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1. 发明授权

US11352464B2 Process to prepare polyester polymer and polyester polymer obtainable thereby 有权
公开(公告)号：US11352464B2
公开(公告)日：2022-06-07
申请号：US16337667
申请日：2017-09-27
申请人： Sulzer Chemtech AG
发明人： Liborio Ivano Costa , Peter Joachim Fleckenstein , Jan-Georg Rosenboom , Giuseppe Storti , Massimo Morbidelli
IPC分类号： C08G63/42 , C08G63/78 , C08G63/181 , C08G63/91 , C08G63/90 , C08K5/06 , C08K5/04 , C08K5/10 , C08K5/13
摘要： A process to produce a polyester polymer by polymerization of a cyclic polyester oligomer composition comprising a cyclic polyester oligomer having furanic units in the presence of a plasticizer, as well as the polyester polymer obtained thereby.

2. 发明授权

US11225551B2 Amphiphilic block copolymer, preparation method thereof and nanomicelle drug-loading system 有权
公开(公告)号：US11225551B2
公开(公告)日：2022-01-18
申请号：US16969397
申请日：2019-02-12
申请人： Fuyao Zhang
发明人： Fuyao Zhang , Yuxiang Shao , Huoming Li
IPC分类号： C08G65/48 , A61K9/107 , C08G63/87 , C08G63/90 , C08G63/91 , C08G65/333 , B82Y5/00
摘要： The present invention relates to an amphiphilic block copolymer represented by formula I, a preparation method thereof, and a nanomicelle drug delivery system formed from the copolymer and a poorly soluble drug. The amphiphilic block copolymer includes a hydrophilic chain segment, a hydrophobic chain segment, and a linker for linking the hydrophilic chain segment to the hydrophobic chain segment. The linker contains an unsaturated structure, which can enhance the interaction between the poorly soluble drug and the copolymer to improve the drug loading ability and stability of the nanomicelle. The invention also relates to a nanomicelle drug-loading system, a preparation method thereof, and the use of the nanomicelle drug-loading system for preparing medicines for treating tumors, inflammation, diabetes, central nervous system diseases, cardiovascular diseases, and psychological disorders.

3. 发明申请

US20210340316A1 METHOD FOR SEPARATING PHA AND PHA PREPARED THEREFROM 有权
公开(公告)号：US20210340316A1
公开(公告)日：2021-11-04
申请号：US17137545
申请日：2020-12-30
申请人： COFCO (jilin) Bio-Chemical Technology CO., Ltd , Nutrition & Health Research Institute, COFCO Corporation , COFCO BIOTECHNOLOGY CO., LTD.
发明人： Yi Tong , Yi Li , Fang Tian , Kejia Xu , Yuanheng Guo , Bo Chen , Tai An , Dayong Li , Haijun Liu , Lida Wu
IPC分类号： C08G63/90 , C12P7/62 , B01D39/08 , B01D1/16 , B01D21/26 , B01D37/02
摘要： Provided a method for separating PHA and PHA prepared therefrom. The method comprises the following steps: subjecting a PHA fermentation broth to solid-liquid separation to obtain a thallus precipitate; breaking cell walls of the thallus precipitate, and subjecting obtained wall-broken products to a plate and frame filtration to obtain PHA; a filter cloth for the plate and frame filtration is pre-coated with a PHA layer. The method adopts a plate and frame separation to replace the traditional centrifugal separation to prepare PHA, and the PHA layer is pre-coated on the filter cloth for the plate and frame filtration, thereby overcome the defects in the prior art such as high cost and operational difficulty caused by adopting multiple centrifugal separations; in addition, the method of the present disclosure also exhibits the advantages of high recovery rate of PHA and high purity of the prepared PHA product.

4. 发明授权

US11149111B2 Process to prepare a cyclic oligomer and a cyclic oligomer obtainable thereby and a process to polymerize it 有权
公开(公告)号：US11149111B2
公开(公告)日：2021-10-19
申请号：US16606388
申请日：2018-03-23
申请人： Sulzer Management AG
发明人： Liborio Ivano Costa , Peter Joachim Fleckenstein , Jan-Georg Rosenboom , Giuseppe Storti , Massimo Morbidelli
IPC分类号： C08G63/181 , C08G63/81 , C08G63/90 , C08G63/91
摘要： A process to prepare a (iv) cyclic polyester oligomer composition includes a cyclic polyester oligomer having furanic units and two to five repeat units. The process includes (a) reacting a monomer composition including: (i) a bifunctional furan-derivative and (ii) a diol in an linear oligomerization step to produce a (iii) linear oligomer composition including a linear oligomer species, (b) reacting the (iii) linear oligomer composition in a distillation-assisted cyclization (DA-C) step to form a (iv) cyclic polyester oligomer composition and a (v) diol byproduct. The (v) diol byproduct is removed by evaporation in the distillation-assisted cyclization (DA-C) step.

5. 发明申请

US20200283568A1 COMPOSITION 审中-公开
公开(公告)号：US20200283568A1
公开(公告)日：2020-09-10
申请号：US16765297
申请日：2018-11-20
申请人： Rebio Technologies Oy , Rebio Technologies Limited , Rebio Technologies Limited
发明人： Jonathan Glen , Harri Jukarainen , Jukka Tuominen
IPC分类号： C08G63/08 , A61K38/26 , A61K9/00 , A61K9/16 , A61K47/34 , C08G63/90
摘要： Provided herein is a bioresorbable polyester wherein the metal content of the polyester is >0 ppm and 0 ppm comprising the steps of: i) dissolving the polyester in an organic solvent to form a polyester-solvent solution, wherein the organic solvent comprises at least one heteroatom selected from oxygen, nitrogen, sulphur and phosphorus; ii) precipitating the polyester from the polyester-solvent solution by combining the polyester-solvent solution with an organic non-solvent, said non-solvent being an alcohol; and (iii) separating the precipitated polyester from the solvent and non-solvent to obtain a purified polyester.

6. 发明申请

US20190352457A1 METHOD FOR THE SEPARATION OF VOLATILE COMPOUNDS FROM VISCOUS PRODUCTS BY MEANS OF A THIN-FILM EVAPORATOR, AND POLYLACTIDE RESIN 审中-公开
公开(公告)号：US20190352457A1
公开(公告)日：2019-11-21
申请号：US16346899
申请日：2017-11-03
申请人： UHDE INVENTA-FISCHER GMBH , thyssenkrupp AG
发明人： Udo MÜHLBAUER , Rainer HAGEN
IPC分类号： C08G63/90 , C08G63/08 , C08G63/78 , B01D1/06 , B01D1/00
摘要： A method for removing compounds in the gaseous aggregate state from PLA-containing products in the viscous aggregate state by means of a thin-film evaporator. The compounds may be present in the liquid or solid aggregate state in the products under standard conditions. The invention further relates to a polylactide resin prepared in accordance with the method of the invention.

7. 发明申请

US20180071438A1 BIODEGRADABLE POLYMERS 审中-公开
公开(公告)号：US20180071438A1
公开(公告)日：2018-03-15
申请号：US15812030
申请日：2017-11-14
申请人： Micell Technologies, Inc.
发明人： Charles Douglas Taylor , James B. McClain , Edward Schmitt
IPC分类号： A61L31/10 , A61K31/435 , C09D5/03 , B05D3/12 , C08G63/06 , A61L31/14 , C09D167/04 , C08L67/04 , C08J7/04 , C08G63/90 , C08G63/08 , A61L31/16
CPC分类号： A61L31/10 , A61K31/435 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2420/02 , A61L2420/06 , A61L2420/08 , B05D3/12 , B05D2254/06 , C08G63/06 , C08G63/08 , C08G63/90 , C08G2150/20 , C08G2230/00 , C08J7/047 , C08L67/04 , C09D5/033 , C09D167/04
摘要： Provided herein is a composition comprising a poly(alpha-hydroxycarboxylic acid) substantially free of acidic impurities wherein the poly(alpha-hydroxycarboxylic acid) is selected from poly(D,L-lactic-co-glycolic acid), poly(L-lactic acid), poly(D-lactic acid) and poly(D,L-lactic acid). Also provided is a device comprising: a substrate, and a coating wherein the coating comprises poly(D,L-lactic-co-glycolic acid) substantially free of acidic impurities.

8. 发明授权

US09790331B2 Process for preparing a bio-resorbable polyester in the form of a powder 有权
公开(公告)号：US09790331B2
公开(公告)日：2017-10-17
申请号：US14912302
申请日：2013-08-29
申请人： Hans Baer , Felix Hofmann , Silke Schminke , Julian Blaesy , Isabel Wahl
发明人： Hans Baer , Felix Hofmann , Silke Schminke , Julian Blaesy , Isabel Wahl
IPC分类号： C08J3/14 , C08J3/12 , C08G63/90 , A61L27/18 , A61L31/06 , A61K47/34 , A61L31/14 , C08G63/08
CPC分类号： C08J3/14 , A61K47/34 , A61L27/18 , A61L31/06 , A61L31/148 , C08G63/08 , C08G63/90 , C08J3/12 , C08J2367/04 , C08L67/04
摘要： The invention refers to a Process for preparing a bio-resorbable polyester the form of a powder with a bulk density of 0.3 g/ml or more, a tapped density of 0.4 g/ml or more and a specific surface area of 2.0 m2/g or less comprising the steps a. dissolving a bio-resorbable polyester in a first solvent to form a polymer solution, b. contacting the polymer solution with a second solvent which is a non-solvent for the bioresorbable polyester and which is mainly water to result the precipitation of the bio-resorbable polyester in the form of a wet polymer mass, c. pre-drying the wet polymer mass at a temperature below the TgO of the bio-resorbable polyester, d. comminuting the pre-dried polymer mass to polymer particles with a size below 10 mm, e. drying the comminuted polymer particles below the TgO of the bio-resorbable polyester to a residual water content of 1% or less by weight/weight, f. post-treatment of the polymer particles from step e at a temperature in the range from the TgO to the TgE of the bio-resorbable polyester, g. comminuting the polymer particles from step f to a powder with a particle size of d50 of 1-300 μm and d90 of more than 30 and up to 3000 μm.

9. 发明授权

US09687594B2 Method of treating with poly(L-lactide) stent with tunable degradation rate 有权
公开(公告)号：US09687594B2
公开(公告)日：2017-06-27
申请号：US14970890
申请日：2015-12-16
申请人： Abbott Cardiovascular Systems Inc.
发明人： Yunbing Wang , Xiao Ma , James Oberhauser
IPC分类号： A61F2/06 , A61L31/14 , A61L31/06 , C08G63/08 , C08G63/90 , A61F2/89 , A61F2/82 , C08L67/04 , C09J167/04 , A61K9/20 , C09D167/04 , A61K9/16 , A61F2/958 , A61F2/30
CPC分类号： A61L31/148 , A61F2/82 , A61F2/89 , A61F2/958 , A61F2002/30062 , A61F2210/0004 , A61K9/1647 , A61K9/204 , A61L31/06 , B29C47/0066 , B29K2067/046 , B29L2031/7534 , C08G63/08 , C08G63/90 , C08J2367/04 , C08L67/04 , C09D167/04 , C09J167/04
摘要： Methods of treating with a biodegradable polymeric stent made from poly(L-lactide) and a low concentration of L-lactide monomer is disclosed. The concentration of L-lactide is adjusted to provide a degradation behavior that is suitable for different treatment applications including coronary, peripheral, and nasal.

10. 发明申请

US20170107324A1 Method of isolation of polyhydroxyalkanoates (PHAs) from biomass fermented by microorganisms producing polyhydroxyalkanoates (PHAs) and/or from biomass containing at least one crop-plant producing polyhydroxyalkanoates 有权
公开(公告)号：US20170107324A1
公开(公告)日：2017-04-20
申请号：US15315895
申请日：2015-06-02
申请人： VYSOKA SKOLA CHEMICKO-TECH-NOLOGICKA V PRAZE , NAFIGATE CORPORATION, A. S.
发明人： Jiri Trejbal , Martin Zapletal
IPC分类号： C08G63/90
CPC分类号： C08G63/90 , C12P7/625
摘要： The invention relates to a method of isolation of polyhydroxyalkanoates from biomass fermented by microorganisms producing polyhydroxyalkanoates and/or from biomass containing at least one crop-plant producing polyhydroxyalkanoates in which from the biomass which, if fermented, is first inspissated by the isolation from a fermentation medium to a dry matter content of at least 20%, polyhydroxyalkanoates are extracted with an extraction agent based on chlorinated hydrocarbon, whereupon from the extraction solution thus obtained an extract is separated, from which the extraction agent is removed and polyhydroxyalkanoates precipitate. Prior to the extraction of polyhydroxyalkanoates, components of the biomass other than polyhydroxyalkanoates are extracted from the biomass by means of an extraction agent based on alkyl alcohol having 2 to 4 carbon atoms in the chain, which is added to the biomass in a weight ratio of 1:0.5 to 1:5, whereby extraction is carried out for 5 to 90 minutes, at a temperature of 20 to 120° C., whereupon the extract containing these components of the biomass is separated from the extraction solution thus obtained by filtration and/or decantation and/or centrifugation, and the remainder of the extraction agent is removed from the solid phase by distillation of an aqueous solution or by stripping with water vapour or by drying. From the solid phase thus pre-cleaned polyhydroxyalkanoates are extracted by an extraction agent based on chlorinated hydrocarbon, which is added to it in a weight ratio of 1:5 to 1:20, whereby this extraction operation is carried out for 5 to 90 minutes, preferably for 20 to 40 minutes, at a temperature in the range of 20 to 120° C., whereupon the extract containing polyhydroxyalkanoates is separated from the extraction solution thus obtained by filtration and/or decantation and/or centrifugation. This extract is subsequently fed or is continuously fed to a circulation loop filled with water having a temperature from 20 to 120° C., or, in case of need, by a mixture made from water and from up to 20% by weight of chlorinated hydrocarbon extraction agent used for the extraction of the polyhydroxyalkanoates, by which means the extraction agent is removed from this extract and polyhydroxyalkanoates precipitate.

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