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21. 发明授权

US5480868A Sustained-release preparation 失效
标题翻译：缓释制剂
公开(公告)号：US5480868A
公开(公告)日：1996-01-02
申请号：US162698
申请日：1993-12-07
申请人： Shigeru Kamei , Yasutaka Igari , Yasuaki Ogawa
发明人： Shigeru Kamei , Yasutaka Igari , Yasuaki Ogawa
IPC分类号： A61K9/52 , A61K20060101 , A61K9/16 , A61K9/22 , A61K9/50 , A61K38/04 , A61K38/09 , A61K38/12 , A61K47/34 , A61K47/42 , C07K7/23 , A61K38/00 , C08G63/08 , C08G63/91 , C08L67/00
CPC分类号： C07K7/23 , A61K38/09 , A61K9/1647 , A61K38/00
摘要： A sustained-release preparation which comprises a physiologically active peptide of general formula ##STR1## wherein X represents an acyl group; R.sub.1, R.sub.2 and R.sub.4 each represents an aromatic cyclic group; R.sub.3 represents a D-amino acid residue or a group of the formula ##STR2## wherein R.sub.3 ' is a heterocyclic group; R.sub.5 represents a group of the formula --(CH.sub.2).sub.n --R.sub.5 ' wherein n is 2 or 3, and R.sub.5 ' is an amino group which may optionally be substituted, an aromatic cyclic group or an O-glycosyl group;R.sub.6 represents a group of the formula --(CH.sub.2).sub.n --R.sub.6 ' wherein n is 2 or 3, and R.sub.6 ' is an amino group which may optionally be substituted;R.sub.7 represents a D-amino acid residue or an azaglycyl residue; andQ represents hydrogen or a lower alkyl group, or a salt thereof and a biodegradable polymer having a terminal carboxyl group.The sustained-release preparation shows a constant release of the peptide over a long time and is substantially free from an initial burst.
摘要翻译：包含通式的生理活性肽的缓释制剂含有酰基; R1，R2和R4各自表示芳族环状基团; R3表示D-氨基酸残基或式“IMAGE”的基团，其中R3'为杂环基; R5表示式 - （CH2）n-R5'的基团，其中n为2或3，R5'为任选取代的氨基，芳族环基或O-糖基; R6表示式 - （CH2）n-R6'的基团，其中n为2或3，R6'为可任意取代的氨基; R7表示D-氨基酸残基或氮杂十八烷基残基; Q表示氢或低级烷基，或其盐和具有末端羧基的生物降解性聚合物。持续释放制剂显示长时间的肽的恒定释放并且基本上没有初始爆发。

22. 发明授权

US5480656A Prolonged release microcapsules 失效
标题翻译：延长释放微胶囊
公开(公告)号：US5480656A
公开(公告)日：1996-01-02
申请号：US188918
申请日：1994-01-31
申请人： Hiroaki Okada , Yayoi Inoue , Yasuaki Ogawa
发明人： Hiroaki Okada , Yayoi Inoue , Yasuaki Ogawa
IPC分类号： A61K9/16 , A61K9/50 , A61K9/52 , A61K38/00 , A61K38/06 , A61K38/08 , A61K38/09 , B01J13/02 , A61K9/62
CPC分类号： A61K9/1647 , A61K38/066 , A61K38/09 , A61K9/5031 , Y10S514/937
摘要： This invention provides a microcapsule designed for zero order release of a physiologically active polypeptide over a period of at least two months, which is produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing about 20 to 70% (w/w) of said polypeptide and an oil layer containing a copolymer or homopolymer having a weight-average molecular weight of 7,000 to 30,000, wherein the composition ratio of lactic acid/glycolic acid in the copolymer or homopolymer is 80/10 to 100/0, and then subjecting said water-in oil emulsion to microencapsulation.
摘要翻译：本发明提供一种设计用于在至少两个月的时间内对生理活性多肽进行零级释放的微胶囊，其通过制备包含含有约20至70％（w / w）的内含水层的油包水乳液制备， w）和含有重均分子量为7000〜30,000的共聚物或均聚物的油层，其中共聚物或均聚物中乳酸/乙醇酸的组成比为80/10〜100/0，然后对所述油包水乳液进行微囊化。

23. 发明授权

US4728721A Polymer, production and use thereof 失效
标题翻译：聚合物，生产和使用
公开(公告)号：US4728721A
公开(公告)日：1988-03-01
申请号：US858040
申请日：1986-05-01
申请人： Masaki Yamamoto , Hiroaki Okada , Yasuaki Ogawa , Tsutomu Miyagawa
发明人： Masaki Yamamoto , Hiroaki Okada , Yasuaki Ogawa , Tsutomu Miyagawa
IPC分类号： A61K9/52 , A61K9/16 , A61K9/50 , A61K45/00 , A61K47/00 , A61K47/34 , B01J13/12 , C08G63/06 , C08G63/78 , C08G63/88 , C08G63/90 , C08L51/00 , C08L51/02 , C08L67/00 , C08L77/00 , C08L101/00 , C08G63/74
CPC分类号： C08G63/06 , A61K9/1647 , A61K9/5031 , B01J13/125 , Y10S514/937
摘要： The present invention provides a biodegradable high molecular polymer characterized in that the content of water-soluble low molecular compounds, as calculated on the assumption that said compounds each is a monobasic acid, is less than 0.01 mole per 100 grams of said high molecular polymer.The thus-obtained molecular polymer has good aging stability and can be used advantageously as an excipient for pharmaceutical preparations.
摘要翻译：本发明提供了一种可生物降解的高分子聚合物，其特征在于，假定所述化合物各自为一元酸，水溶性低分子化合物的含量小于0.01摩尔/ 100克所述高分子聚合物。由此获得的分子聚合物具有良好的老化稳定性，可以有利地用作药物制剂的赋形剂。

24. 发明授权

US4572832A Soft buccal 失效
标题翻译：软颊
公开(公告)号：US4572832A
公开(公告)日：1986-02-25
申请号：US540161
申请日：1983-10-07
申请人： Kazuo Kigasawa , Hiroaki Shimizu , Toshihiro Hayashi , Kazuo Watabe , Akira Tanizaki , Osamu Koyama , Kikuo Wakisaka , Yasuaki Ogawa
发明人： Kazuo Kigasawa , Hiroaki Shimizu , Toshihiro Hayashi , Kazuo Watabe , Akira Tanizaki , Osamu Koyama , Kikuo Wakisaka , Yasuaki Ogawa
IPC分类号： A61K9/00 , A61K9/20 , A61K9/22 , A61K47/00
CPC分类号： A61K9/2004 , A61K9/006
摘要： A soft buccal containing (1) a medicament to be absorbed through the oral mucosa, (2) a water-soluble protein, (3) a polyhydric alcohol, and (4) a fatty acid ester or/and a carboxyvinyl polymer, has various advantages such as good feeling in use, good retainability within the mouth, slow release, improved absorbability of drug through the mucosa, improved bioavailability, etc., and therefore can be used an excellent pharmaceutical preparation for administration to the mucous membrane of the mouth.
摘要翻译：一种软颊含有（1）通过口腔粘膜吸收的药物，（2）水溶性蛋白质，（3）多元醇，和（4）脂肪酸酯或/和羧乙烯基聚合物，各种各样的口感好，口内保留性好，缓释，药物通过粘膜吸收性好，生物利用度提高等优点，因此可用于向口腔粘膜施用的优良药物制剂。

25. 发明授权

US08651384B2 Code reading apparatus and computer program product 有权
标题翻译：代码阅读器和计算机程序产品
公开(公告)号：US08651384B2
公开(公告)日：2014-02-18
申请号：US13434246
申请日：2012-03-29
申请人： Yasuaki Ogawa , Keiichi Tanioka
发明人： Yasuaki Ogawa , Keiichi Tanioka
IPC分类号： G06K7/10 , G02B1/06
CPC分类号： G06K7/10811 , G02B7/36 , G02B26/10 , G03B3/10
摘要： A code reading apparatus includes: a storage section storing an applied voltage table showing a relationship between a focal distance of a liquid lens and an applied voltage to the liquid lens; a laser focus section performing laser focus adjustment; a contrast focus section performing contrast focus adjustment; and a correction section correcting a content of the applied voltage table based on a distance from the liquid lens to a subject found by the laser focus section and a corresponding applied voltage with which the subject is brought into focus by the contrast focus section.
摘要翻译：代码读取装置包括：存储部分，存储施加的电压表，其示出液体透镜的焦距与施加的电压对液体透镜之间的关系; 进行激光聚焦调整的激光对焦部; 执行对比度聚焦调整的对比度焦点部分; 以及校正部，其基于从所述激光聚焦部发现的从所述液体透镜到所述被摄体的距离，以及由所述对比度聚焦部使所述被摄体对焦的对应的施加电压来校正所施加的电压表的内容。

26. 发明授权

US08608075B2 Code reading apparatus and computer program product 有权
标题翻译：代码阅读器和计算机程序产品
公开(公告)号：US08608075B2
公开(公告)日：2013-12-17
申请号：US13435724
申请日：2012-03-30
申请人： Masanori Tanimoto , Yasuaki Ogawa , Keiichi Tanioka
发明人： Masanori Tanimoto , Yasuaki Ogawa , Keiichi Tanioka
IPC分类号： G06K7/10
CPC分类号： G06K7/10811 , G06K7/10722
摘要： Disclosed is a code reading apparatus including a control section including: a first adjustment section repeating focus setting within a first execution time to execute first focus adjustment; a second adjustment section changing a focal position of a variable focal lens within a second execution time to execute second focus adjustment; a timer section counting a first execution number of the first focus adjustment and a second execution number of the second focus adjustment; and a time setting section setting the first execution time to be shortened starting from a predetermined first initial set time such that the first execution time is shortened as the first execution number increases, and setting the second execution time to be shortened starting from a predetermined second initial set time such that the second execution time is shortened as the second execution number increases.
摘要翻译：公开了一种代码读取装置，包括：控制部分，包括：第一调整部分，在第一执行时间内重复聚焦设置，以执行第一焦点调整; 第二调整部分，在第二执行时间内改变可变焦点透镜的焦点位置，以执行第二焦点调整; 计数第一焦点调整的第一执行次数和第二焦点调整的第二执行次数的定时器部分; 以及时间设定部，其从预定的第一初始设定时刻开始，将第一执行时间设定为缩短，使得随着第一执行次数增加，第一执行时间缩短，并且从预定秒开始将第二执行时间设定为缩短初始设定时间，使得随着第二执行次数增加，第二执行时间缩短。

27. 发明授权

US08456567B2 Imaging apparatus, imaging method, and computer-readable storage medium storing program therein 失效
标题翻译：成像装置，成像方法和存储程序的计算机可读存储介质
公开(公告)号：US08456567B2
公开(公告)日：2013-06-04
申请号：US12761695
申请日：2010-04-16
申请人： Tsuyoshi Endoh , Yasuaki Ogawa , Keiichi Tanioka
发明人： Tsuyoshi Endoh , Yasuaki Ogawa , Keiichi Tanioka
IPC分类号： H04N5/232
CPC分类号： G02B7/36 , G06K9/00228 , G06K9/209 , H04N5/23212 , H04N5/23219 , H04N5/23222
摘要： An imaging apparatus is equipped with a voltage control section, which individually controls the focus distance of a lens managed on the basis of each of a plurality of pieces of management information in accordance with a predetermined control condition corresponding to each of the pieces of management information and switches the focus distance of the lens at the time of imaging at a predetermined switching period in accordance with the focus distance indicated by each piece of management information while switching the plurality of pieces of management information at the predetermined switching period.
摘要翻译：成像装置配备有电压控制部，该电压控制部根据与各个管理信息对应的规定的控制条件，分别控制基于多个管理信息中的每一个管理的镜头的聚焦距离并根据每条管理信息指示的焦点距离，在预定的切换期间，在成像时切换镜头的聚焦距离，同时在预定切换周期切换多条管理信息。

28. 发明授权

US07378394B2 Sustained-release microparticle preparation of human growth hormone and process for producing thereof 失效
标题翻译：人生长激素的缓释微粒制剂及其制备方法
公开(公告)号：US07378394B2
公开(公告)日：2008-05-27
申请号：US10554574
申请日：2004-06-15
申请人： Yasuaki Ogawa , Takao Fujii , Yoko Miyamoto , Jun Niimi , Toshiyuki Ikoma , Junzo Tanaka
发明人： Yasuaki Ogawa , Takao Fujii , Yoko Miyamoto , Jun Niimi , Toshiyuki Ikoma , Junzo Tanaka
IPC分类号： A61K38/27 , A61K9/22
CPC分类号： A61K9/0019 , A61K9/1611 , A61K9/1694 , A61K9/19 , A61K38/27
摘要： Provided is a sustained-release microparticle preparation of a human growth hormone which combines biodegradability with sustained-release performance while avoiding the use of an organic solvent as much as possible, allows the sustained-release of a human growth hormone over 3 days or more and reduction in the initial burst release, can contain a human growth hormone at 10% or more, can quantitatively adsorb and encapsulate a human growth hormone at up to 20%, and has excellent dispersion and needle penetration properties. A process for producing the sustained-release microparticle preparation of a human growth hormone is also provided. The sustained-release microparticle preparation comprises a porous apatite derivative, a human growth hormone, and a water-soluble divalent metal compound.
摘要翻译：本发明提供了尽可能地避免使用有机溶剂的生物降解性与持续释放性能结合的人生长激素的持续释放微粒制剂，能够持续释放3天以上的人生长激素，初始爆发释放的减少可以含有10％以上的人生长激素，可以定量吸附和包封人生长激素达20％，具有优异的分散性和针刺性。还提供了生产人生长激素的缓释微粒制剂的方法。缓释微粒制剂包括多孔磷灰石衍生物，人生长激素和水溶性二价金属化合物。

29. 发明授权

US5668111A Sustained-release preparation 失效
标题翻译：缓释制剂
公开(公告)号：US5668111A
公开(公告)日：1997-09-16
申请号：US471382
申请日：1995-06-06
申请人： Shigeru Kamei , Yasutaka Igari , Yasuaki Ogawa
发明人： Shigeru Kamei , Yasutaka Igari , Yasuaki Ogawa
IPC分类号： A61K9/52 , A61K20060101 , A61K9/16 , A61K9/22 , A61K9/50 , A61K38/04 , A61K38/09 , A61K38/12 , A61K47/34 , A61K47/42 , C07K7/23 , A61K38/00 , C08G63/08
CPC分类号： C07K7/23 , A61K38/09 , A61K9/1647 , A61K38/00
摘要： A sustained-release preparation which comprises a physiologically active peptide of general formula ##STR1## wherein X represents an acyl group; R.sub.1, R.sub.2 and R.sub.4 each represents an aromatic cyclic group; R.sub.3 represents a D-amino acid residue or a group of the formula ##STR2## wherein R.sub.3 ' is a heterocyclic group; R.sub.5 represents a group of the formula --(CH.sub.2).sub.n --R.sub.5 ' wherein n is 2 or 3, and R.sub.5 ' is an amino group which may optionally be substituted, an aromatic cyclic group or an O-glycosyl group;R.sub.6 represents a group of the formula --(CH.sub.2).sub.n --R.sub.6 ' wherein n is 2 or 3, and R.sub.6 ' is an amino group which may optionally be substituted;R.sub.7 represents a D-amino acid residue or an azaglycyl residue; andQ represents hydrogen or a lower alkyl group, or a salt thereof and a biodegradable polymer having a terminal carboxyl group.The sustained-release preparation shows a constant release of the peptide over a long time and is substantially free from an initial burst.
摘要翻译：包含通式的生理活性肽的缓释制剂含有酰基; R1，R2和R4各自表示芳族环状基团; R 3表示D-氨基酸残基或式（D）的基团，其中R 3'为杂环基; R5表示式 - （CH2）n-R5'的基团，其中n为2或3，R5'为任选取代的氨基，芳族环基或O-糖基; R6表示式 - （CH2）n-R6'的基团，其中n为2或3，R6'为可任意取代的氨基; R7表示D-氨基酸残基或氮杂十八烷基残基; Q表示氢或低级烷基，或其盐和具有末端羧基的生物降解性聚合物。持续释放制剂显示长时间的肽的恒定释放并且基本上没有初始爆发。

30. 发明授权

US5651990A Prolonged release microparticle preparation and production of the same 失效
标题翻译：延长释放微粒的制备和生产相同
公开(公告)号：US5651990A
公开(公告)日：1997-07-29
申请号：US387392
申请日：1995-02-13
申请人： Shigeyuki Takada , Yoshiaki Uda , Yasuaki Ogawa
发明人： Shigeyuki Takada , Yoshiaki Uda , Yasuaki Ogawa
IPC分类号： A61K9/16 , A61K9/50 , A61K9/58 , A61K9/62 , B01J13/04
CPC分类号： A61K9/1694 , A61K9/1647 , A61K9/5015 , A61K9/5057 , A61K9/5073 , A61K9/5089 , Y10S514/963 , Y10T428/2984 , Y10T428/2985
摘要： A novel microparticle preparation comprising microparticles of a polymer which contain a drug and are coated with a film of an agent for preventing aggregation of the microparticles is disclosed. The preparation is produced by spraying a solution of a polymer containing a drug and an aqueous solution of an agent for preventing aggregation of the microparticles separately from different nozzles and contacting them with each other in a spray dryer.
摘要翻译：公开了一种新颖的微粒制剂，其包含含有药物的聚合物的微粒并涂覆有用于防止微粒聚集的试剂的膜。该制剂是通过喷雾含有药物的聚合物的溶液和用于防止微粒聚集的试剂的水溶液与不同的喷嘴分开并在喷雾干燥器中彼此接触来制备的。

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