US4166180A 2-Arylpiperazine derivatives and the preparation thereof 失效
标题翻译： 2-ARYLPIPERAZINE DORIVATIVES及其制备方法
公开(公告)号：US4166180A
公开(公告)日：1979-08-28
申请号：US795869
申请日：1977-05-11
申请人： Hideo Kato , Eiichi Koshinaka , Nobuo Ogawa
发明人： Hideo Kato , Eiichi Koshinaka , Nobuo Ogawa
IPC分类号： A61K31/495 , A61P9/08 , A61P25/00 , A61P25/04 , A61P25/08 , C07D241/04 , C07D317/58 , C07D405/04 , C07D241/12
CPC分类号： C07D241/04 , C07D317/58
摘要： A process is provided for preparing 2-arylpiperazine derivatives and more particularly, 2-phenylpiperazine derivatives of the formula ##STR1## wherein R represents a group selected from the group consisting of a halogen atom, a lower alkyl group (having carbon atoms of 1 to about 8, preferably 1 to 4), a lower alkoxy group (having carbon atoms of 1 to about 8, preferably 1 to 4), a nitro group, a cyano group, a benzyloxy group, a hydroxy group and when n is 2 R is a methylenedioxy group, and n represents 1, 2 or 3.

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