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1. 发明授权

US4478838A 1-(3,4,5-Trimethoxycinnamoyl)-4-alkylaminocarbonylethyl piperazines 失效
标题翻译： 1-（3,4,5-三甲氧基肉桂酰基）-4-烷基氨基羰基乙基哌嗪
公开(公告)号：US4478838A
公开(公告)日：1984-10-23
申请号：US441635
申请日：1982-11-15
申请人： Yasuo Itho , Hideo Kato , Eiichi Koshinaka , Nobuo Ogawa , Sakae Kurata , Kagari Yamagishi
发明人： Yasuo Itho , Hideo Kato , Eiichi Koshinaka , Nobuo Ogawa , Sakae Kurata , Kagari Yamagishi
IPC分类号： C07D243/08 , A61K31/55 , A61P9/08 , C07D295/18 , C07D295/185 , A61K31/495 , C07D241/04
CPC分类号： C07D295/185 , Y10S514/929
摘要： 1-(3,4,5-Trimethoxycinnamoyl)-4-aminocarbonylethyl-substituted piperazine derivatives represented by general formula (I): ##STR1## wherein R is a straight- or branched-chain alkyl group having 1 to 6 carbon atoms or a cycloalkyl group having 5 to 7 carbon atoms, and pharmaceutically acceptable acid addition salts thereof are disclosed.The 1-(3,4,5-trimethoxycinnamoyl)-4-aminocarbonylethyl-substituted piperazine derivatives are useful as vasodilator agents.
摘要翻译：由通式（I）表示的1-（3,4,5-三甲氧基肉桂酰基）-4-氨基羰基乙基取代的哌嗪衍生物：其中R是具有1至6个碳原子的直链或支链烷基或公开了具有5至7个碳原子的环烷基基团及其药学上可接受的酸加成盐。 1-（3,4,5-三甲氧基肉桂酰基）-4-氨基羰基乙基取代的哌嗪衍生物可用作血管舒张剂。

2. 发明授权

US4525356A N-substituted flavone-8-carboxamides 失效
标题翻译： N-取代的黄酮-8-甲酰胺
公开(公告)号：US4525356A
公开(公告)日：1985-06-25
申请号：US546481
申请日：1983-10-28
申请人： Yasuo Itho , Hideo Kato , Nobuo Ogawa , Kagari Yamagishi , Eiichi Koshinaka , Kazuya Mitani
发明人： Yasuo Itho , Hideo Kato , Nobuo Ogawa , Kagari Yamagishi , Eiichi Koshinaka , Kazuya Mitani
IPC分类号： C07D311/30 , C07D405/12 , A61K31/35 , C07D405/10
CPC分类号： C07D405/12 , C07D311/30
摘要： Derivatives of N-substituted flavone-8-carboxamides represented by general formula (I) ##STR1## wherein R.sub.1 represents a hydrogen atom, a methyl group or an ethyl group, R.sub.2 represents a hydrogen atom, a lower alkyl group, a lower alkoxyl group, a halogen atom or a nitro group, R.sub.3 represents a hydrogen atom or a lower alkyl group, k represents 0, 1, 2, or 3, m represents 0 or 1; X and Y, which must be different, represent a hydrogen atom or methyl group. A represents an amino group having the formula ##STR2## wherein, R.sub.4 and R.sub.5, which may be the same or different, represent a lower alkyl group or a cyclic amino group together with the nitrogen atom and with or without an oxygen atom, R.sub.6 represents a lower alkyl group and n represents 2 or 3, are disclosed, as well as pharmaceutical compositions thereof and method of treating therewith.The N-substituted flavone-8-carboxamides derivatives are useful as agents for treatment of dysurea.
摘要翻译：由通式（I）表示的N-取代的黄酮-8-甲酰胺的衍生物其中R1表示氢原子，甲基或乙基，R2表示氢原子，低级烷基，低级烷氧基卤素原子或硝基，R3表示氢原子或低级烷基，k表示0,1,2或3，m表示0或1; X和Y必须不同，表示氢原子或甲基。 A表示具有式“IMAGE”的氨基，其中可以相同或不同的R 4和R 5与氮原子一起表示低级烷基或环状氨基，并且具有或不具有氧原子，R6表示低级烷基和n代表2或3，以及其药物组合物和其处理方法。 N-取代的黄酮-8-甲酰胺衍生物可用作治疗尿素的药剂。

3. 发明授权

US4638009A Derivatives of 3-pyrrolidinopropiophenone and a process for preparation thereof 失效
标题翻译： 3-吡咯烷基苯丙酮的衍生物及其制备方法
公开(公告)号：US4638009A
公开(公告)日：1987-01-20
申请号：US573862
申请日：1984-01-25
申请人： Yasuo Itho , Hideo Kato , Nobuo Ogawa , Kagari Yamagishi , Eiichi Koshinaka , Hiroyuki Nishino
发明人： Yasuo Itho , Hideo Kato , Nobuo Ogawa , Kagari Yamagishi , Eiichi Koshinaka , Hiroyuki Nishino
IPC分类号： C07D295/108 , A61K31/41 , C07D207/06
CPC分类号： C07D295/108
摘要： Certain 4'-alkyl-2-methyl-3-pyrrolidinopropiophenones, acid addition salts thereof, their method of preparation, pharmaceutical compositions embodying the same, and a method of muscle relaxation therewith, are disclosed.
摘要翻译：公开了某些4'-烷基-2-甲基-3-吡咯烷基苯丙酮，其酸加成盐，其制备方法，含有其的药物组合物及其与肌肉松弛的方法。

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